Browsing Articles publicats (Medicina Experimental) by Author "Yuste Mateos, Víctor J. (Víctor José)"
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2-phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53
Mattiolo, Paolo; Barbero-Farran A.; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Elsevier, 2014)2-Phenylethynesulfonamide (PES) or pifithrin-μ is a promising anticancer agent with preferential toxicity for cancer cells. The type of cell death and the molecular cascades activated by this compound are controversial. ... -
7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death
Ribas i Fortuny, Judit; Yuste Mateos, Víctor J. (Víctor José); Garrofé Ochoa, Xènia; Meijer, Laurent; Esquerda Colell, Josep; Boix Torras, Jacint (Elsevier, 2008)The new 7-bromoindirubin-3′-oxime (7BIO) compound induces caspase-independent cell death in all cell lines tested to date. Irrespective of the cell line, a 25 μM treatment for 24 h is lethal for the entire cell population. ... -
An early and robust activation of caspases heads cells for a regulated form of necrotic-like cell death
Garcia-Belinchón, Mercè; Sánchez Osuna, María; Martínez Escardó, Laura; Granados-Colomina, Carla; Pascual-Guiral, Sònia; Iglesias-Guimarais, Victoria; Casanelles, Elisenda; Ribas i Fortuny, Judit; Yuste Mateos, Víctor J. (Víctor José) (American Society for Biochemistry and Molecular Biology, 2015)Apoptosis is triggered by the activation of caspases and characterized by chromatin condensation and nuclear fragmentation (type II nuclear morphology). Necrosis is depicted by a gain in cell volume (oncosis), swelling ... -
Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation
Mattiolo, Paolo; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Elsevier, 2015-12)Autophagy is generally regarded as a mechanism to promote cell survival. However, autophagy can occasionally be the mechanism responsible of cell demise. We have found that a concomitant depletion of glucose, nutrients and ... -
Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton
Barbier, Sardine; Chatre, Laurent; Bras, Marlène; Sancho, Patricia; Roué, Gaël; Virely, Clémence; Yuste Mateos, Víctor J. (Víctor José); Baudet, Sylvie; Rubio, Manuel; Esquerda Colell, Josep; Sarfati, Marika; Merle-Béral, Hélène; Susin, Santos A. (Ferrata Storti Foundation, 2009)Background Programmed cell death has been traditionally related with caspase activation. However, it is now accepted that caspase-independent forms of programmed cell death also regulate cell death. In chronic lymphocytic ... -
Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage
Chicote, Javier; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Frontiers Media, 2020-10-15)Macroautophagy (hereafter autophagy) is a multistep intracellular catabolic process with pleiotropic implications in cell fate. Attending to its activation, autophagy can be classified into inducible or constitutive. ... -
Characterization of the Cell Death Process Induced by Staurosporine in Human Neuroblastoma Cell Lines
Boix Torras, Jacint; Llecha Cano, Núria; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Elsevier, 1997)Staurosporine is a potent and non-specific inhibitor of protein kinases. There is also evidence of staurosporine being a potent inducer of apoptosis. In several human neuroblastoma cell lines (SH-SY5Y, NB69, IMR-5 and ... -
Gossypol Treatment Restores Insufficient Apoptotic Function of DFF40/CAD in Human Glioblastoma Cells
Martínez Escardó, Laura; Alemany, Montse; Sánchez Osuna, María; Sánchez Chardi, Alejandro; Roig Martínez, Meritxell; Suárez García, Salvio; Ruiz Molina, Daniel; Vidal, Noemí; Plans, Gerard; Majós, Carles; Ribas i Fortuny, Judit; Baltrons, María Antonia; Bayascas Ramírez, José Ramón; Barcia, Carlos; Bruna, Jordi; Yuste Mateos, Víctor J. (Víctor José) (MDPI, 2021)Glioblastoma (GBM) is a highly aggressive brain tumor and almost all patients die because of relapses. GBM-derived cells undergo cell death without nuclear fragmentation upon treatment with different apoptotic agents. ... -
Serum Deprivation and Protein Synthesis Inhibition Induce Two Different Apoptotic Processes in N18 Neuroblastoma Cells
Fibla Palazón, Joan; Yuste Mateos, Víctor J. (Víctor José); Piulats, J.M; Llecha Cano, Núria; Comella i Carnicé, Joan Xavier; Boix Torras, Jacint (Elsevier, 1998)N18 are murine neuroblastoma cells that underwent cell death upon serum deprivation or inhibition of protein synthesis by means of cycloheximide (CHX). In both cases, an ultrastructural morphology and an internucleosomal ... -
The prevention of the staurosporine-induced apoptosis by Bcl-XL, but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells
Yuste Mateos, Víctor J. (Víctor José); Sánchez-López, Isabel; Solé Serra, Carme; Encinas Martín, Mario; Bayascas Ramírez, José Ramón; Boix Torras, Jacint; Comella i Carnicé, Joan Xavier (Wiley, 2002)Staurosporine is one of the best apoptotic inducers in different cell types including neuroblastomas. In this study we have compared the efficiency and final outcome of three different anti-apoptotic strategies in ...