Now showing items 21-39 of 39

    • Mitochondrial calcium signaling and neurodegenerative diseases 

      Britti, Elena; Delaspre, Fabien; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Portland Press, 2018-11-16)
      Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium ...
    • Mitochondrial Hsp60, resistance to oxidative stress, and the labile iron pool are closely connected in Saccharomyces cerevisiae 

      Cabiscol Català, Elisa; Bellí i Martínez, Gemma; Tamarit Sumalla, Jordi; Echave Lozano, Pedro; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2002)
      In the present study, we have analyzed the role of the molecular chaperone Hsp60 in protection of Saccharo- myces cerevisiae against oxidative damage. We con- structed mutant strains in which the levels of Hsp60 protein, ...
    • Nitric oxide prevents Aft1 activation and metabolic remodeling in frataxindeficient yeast 

      Alsina Obiols, David; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2018)
      Yeast frataxin homolog (Yfh1) is the orthologue of human frataxin, a mitochondrial protein whose deficiency causes Friedreich Ataxia. Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in ...
    • Novel Antioxidant Role of Alcohol Dehydrogenase E from Escherichia coli 

      Echave Lozano, Pedro; Tamarit Sumalla, Jordi; Cabiscol Català, Elisa; Ros Salvador, Joaquim (American Society for Biochemistry and Molecular Biology, 2003)
      Alcohol dehydrogenase E (AdhE) is an Fe-enzyme that, under anaerobic conditions, is involved in dissimilation of glucose. The enzyme is also present under aerobic conditions, its amount is about one-third and its activity ...
    • Oxidative Damage to Specific Proteins in Replicative and Chronological-aged Saccharomyces cerevisiae 

      Reverter Branchat, Gemma; Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (American Society for Biochemistry and Molecular Biology, 2004)
      Oxidative modifications of cellular components have been described as one of the main contributions to aged phenotype. In Saccharomyces cerevisiae, two distinct life spans can be considered, replicative and chronological. The ...
    • Oxidative stress in bacteria and protein damage by reactive oxygen species 

      Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Springer-Verlag Ibérica, 2000)
      The advent of O2 in the atmosphere was among the first major pollution events occurred on earth. The reaction between ferrous iron, very abundant in the reductive early atmosphere, and oxygen results in the formation of ...
    • PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia 

      Rodríguez-Pascau, Laura; Britti, Elena; Calap Quintana, Pablo; Na Dong, Yi; Vergara, Cristina; Delaspre, Fabien; Medina Carbonero, Marta; Tamarit Sumalla, Jordi; Pallardó, Federico V.; Gonzalez Cabo, Pilar; Ros, Joaquim; Lynch, David R.; Martinell, Marc; Pizcueta, Pilar (Elsevier, 2021)
      Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts, cardiomyopathy, and increased incidence in diabetes. The ...
    • Protein carbonylation: proteomics, specificity and relevance to aging 

      Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Wiley, 2013)
      Detection and quantification of protein carbonyls present in biological samples has become a popular, albeit indirect, method to determine the existence of oxidative stress. Moreover, the rise of proteomics has allowed ...
    • Protein oxidation in Huntington disease 

      Sorolla Bardají, Maria Alba; Rodríguez Colman, Maria José; Vall-llaura Espinosa, Núria; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Wiley, 2012-05)
      Huntington disease (HD) is an inherited neurodegenerative disorder caused by expansion of CAG repeats in the huntingtin gene, affecting initially the striatum and progressively the cortex. Oxidative stress, and consequent ...
    • Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism 

      Sorolla Bardají, Maria Alba; Rodríguez Colman, Maria José; Tamarit Sumalla, Jordi; Ortega, Zaira; Lucas, José J.; Ferrer, Isidre; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Elsevier, 2010)
      Huntington disease (HD) is an inherited neurodegenerative disorder that initially affects the striatum and progressively the cortex. Oxidative stress in HD has been described as important to disease progression. In ...
    • Proteomic and oxidative stress analysis in human brain samples of Huntington disease 

      Sorolla Bardají, Maria Alba; Reverter Branchat, Gemma; Tamarit Sumalla, Jordi; Ferrer, Isidre; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Elsevier, 2008)
      Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG repeats in exon 1 of the huntingtin gene, affecting initially the striatum and progressively the cortex. This work reports a proteomic analysis ...
    • Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases 

