Recent Submissions

  • Creixement tumoral i metabolisme de l'hoste: dues cares d'una mateixa moneda 

    Argilés, Josep M.; Llovera i Tomàs, Marta; López-Soriano, Francisco J. (Institut d'Estudis Catalans, 1993)
    L'etiologia del càncer es basa fonamentalment en l'aparició d'un dany genètic en una cèl·lula que ocasiona una expressió anormal de determinats gens, els productes dels quals canvien dramàticament el fenotip cel·lular. Com ...
  • Non-invasive imaging techniques and assessment of carotid vasa vasorum neovascularization: promises and pitfalls 

    Pereira, Tania; Betriu i Bars, M. Àngels; Alves, Rui (Elsevier, 2018)
    Carotid adventitia vasa vasorum neovascularization (VVn) is associated with the initial stages of arteriosclerosis and with the formation of unstable plaque. However, techniques to accurately quantify that neovascularization ...
  • Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice 

    Fuente Ruiz, Sandra de la; Sansa Zaragoza, Alba; Periyakaruppiah, Ambika; Garcera, Ana; Soler i Tatché, Rosa Ma. (Springer Verlag, 2018)
    Spinal muscular atrophy (SMA), a leading genetic cause of infant death, is caused by the loss of survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration and loss of spinal cord motoneurons (MNs), ...
  • Iron in Friedreich Ataxia: A Central Role in the Pathophysiology or an Epiphenomenon? 

    Alsina Obiols, David; Purroy, Rosa; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (MDPI, 2018)
    Friedreich ataxia is a neurodegenerative disease with an autosomal recessive inheritance. In most patients, the disease is caused by the presence of trinucleotide GAA expansions in the first intron of the frataxin gene. ...
  • L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial–mesenchymal transition 

    Versluis, MAC; Plat, A; de Bruyn, M; Matias-Guiu, Xavier; Trovik, Jone; Krakstad, Camilla; Nijman, Hans W.; Bosse, Tjalling; de Bock, GH; Hollema, H (Springer Verlag, 2018)
    Uterine carcinosarcoma (UCS) has been proposed as a model for epithelial–mesenchymal transition (EMT), a process characterized by a functional change facilitating migration and metastasis in many types of cancer. L1CAMis ...
  • Social environment mediates cancer progression in Drosophila 

    Dawson, Erika H.; Bailly, Tiphaine P. M.; Dos Santos, Julie; Moreno, Céline; Devilliers, Maëlle; Maroni, Brigitte; Sueur, Cédric; Casali, Andreu; Ujvari, Beata; Thomas, Frederic; Montagne, Jacques; Mery, Frederic (Springer Nature, 2018)
    The influence of oncogenic phenomena on the ecology and evolution of animal species is becoming an important research topic. Similar to host–pathogen interactions, cancer negatively affects host fitness, which should ...
  • Erectile dysfunction in obstructive sleep apnea patients: A randomized trial on the effects of Continuous Positive Airway Pressure (CPAP) 

    Pascual, Mercè; Batlle Garcia, Jordi de; Barbé Illa, Ferran; Castro-Grattoni, Anabel L.; Auguet, Josep M.; Pascual, Lydia; Vilà, Manel; Cortijo, Anunciación; Sánchez de la Torre, Manuel (Public Library of Science, 2018)
    Objectives Obstructive sleep apnea (OSA) is among the least studied risk factors for erectile dysfunction (ED). We aimed to determine ED prevalence in newly-diagnosed OSA patients, describe their main characteristics ...
  • Hippocampal neurons require a large pool of glutathione to sustain dendrite integrity and cognitive function 

