Now showing items 21-40 of 330

    • Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study 

      de Rojas, Itziar; Hernández, Isabel; Montrreal, Laura; Quintela, Inés; Calero, Miguel; Royo, Jose Luís; Huerto Vilas, Raquel; González Pérez, Antonio; Franco Macías, Emilio; Macías, Juan; Menéndez González, Manuel; Frank García, Ana; Diez Fairen, Mónica; Lage, Carmen; García Madrona, Sebastián; Aguilera, Nuria; García González, Pablo; Puerta, Raquel; Sotolongo Grau, Oscar; Alonso Lana, Silvia; Rábano, Alberto; Arias Pastor, Alfonso; Pastor, Ana Belén; Corma Gómez, Anaïs; Martín Montes, Ángel; Martínez Rodríguez, Carmen; Buiza Rueda, Dolores; Rodríguez Rodríguez, Eloy; Álvarez, Ignacio; Rosas Allende, Irene; Pineda, Juan A.; Bernal Sánchez-Arjona, María; Fernández Fuertes, Marta; Mendoza, Silvia; Del Ser, Teodoro; García Ribas, Guillermo; Sánchez Juan, Pascual; Pastor, Pau; Bullido, María J.; Álvarez, Victoria; Real, Luis M; Mir, Pablo; Piñol Ripoll, Gerard; García Alberca, Jose María; Medina, Miguel; Orellana, Adelina; Butler, Chris R.; Marquié, Marta; Sáez, María Eugenia; Carracedo, Angel; Tárraga, Lluís; Boada, Mercè; Ruiz, Agustín (MDPI, 2021)
      Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study ...
    • Gut microbes shape microglia and cognitive function during malnutrition 

      Bauer, Kylynda C.; York, Elisa M.; Cirstea, Mihai; Radisavljevic, Nina; Petersen, Charisse; Huus, Kelsey E.; Brown, Eric M.; Bozorgmehr, Tahereh; Berdún Hernández, Rebeca; Bernier, Louis-Philippe; Lee, Amy H.Y.; Woodward, Sarah E.; Krekhno, Zakhar; Han, Jun; Hancock, Robert E.W.; Ayala Jové, Ma. Victoria (Maria Victoria); MacVicar, Brian A.; Finlay, Barton Brett (Wiley Periodicals, 2022)
      Fecal-oral contamination promotes malnutrition pathology. Lasting consequences of early life malnutrition include cognitive impairment, but the underlying pathology and influence of gut microbes remain largely unknown. ...
    • Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease 

      Castelblanco Echavarría, Esmeralda; Sarrias, Maria-Rosa; Betriu i Bars, M. Àngels; Soldevila, Berta; Barranco Altirriba, María; Franch-Nadal, Josep; Valdivielso Revilla, José Manuel; Bermúdez López, Marcelino; Groop, Per-Henrik; Fernández i Giráldez, Elvira; Alonso, Núria; Mauricio Puente, Dídac (Impact Journals, 2021)
      This study assessed the association of CD5L and soluble CD36 (sCD36) with the risk of a cardiovascular event (CVE), including CV death and all-cause mortality in CKD. We evaluated the association of CD5L and sCD36 with a ...
    • Advanced lipoprotein parameters could better explain atheromatosis in non-diabetic chronic kidney disease patients 

      Bermúdez López, Marcelino; Perpiñán, Hèctor; Amigó, Núria; Castro-Boqué, Eva; Alonso, Núria; Mauricio Puente, Dídac; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (European Renal Association - European Dialysis and Transplant Association (ERA-EDTA); Oxford University Press, 2021)
      Background: Chronic kidney disease (CKD) patients have a high burden of atheromatous cardiovascular disease (ASCVD) not fully explained by traditional lipid parameters. Lipoprotein composition and subclass particle number ...
    • ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma 

      Megino-Luque, Cristina; Sisó, Pol; Mota Martorell, Natàlia; Navaridas Fernández de Bobadilla, Raúl; de la Rosa, Inés; Urdanibia, Izaskun; Albertí Valls, Manel; Santacana Espasa, Maria; Pinyol, Miquel; Bonifaci, Núria; Macià Armengol, Anna; Llobet Navàs, David; Gatius Calderó, Sònia; Matias-Guiu, Xavier; Eritja Sánchez, Núria (Federation of European Biochemical Societies; John Wiley & Sons, 2022)
      AT-rich interactive domain-containing protein 1A (ARID1A) loss-of-function mutation accompanied by a loss of ARID1A protein expression is frequently observed in endometrial carcinomas. However, the molecular mechanisms ...
    • Differential Immunoexpression of BRAF/V600E, Senescence Markers, PTEN, and T-type Calcium Channels in Acquired Naevi According to their Histopathological and Dermoscopic Classification 