      Garcera, Ana; Barreto Parra, Lina Patricia; Piedrafita Llorens, Lídia; Tamarit Sumalla, Jordi; Herrero Perpiñán, Enrique (Biochemical Society, 2006)
      The Saccharomyces cerevisiae genome encodes three proteins that Analysis of point mutants derived from wild-type Gto2 indicates display similarities with human GSTOs (Omega class glutathione that, among the three cysteine ...
    • Sir2 is induced by oxidative stress in a yeast model of Huntington disease and its activation reduces protein aggregation 

      Sorolla Bardají, Maria Alba; Nierga, Clara; Rodríguez Colman, Maria José; Reverter Branchat, Gemma; Arenas, Alicia; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Elsevier, 2011)
      Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG trinucleotide repeats, leading to an elongated polyglutamine sequence (polyQ) in the huntingtin protein. Misfolding of mutant polyQ ...
    • Structure-function analysis of yeast Grx5 monothiol glutaredoxin defines essential amino acids for the function of the protein 

      Bellí i Martínez, Gemma; Polaina, Julio; Tamarit Sumalla, Jordi; Torre Ruiz, M. A. de la; Rodríguez Manzanaque, Maria Teresa; Ros Salvador, Joaquim; Herrero Perpiñán, Enrique (The American Society for Biochemistry and Molecular Biology, 2002)
      Grx5 defines a family of yeast monothiol glutaredox- ins that also includes Grx3 and Grx4. All three proteins display significant sequence homology with proteins found from bacteria to humans. Grx5 is involved in ...
    • The Activating Component of the Anaerobic Ribonucleotide Reductase from Escherichia coli 

      Tamarit Sumalla, Jordi; Gerez, Catherine; Meier, Christian; Mulliez, Etienne; Trautwein, Alfred; Fontecave, Marc (American Society for Biochemistry and Molecular Biology, 2000)
      Class III anaerobic ribonucleotide reductase small component, named protein b, contains a (4Fe-4S) center. Its function is to mediate electron transfer from reduced flavodoxin to S-adenosylmethionine, required for ...
    • The Anaerobic Ribonucleotide Reductase from Escherichia coli 

      Tamarit Sumalla, Jordi; Mulliez, Etienne; Meier, Christian; Trautwein, Alfred; Fontecave, Marc (American Society for Biochemistry and Molecular Biology, 1999)
      For deoxyribonucleotide synthesis during anaerobic growth, Escherichia coli cells depend on an oxygen-sensitive class III ribonucleotide reductase. The enzyme system consists of two proteins: protein a, on which ribo ...
    • The Forkhead Transcription Factor Hcm1 Promotes Mitochondrial Biogenesis and Stress Resistance in Yeast 

      Rodríguez Colman, Maria José; Reverter Branchat, Gemma; Sorolla Bardají, Maria Alba; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim; Cabiscol Català, Elisa (American Society for Biochemistry and Molecular Biology, 2010)
      In Saccharomyces cerevisiae, the forkhead transcription factor Hcm1 is involved in chromosome segregation, spindle pole dynamics, and budding. We found that Hcm1 interacts with the histone deacetylase Sir2 and shifts ...
    • The FOX transcription factor Hcm1 regulates oxidative metabolism in response to early nutrient limitation in yeast. Role of Snf1 and Tor1/Sch9 kinases 

      Rodríguez Colman, Maria José; Sorolla Bardají, Maria Alba; Vall-llaura Espinosa, Núria; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Elsevier, 2013)
      Within Saccharomyces cerevisiae, Hcm1is a member of the forkhead transcription factor family with a role in chromosome organization. Our group recently described its involvement in mitochondrial biogenesis and stress ...
    • Yeast frataxin mutants display decreased superoxide dismutase activity crucial to promote protein oxidative damage 

      Irazusta, Verónica Patricia; Obis Monné, Èlia; Moreno Cermeño, Armando J.; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2010)
      Iron overload is involved in several pathological conditions, including Friedreich ataxia, a disease caused by decreased expression of the mitochondrial protein frataxin. In a previous study, we identified 14 proteins ...