    Fernandez-Fernandez, Seila; Bobo-Jimenez, Veronica; Requejo-Aguilar, Raquel; Gonzalez-Fernandez, Silvia; Resch, Monica; Carabias-Carrascoa, Monica; Ros Salvador, Joaquim; Almeida, Angeles; Bolaños, Juan P. (Elsevier, 2018)
    Loss of brain glutathione has been associated with cognitive decline and neuronal death during aging and neurodegenerative diseases. However, whether decreased glutathione precedes or follows neuronal dysfunction has not ...
  • Patient-Derived Xenograft Models for Endometrial Cancer Research 

    Moiola, Cristian P.; Lopez-Gil, Carlos; Cabrera, Silvia; Garcia, Angel; Van Nyen, Tom; Annibali, Daniela; Fonnes, Tina; Vidal, August; Villanueva, Alberto; Matias-Guiu, Xavier; Krakstad, Camilla; Amant, Frederic; Gil Moreno, Antonio; Colas, Eva (MDPI, 2018)
    Endometrial cancer (EC) is the most common malignancy of the genital tract among women in developed countries. Recently, a molecular classification of EC has been performed providing a system that, in conjunction with ...
  • Cytokeratin profile of basal cell carcinomas according to the degree of sun exposure and to the anatomical localization 

    García de la Fuente, María Reyes; Santacana Espasa, Maria; Valls Marsal, Joan; Vilardell, Felip; Fernández Armenteros, José Manuel; Pujol, Ramon; Garí Marsol, Eloi; Casanova i Seuma, Josep M. (Josep Manel) (Wolters Kluwer Health, Inc.International Society of Dermatopathology (ISDP), 2018)
    Basal cell carcinoma (BCC) seems to originate from ultraviolet light-induced mutations involving the bulge or the outer sheath of the hair follicle cells. However, the etiopathogenic mechanisms involved in the development ...
  • Comparative analysis of predictive methods for early assessment of compliance with continuous positive airway pressure therapy 

    Rafael-Palou, Xavier; Turino, Cecilia; Steblin, Alexander; Sánchez de la Torre, Manuel; Barbé Illa, Ferran; Vargiu, Eloisa (BMC, 2018)
    Background: Patients suffering obstructive sleep apnea are mainly treated with continuous positive airway pressure (CPAP). Although it is a highly effective treatment, compliance with this therapy is problematic to achieve ...
  • Combination of Vorinostat and caspase-8 inhibition exhibitshigh anti-tumoral activity on endometrial cancer cells 

    Eritja Sánchez, Núria; Bergadà Bertran, Laura; Sorolla Bardají, Anabel; Yeramian Hakim, Andree; Mirantes, Cristina; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Elsevier, 2013)
    Histone deacetylase inhibitors such as Vorinostat display anti-neoplastic activity against avariety of solid tumors. Here, we have investigated the anti-tumoral activity of Vorinostaton endometrial cancer cells. We have ...
  • A New Gender-Specific Formula to Estimate 24-Hour Urine Protein from Protein to Creatinine Ratio 

    Marco Mayayo, M. Paz; Martínez Alonso, Montserrat; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (Karger, 2016-07-20)
    Background: The quantification of proteinuria with the protein to creatinine ratio (PCR) is influenced by the excretion of creatinine, which, in turn, varies according to muscle mass and hence, to gender. Aims: To assess ...
  • A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium 

    Eritja Sánchez, Núria; Felip, Isidre; Dosil Garcia, Maria Alba; Vigezzi, Lucia; Mirantes Barbeito, Cristina; Yeramian Hakim, Andree; Navaridas Fernández de Bobadilla, Raúl; Santacana Espasa, Maria; Llobet Navàs, David; Yoshimura, Akihiko; Nomura, Masatoshi; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Nature Publishing Group, 2017-05-19)
    The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apoptosis, and their alterations lead to cancer development. TGF-β acts as a tumor suppressor in premalignant cells, but it ...
  • Acetylsalicylic acid prevents intermittent hypoxia-induced vascular remodeling in a murine model of sleep apnea 

    Suarez-Giron, Monique C.; Castro-Grattoni, Anabel L.; Torres, Marta; Farré, Ramon; Barbé Illa, Ferran; Sánchez de la Torre, Manuel; Gozal, David; Picado, Cesar; Montserrat i Capdevila, Josep; Almendros, Isaac (Frontiers Media, 2018)
    Study objectives: Chronic intermittent hypoxia (CIH), a hallmark feature of obstructive sleep apnea (OSA), induces accelerated atherogenesis as well as aorta vascular remodeling. Although the cyclooxygenase (COX) pathway ...
  • Palbociclib has antitumour effects on Pten-deficient endometrial neoplasias. 

