Now showing items 210-229 of 501

    • GATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1 

      Zhong, Yi; Wang, Zheng; Fu, Baojin; Pan, Fan; Yachida, Shinichi; Dhara, Mousumi; Albesiano, Emilia; Li, Li; Naito, Yoshiki; Vilardell, Felip; Cummings, Christopher; Martinelli, Paola; Li, Ang; Yonescu, Raluca; Ma, Qingyong; Griffin, Constance A.; Real, Francisco X.; Iacobuzio-Donahue, Christine A. (Public Library of Science, 2011)
      Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease characterized by late diagnosis and treatment resistance. Recurrent genetic alterations in defined genes in association with perturbations of developmental ...
    • Gender, sequence of cases and day effects on clinical skills assessment with standardized patients 

      Gispert i Magarolas, Rosa; Rué i Monné, Montserrat; Roma, J.; Martinez-Carretero, M. (Wiley, 1999)
      Context Clinical skills assessment using standardized patients (SPs) is an accepted method of professional testing, but some factors can threaten the validity of the scores obtained. Objective The main objective of ...
    • Genetic associations of the vitamin D and antiviral pathways with natural resistance to HIV-1 infection are influenced by interpopulation variability 

      Aguilar-Jiménez, Wbeimar; Zapata, Wildeman; Rivero-Juárez, Antonio; Pineda, Juan Antonio; Laplana Lafaja, Marina; Taborda, Natalia A.; Biasin, Mara; Clerici, Mario; Caruz, Antonio; Fibla Palazón, Joan; Rugeles, Maía T. (Elsevier, 2019)
      Vitamin D (VitD) may modulate anti-HIV-1 responses modifying the risk to acquire the HIV-1-infection. We performed a nested case-control exploratory study involving 413 individuals; HIV-1-exposed seropositives (cases) and ...
    • Genetic structure of the Spanish population 

      Gayán, Javier; Galan, José J.; González-Pérez, Antonio; Sáez, María Eugenia; Martínez-Larrad, María Teresa; Zabena, Carina; Rivero, M. Carmen; Salinas, Ana; Ramírez-Lorca, Reposo; Morón, Francisco J.; Royo Sánchez-Palencia, José Luis; Moreno-Rey, Concha; Velasco, Juan; Carrasco, José M.; Molero, Eva; Ochoa, Carolina; Ochoa, María Dolores; Gutiérrez, Marta; Reina, Mercedes; Pascual, Rocío; Romo-Astorga, Alejandro; Susillo-González, Juan Luis; Vázquez, Enrique; Real, Luis M.; Ruiz, Agustín; Serrano-Ríos, Manuel (BioMed Central, 2010-05-25)
      Background Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. ...
    • Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer’s disease 

      Sáez, M. E.; González-Pérez, Antonio; Hernández-Olasagarre, B.; Beà Tàrrega, Aida; Moreno-Grau, S.; de Rojas, I.; Monté-Rubio, G.; Orellana, A.; Valero, S.; Comella i Carnicé, Joan Xavier; Sanchis, Daniel; Ruiz, Agustín (Nature Publishing Group, 2019)
      Echocardiography has become an indispensable tool for the study of heart performance, improving the monitoring of individuals with cardiac diseases. Diverse genetic factors associated with echocardiographic measures have ...
    • Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain 

      Cullell, Natalia; Carrera, Caty; Muiño, Elena; Torres-Aguila, Nuria-Paz; Cárcel-Márquez, Jara; González-Sánchez, Jonathan; Gallego Fabrega, Cristina; Molina, Jessica; Besora, Sarah; Sotoca, Javier; Buongiorno, Maria-Teresa; Jiménez-Conde, Jordi; Giralt-Steinhauer, Eva; de Torres-Chacón, Reyes; Montaner, Joan; Mancha, Fernando; Cabezas, Juan A.; Martí Fàbregas, Joan; Prats Sánchez, Luis; Camps Renom, Pol; Purroy Garcia, Francisco; Cambray Carner, Serafí; Freijo, María del Mar; Vives-Bauzá, Cristòfol; Tur, Silvia; Font, Maria-Àngels; López-Cancio, Elena; Hernandez-Perez, Maria; Obach, Victor; Calleja, Ana; Arenillas, Juan; Rodríguez-Yáñez, Manuel; Castillo, José; Sobrino, Tomas; Fernández-Cádenas, Israel; Krupinski, Jerzy (Nature Publishing Group, 2020)
      Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms ...
    • Genomic profiling of primary and recurrent adult granulosa cell tumors of the ovary 

