Now showing items 63-82 of 501

    • Calcium channel expression and applicability as targeted therapies in melanoma 

      Macià Armengol, Anna; Herreros Danés, Judit; Martí Laborda, Rosa Ma.; Cantí Nicolás, Carles (Hindawi Publishing Corporation, 2015)
      The remodeling of Ca2+ signaling is a common finding in cancer pathophysiology serving the purpose of facilitating proliferation, migration, or survival of cancer cells subjected to stressful conditions. One particular ...
    • Calcium Influx Activates Extracellular-regulated Kinase/Mitogen-activated Protein Kinase Pathway through a Calmodulin-sensitive Mechanism in PC12 Cells 

      Egea Navarro, Joaquim; Espinet Mestre, Carme; Comella i Carnicé, Joan Xavier (American Society for Biochemistry and Molecular Biology, 1999)
      Evidence suggests that membrane depolarization is able to promote neuronal survival through a sustained, although moderate, increase in the intracellular calcium. We have used the PC12 cell line to study the ...
    • Calcium phosphate product is associated with subclinical carotid atherosclerosis in type 2 diabetes 

      Ramírez-Morros, Anna; Granado Casas, Minerva; Alcubierre Calvo, Núria; Martínez Alonso, Montserrat; Real, Jordi; Castelblanco Echavarría, Esmeralda; Esquerda, Aureli; Cao, Gonzalo; Rubinat, Esther; Hernández, Marta; Alonso, Núria; Fernández i Giráldez, Elvira; Mauricio Puente, Dídac (Hindawi Publishing Corporation, 2017)
      Aims. To assess whether circulating 25-hydroxyvitamin D3 (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined ...
    • Calmodulin Modulates Mitogen-Activated Protein Kinase Activation in Response to Membrane Depolarization in PC12 Cells 

      Egea Navarro, Joaquim; Espinet Mestre, Carme; Comella i Carnicé, Joan Xavier (Wiley, 1998)
      In the absence of neurotrophic factors, chronic depolarization of plasma membrane has been shown to maintain several populations of primary neurons in culture. We report that in the PC12 cell line, depolarization causes ...
    • Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model 

      Gou Fabregas, Myriam; Ramírez-Núñez, Omar; Cacabelos Barral, Daniel; Bahi i Pla, Núria; Portero Otín, Manuel; Garcera, Ana; Soler i Tatché, Rosa Ma. (Elsevier, 2014)
      Amyotrophic Lateral Sclerosis (ALS), a severe neurodegenerative disease, affects the upper and lower motor neurons in the brain and spinal cord. In some studies, ALS disease progression has been associatedwith an increase ...
    • Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice 

      Fuente Ruiz, Sandra de la; Sansa Zaragoza, Alba; Periyakaruppiah, Ambika; Garcera, Ana; Soler i Tatché, Rosa Ma. (Springer Verlag, 2018)
      Spinal muscular atrophy (SMA), a leading genetic cause of infant death, is caused by the loss of survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration and loss of spinal cord motoneurons (MNs), ...
    • Can eukaryotic cells monitor the presence of unreplicated DNA? 

      Torres Rosell, Jordi; Piccoli, Giacomo De; Aragón, Luis (BioMed Central, 2007)
      Completion of DNA replication before mitosis is essential for genome stability and cell viability. Cellular controls called checkpoints act as surveillance mechanisms capable of detecting errors and blocking cell cycle ...
    • Carbonic Anhydrase III. Oxidative modification in vivo and loss of phosphatase activity during aging 

      Cabiscol Català, Elisa; Levine, Rodney L. (American Society for Biochemistry and Molecular Biology, 1995)
      Oxidative modification of DNA, lipids, and proteins occurs as a consequence of reaction with free radicals and activated oxygen. Oxidative modification of total cellular proteins has been described under many pathologic ...
    • Cardiac troponin values in patients with acute coronary syndrome and sleep apnea: a pilot study 

      Sánchez de la Torre, Alicia; Soler, Xavier; Barbé Illa, Ferran; Florés, Marina; Maisel, Alan; Malhotra, Atul; Rué i Monné, Montserrat; Bertran, Sandra; Aldomá, Albina; Worner, Fernando; Valls Marsal, Joan; Lee, Chi-Hang; Turino, Cecilia; Galera, Estefanía; Batlle Garcia, Jordi de; Sánchez de la Torre, Manuel (Elsevier, 2018)
      Background: An analysis of cardiac injury markers in patients with OSA who sustain an episode of acute coronary syndrome (ACS) may contribute to a better understanding of the interactions and impact of OSA in subjects with ...
    • Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin. 

      Blasco Angulo, Natividad; Cámara, Yolanda; Núñez, Estefanía; Beà Tàrrega, Aida; Barés Junqué, Gisel; Forné Izquierdo, Carles; Ruiz Meana, Marisol; Girón, Cristina; Barba, Ignasi; García Arumí, Elena; García Dorado, David; Vázquez, Jesús; Martí, Ramón; Llovera i Tomàs, Marta; Sanchis, Daniel (Elsevier, 2018-03-01)
      The endonuclease G gene (Endog), which codes for a mitochondrial nuclease, was identified as a determinant of cardiac hypertrophy. How ENDOG controls cardiomyocyte growth is still unknown. Thus, we aimed at finding the ...
    • Central Nervous System Metastases in Women who Receive Trastuzumab-Based Therapy for Metastatic Breast Carcinoma 

