Browsing Articles publicats (Ciències Mèdiques Bàsiques) by Title
Now showing items 225-244 of 502
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HBPF: a Home Blood Pressure Framework with SLA guarantees to follow up hypertensive patients
(PeerJ, 2016)Hypertension or high blood pressure is a condition on the rise. Not only does it affect the elderly but is also increasingly spreading to younger sectors of the population. Treating it involves exhaustive monitoring of ... -
Heat shock response in yeast involves changes in both transcription rates and mRNA stabilities
(Public Library of Science (PLoS), 2011)We have analyzed the heat stress response in the yeast Saccharomyces cerevisiae by determining mRNA levels and transcription rates for the whole transcriptome after a shift from 25uC to 37uC. Using an established mathematical ... -
Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis
(Elsevier, 2016)Background & Aims The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote ... -
HGF regulates the development of cortical pyramidal dendrites
(Company of Biologists Ltd., 2004-08)Although hepatocyte growth factor (HGF) and its receptor tyrosine kinase MET are widely expressed in the developing and mature central nervous system, little is known about the role of MET signaling in the brain. We have ... -
HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy
(Nature Publishing Group, 2017-12-01)Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For ... -
High levels of hemoglobin promote carotid adventitial vasa vasorum neoangiogenesis in chronic kidney disease
(Hindawi, 2017-01-04)Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa ... -
High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene
(Elsevier, 2004)The gene encoding AIB1, an estrogen receptor coactivator, is amplified in a subset of human breast cancers. Here we show that overexpression of AIB1 in transgenic mice (AIB1-tg) leads to mammary hypertrophy, hyperplasia, ... -
High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations
(Lippincott, Williams & Wilkins, 2019)This review of challenging diagnostic issues concerning high-grade endometrial carcinomasisderivedfromtheauthors’ reviewoftheliteraturefollowedbydiscussionsatthe Endometrial Cancer Workshop sponsored by the International ... -
Hippocampal neurons require a large pool of glutathione to sustain dendrite integrity and cognitive function
(Elsevier, 2018)Loss of brain glutathione has been associated with cognitive decline and neuronal death during aging and neurodegenerative diseases. However, whether decreased glutathione precedes or follows neuronal dysfunction has not ... -
Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe
(Nature Publishing Group, 2014-10-02)Glioblastoma multiforme is resistant to conventional anti-tumoral treatments due to its infiltrative nature and capability of relapse; therefore, research efforts focus on characterizing gliomagenesis and identifying ... -
Human Menstrual Blood-Derived Mesenchymal Stem Cells as Potential Cell Carriers for Oncolytic Adenovirus
(Hindawi, 2017)Antitumor efficacy of systemically administered oncolytic adenoviruses (OAdv) is limited due to diverse factors such as liver sequestration, neutralizing interactions in blood, elimination by the immune system, and physical ... -
Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
(Nature Publishing Group, 2016-10-11)Background: Histone deacetylase inhibitors (HDACis) like vorinostat are promising radiosensitisers in prostate cancer, but their effect under hypoxia is not known. We investigated gene expression associated with ... -
Hysteretic and graded responses in bacterial two-component signal transduction
(Blackwell, 2008)Bacterial two-component systems (TCS) are key signal transduction networks regulating global responses to environmental change. Environmental signals may modulate the phosphorylation state of sensor kinases (SK). ... -
Identification and Analysis of Conserved cis-Regulatory Regions of the MEIS1 Gene
(Public Library of Science, 2012)Meis1, a conserved transcription factor of the TALE-homeodomain class, is expressed in a wide variety of tissues during development. Its complex expression pattern is likely to be controlled by an equally complex regulatory ... -
Identification of line-specific strategies for improving carotenoid production in synthetic maize through data-driven mathematical modeling
(Wiley online library, 2016)Plant synthetic biology is still in its infancy. However, synthetic biology approaches have been used to manipulate and improve the nutritional and health value of staple food crops such as rice, potato and maize. With ... -
Identification of regulatory structure and kinetic parameters of biochemical networks via mixed-integer dynamic optimization
(BioMed Central, 2013)Background: Recovering the network topology and associated kinetic parameter values from time-series data are central topics in systems biology. Nevertheless, methods that simultaneously do both are few and lack ... -
Identification of the Major Oxidatively Damaged Proteins in Escherichia coli Cells Exposed to Oxidative Stress
(American Society for Biochemistry and Molecular Biology, 1998)In the present study we have analyzed protein oxidation on Escherichia coli when these cells were submitted to different stress conditions such as hydrogen peroxide, superoxide-generating compounds, and iron ... -
Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive responses
(BioMed Central, 2009)Background: Optimization methods allow designing changes in a system so that specific goals are attained. These techniques are fundamental for metabolic engineering. However, they are not directly applicable for investigating ... -
Identifying the preferred subset of enzymatic profiles in nonlinear kinetic metabolic models via multiobjective global optimization and pareto filters
(Public Library of Science (PLoS), 2012)Optimization models in metabolic engineering and systems biology focus typically on optimizing a unique criterion, usually the synthesis rate of a metabolite of interest or the rate of growth. Connectivity and non-linear ... -
Identifying thoracic malignancies through pleural fluid biomarkers: a predictive multivariate model
(Wolters Kluwer Health, 2016-03-01)The diagnosis of malignant pleural effusions may be challenging when cytological examination of aspirated pleural fluid is equivocal or noncontributory. The purpose of this study was to identify protein candidate biomarkers ...