Now showing items 72-91 of 559

    • Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia 

      Britti, Elena; Delaspre, Fabien; Sanz Alcázar, Arabela; Medina Carbonero, Marta; Llovera i Tomàs, Marta; Purroy Lledós, Rosa; Mincheva Tasheva, Stefka; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Portland Press; Biochemical Society, 2021)
      Friedreich Ataxia (FA) is a neurodegenerative disease caused by the deficiency of frataxin, a mitochondrial protein. In primary cultures of dorsl root ganglia neurons, we showed that frataxin depletion resulted in decreased ...
    • Calcium channel expression and applicability as targeted therapies in melanoma 

      Macià Armengol, Anna; Herreros Danés, Judit; Martí Laborda, Rosa Ma.; Cantí Nicolás, Carles (Hindawi Publishing Corporation, 2015)
      The remodeling of Ca2+ signaling is a common finding in cancer pathophysiology serving the purpose of facilitating proliferation, migration, or survival of cancer cells subjected to stressful conditions. One particular ...
    • Calcium Influx Activates Extracellular-regulated Kinase/Mitogen-activated Protein Kinase Pathway through a Calmodulin-sensitive Mechanism in PC12 Cells 

      Egea Navarro, Joaquim; Espinet Mestre, Carme; Comella i Carnicé, Joan Xavier (American Society for Biochemistry and Molecular Biology, 1999)
      Evidence suggests that membrane depolarization is able to promote neuronal survival through a sustained, although moderate, increase in the intracellular calcium. We have used the PC12 cell line to study the ...
    • Calcium phosphate product is associated with subclinical carotid atherosclerosis in type 2 diabetes 

      Ramírez-Morros, Anna; Granado Casas, Minerva; Alcubierre Calvo, Núria; Martínez Alonso, Montserrat; Real, Jordi; Castelblanco Echavarría, Esmeralda; Esquerda, Aureli; Cao, Gonzalo; Rubinat, Esther; Hernández García, Marta; Alonso, Núria; Fernández i Giráldez, Elvira; Mauricio Puente, Dídac (Hindawi Publishing Corporation, 2017)
      Aims. To assess whether circulating 25-hydroxyvitamin D3 (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined ...
    • Calmodulin Modulates Mitogen-Activated Protein Kinase Activation in Response to Membrane Depolarization in PC12 Cells 

      Egea Navarro, Joaquim; Espinet Mestre, Carme; Comella i Carnicé, Joan Xavier (Wiley, 1998)
      In the absence of neurotrophic factors, chronic depolarization of plasma membrane has been shown to maintain several populations of primary neurons in culture. We report that in the PC12 cell line, depolarization causes ...
    • Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model 

      Gou Fabregas, Myriam; Ramírez-Núñez, Omar; Cacabelos Barral, Daniel; Bahi i Pla, Núria; Portero Otín, Manuel; Garcera, Ana; Soler i Tatché, Rosa Ma. (Elsevier, 2014)
      Amyotrophic Lateral Sclerosis (ALS), a severe neurodegenerative disease, affects the upper and lower motor neurons in the brain and spinal cord. In some studies, ALS disease progression has been associatedwith an increase ...
    • Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice 

      Fuente Ruiz, Sandra de la; Sansa Zaragoza, Alba; Periyakaruppiah, Ambika; Garcera, Ana; Soler i Tatché, Rosa Ma. (Springer Verlag, 2018)
      Spinal muscular atrophy (SMA), a leading genetic cause of infant death, is caused by the loss of survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration and loss of spinal cord motoneurons (MNs), ...
    • CAM Models: Lessons and Implications for CAM Evolution 

      Burgos, Asdrubal; Miranda, Enoc; Vilaprinyo Terré, Ester; Meza Canales, Iván David; Alves, Rui (Frontiers Media, 2022)
      The evolution of Crassulacean acid metabolism (CAM) by plants has been one of the most successful strategies in response to aridity. On the onset of climate change, expanding the use of water efficient crops and engineering ...
    • Can eukaryotic cells monitor the presence of unreplicated DNA? 

      Torres Rosell, Jordi; Piccoli, Giacomo De; Aragón, Luis (BioMed Central, 2007)
      Completion of DNA replication before mitosis is essential for genome stability and cell viability. Cellular controls called checkpoints act as surveillance mechanisms capable of detecting errors and blocking cell cycle ...
    • Carbonic Anhydrase III. Oxidative modification in vivo and loss of phosphatase activity during aging 

      Cabiscol Català, Elisa; Levine, Rodney L. (American Society for Biochemistry and Molecular Biology, 1995)
      Oxidative modification of DNA, lipids, and proteins occurs as a consequence of reaction with free radicals and activated oxygen. Oxidative modification of total cellular proteins has been described under many pathologic ...
    • Cardiac fibroblasts display endurance to ischemia, high ROS control and elevated respiration regulated by the JAK2/STAT pathway 

      Beà Tàrrega, Aida; García Valero, Juan; Irazoki, Andrea; Lana, Carlos; López-Lluch, Guillermo; Portero Otín, Manuel; Pérez Galán, Patricia; Inserte Igual, Javier; Ruiz Meana, Marisol; Zorzano, Antonio; Llovera i Tomàs, Marta; Sanchis, Daniel (John Wiley & Sons, 2021)
      Cardiovascular diseases are the leading cause of death globally and more than four out of five cases are due to ischemic events. Cardiac fibroblasts (CF) contribute to normal heart development and function, and produce the ...
    • Cardiac troponin values in patients with acute coronary syndrome and sleep apnea: a pilot study 

      Sánchez de la Torre, Alicia; Soler, Xavier; Barbé Illa, Ferran; Florés, Marina; Maisel, Alan; Malhotra, Atul; Rué i Monné, Montserrat; Bertran, Sandra; Aldomá, Albina; Worner, Fernando; Valls Marsal, Joan; Lee, Chi-Hang; Turino, Cecilia; Galera, Estefanía; Batlle Garcia, Jordi de; Sánchez de la Torre, Manuel (Elsevier, 2018)
      Background: An analysis of cardiac injury markers in patients with OSA who sustain an episode of acute coronary syndrome (ACS) may contribute to a better understanding of the interactions and impact of OSA in subjects with ...
    • Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin. 

