Recent Submissions

  • Evaluation of tumor interstitial fluid-extraction methods for proteome analysis: comparison of biopsy elution versus centrifugation 

    Matas Nadal, Clara; Bech Serra, Joan Josep; Guasch Vallés, Marta; Fernández Armenteros, José Manuel; Barceló Gómez, Carla; Casanova i Seuma, Josep M. (Josep Manel); de la Torre Gómez, Carolina; Aguayo Ortiz, Rafael; Garí Marsol, Eloi (American Chemical Society, 2020-01-01)
    The analysis of Tumor Interstitial Fluid (TIF) composition is a valuable procedure to identify anti-metastatic targets, and different laboratories have set up techniques for TIF isolation and proteomic analyses. However, ...
  • Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear Translocation 

    Eritja Sánchez, Núria; Navaridas Fernández de Bobadilla, Raúl; Ruiz Mitjana,Anna; Vidal Sabanés, Maria; Egea Navarro, Joaquim; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (MDPI, 2021-10-05)
    TGF-β has a dichotomous function, acting as tumor suppressor in premalignant cells but as a tumor promoter for cancerous cells. These contradictory functions of TGF-β are caused by different cellular contexts, including ...
  • PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia 

    Rodríguez-Pascau, Laura; Britti, Elena; Calap Quintana, Pablo; Na Dong, Yi; Vergara, Cristina; Delaspre, Fabien; Medina Carbonero, Marta; Tamarit Sumalla, Jordi; Pallardó, Federico V.; Gonzalez Cabo, Pilar; Ros, Joaquim; Lynch, David R.; Martinell, Marc; Pizcueta, Pilar (Elsevier, 2021)
    Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts, cardiomyopathy, and increased incidence in diabetes. The ...
  • Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity 

    Mota Martorell, Natàlia; Jové Font, Mariona; Pradas Barriga, Irene; Berdún Hernández, Rebeca; Sanchez, Isabel; Naudí i Farré, Alba; Garí Marsol, Eloi; Barja, Gustavo; Pamplona Gras, Reinald (Springer, 2020-08-01)
    Maximum longevity (ML) varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of ML could to converge ...
  • Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin 

    Pérez Fusté, Noel; Fernández Hernández, Rita; Cemeli, Tània; Mirantes Barbeito, Cristina; Pedraza González, Neus; Rafel i Borrell, Marta; Torres Rosell, Jordi; Colomina i Gabarrella, Neus; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Garí Marsol, Eloi (Nature Research, 2016-05-16)
    Cyclin D1 (Ccnd1) together with its binding partner Cdk4 act as a transcriptional regulator to control cell proliferation and migration, and abnormal Ccnd1 . Cdk4 expression promotes tumour growth and metastasis. While ...
  • Sensitive High-Throughput Assays for Tumour Burden Reveal the Response of a Drosophila melanogaster Model of Colorectal Cancer to Standard Chemotherapies 

    Adams, Jamie; Casali, Andreu; Campbell, Kyra (MDPI, 2021)
    Drosophila melanogaster (Drosophila) models of cancer are emerging as powerful tools to investigate the basic mechanisms underlying tumour progression and identify novel therapeutics. Rapid and inexpensive, it is possible ...
  • A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion 

    Witte, Franziska; Ruiz Orera, Jorge; Ciolli Mattioli, Camilla; Blachut, Susanne; Adami, Eleonora; Felicitas Schulz, Jana; Schneider-Lunitz, Valentin; Hummel, Oliver; Patone, Giannino; Mücke, Michael Benedikt; Šilhavý, Jan; Heinig, Matthias; Bottolo, Leonardo; Sanchis, Daniel; Vingron, Martin; Chekulaeva, Marina; Pravenec, Michal; Hubner, Norbert; Van Heesch, Sebastiaan (BMC, 2021)
    Background: Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic loci on the efficiency ...
  • Una aproximación desde la etnografía focalizada al papel de la religiosidad durante la vivencia del cáncer de mama 

    Laza-Vásquez, Celmira; Gea Sánchez, Montserrat (Faculdade de Saúde Pública, Universidade de São Paulo. Associação Paulista de Saúde Pública., 2021-09-03)
    En este trabajo se exploró el papel de la religiosidad durante la vivencia del cáncer de mama de un grupo de mujeres del sur de Colombia. Se realizó una etnografía focalizada donde participaron 17 mujeres que padecen cáncer ...
  • Maximization of information transmission influences selection of native phosphorelay architectures 

    Alves, Rui; Salvadó López, Baldiri; Milo, Ron; Vilaprinyo Terré, Ester; Sorribas Tello, Albert (PeerJ, 2021)
    Phosphorelays are signal transduction circuits that sense environmental changes and adjust cellular metabolism. Five different circuit architectures account for 99% of all phosphorelay operons annotated in over 9,000 ...
  • ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status 

    Barés Junqué, Gisel; Beà Tàrrega, Aida; Hernández, Luís; Navaridas Fernández de Bobadilla, Raúl; Felip, Isidre; Megino-Luque, Cristina; Blasco Angulo, Natividad; Nadeu, Ferran; Campo, Elías; Llovera i Tomàs, Marta; Dolcet Roca, Xavier; Sanchis, Daniel (MDPI, 2021)
    EndoG influences mitochondrial DNA replication and is involved in somatic cell proliferation. Here, we investigated the effect of ENDOG/Endog expression on proliferation in different tumor models. Noteworthy, ENDOG ...
  • Identifying thoracic malignancies through pleural fluid biomarkers: a predictive multivariate model 