      Moreno, Sara; Maiques Carlos, Oscar; Barceló Gómez, Carla; Romero, Marta; Santacana Espasa, Maria; Gómez, Ignacio; Cuevas Sánchez, Dolors; Velasco Sánchez, Ana; Veà Jódar, Àlvar; Macià Armengol, Anna; Boix, Ramon; Valls Marsal, Joan; Gatius Calderó, Sònia; Cantí Nicolás, Carles; Matias-Guiu, Xavier; Soria, Xavier; Martí Laborda, Rosa Ma. (Society for Publication of Acta Dermato-Venereologica, 2021)
      BRAF/V600E mutation and other cell growth/growth-control mechanisms are involved in naevogenesis and melanomagenesis. Immunoexpression of BRAF/V600E and other molecules (p16, phosphatase and tensin homologue (PTEN), Ki67, ...
    • PEG-Interferon-α ribavirin-induced HCV viral clearance: a pharmacogenetic multicenter Spanish study 

      Milara, Javier; Outeda Macias, María; Aumente Rubio, Mª Dolores; Más Serrano, Patricio; Aldaz, Azucena; Calvo, Mª Victoria; García Simón, Mª Sergia; Martín Barbero, Marisa; SEFH-PkGen research group (Sociedad Española de Farmacia Hospitalaria, 2015)
      Objective: Dual PEGylated interferon-α (PEG-IFN) and ribavirin therapy has been the main hepatitis C virus (HCV) treatment of the last decade. Current direct-acting antiviral agents have improved the outcome of therapy but ...
    • Two vs. three weeks of treatment with amoxicillin-clavulanate for stabilized community-acquired complicated parapneumonic effusions. A preliminary non-inferiority, double-blind, randomized, controlled trial 

      Porcel Pérez, José Manuel; Ferreiro, Lucía; Rumi, Laura; Espino Paisán, Esther; Civit, Carmen; Pardina Solano, Marina Asunción; Schoenenberger, Joan Antoni; Valdés, Luis; Bielsa Martín, Silvia (De Gruyter, 2020)
      Background: The optimal duration of antibiotic treatment for complicated parapneumonic effusions (CPPEs) has not been properly defined. Our aim was to compare the efficacy of amoxicillin-clavulanate for 2 vs. 3 weeks in ...
    • Distinctive Under-Expression Profile of Inflammatory and Redox Genes in the Blood of Elderly Patients with Cardiovascular Disease 

      Milanesi, Elena; Manda, Gina; Dobre, Maria; Codrici, Elena; Neagoe, Ionela Victoria; Popescu, Bogdan Ovidiu; Bajenaru, Ovidiu Alexandru; Spiru, Luiza; Tudose, Catalina; Prada, Gabriel-Ioan; Davidescu, Eugenia Irene; Piñol Ripoll, Gerard; Cuadrado, Antonio (Dove Medical Press, 2021)
      Purpose: Chronic low-grade inflammation and oxidative stress are present in most of the pathologic mechanisms underlying non-communicable diseases. Inflammation and redox biomarkers might therefore have a value in disease ...
    • Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club 

      Escrichs, Anira; Biarnés, Carles; Garre Olmo, Josep; Fernández Real, Xavier; Ramos, Rafel; Pamplona Gras, Reinald; Brugada, Ramon; Serena, Joaquín; Ramió Torrentà, Lluís; Coll-De-Tuero, Gabriel; Gallart, Luís; Barretina Ginesta, Jordi; Vilanova, Joan Carles; Mayneris Perxachs, Jordi; Essig, Marco; Figley, Chase R.; Pedraza, Salvador; Puig, Josep; Deco, Gustavo (Oxford University Press, 2021)
      Normal aging causes disruptions in the brain that can lead to cognitive decline. Resting-state functional magnetic resonance imaging studies have found significant age-related alterations in functional connectivity across ...
    • Lipidomic profiling identifies signatures of metabolic risk 

      Yin, Xiaoyan; Willinger, Christine M.; Keefe, Joshua; Liu, Jun; Fernández Ortiz, Antonio; Ibáñez, Borja; Peñalvo, José L.; Adourian, Aram; Chen, George; Corella, Dolores; Pamplona Gras, Reinald; Portero Otín, Manuel; Jové Font, Mariona; Courchesne, Paul; van Duijn, Cornelia M.; Fuster, Valentín; Ordovás, José M.; Demirkan, Ayşe; Larson, Martin G.; Levy, Daniel (Elsevier, 2020)
      Background: Metabolic syndrome (MetS), the clustering of metabolic risk factors, is associated with cardiovascular disease risk. We sought to determine if dysregulation of the lipidome may contribute to metabolic risk ...
    • Essential Physiological Differences Characterize Short- and Long-Lived Strains of Drosophila melanogaster 

      Gubina, Nina; Naudí i Farré, Alba; Stefanatos, Rhoda; Jové Font, Mariona; Scialò, Filippo; Fernández Ayala, Daniel J.; Rantapero, Tommi; Yurkevych, Ihor; Portero Otín, Manuel; Nykter, Matti; Lushchak, Oleh; Navas, Placido; Pamplona Gras, Reinald; Sanz, Alberto (Gerontological Society of America; Oxford University Press, 2019)
      Aging is a multifactorial process which affects all animals. Aging as a result of damage accumulation is the most accepted explanation but the proximal causes remain to be elucidated. There is also evidence indicating that ...
    • mTORC1 is also involved in longevity between species 

      Barja, Gustavo; Pamplona Gras, Reinald (Impact Journals, 2021-05-29)
    • Plasma methionine metabolic profile is associated with longevity in mammals 

      Mota Martorell, Natàlia; Jové Font, Mariona; Berdún Hernández, Rebeca; Pamplona Gras, Reinald (Nature Research, 2021-06-11)
      Methionine metabolism arises as a key target to elucidate the molecular adaptations underlying animal longevity due to the negative association between longevity and methionine content. The present study follows a comparative ...
    • Dysregulated protein phosphorylation: A determining condition in the continuum of brain aging and Alzheimer's disease 

      Ferrer, Isidre; Andrés Benito, Pol; Ausín, Karina; Pamplona Gras, Reinald; del Rio, José Antonio; Fernández-Irigoyen, Joaquín; Santamaría, Enrique (John Wiley & Sons Ltd, 2021-11-01)
      Tau hyperphosphorylation is the first step of neurofibrillary tangle (NFT) formation. In the present study, samples of the entorhinal cortex (EC) and frontal cortex area 8 (FC) of cases with NFT pathology classified as ...
    • Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus 

      Borràs, Consuelo; Abdelaziz, Kheira M.; Díaz, Ana; Gambini,Juan; Jové Font, Mariona; López-Grueso, Raul; Mas-Bargues, Cristina; Monleón, Daniel; Pamplona Gras, Reinald; Viña Ribes, José (Elsevier, 2021-12-01)
      Soya consumption can decrease oxidative stress in animal models. Moreover, phytoestrogens such as genistein, present in soya, can mimic some of the beneficial effects of estrogens and are devoid of significant side effects, ...
    • Age-Related Changes in Lipidome of Rat Frontal Cortex and Cerebellum Are Partially Reversed by Methionine Restriction Applied in Old Age 

      Jové Font, Mariona; Cabré, Rosanna; Mota Martorell, Natàlia; Martin Garí, Meritxell; Obis, Èlia; Ramos, Paula; Canales , Iván; Galo-Licona, José Daniel; Sol, Joaquim; Nogueras Penabad, Lara; Torres Cabestany, Pascual; Portero Otín, Manuel; Ayala Jové, Ma. Victoria (Maria Victoria); Ferrer, Isidre; Pamplona Gras, Reinald (MDPI, 2021-11-20)
      Lipids are closely associated with brain structure and function. However, the potential changes in the lipidome induced by aging remain to be elucidated. In this study, we used chromatographic techniques and a mass ...
    • Lipidomic traits of plasma and cerebrospinal fluid in amyotrophic lateral sclerosis correlate with disease progression 

      Sol, Joaquim; Jové Font, Mariona; Povedano, Mònica; Sproviero, William; Dominguez, Raul; Piñol Ripoll, Gerard; Romero Guevara, Ricardo; Hye, Abdul; Al-Chalabi, Ammar; Torres Cabestany, Pascual; Andrés Benito, Pol; Area Gomez, Estela; Pamplona Gras, Reinald; Ferrer, Isidre; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel (Oxford University Press, 2021)
      Since amyotrophic lateral sclerosis cases exhibit significant heterogeneity, we aim to investigate the association of lipid composition of plasma and CSF with amyotrophic lateral sclerosis diagnosis, its progression and ...
    • Neural architecture of the vertebrate brain: implications for the interaction between emotion and cognition 

      Pessoa, Luiz; Medina Hernández, Loreta Mª; Hof, Patrick R.; Desfilis, Ester (Elsevier, 2019)
      Cognition is considered a hallmark of the primate brain that requires a high degree of signal integration, such as achieved in the prefrontal cortex. Moreover, it is often assumed that cognitive capabilities imply “superior” ...
    • Refocusing Neuroscience: Moving Away from Mental Categories and Toward Complex Behaviors 

      Pessoa, Luiz; Medina Hernández, Loreta Mª; Desfilis, Ester (The Royal Society, 2021)
      Mental terms—such as perception, cognition, action, emotion, as well as attention, memory, decision-making—are epistemically sterile. We support our thesis based on extensive comparative neuroanatomy knowledge of the ...