      Gatius Calderó, Sònia; Cruz Paula, Arnaud Da; Silva, Edaise M. da; Segura, Sheila E.; Pareja, Fresia; Bi, Rui; Selenica, Pier; Kim, Sarah H.; Ferrando, Lorenzo; Vahdatinia, Mahsa; Soslow, Robert A.; Vidal, August; Przybycin, Christopher G.; Abu-Rustum, Nadeem R.; Matias-Guiu, Xavier; Rubin, Brian P.; Reis-Filho, Jorge S.; DeLair, Deborah F.; Weigelt, Britta (2020)
      Adult-type granulosa cell tumor (aGCT) is a rare malignant ovarian sex cord-stromal tumor, harboring recurrent FOXL2 c.C402G/p.C134W hotspot mutations in 97% of cases. These tumors are considered to have a favorable ...
    • Genotyping of common SIRPB1 copy number variant using Paralogue Ratio Test coupled to MALDI-MS quantification 

      Royo Sánchez-Palencia, José Luis; Pascual Pons, Mariona; Lupiañez, Arantxa; Sanchez Lopez, Isabel; Fibla Palazón, Joan (Elsevier, 2015)
      Copy number variant (CNV) regions have been proven to have a significant impact on gene expression. Some of them have been also found to be associated to different human diseases. CNV genotyping is often prone to error and ...
    • GESAP trial rationale and methodology: management of patients with suspected obstructive sleep apnea in primary care units compared to sleep units 

      Tarraubella Balanya, Núria; Batlle Garcia, Jordi de; Nadal Braque, Núria; Castro-Grattoni, Anabel L.; Gómez Falguera, Silvia; Sánchez de la Torre, Manuel; Barbé Illa, Ferran (Nature Publishing Group, 2016-12)
      BACKGROUND Obstructive sleep apnea syndrome (OSA) is a chronic sleep disorder characterized by repeated episodes of upper airway collapse during sleep. This leads to arterial hypoxemia and sleep disruption and causes daytime ...
    • Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae 

      Pujol Carrión, Núria; Bellí i Martínez, Gemma; Herrero Perpiñán, Enrique; Nogues, Antoni; Torre Ruiz, M. A. de la (Company of Biologists, 2006)
      Grx3 and Grx4, two monothiol glutaredoxins of Saccharomyces cerevisiae, regulate Aft1 nuclear localisation. We provide evidence of a negative regulation of Aft1 activity by Grx3 and Grx4. The Grx domain of both proteins ...
    • Glutaredoxins Grx4 and Grx3 of Saccharomyces cerevisiae Play a Role in Actin Dynamics through Their Trx Domains, Which Contributes to Oxidative Stress Resistance 

      Pujol Carrión, Núria; Torre Ruiz, M. A. de la (American Society for Microbiology, 2010)
      Grx3 and Grx4 are two monothiol glutaredoxins of Saccharomyces cerevisiae that have previously been characterized as regulators of Aft1 localization and therefore of iron homeostasis. In this study, we present data showing ...
    • Glutaredoxins in fungi 

      Herrero Perpiñán, Enrique; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi; Bellí i Martínez, Gemma (Springer, 2006)
      Glutaredoxins (GRXs) can be subdivided into two subfamilies: dithiol GRXs with the CPY/FC active site motif, and monothiol GRXs with the CGFS motif. Both subfamilies share a thioredoxin-fold structure. Monothiol GRXs exist ...
    • Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae 

