Browsing Articles publicats (Medicina Experimental) by Subject "Neuromuscular junction"
Now showing items 1-2 of 2
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Chronic treatment with the AMPA agonist AICAR prevents skeletal muscle pathology but fails to improve clinical outcome in a mouse model of severe spinal muscular atrophy
(Springer Verlag, 2016)Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder characterized by spinal and brainstem motor neuron (MN) loss and skeletal muscle paralysis. Currently there is no effective treatment other than supportive ... -
Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice
(Wiley, 2020-07-20)Background The cellular mechanisms underlying the age‐associated loss of muscle mass and function (sarcopenia) are poorly understood, hampering the development of effective treatment strategies. Here, we performed a detailed ...