Now showing items 21-40 of 44

    • Iron in Friedreich Ataxia: A Central Role in the Pathophysiology or an Epiphenomenon? 

      Alsina Obiols, David; Purroy, Rosa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (MDPI, 2018)
      Friedreich ataxia is a neurodegenerative disease with an autosomal recessive inheritance. In most patients, the disease is caused by the presence of trinucleotide GAA expansions in the first intron of the frataxin gene. ...
    • Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins 

      Irazusta, Verónica Patricia; Moreno Cermeño, Armando J.; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2008)
      Iron accumulation has been associated with several pathological conditions such as Friedreich ataxia. This human disorder is caused by decreased expression of frataxin. Iron-overload triggers oxidative stress, but the ...
    • Manganese Is the Link between Frataxin and Iron-Sulfur Deficiency in the Yeast Model of Friedreich Ataxia 

      Irazusta, Verónica Patricia; Cabiscol Català, Elisa; Reverter Branchat, Gemma; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (American Society for Biochemistry and Molecular Biology, 2006)
      Friedreich ataxia is a human neurodegenerative and myocardial disease caused by decreased expression of the mitochondrial protein frataxin. Proteomic analysis of the mutant yeast model of Friedreich ataxia presented in ...
    • Metabolic remodeling in frataxin-deficient yeast is mediated by Cth2 and Adr1 

      Moreno Cermeño, Armando J.; Alsina Obiols, David; Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Elsevier, 2013)
      Frataxin is a mitochondrial protein involved in iron metabolism whose deficiency in humans causes Friedreich ataxia. We performed transcriptomic and proteomic analyses of conditional Yeast Frataxin Homologue (Yfh1) mutants ...
    • Metal-catalyzed Oxidation of Fe2+ Dehydrogenases: consensus target sequence between Propanediol Oxidoreductase of Escherichia Coli and alcohol dehydrogenase I1 of Zymomonas Mobilis 

      Cabiscol Català, Elisa; Aguilar, Juan; Ros Salvador, Joaquim (American Society for Biochemistry and Molecular Biology, 1994)
      We have studied two enzymes of a newly described family of dehydrogenases with high sequence homology, 1,2-propanediol oxidoreductase of Escherichia coli and alcohol dehydrogenase II of Zymomonas mobilis. These enzymes ...
    • Mitochondrial calcium signaling and neurodegenerative diseases 

      Britti, Elena; Delaspre, Fabien; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Portland Press, 2018-11-16)
      Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium ...
    • Mitochondrial Hsp60, resistance to oxidative stress, and the labile iron pool are closely connected in Saccharomyces cerevisiae 

      Cabiscol Català, Elisa; Bellí i Martínez, Gemma; Tamarit Sumalla, Jordi; Echave Lozano, Pedro; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2002)
      In the present study, we have analyzed the role of the molecular chaperone Hsp60 in protection of Saccharo- myces cerevisiae against oxidative damage. We con- structed mutant strains in which the levels of Hsp60 protein, ...
    • Mitochondrial localization of the yeast forkhead factor Hcm1 

      Rodríguez Colman, Maria José; Ros Salvador, Joaquim; Cabiscol Català, Elisa (MDPI, 2020-12)
      Hcm1 is a member of the forkhead transcription factor family involved in segregation, spindle pole dynamics, and budding in Saccharomyces cerevisiae. Our group described the role of Hcm1 in mitochondrial biogenesis and ...
    • Nitric oxide prevents Aft1 activation and metabolic remodeling in frataxindeficient yeast 

      Alsina Obiols, David; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2018)
      Yeast frataxin homolog (Yfh1) is the orthologue of human frataxin, a mitochondrial protein whose deficiency causes Friedreich Ataxia. Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in ...
    • Novel Antioxidant Role of Alcohol Dehydrogenase E from Escherichia coli 

      Echave Lozano, Pedro; Tamarit Sumalla, Jordi; Cabiscol Català, Elisa; Ros Salvador, Joaquim (American Society for Biochemistry and Molecular Biology, 2003)
      Alcohol dehydrogenase E (AdhE) is an Fe-enzyme that, under anaerobic conditions, is involved in dissimilation of glucose. The enzyme is also present under aerobic conditions, its amount is about one-third and its activity ...
    • Oxidative Damage to Specific Proteins in Replicative and Chronological-aged Saccharomyces cerevisiae 

