Browsing Articles publicats (Ciències Mèdiques Bàsiques) by Title
Now showing items 3-22 of 559
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A common copy-number variant within SIRPB1 correlates with human Out-of-Africa migration after genetic drift correction
(Public Library of Science, 2018)Previous reports have proposed that personality may have played a role on human Out-Of- Africa migration, pinpointing some genetic variants that were positively selected in the migrating populations. In this work, we ... -
A genome-wide transcriptional study reveals that iron deficiency inhibits the yeast TORC1 pathway
(Elsevier, 2019-09)Iron is an essential micronutrient that participates as a cofactor in a broad range of metabolic processes including mitochondrial respiration, DNA replication, protein translation and lipid biosynthesis. Adaptation to ... -
A low fractional excretion of Phosphate/Fgf23 ratio is associated with severe abdominal Aortic calcification in stage 3 and 4 kidney disease patients
(BioMed Central, 2013)Background: Vascular calcification (VC) contributes to high mortality rates in chronic kidney disease (CKD). High serum phosphate and FGF23 levels and impaired phosphaturic response to FGF23 may affect VC. Therefore, ... -
A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis
(BioMed Central, 2008)Background: The difficulty in elucidating the genetic basis of complex diseases roots in the many factors that can affect the development of a disease. Some of these genetic effects may interact in complex ways, proving ... -
A multicentre study investigating parameters which influence direct bacterial identification from urine
(Public Library of Science, 2018)Rapid diagnosis is one of the best ways to improve patient management and prognosis as well as to combat the development of bacterial resistance. The aim of this study was to study parameters that impact the achievement ... -
A New Gender-Specific Formula to Estimate 24-Hour Urine Protein from Protein to Creatinine Ratio
(Karger, 2016-07-20)Background: The quantification of proteinuria with the protein to creatinine ratio (PCR) is influenced by the excretion of creatinine, which, in turn, varies according to muscle mass and hence, to gender. Aims: To assess ... -
A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart
(Company of Biologists Ltd., 2013)Polypyrimidine tract binding protein (PTB) regulates pre-mRNA splicing, having special relevance for determining gene expression in the differentiating muscle. We have previously shown that PTB protein abundance is ... -
A peroxisomal glutathione transferase of Saccharomyces cerevisiae is functionally related to sulfur amino acid metabolism
(American Society for Microbiology, 2006)Saccharomyces cerevisiae cells contain three omega-class glutathione transferases with glutaredoxin activity (Gto1, Gto2, and Gto3), in addition to two glutathione transferases (Gtt1 and Gtt2) not classifiable into standard ... -
A prospective cross-sectional study on quality of life and treatment satisfaction in type 2 diabetic patients with retinopathy without other major late diabetic complications
(BioMed Central, 2014)Background: To assess quality of life and treatment satisfaction in patients with type 2 diabetes mellitus with diabetic retinopathy (DR) using validated instruments, with comparison to patients without DR. Methods: A ... -
A scaffold protein that chaperones a cysteine-sulfenic acid in H2O2 signaling
(Nature Reseach, 2017)In Saccharomyces cerevisiae, Yap1 regulates an H2O2-inducible transcriptional response that controls cellular H2O2 homeostasis. H2O2 activates Yap1 by oxidation through the intermediacy of the thiol-peroxidase Orp1. Upon ... -
A Simple Scoring System to Differentiate Bacterial from Viral Infections in Acute Exacerbations of COPD Requiring Hospitalization
(Dove Press, 2022)Objective: Both bacteria and viruses may cause acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The objective of this study was to identify readily available clinical parameters to discriminate between ... -
A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium
(Nature Publishing Group, 2017-05-19)The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apoptosis, and their alterations lead to cancer development. TGF-β acts as a tumor suppressor in premalignant cells, but it ... -
A SUMO-Dependent Step during Establishment of Sister Chromatid Chohesion
(Elsevier, 2012-09-11)Cohesin is a protein complex that ties sister DNA molecules from the time of DNA replication until the metaphase to anaphase transition. Current models propose that the association of the Smc1, Smc3, and Scc1/Mcd1 subunits ... -
A survey of HK, HPt, and RR domains and their organization in two-component systems and phosphorelay proteins of organisms with fully sequenced genomes
(PeerJ, 2015)Two Component Systems and Phosphorelays (TCS/PR) are environmental signal transduction cascades in prokaryotes and, less frequently, in eukaryotes. The internal domain organization of proteins and the topology of TCS/PR ... -
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion
(BMC, 2021)Background: Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic loci on the efficiency ... -
A TrkB/EphrinA Interaction Controls Retinal Axon Branching and Synaptogenesis
(Society for Neuroscience, 2008)Toward understanding topographically specific branching of retinal axons in their target area, we have studied the interaction between neurotrophin receptors and members of the Eph family. TrkB and its ligand BDNF are ... -
Abdominal tuberculosis mimicking Crohn’s disease’s exacerbation: a clinical, diagnostic and surgical dilemma. A case report
(Elsevier, 2015)INTRODUCTION: Tuberculosis in Europe is a health public problem, which has increased constantly over the last few decades. The most common clinical manifestation of tuberculosis is pulmonary. The diagnosis of extrapulmonary ... -
Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease
(Nature, 2017)Huntington’s Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery ... -
Abnormalities in the NF-κB family and related proteins in endometrial carcinoma
(Wiley, 2004)The NF-κB family of transcription factors regulates a wide variety of cellular processes including cell growth, differentiation, and apoptosis. A tissue microarray was constructed from paraffin wax-embedded blocks from ... -
Absence of Nuclear p16 Is a Diagnostic and Independent Prognostic Biomarker in Squamous Cell Carcinoma of the Cervix
(MDPI, 2020)The tumor-suppressor protein p16 is paradoxically overexpressed in cervical cancer (CC). Despite its potential as a biomarker, its clinical value and the reasons for its failure in tumor suppression remain unclear. Our ...