Now showing items 56-75 of 559

    • Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts 

      Pérez Fusté, Noel; Guasch Vallés, Marta; Guillén, Pere; Anerillas, Carlos; Cemeli, Tània; Pedraza González, Neus; Ferrezuelo, Francisco; Encinas Martín, Mario; Moralejo Vidal, Mª Angeles; Garí Marsol, Eloi (Elsevier, 2019)
      β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. ...
    • Barriers and facilitators to the implementation of a personalized breast cancer screening program: Views of Spanish health professionals 

      Laza-Vásquez, Celmira; Hernández-Leal, María José; Carles Lavila, Misericordia; Pérez Lacasta, María José; Cruz Esteve, María Inés; Rué i Monné, Montserrat (MDPI, 2022)
      Abstract:This study explored the barriers and facilitators to the implementation of a risk-basedbreast cancer screening program from the point of view of Spanish health professionals. A cross-sectional study with 220 ...
    • Bayesian joint ordinal and survival modeling for breast cancer risk assessment 

      Armero, Carmen; Forné Izquierdo, Carles; Rué i Monné, Montserrat; Forte, Anabel; Perpiñán, Hèctor; Gómez, Guadalupe; Baré, Marisa (Wiley, 2016)
      We propose a joint model to analyze the structure and intensity of the association between longitudinal measurements of an ordinal marker and time to a relevant event. The longitudinal process is defined in terms of a ...
    • Bck2 is a phase-independent activator of cell cycle-regulated genes in yeast 

      Ferrezuelo, Francisco; Aldea, Martí; Futcher, Bruce (Landes Bioscience, 2009)
      During the cell division cycle of the yeast Saccharomyces cerevisiae, the G1-to-S transition depends upon the activation of two transcription factors (SBF and MBF), which are responsible for the cell cycle-regulated ...
    • BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs 

      Gozzelino, Raffaella; Solé Serra, Carme; Llecha Cano, Núria; Segura Ginard, Miguel Francisco; Moubarak, Rana S.; Iglesias Guimarais, Victoria; Pérez García, María José; Reix, Stéphanie; Zhang, Jisheng; Badiola, Nahuai; Sanchis, Daniel; Rodríguez Álvarez, José; Trullas, Ramon; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Springer Nature, 2008)
      Upon activation, tumor necrosis factor alpha (TNF-α) receptor can engage apoptotic or survival pathways. Inhibition of macromolecular synthesis is known to sensitize cells to TNF-α-induced cell death. It is believed that ...
    • Benefits of low weekly doses of methotrexate in steroid-dependent asthmatic patients. A doubleblind, randomized, placebo-controlled study 

      Comet, Ricard; Domingo, Christian; Larrosa, Marta; Morón, Anisi; Rué i Monné, Montserrat; Amengual, Maria José; Martín, Albert (Elsevier, 2006)
      Background: Though several drugs have been tested, the choice of the ideal steroidsparing agent in steroid-dependent asthmatic patients remains unclear. Our objective was to evaluate the efficacy and tolerance of ...
    • Biblio-MetReS for user-friendly mining of genes and biological processes in scientific documents 

      Usié Chimenos, Anabel; Karathia, Hiren; Teixidó Torrelles, Ivan; Alves, Rui; Solsona Tehàs, Francesc (PeerJ, 2014)
      One way to initiate the reconstruction of molecular circuits is by using automated text-mining techniques. Developing more efficient methods for such reconstruction is a topic of active research, and those methods are ...
    • Biblio-MetReS: A bibliometric network reconstruction application and server 

      Usié Chimenos, Anabel; Karathia, Hiren; Teixidó Torrelles, Ivan; Valls Marsal, Joan; Faus i Torà, Xavier; Alves, Rui; Solsona Tehàs, Francesc (BioMed Central, 2011)
      Background: Reconstruction of genes and/or protein networks from automated analysis of the literature is one of the current targets of text mining in biomedical research. Some user-friendly tools already perform this ...
    • Bidirectional Eph–ephrin signaling during axon guidance 

      Egea Navarro, Joaquim; Klein, Rüdiger (Elsevier, 2007)
      Ephrins are cell-surface tethered guidance cues that bind to Eph receptor tyrosine kinases in trans on opposing cells. In the developing nervous system, the Eph-ephrin signaling system controls a large variety of cellular ...
    • Biochemical characterization of yeast mitochondrial Grx5 monothiol glutaredoxin 

      Tamarit Sumalla, Jordi; Bellí i Martínez, Gemma; Cabiscol Català, Elisa; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2003)
      Grx5 is a yeast mitochondrial protein involved in iron- sulfur biogenesis that belongs to a recently described family of monothiolic glutaredoxin-like proteins. No member of this family has been biochemically charac- terized ...
    • Biphasic modulation of fatty acid synthase by hydrogen peroxide in Saccharomyces cerevisiae 

      Matias, Ana C.; Marinho, H. Susana; Cyrne, Luísa; Herrero Perpiñán, Enrique; Antunes, Fernando (Elsevier, 2011)
      Taking into account published contradictory results concerning the regulation of fatty acid synthase (Fas) by H2O2, we carried out a systematic study where two methods of H2O2 delivery (steady-state and bolus addition) ...
    • Both human and soya bean ferritins highly improve the accumulation of bioavailable iron and contribute to extend the chronological life in budding yeast 

