Now showing items 192-211 of 502

    • Factors predicting cardiovascular events in chronic kidney disease patients. Role of subclinical atheromatosis extent assessed by vascular ultrasound 

      Valdivielso Revilla, José Manuel; Betriu i Bars, M. Àngels; Martínez Alonso, Montserrat; Arroyo, David; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira (Public Library of Science, 2017)
      Patients with chronic kidney disease (CKD) have an increased incidence of cardiovascular events (CVE). The contribution of subclinical atheromatosis extent, including femoral arteries, to CVE in CKD patients has not been ...
    • Factors predicting failure of endoscopic injection therapy in bleeding duodenal ulcer 

      Brullet, Enric; Calvet, Xavier; Campo, Rafel; Rué i Monné, Montserrat; Catot, Llúcia; Donoso, Lluis (Elsevier, 1996)
      Background: The aim of this study was to assess the factors that may cause failure of endoscopic injection in patients bleeding from a duodenal ulcer. Methods: One hundred twenty patients admitted for a bleeding duodenal ...
    • Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia 

      Granado-Serrano, Ana Belén; Martín Garí, Meritxell; Sánchez, V.; Riart Solans, M.; Berdún Hernández, Rebeca; Ludwig, Iziar A.; Rubió Piqué, Laura; Vilaprinyo Terré, Ester; Portero Otín, Manuel; Serrano Casasola, José Carlos Enrique (Nature Research, 2019)
      Gut microbiota has been suggested to affect lipid metabolism. The objective of this study was to characterize the faecal microbiota signature and both short chain fatty acids (SCFAs) and bile acids (BA) profile of ...
    • FAIM-L Is an IAP-Binding Protein That Inhibits XIAP Ubiquitinylation and Protects from Fas-Induced Apoptosis 

      Moubarak, Rana S.; Planells Ferrer, Laura; Urresti, Jorge; Reix, Stéphanie; Segura Ginard, Miguel Francisco; Carriba, Paulina; Marqués Fernàndez, Fernando; Solé Serra, Carme; Llecha Cano, Núria; López Soriano, Joaquin; Sanchis, Daniel; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Society for Neuroscience, 2013)
      The neuronal long isoform of Fas Apoptotic Inhibitory Molecule (FAIM-L) protects from death receptor (DR)-induced apoptosis, yet its mechanism of protection remains unknown. Here, we show that FAIM-L protects rat neuronal ...
    • FAK inhibition induces glioblastoma cell senescence-like state through p62 and p27 

      Alza, Lía; Nàger Grifo, Mireia; Visa Pretel, Anna; Cantí Nicolás, Carles; Herreros Danés, Judit (MDPI, 2020-04-27)
      Focal adhesion kinase (FAK) is a central component of focal adhesions that regulate cancer cell proliferation and migration. Here, we studied the effects of FAK inhibition in glioblastoma (GBM), a fast growing brain tumor ...
    • Feasibility and acceptability of personalised breast cancer screening (DECIDO study): protocol of a single-arm proof-of-concept trial 

      Pons Rodríguez, Anna; Forné Izquierdo, Carles; Vilaplana Mayoral, Jordi; Cruz Esteve, María Inés; Sánchez-López, Isabel; Reñé Reñé, Mercè; Cazorla, Cristina; Hernández Andreu, Marta; Galindo Ortego, Gisela; Llorens Gabandé, Montserrat; Laza-Vásquez, Celmira; Balaguer Llaquet, Pau; Martínez Alonso, Montserrat; Rué i Monné, Montserrat (BMJ Publishing Group, 2020-12-23)
      Introduction Personalised cancer screening aims to improve benefits, reduce harms and being more cost-effective than age-based screening. The objective of the DECIDO study is to assess the acceptability and feasibility of ...
    • First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass 

      Wang, Guangliang; Rajpurohit, Surendra K.; Delaspre, Fabien; Walker, Steven L.; White, David T.; Ceasrine, Alexis; Kuruvilla, Rejji; Li, Ruo-jing; Shim, Joong S.; Liu, Jun O.; Parsons, Michael J.; Mumm, Jeff S. (eLife Sciences Publications, 2015-07-28)
      Whole-organism chemical screening can circumvent bottlenecks that impede drug discovery. However, in vivo screens have not attained throughput capacities possible with in vitro assays. We therefore developed a method ...
    • FISH analysis of PTEN in endometrial carcinoma. Comparison with SNP arrays and MLPA 

      Maiques Carlos, Oscar; Cuevas, Dolors; García Dios, Diego Andrés; Coenegrachts, Lieve; Santacana, Maria; Velasco, Ana; Romero, Marta; Gatius Calderó, Sònia; Lambrechts, Diether; Müller, Sven; Pedersen, Hans Christian; Dolcet Roca, Xavier; Amant, Frederic; Matias-Guiu, Xavier (Wiley, 2014)
      Aims: To check the usefulness of a standardized protocol of PTEN FISH in 31 endometrial carcinomas (ECs) in comparison with SNP array (SNPA), multiplex ligation-dependent probe amplification (MLPA), and immunohistochemistry. ...
    • FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis 