      Reverter Branchat, Gemma; Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (American Society for Biochemistry and Molecular Biology, 2004)
      Oxidative modifications of cellular components have been described as one of the main contributions to aged phenotype. In Saccharomyces cerevisiae, two distinct life spans can be considered, replicative and chronological. The ...
    • Oxidative stress in bacteria and protein damage by reactive oxygen species 

      Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Springer-Verlag Ibérica, 2000)
      The advent of O2 in the atmosphere was among the first major pollution events occurred on earth. The reaction between ferrous iron, very abundant in the reductive early atmosphere, and oxygen results in the formation of ...
    • Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae 

      Cabiscol Català, Elisa; Piulats Combalia, Eva; Echave Lozano, Pedro; Herrero Perpiñán, Enrique; Ros Salvador, Joaquim (The American Society for Biochemistry and Molecular Biology, 2000)
      We have analyzed the proteins that are oxidatively damaged when Saccharomyces cerevisiae cells are ex- posed to stressing conditions. Carbonyl groups generated by hydrogen peroxide or menadione on proteins of aero- bically ...
    • Protein carbonylation: proteomics, specificity and relevance to aging 

      Cabiscol Català, Elisa; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim (Wiley, 2013)
      Detection and quantification of protein carbonyls present in biological samples has become a popular, albeit indirect, method to determine the existence of oxidative stress. Moreover, the rise of proteomics has allowed ...
    • Protein oxidation in Huntington disease 

      Sorolla Bardají, Maria Alba; Rodríguez Colman, Maria José; Vall-llaura Espinosa, Núria; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Wiley, 2012-05)
      Huntington disease (HD) is an inherited neurodegenerative disorder caused by expansion of CAG repeats in the huntingtin gene, affecting initially the striatum and progressively the cortex. Oxidative stress, and consequent ...
    • Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism 

      Sorolla Bardají, Maria Alba; Rodríguez Colman, Maria José; Tamarit Sumalla, Jordi; Ortega, Zaira; Lucas, José J.; Ferrer, Isidre; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Elsevier, 2010)
      Huntington disease (HD) is an inherited neurodegenerative disorder that initially affects the striatum and progressively the cortex. Oxidative stress in HD has been described as important to disease progression. In ...
    • Proteomic and oxidative stress analysis in human brain samples of Huntington disease 

      Sorolla Bardají, Maria Alba; Reverter Branchat, Gemma; Tamarit Sumalla, Jordi; Ferrer, Isidre; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Elsevier, 2008)
      Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG repeats in exon 1 of the huntingtin gene, affecting initially the striatum and progressively the cortex. This work reports a proteomic analysis ...
    • Redox control and oxidative stress in yeast cells 

      Herrero Perpiñán, Enrique; Ros Salvador, Joaquim; Bellí i Martínez, Gemma; Cabiscol Català, Elisa (Elsevier, 2008)
      Protein structure and function can be altered by reactive oxygen species produced either by cell metabolism or by external oxidants. Although catalases, superoxide dismutases and peroxidases contribute to maintaining ...
    • Reduction of oxidative cellular damage by overexpression of the thioredoxin TRX2 gene improves yield and quality of wine yeast dry active biomass 

      Gómez-Pastor, Rocío; Pérez-Torrado, Roberto; Cabiscol Català, Elisa; Ros Salvador, Joaquim; Matallana, Emilia (BioMed Central, 2010)
      Background: Wine Saccharomyces cerevisiae strains, adapted to anaerobic must fermentations, suffer oxidative stress when they are grown under aerobic conditions for biomass propagation in the industrial process of active ...
    • Sir2 is induced by oxidative stress in a yeast model of Huntington disease and its activation reduces protein aggregation 

      Sorolla Bardají, Maria Alba; Nierga, Clara; Rodríguez Colman, Maria José; Reverter Branchat, Gemma; Arenas, Alicia; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Elsevier, 2011)
      Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG trinucleotide repeats, leading to an elongated polyglutamine sequence (polyQ) in the huntingtin protein. Misfolding of mutant polyQ ...