Now showing items 1-5 of 5

    • Exploiting parallelism on progressive alignment methods 

      Orobitg Cortada, Miquel; Guirado Fernández, Fernando; Notredame, Cedric; Cores Prado, Fernando (Springer Verlag, 2011)
      Multiple Sequence Alignment (MSA) constitutes an extremely powerful tool for important biological applications such as phylogenetic analysis, identification of conserved motifs and domains and structure prediction. In ...
    • High Performance computing improvements on bioinformatics consistency-based multiple sequence alignment tools 

      Orobitg Cortada, Miquel; Guirado Fernández, Fernando; Cores Prado, Fernando; Lladós Segura, Jordi; Notredame, Cedric (Elsevier, 2014-10-08)
      Multiple Sequence Alignment (MSA) is essential for a wide range of applications in Bioinformatics. Traditionally, the alignment accuracy was the main metric used to evaluate the goodness of MSA tools. However, with the ...
    • Optimization of Consistency-Based Multiple Sequence Alignment using Big Data technologies 

      Lladós Segura, Jordi; Cores Prado, Fernando; Guirado Fernández, Fernando (Springer, 2019)
      With the advent of new high-throughput next-generation sequencing technologies, the volume of genetic data processed has increased significantly. It is becoming essential for these applications to achieve large-scale alignments ...
    • PPCAS: Implementation of a Probabilistic Pairwise Model for Consistency-Based Multiple Alignment in Apache Spark 

      Lladós Segura, Jordi; Guirado Fernández, Fernando; Cores Prado, Fernando (Springer, 2017)
      Large-scale data processing techniques, currently known as Big-Data, are used to manage the huge amount of data that are generated by sequencers. Although these techniques have significant advantages, few biological ...
    • Recovering accuracy methods for scalable consistency library 

      Lladós Segura, Jordi; Guirado Fernández, Fernando; Cores Prado, Fernando; Lérida Monsó, Josep Lluís; Notredame, Cedric (Springer Verlag, 2015-05-01)
      Multiple sequence alignment (MSA) is crucial for high-throughput next generation sequencing applications. Large-scale alignments with thousands of sequences are necessary for these applications. However, the quality of the ...