      Dolcet Roca, Xavier; Llobet Navàs, David; Pallares, Judit; Rué i Monné, Montserrat; Comella i Carnicé, Joan Xavier; Matias-Guiu, Xavier (Nature Publishing Group, 2005)
      The FLICE-inhibitory protein (FLIP) plays a key role in the regulation of apoptosis triggered by death ligands. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis in some types ...
    • FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons 

      Yamagishi, Satoru; Hampel, Falko; Hata, Katsuhiko; Toro, Daniel del; Schwark, Manuela; Kvachnina, Elena; Bastmeyer, Martin; Yamashita, Toshihide; Tarabykin, Victor; Klein, Rüdiger; Egea Navarro, Joaquim (EMBO Press, 2011)
      Netrin-1 induces repulsive axon guidance by binding to the mammalian Unc5 receptor family (Unc5A–Unc5D). Mouse genetic analysis of selected members of the Unc5 family, however, revealed essential functions independent of ...
    • FLRT3 Is a Robo1-Interacting Protein that Determines Netrin-1 Attraction in Developing Axons 

      Leyva-Díaz, Eduardo; Toro, Daniel del; Menal Castellote, Maria José; Cambray Carner, Serafí; Susín, Rafael; Tessier-Lavigne, Marc; Klein, Rüdiger; Egea Navarro, Joaquim; López-Bendito, Guillermina (Elsevier, 2014)
      Background: Guidance molecules are normally presented to cells in an overlapping fashion; however, little is known about how their signals are integrated to control the formation of neural circuits. In the thalamocortical ...
    • Foundations of Theoretical Approaches in Systems Biology 

      Marin-Sanguino, Alberto; Vera, Julio; Alves, Rui (Frontiers Media, 2018)
    • Fracaso renal agudo secundario a crisis de hipercalcemia muy severa por hiperparatiroidismo primario 

      Chacón, Andrea; Vilar, Ana; Arroyo, David; Sarró, Felipe; Craver Hospital, Lourdes; Ros López, Susana; López, Carolina; Castillo, Alex; Matias-Guiu, Xavier; Fernández i Giráldez, Elvira (Elsevier, 2015)
      La crisis hipercalcémica es una forma de presentación poco frecuente del hiperparatiroidismo primario. Solo existen pequeñas series de casos reportadas en la literatura1 and 2. Se caracteriza por hipercalcemia severa, ...
    • Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism 

      Obis Monné, Èlia; Irazusta, Verónica Patricia; Sanchis, Daniel; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2014)
      Friedreich ataxia (FRDA) is a hereditary disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis, energy metabolism, and oxidative stress. Patients with FRDA experience ...
    • Frataxin depletion in yeast triggers up-regulation of iron transport systems before affecting iron-sulfur enzyme activities 

      Moreno Cermeño, Armando J.; Obis Monné, Èlia; Bellí i Martínez, Gemma; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (The American Society for Biochemistry and Molecular Biology, 2010)
      The primary function of frataxin, a mitochondrial protein involved in iron homeostasis, remains controversial. Using a yeast model of conditional expression of the frataxin homologue YFH1, we analyzed the primary effects ...
    • Frataxin-deficient cardiomyocytes present an altered thiol-redox state which targets actin and pyruvate dehydrogenase 

      Purroy Lledós, Rosa; Medina-Carbonero, Marta; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2020)
      Friedreich ataxia (FA) is a cardioneurodegenerative disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis, energy metabolism, and oxidative stress. Previously, we ...
    • Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment 

      Britti, Elena; Delaspre, Fabien; Feldman, Anat; Osborne, Melissa; Greif, Hagar; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Wiley Open Access, 2018)
      Friedreich ataxia (FA) is a rare disease caused by deficiency of frataxin, a mitochondrial protein. As there is no cure available for this disease, many strategies have been developed to reduce the deleterious effects of ...
    • Frequentist and Bayesian approaches for a joint model for prostate cancer risk and longitudinal PSA data 

      Serrat, Carles; Rué i Monné, Montserrat; Armero, Carmen; Piulachs, Xavier; Perpiñán, Hèctor; Forte, Anabel; Páez, Álvaro; Gómez, Guadalupe (Taylor & Francis, 2014)
      The paper describes the use of frequentist and Bayesian shared-parameter joint models of longitudinal measurements of prostate specific antigen (PSA) and the risk of prostate cancer (PCa). The motivating dataset corresponds ...
    • GATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1 

      Zhong, Yi; Wang, Zheng; Fu, Baojin; Pan, Fan; Yachida, Shinichi; Dhara, Mousumi; Albesiano, Emilia; Li, Li; Naito, Yoshiki; Vilardell, Felip; Cummings, Christopher; Martinelli, Paola; Li, Ang; Yonescu, Raluca; Ma, Qingyong; Griffin, Constance A.; Real, Francisco X.; Iacobuzio-Donahue, Christine A. (Public Library of Science, 2011)
      Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease characterized by late diagnosis and treatment resistance. Recurrent genetic alterations in defined genes in association with perturbations of developmental ...
    • Gender, sequence of cases and day effects on clinical skills assessment with standardized patients 

      Gispert i Magarolas, Rosa; Rué i Monné, Montserrat; Roma, J.; Martinez-Carretero, M. (Wiley, 1999)
      Context Clinical skills assessment using standardized patients (SPs) is an accepted method of professional testing, but some factors can threaten the validity of the scores obtained. Objective The main objective of ...