      Rodríguez Manzanaque, Maria Teresa; Ros Salvador, Joaquim; Cabiscol Català, Elisa; Sorribas Tello, Albert; Herrero Perpiñán, Enrique (American Society for Microbiology, 1999)
      Glutaredoxins are members of a superfamily of thiol disulfide oxidoreductases involved in maintaining the redox state of target proteins. In Saccharomyces cerevisiae, two glutaredoxins (Grx1 and Grx2) containing a cysteine ...
    • Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes 

      Rodríguez-Manzaneque Martínez, María Teresa; Tamarit Sumalla, Jordi; Bellí i Martínez, Gemma; Ros Salvador, Joaquim; Herrero Perpiñán, Enrique (American Society for Cell Biology, 2002)
      Yeast cells contain a family of three monothiol glutaredoxins: Grx3, 4, and 5. Absence of Grx5 leads to constitutive oxidative damage, exacerbating that caused by external oxidants. Phenotypic defects associated with the ...
    • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 

      Klionsky, Daniel J.; Cantí Nicolás, Carles; Garcera, Ana; Herreros Danés, Judit; Soler i Tatché, Rosa Ma.; others (Taylor & Francis, 2021-02-08)
      In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant ...
    • HBPF: a Home Blood Pressure Framework with SLA guarantees to follow up hypertensive patients 

      Cuadrado, Josep; Vilaplana Mayoral, Jordi; Mateo Fornés, Jordi; Solsona Tehàs, Francesc; Solsona, Sara; Rius Torrentó, Josep Maria; Alves, Rui; Camafort, Miguel; Torres, Gerard; Betriu i Bars, M. Àngels; Gutiérrez Vilaplana, Josep M.; Fernández i Giráldez, Elvira (PeerJ, 2016)
      Hypertension or high blood pressure is a condition on the rise. Not only does it affect the elderly but is also increasingly spreading to younger sectors of the population. Treating it involves exhaustive monitoring of ...
    • Heat shock response in yeast involves changes in both transcription rates and mRNA stabilities 

      Castells i Roca, Laia; García-Martínez, José; Moreno, Joaquín; Herrero Perpiñán, Enrique; Bellí i Martínez, Gemma; Pérez-Ortín, José E. (Public Library of Science (PLoS), 2011)
      We have analyzed the heat stress response in the yeast Saccharomyces cerevisiae by determining mRNA levels and transcription rates for the whole transcriptome after a shift from 25uC to 37uC. Using an established mathematical ...
    • Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis 

      Bozić Stanojević, Milica; Guzmán, Carla; Benet, Marta; Sánchez-Campos, Sonia; García-Monzón, Carmelo; Garí Marsol, Eloi; Gatius Calderó, Sònia; Valdivielso Revilla, José Manuel; Jover, Ramiro (Elsevier, 2016)
      Background & Aims The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote ...
    • HGF regulates the development of cortical pyramidal dendrites 

      Gutierrez, Humberto; Dolcet Roca, Xavier; Tolcos, Mary; Davies, Alun M. (Company of Biologists Ltd., 2004-08)
      Although hepatocyte growth factor (HGF) and its receptor tyrosine kinase MET are widely expressed in the developing and mature central nervous system, little is known about the role of MET signaling in the brain. We have ...
    • HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy 

      Mangraviti, Antonella; Raghavan, Tula; Volpin, Francesco; Skuli, Nicolas; Gullotti, David; Zhou, Jinyuan; Asnaghi, Laura; Sankey, Eric; Liu, Ann; Wang, Yuan; Lee, Dong-Hoon; Gorelick, Noah; Serra, Riccardo; Peters, Michael; Schriefer, Destiny; Delaspre, Fabien; Rodriguez, Fausto J.; Eberhart, Charles G.; Brem, Henry; Olivi, Alessandro; Tyler, Betty (Nature Publishing Group, 2017-12-01)
      Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For ...