      Blasco Angulo, Natividad; Cámara, Yolanda; Núñez, Estefanía; Beà Tàrrega, Aida; Barés Junqué, Gisel; Forné Izquierdo, Carles; Ruiz Meana, Marisol; Girón, Cristina; Barba, Ignasi; García Arumí, Elena; García Dorado, David; Vázquez, Jesús; Martí, Ramón; Llovera i Tomàs, Marta; Sanchis, Daniel (Elsevier, 2018-03-01)
      The endonuclease G gene (Endog), which codes for a mitochondrial nuclease, was identified as a determinant of cardiac hypertrophy. How ENDOG controls cardiomyocyte growth is still unknown. Thus, we aimed at finding the ...
    • Central Nervous System Metastases in Women who Receive Trastuzumab-Based Therapy for Metastatic Breast Carcinoma 

      Bendell, Johanna C.; Domchek, Susan M.; Burstein, Harold J.; Harris, Lyndsay; Younger, Jerry; Kuter, Irene; Bunnell, Craig; Rué i Monné, Montserrat; Gelman, Rebecca; Winer, Eric (Wiley, 2003)
      BACKGROUND: Women with HER-2 overexpressing metastatic breast carcinoma benefit from trastuzumab-based therapy, but trastuzumab does not cross the blood-brain barrier. The authors characterized central nervous system (CNS) ...
    • Central sleep apnoea is related to the severity and short-term prognosis of acute coronary syndrome 

      Florés, Marina; Batlle Garcia, Jordi de; Sánchez de la Torre, Alicia; Sánchez de la Torre, Manuel; Aldomá, Albina; Worner, Fernando; Galera, Estefanía; Seminario, Asunción; Torres, Gerard; Dalmases, Mireia; Montserrat i Capdevila, Josep; Garmendia, Onintza; Barbé Illa, Ferran (Public Library of Science, 2016)
      Objective To evaluate the relation of central sleep apnoea (CSA) to the severity and short-term prognosis of patients who experience acute coronary syndrome (ACS). Methods Observational study with cross-sectional and ...
    • Characterisation of the inflammatory response triggered by topical ingenol mebutate 0.05% gel in basal cell carcinoma 

      García de la Fuente, María Reyes; Santacana Espasa, Maria; Verdaguer Autonell, Joan; Vilardell, Felip; Garí Marsol, Eloi; Casanova i Seuma, Josep M. (Josep Manel) (Wiley; Australasian College of Dermatologists, 2020-01-16)
      Background/Objective Ingenol mebutate gel is approved for actinic keratosis field therapy, but little has been published as a treatment of basal cell carcinoma (BCC). Our objective is to characterise the histopathological ...
    • Characterization of a Candida albicans gene encoding a putative transcriptional factor required for cell wall integrity 

      Moreno, Inmaculada; Pedreño, Yolanda; Maicas i Prieto, Sergio; Sentandreu, Rafael; Herrero Perpiñán, Enrique; Valentín, Eulogio (Elsevier, 2003)
      After screening a Candida albicans genome database the product of an open reading frame (ORF) (CA2880) with 49% homology to the product of Saccharomyces cerevisiae YPL133c, a putative transcriptional factor, was identified. ...
    • Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer 

      Pérez Fusté, Noel; Castelblanco Echavarría, Esmeralda; Felip, Isidre; Santacana Espasa, Maria; Fernández Hernández, Rita; Gatius Calderó, Sònia; Pedraza González, Neus; Pallares, Judit; Cemeli, Tània; Valls Marsal, Joan; Tarrés Escalona, Marc; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Matias-Guiu, Xavier; Garí Marsol, Eloi (Impact Journals, 2016)
      Cyclin D1 (Ccnd1) is a proto-oncogen amplified in many different cancers and nuclear accumulation of Ccnd1 is a characteristic of tumor cells. Ccnd1 activates the transcription of a large set of genes involved in cell ...
    • Characterization of the CPAP-treated patient population in Catalonia 

      Turino, Cecilia; Bertran, Sandra; Gavaldá, Ricard; Teixidó Torrelles, Ivan; Woehrle, Holger; Rué i Monné, Montserrat; Solsona Tehàs, Francesc; Escarrabill, Joan; Colls, Cristina; García-Altés, Anna; Batlle Garcia, Jordi de; Sánchez de la Torre, Manuel; Barbé Illa, Ferran (Public Library of Science, 2017)
      There are different phenotypes of obstructive sleep apnoea (OSA), many of which have not been characterised. Identification of these different phenotypes is important in defining prognosis and guiding the therapeutic ...
    • Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling 

      Bhardwaj, Deepshikha; Nàger Grifo, Mireia; Camats, Judith; David, Mónica Delia; Benguria, Alberto; Dopazo, Ana; Cantí Nicolás, Carles; Herreros Danés, Judit (Frontiers, 2013)
      Axon morphogenesis is a complex process regulated by a variety of secreted molecules, including morphogens and growth factors, resulting in the establishment of the neuronal circuitry. Our previous work demonstrated that ...