    Porcel Pérez, José Manuel; Esquerda, Aureli; Martínez Alonso, Montserrat; Bielsa Martín, Silvia; Salud Salvia, Maria Antonieta (Wolters Kluwer Health, 2016-03-01)
    The diagnosis of malignant pleural effusions may be challenging when cytological examination of aspirated pleural fluid is equivocal or noncontributory. The purpose of this study was to identify protein candidate biomarkers ...
  • The Power-law formalism as a tool for modeling hormonal systems 

    Sorribas Tello, Albert; González Sistal, Ángel (Hindawi, 1999)
    Modeling a hormone system requires a number of simplifying assumptions. Often, the final conceptual model incorporates a number of aggregated processes that have no correspondence with a single enzyme-catalyzed ...
  • TControl: A mobile app to follow up tobacco-quitting patients 

    Pifarré Montalà, Marc; Carrera Peruga, Adrián; Vilaplana Mayoral, Jordi; Cuadrado, Josep; Solsona, Sara; Abella i Pons, Francesc; Solsona Tehàs, Francesc; Alves, Rui (Elsevier, 2017-04)
    Background and Objective Tobacco smoking is a major risk factor for a wide range of respiratory and circulatory diseases in active and passive smokers. Well-designed campaigns are raising awareness to the problem and an ...
  • Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction 

    Gutierrez Escribano, Pilar; Hormeño, Silvia; Madariaga Marcos, Julene; Solé Soler, Roger; O'Reilly, Francis J.; Morris, Kyle; Aicart Ramos, Clara; Aramayo, Ricardo; Montoya, Alex; Kramer, Holger; Rappsilber, Juri; Torres Rosell, Jordi; Moreno Herrero, Fernando; Aragon, Luis (Elsevier, 2020-12-17)
    Eukaryotic SMC complexes, cohesin, condensin, and Smc5/6, use ATP hydrolysis to power a plethora of functions requiring organization and restructuring of eukaryotic chromosomes in interphase and during mitosis. The Smc5/6 ...
  • Extensive nasal plaque: an unusual presentation of IgG4-related disease 

    Cortés, Camila; Bielsa Martín, Silvia; Fernández, Josep Manel; Vilardell, Felip; Gonzalez-Farré, Blanca; Casanova i Seuma, Josep M. (Josep Manel) (Society for Publication of Acta Dermato-Venereologica, 2018)
    IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition characterized mainly by tissue infiltration by IgG4+ plasma cells with a tendency to mass forming. IgG4-RD can involve any part of the body, including ...
  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 

    Klionsky, Daniel J.; Cantí Nicolás, Carles; Garcera, Ana; Herreros Danés, Judit; Soler i Tatché, Rosa Ma.; others (Taylor & Francis, 2021-02-08)
    In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant ...
  • Incidence of COVID-19 in patients exposed to chloroquine and hydroxychloroquine: results from a population-based prospective cohort in Catalonia, Spain, 2020 

    Vivanco-Hidalgo, Rosa Maria; Molina, Israel; Martinez, Elisenda; Roman-Viñas, Ramón; Sánchez-Montalvá, Adrián; Fibla Palazón, Joan; Pontes, Caridad; Velasco Muñoz, César (European Centre for Disease Prevention and Control, 2021)
    Background: Several clinical trials have assessed the protective potential of chloroquine and hydroxychloroquine. Chronic exposure to such drugs might lower the risk of infection with severe acute respiratory syndrome ...
  • Peritoneal Dialysis Is an Independent Factor Associated to Lower Intima Media Thickness in Dialysis Patients Free From Previous Cardiovascular Disease 

    Borràs, Mercè; Cambray Carner, Serafí; Crespo Masip, Maria; Pérez Fontán, Miguel; Bozić Stanojević, Milica; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Betriu i Bars, M. Àngels; Valdivielso Revilla, José Manuel (Frontiers Media, 2018)
  • FISH analysis of PTEN in endometrial carcinoma. Comparison with SNP arrays and MLPA 

    Maiques Carlos, Oscar; Cuevas, Dolors; García Dios, Diego Andrés; Coenegrachts, Lieve; Santacana, Maria; Velasco, Ana; Romero, Marta; Gatius Calderó, Sònia; Lambrechts, Diether; Müller, Sven; Pedersen, Hans Christian; Dolcet Roca, Xavier; Amant, Frederic; Matias-Guiu, Xavier (Wiley, 2014)
    Aims: To check the usefulness of a standardized protocol of PTEN FISH in 31 endometrial carcinomas (ECs) in comparison with SNP array (SNPA), multiplex ligation-dependent probe amplification (MLPA), and immunohistochemistry. ...
  • Human Menstrual Blood-Derived Mesenchymal Stem Cells as Potential Cell Carriers for Oncolytic Adenovirus 

    Moreno, R.; Rojas, L.A.; Vilardell, Felip; Cervera Soriano, Vanessa; García-Castro, J.; Fajardo, C. A.; Alemany, R. (Hindawi, 2017)
    Antitumor efficacy of systemically administered oncolytic adenoviruses (OAdv) is limited due to diverse factors such as liver sequestration, neutralizing interactions in blood, elimination by the immune system, and physical ...

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