      Pujol Carrión, Núria; González-Alfonso, Alma; Puig, Sergi; Torre Ruiz, M. A. de la (Society for Applied Microbiology; John Wiley & Sons Ltd., 2021)
      Ferritin proteins have an enormous capacity to store iron in cells. In search for the best conditions to accumulate and store bioavailable iron, we made use of a double mutant null for the monothiol glutaredoxins GRX3 and ...
    • BRAFV600E Mutant Allele Frequency (MAF) Influences Melanoma Clinicopathologic Characteristics 

      Soria, Xavier; Vilardell, Felip; Maiques Carlos, Oscar; Barceló Gómez, Carla; Sisó, Pol; de la Rosa, Inés; Velasco Sánchez, Ana; Cuevas Sánchez, Dolors; Santacana Espasa, Maria; Gatius Calderó, Sònia; Matias-Guiu, Xavier; Rodrigo, Alberto; Macià Armengol, Anna; Martí Laborda, Rosa Ma. (MDPI, 2021)
      Background: Cutaneous melanoma shows high variability regarding clinicopathological presentation, evolution and prognosis. Methods: Next generation sequencing was performed to analyze hotspot mutations in different areas ...
    • BRCA1 loss activates cathepsin L–mediated degradation of 53BP1 in breast cancer cells 

      Grotsky, David A.; González-Suárez, Ignacio; Novell Álvarez, Anna; Neumann, Martin; Yaddanapudi, Sree C.; Croke, Monica; Martínez Alonso, Montserrat; Redwood, Abena B.; Ortega-Martinez, Sylvia; Feng, Zhihui; Lerma, Enrique; Ramon y Cajal, Teresa; Zhang, Junran; Matias-Guiu, Xavier; Dusso Rosso, Adriana; Gonzalo, Susana (The Rockefeller University Press, 2013)
      Loss of 53BP1 rescues BRCA1 deficiency and is associated with BRCA1-deficient and triple-negative breast cancers (TNBC) and with resistance to genotoxic drugs. The mechanisms responsible for decreased 53BP1 transcript ...
    • Breast cancer incidence and overdiagnosis in Catalonia (Spain) 

      Martínez Alonso, Montserrat; Vilaprinyo Terré, Ester; Marcos-Gragera, Rafael; Rué i Monné, Montserrat (BioMed Central, 2010)
      Introduction: Early detection of breast cancer (BC) with mammography may cause overdiagnosis and overtreatment, detecting tumors which would remain undiagnosed during a lifetime. The aims of this study were: first, to ...
    • Budget impact analysis of switching to digital mammography in a population-based breast cancer screening program: a discrete event simulation model 

      Comas, Mercè; Arrospide, Arantzazu; Mar, Javier; Sala i Serra, Maria; Vilaprinyo Terré, Ester; Hernández, Cristina; Cots, Francesc; Martínez, Juan; Castells, Xavier (Public Library of Science, 2014)
      Objective: To assess the budgetary impact of switching from screen-film mammography to full-field digital mammography in a population-based breast cancer screening program. Methods: A discrete-event simulation model was ...
    • Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia 

      Britti, Elena; Delaspre, Fabien; Sanz Alcázar, Arabela; Medina Carbonero, Marta; Llovera i Tomàs, Marta; Purroy Lledós, Rosa; Mincheva Tasheva, Stefka; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Portland Press; Biochemical Society, 2021)
      Friedreich Ataxia (FA) is a neurodegenerative disease caused by the deficiency of frataxin, a mitochondrial protein. In primary cultures of dorsl root ganglia neurons, we showed that frataxin depletion resulted in decreased ...
    • Calcium channel expression and applicability as targeted therapies in melanoma 

      Macià Armengol, Anna; Herreros Danés, Judit; Martí Laborda, Rosa Ma.; Cantí Nicolás, Carles (Hindawi Publishing Corporation, 2015)
      The remodeling of Ca2+ signaling is a common finding in cancer pathophysiology serving the purpose of facilitating proliferation, migration, or survival of cancer cells subjected to stressful conditions. One particular ...
    • Calcium Influx Activates Extracellular-regulated Kinase/Mitogen-activated Protein Kinase Pathway through a Calmodulin-sensitive Mechanism in PC12 Cells 

      Egea Navarro, Joaquim; Espinet Mestre, Carme; Comella i Carnicé, Joan Xavier (American Society for Biochemistry and Molecular Biology, 1999)
      Evidence suggests that membrane depolarization is able to promote neuronal survival through a sustained, although moderate, increase in the intracellular calcium. We have used the PC12 cell line to study the ...
    • Calcium phosphate product is associated with subclinical carotid atherosclerosis in type 2 diabetes 

      Ramírez-Morros, Anna; Granado Casas, Minerva; Alcubierre Calvo, Núria; Martínez Alonso, Montserrat; Real, Jordi; Castelblanco Echavarría, Esmeralda; Esquerda, Aureli; Cao, Gonzalo; Rubinat, Esther; Hernández García, Marta; Alonso, Núria; Fernández i Giráldez, Elvira; Mauricio Puente, Dídac (Hindawi Publishing Corporation, 2017)
      Aims. To assess whether circulating 25-hydroxyvitamin D3 (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined ...