Browsing Articles publicats (Medicina Experimental) by Title
Now showing items 1-20 of 297
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2-phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53
(Elsevier, 2014)2-Phenylethynesulfonamide (PES) or pifithrin-μ is a promising anticancer agent with preferential toxicity for cancer cells. The type of cell death and the molecular cascades activated by this compound are controversial. ... -
2-phenylethynesulphonamide (PFT-μ) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by reducing GSH levels
(Wiley online library, 2016)Heat shock proteins (HSPs), are molecular chaperones that assist the proper folding of nascent proteins. This study aims to evaluate the antitumour effects of the hsp90 inhibitor NVP-AUY922 in melanoma, both in vitro ... -
7-Bromoindirubin-3'-oxime induces caspase-independent cell death
(Nature Publishing Group, 2006)Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the aryl hydrocarbon receptor (AhR). Indirubin is the active ... -
7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death
(Elsevier, 2008)The new 7-bromoindirubin-3′-oxime (7BIO) compound induces caspase-independent cell death in all cell lines tested to date. Irrespective of the cell line, a 25 μM treatment for 24 h is lethal for the entire cell population. ... -
7-dehydrocholesterol efficiently supports Ret signaling in a mouse model of Smith-Opitz-Lemli syndrome
(Nature Publishing Group, 2016)Smith-Lemli-Opitz syndrome (SLOS) is a rare disorder of cholesterol synthesis. Affected individuals exhibit growth failure, intellectual disability and a broad spectrum of developmental malformations. Among them, renal ... -
A 3D MRI‐based atlas of a lizard brain
(Wiley, 2018)Magnetic resonance imaging (MRI) is an established technique for neuroanatomical analysis, being particularly useful in the medical sciences. However, the application of MRI to evolutionary neuroscience is still in its ... -
A model of protein association based on their hydrophobic and electric interactions
(Public Library of Science, 2014)The propensity of many proteins to oligomerize and associate to form complex structures from their constituent monomers, is analyzed in terms of their hydrophobic (H), and electric pseudo-dipole (D) moment vectors. In ... -
A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts
(Oxford University Press, 2012)miR-21 is the most commonly over-expressed microRNA (miRNA) in cancer and a proven oncogene. Hsa-miR-21 is located on chromosome 17q23.2, immediately downstream of the vacuole membrane protein-1 (VMP1) gene, also known as ... -
A plasma metabolomic signature discloses human breast cancer
(Impact Journals, 2017)Purpose: Metabolomics is the comprehensive global study of metabolites in biological samples. In this retrospective pilot study we explored whether serum metabolomic profile can discriminate the presence of human breast ... -
A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma
(BMC (part of Springer Nature), 2019-05-22)Background: We wanted to define metabolomic patterns in plasma to predict a negative outcome in severe trauma patients. Methods: A prospective pilot study was designed to evaluate plasma metabolomic patterns, established ... -
A salmon peptide diet alleviates experimental colitis as compared with fish oil
(Cambridge University Press, 2013)Fish oil (FO) has been shown to have anti-inflammatory properties in animal models of inflammatory bowel disease, but how fish peptides (FP) influence intestinal inflammation has been less studied. Male Wistar rats, divided ... -
A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium
(Nature Publishing Group, 2017-05-19)The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apoptosis, and their alterations lead to cancer development. TGF-β acts as a tumor suppressor in premalignant cells, but it ... -
Aberrant regulation of the GSK-3b/NRF2 axis unveils a novel therapy for adrenoleukodystrophy
(Wiley Open Access, 2018)The nuclear factor erythroid 2-like 2 (NRF2) is the master regulator of endogenous antioxidant responses. Oxidative damage is a shared and early-appearing feature in X-linked adrenoleukodystrophy (X-ALD) patients and ... -
Accumulation of misfolded SOD1 in dorsal root ganglion degenerating propioceptive sensory neurons of transgenic mice with amyotrophic lateral sclerosis
(Hindawi Publishing Corporation, 2014)Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disease affecting upper and lower motoneurons (MNs). Although the motor phenotype is a hallmark for ALS, there is increasing evidence that ... -
Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA
(Nature Research, 2018)Spinal muscular atrophy (SMA) is a severe motor neuron (MN) disease caused by the deletion or mutation of the survival motor neuron 1 (SMN1) gene, which results in reduced levels of the SMN protein and the selective ... -
Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy
(Macmillan Publishers, 2015)Oxidative stress and mitochondrial failure are prominent factors in the axonal degeneration process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the mitochondrial function, is impaired in the ... -
Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype
(Nature Research, 2021)Senescent cells are capable of expressing a myriad of infammatory cytokines and this proinfammatory phenomenon is known as senescence-associated secretory phenotype (SASP). The contribution of this phenomenon in brain ... -
Adipose Tissue Mitochondrial Factors Profile after Dietary Bioactive Compound Weight Reduction Treatments in a Mice Obesity Model
(MDPI, 2019)Prolonged caloric intake above energy needs disturbs the body's ability to store and manage the excess of energy intake, leading to the onset of chronic degenerative diseases. This study aimed to compare the effect of three ... -
Adipose Tissue Protein Glycoxidation is Associated with Weight‐Loss Potential
(Wiley online library, 2019-05)Objective: This study aimed to characterize the differences in protein oxidation biomarkers in adipose tissue (AT) as an indicator of AT metabolism and bariatric surgery weight‐loss success. Methods: A human model, in ... -
Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence
(Karger Publishers Open Access, 2018-11-18)Background/Aims: Thyroid hormones have been recently linked to senescence and longevity. Given the recent description of TSHB mRNA in human adipose tissue (AT), we aimed to investigate the relationship ...