Browsing Articles publicats (Ciències Mèdiques Bàsiques) by Title
Now showing items 216-235 of 559
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Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes
(Shiraz University of Medical Sciences, 2021)BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) has a prognostic value in locally advanced rectal cancer (LARC). This study aimed to evaluate the ability to predict pCR using ... -
Factors predicting cardiovascular events in chronic kidney disease patients. Role of subclinical atheromatosis extent assessed by vascular ultrasound
(Public Library of Science, 2017)Patients with chronic kidney disease (CKD) have an increased incidence of cardiovascular events (CVE). The contribution of subclinical atheromatosis extent, including femoral arteries, to CVE in CKD patients has not been ... -
Factors predicting failure of endoscopic injection therapy in bleeding duodenal ulcer
(Elsevier, 1996)Background: The aim of this study was to assess the factors that may cause failure of endoscopic injection in patients bleeding from a duodenal ulcer. Methods: One hundred twenty patients admitted for a bleeding duodenal ... -
Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia
(Nature Research, 2019)Gut microbiota has been suggested to affect lipid metabolism. The objective of this study was to characterize the faecal microbiota signature and both short chain fatty acids (SCFAs) and bile acids (BA) profile of ... -
FAIM-L Is an IAP-Binding Protein That Inhibits XIAP Ubiquitinylation and Protects from Fas-Induced Apoptosis
(Society for Neuroscience, 2013)The neuronal long isoform of Fas Apoptotic Inhibitory Molecule (FAIM-L) protects from death receptor (DR)-induced apoptosis, yet its mechanism of protection remains unknown. Here, we show that FAIM-L protects rat neuronal ... -
FAK inhibition induces glioblastoma cell senescence-like state through p62 and p27
(MDPI, 2020-04-27)Focal adhesion kinase (FAK) is a central component of focal adhesions that regulate cancer cell proliferation and migration. Here, we studied the effects of FAK inhibition in glioblastoma (GBM), a fast growing brain tumor ... -
Feasibility and acceptability of personalised breast cancer screening (DECIDO study): protocol of a single-arm proof-of-concept trial
(BMJ Publishing Group, 2020-12-23)Introduction Personalised cancer screening aims to improve benefits, reduce harms and being more cost-effective than age-based screening. The objective of the DECIDO study is to assess the acceptability and feasibility of ... -
First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass
(eLife Sciences Publications, 2015-07-28)Whole-organism chemical screening can circumvent bottlenecks that impede drug discovery. However, in vivo screens have not attained throughput capacities possible with in vitro assays. We therefore developed a method ... -
FISH analysis of PTEN in endometrial carcinoma. Comparison with SNP arrays and MLPA
(Wiley, 2014)Aims: To check the usefulness of a standardized protocol of PTEN FISH in 31 endometrial carcinomas (ECs) in comparison with SNP array (SNPA), multiplex ligation-dependent probe amplification (MLPA), and immunohistochemistry. ... -
FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis
(Nature Publishing Group, 2005)The FLICE-inhibitory protein (FLIP) plays a key role in the regulation of apoptosis triggered by death ligands. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis in some types ... -
FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons
(EMBO Press, 2011)Netrin-1 induces repulsive axon guidance by binding to the mammalian Unc5 receptor family (Unc5A–Unc5D). Mouse genetic analysis of selected members of the Unc5 family, however, revealed essential functions independent of ... -
FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development
(Society for Neuroscience, 2021)Neuron migration is a hallmark of nervous system development that allows gathering of neurons from different origins for assembling of functional neuronal circuits. Cortical inhibitory interneurons arise in the ventral ... -
FLRT3 Is a Robo1-Interacting Protein that Determines Netrin-1 Attraction in Developing Axons
(Elsevier, 2014)Background: Guidance molecules are normally presented to cells in an overlapping fashion; however, little is known about how their signals are integrated to control the formation of neural circuits. In the thalamocortical ... -
Foundations of Theoretical Approaches in Systems Biology
(Frontiers Media, 2018) -
Fracaso renal agudo secundario a crisis de hipercalcemia muy severa por hiperparatiroidismo primario
(Elsevier, 2015)La crisis hipercalcémica es una forma de presentación poco frecuente del hiperparatiroidismo primario. Solo existen pequeñas series de casos reportadas en la literatura1 and 2. Se caracteriza por hipercalcemia severa, ... -
Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism
(Elsevier, 2014)Friedreich ataxia (FRDA) is a hereditary disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis, energy metabolism, and oxidative stress. Patients with FRDA experience ... -
Frataxin depletion in yeast triggers up-regulation of iron transport systems before affecting iron-sulfur enzyme activities
(The American Society for Biochemistry and Molecular Biology, 2010)The primary function of frataxin, a mitochondrial protein involved in iron homeostasis, remains controversial. Using a yeast model of conditional expression of the frataxin homologue YFH1, we analyzed the primary effects ... -
Frataxin-deficient cardiomyocytes present an altered thiol-redox state which targets actin and pyruvate dehydrogenase
(Elsevier, 2020)Friedreich ataxia (FA) is a cardioneurodegenerative disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis, energy metabolism, and oxidative stress. Previously, we ... -
Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment
(Wiley Open Access, 2018)Friedreich ataxia (FA) is a rare disease caused by deficiency of frataxin, a mitochondrial protein. As there is no cure available for this disease, many strategies have been developed to reduce the deleterious effects of ... -
Frequentist and Bayesian approaches for a joint model for prostate cancer risk and longitudinal PSA data
(Taylor & Francis, 2014)The paper describes the use of frequentist and Bayesian shared-parameter joint models of longitudinal measurements of prostate specific antigen (PSA) and the risk of prostate cancer (PCa). The motivating dataset corresponds ...