    Dosil Garcia, Maria Alba; Mirantes Barbeito, Cristina; Eritja Sánchez, Núria; Felip, Isidre; Navaridas Fernández de Bobadilla, Raúl; Gatius, Sònia; Santacana Espasa, Maria; Colàs, Eva; Moiola, Cristian P.; Schoenenberger, Joan Antoni; Encinas Martín, Mario; Garí Marsol, Eloi; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Wiley, 2017-04-28)
    PTEN is one of the most frequently mutated genes in human cancers. The frequency of PTEN alterations is particularly high in endometrial carcinomas. Loss of PTEN leads to dysregulation of cell division, and promotes the ...
  • Assessing sleep health in a European population: results of the catalan health survey 2015 

    Dalmases, Mireia; Benítez, Ivan D.; Mas, Anna; Garcia-Codina, Oriol; Medina-Bustos, Antonia; Escarrabill, Joan; Saltó, Esteve; Buysse, Daniel J.; Roure, Núria; Sánchez de la Torre, Manuel; Rué i Monné, Montserrat; Barbé Illa, Ferran; Batlle Garcia, Jordi de (Public Library of Science, 2018)
    Objective To describe the overall sleep health of the Catalan population using data from the 2015 Catalan Health Survey and to compare the performance of two sleep health indicators: sleep duration and a 5-dimension sleep ...
  • Predictors of Subclinical Atheromatosis Progression over 2 Years in Patients with Different Stages of CKD 

    Gracia, Marta; Betriu i Bars, M. Àngels; Martínez Alonso, Montserrat; Arroyo, David; Abajo, María; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (American Society of Nephrology, 2016-02)
    Background and objectives Ultrasonographic detection of subclinical atheromatosis is a noninvasive method predicting cardiovascular events. Risk factors predicting atheromatosis progression in CKD are unknown. Predictors ...
  • Cardiac troponin values in patients with acute coronary syndrome and sleep apnea: a pilot study 

    Sánchez de la Torre, Alicia; Soler, Xavier; Barbé Illa, Ferran; Florés, Marina; Maisel, Alan; Malhotra, Atul; Rué i Monné, Montserrat; Bertran, Sandra; Aldomá, Albina; Worner, Fernando; Valls Marsal, Joan; Lee, Chi-Hang; Turino, Cecilia; Galera, Estefanía; Batlle Garcia, Jordi de; Sánchez de la Torre, Manuel (Elsevier, 2018)
    Background: An analysis of cardiac injury markers in patients with OSA who sustain an episode of acute coronary syndrome (ACS) may contribute to a better understanding of the interactions and impact of OSA in subjects with ...
  • Effect of obstructive sleep apnoea on severity and short-term prognosis of acute coronary syndrome 

    Barbé Illa, Ferran; Sánchez de la Torre, Alicia; Abad, Jorge; Durán-Cantolla, Joaquín; Mediano, Olga; Amilibia, Jose; Masdeu, María José; Florés, Marina; Barceló Bennasar, Antònia; Peña, Mónica de la; Aldomá, Albina; Worner, Fernando; Valls Marsal, Joan; Castellà, Gerard; Sánchez de la Torre, Manuel (European Respiratory Society, 2015)
    The goal of this study was to evaluate the influence of obstructive sleep apnoea on the severity and short-term prognosis of patients admitted for acute coronary syndrome. Obstructive sleep apnoea was defined as an ...

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