      Bendell, Johanna C.; Domchek, Susan M.; Burstein, Harold J.; Harris, Lyndsay; Younger, Jerry; Kuter, Irene; Bunnell, Craig; Rué i Monné, Montserrat; Gelman, Rebecca; Winer, Eric (Wiley, 2003)
      BACKGROUND: Women with HER-2 overexpressing metastatic breast carcinoma benefit from trastuzumab-based therapy, but trastuzumab does not cross the blood-brain barrier. The authors characterized central nervous system (CNS) ...
    • Central sleep apnoea is related to the severity and short-term prognosis of acute coronary syndrome 

      Florés, Marina; Batlle Garcia, Jordi de; Sánchez de la Torre, Alicia; Sánchez de la Torre, Manuel; Aldomá, Albina; Worner, Fernando; Galera, Estefanía; Seminario, Asunción; Torres, Gerard; Dalmases, Mireia; Montserrat i Capdevila, Josep; Garmendia, Onintza; Barbé Illa, Ferran (Public Library of Science, 2016)
      Objective To evaluate the relation of central sleep apnoea (CSA) to the severity and short-term prognosis of patients who experience acute coronary syndrome (ACS). Methods Observational study with cross-sectional and ...
    • Characterization of a Candida albicans gene encoding a putative transcriptional factor required for cell wall integrity 

      Moreno, Inmaculada; Pedreño, Yolanda; Maicas i Prieto, Sergio; Sentandreu, Rafael; Herrero Perpiñán, Enrique; Valentín, Eulogio (Elsevier, 2003)
      After screening a Candida albicans genome database the product of an open reading frame (ORF) (CA2880) with 49% homology to the product of Saccharomyces cerevisiae YPL133c, a putative transcriptional factor, was identified. ...
    • Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer 

      Pérez Fusté, Noel; Castelblanco Echavarría, Esmeralda; Felip, Isidre; Santacana Espasa, Maria; Fernández-Hernández, Rita; Gatius Calderó, Sònia; Pedraza González, Neus; Pallares, Judit; Cemeli, Tània; Valls Marsal, Joan; Tarres, Marc; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Matias-Guiu, Xavier; Garí Marsol, Eloi (Impact Journals, 2016)
      Cyclin D1 (Ccnd1) is a proto-oncogen amplified in many different cancers and nuclear accumulation of Ccnd1 is a characteristic of tumor cells. Ccnd1 activates the transcription of a large set of genes involved in cell ...
    • Characterization of the CPAP-treated patient population in Catalonia 

      Turino, Cecilia; Bertran, Sandra; Gavaldá, Ricard; Teixidó Torrelles, Ivan; Woehrle, Holger; Rué i Monné, Montserrat; Solsona Tehàs, Francesc; Escarrabill, Joan; Colls, Cristina; García-Altés, Anna; Batlle Garcia, Jordi de; Sánchez de la Torre, Manuel; Barbé Illa, Ferran (Public Library of Science, 2017)
      There are different phenotypes of obstructive sleep apnoea (OSA), many of which have not been characterised. Identification of these different phenotypes is important in defining prognosis and guiding the therapeutic ...
    • Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling 

      Bhardwaj, Deepshikha; Nàger Grifo, Mireia; Camats, Judith; David, Mónica Delia; Benguria, Alberto; Dopazo, Ana; Cantí Nicolás, Carles; Herreros Danés, Judit (Frontiers, 2013)
      Axon morphogenesis is a complex process regulated by a variety of secreted molecules, including morphogens and growth factors, resulting in the establishment of the neuronal circuitry. Our previous work demonstrated that ...
    • CheNER: Chemical Named Entity Recognizer 

      Usié Chimenos, Anabel; Alves, Rui; Solsona Tehàs, Francesc; Vázquez, Miguel; Valéncia, Alfonso (Oxford University Press, 2013)
      Motivation: Chemical named entity recognition is used to automatically identify mentions to chemical compounds in text, and is the basis for more elaborate information extraction. However, only a small number of ...
    • Chloroplast monothiol glutaredoxins as scaffold proteins for the assembly and delivery of [2Fe–2S] clusters 

      Bandyopadhyay, Sibali; Gama, Filipe; Molina Navarro, Maria Micaela; Gualberto, José Manuel; Claxton, Ronald; Huynh, Boi Hanh; Herrero Perpiñán, Enrique; Jacquot, Jean Pierre; Johnson, Michael K.; Naik, Sunil G.; Rouhier, Nicolas (EMBO Press, 2008)
      Glutaredoxins (Grxs) are small oxidoreductases that reduce disulphide bonds or protein-glutathione mixed disulphides. More than 30 distinct grx genes are expressed in higher plants, but little is currently known ...
    • Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1 

      Reverter Branchat, Gemma; Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Sorolla Bardají, Maria Alba; Torre Ruiz, M. A. de la; Ros Salvador, Joaquim (Microbiology Society, 2007)
      Alcohol dehydrogenase 1 (Adh1)p catalyses the conversion of acetaldehyde to ethanol, regenerating NAD+. In Saccharomyces cerevisiae, Adh1p is oxidatively modified during ageing and, consequently, its activity becomes ...
    • Circulating microRNA profile as a potential biomarker for obstructive sleep apnea diagnosis 

      Santamaria-Martos, Fernando; Benítez, Iván; Ortega Delgado, Francisco José; Zapater, Andrea; Giron, Cristina; Pinilla, Lucía; Pacual, Lydia; Cortijo, Anunciación; Dalmases, Mireia; Fernandez-Real, Jose Manuel; Barbé Illa, Ferran; Sánchez de la Torre, Manuel (Nature Publishing Group, 2019)
      Evaluation of microRNAs (miRNAs) could allow characterization of the obstructive sleep apnea (OSA) and help diagnose it more accurately. We aimed to examine circulating miRNA profiles to establish the differences between ...