Now showing items 1-13 of 13

    • Biosynthesis de novo of glycerophospholipids and longevity 

      Mota Martorell, Natàlia; Pradas Barriga, Irene; Jové Font, Mariona; Naudí i Farré, Alba; Pamplona Gras, Reinald (Sociedad Española de Geriatría y Gerontología, 2019-03-30)
      Introducción. Entre los principales componentes lipídicos de las membranas celulares se encuentran los glicerofosfolípidos (GFL), que se sintetizan en una vía de novo a partir del diacilglicerol (DAG). El perfil lipídico ...
    • Effects of aging and methionine restriction on rat kidney metabolome 

      Pradas Barriga, Irene; Jové Font, Mariona; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Mota Martorell, Natàlia; Pamplona Gras, Reinald (MDPI, 2019-11-14)
      Methionine restriction (MetR) in animal models extends maximum longevity and seems to promote renoprotection by attenuating kidney injury. MetR has also been proven to affect several metabolic pathways including lipid ...
    • Exceptional human longevity is associated with a specific plasma phenotype of ether lipids 

      Pradas Barriga, Irene; Jové Font, Mariona; Huynh, Karina; Puig Farré, Josep; Inglés, Marta; Borràs, Consuelo; Viña Ribes, José; Meikle, Peter J.; Pamplona Gras, Reinald (Elsevier, 2019)
      A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to ...
    • Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity 

      Mota Martorell, Natàlia; Jové Font, Mariona; Pradas Barriga, Irene; Berdún Hernández, Rebeca; Sanchez, Isabel; Naudí i Farré, Alba; Garí Marsol, Eloi; Barja, Gustavo; Pamplona Gras, Reinald (Springer, 2020-08-01)
      Maximum longevity (ML) varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of ML could to converge ...
    • Lipidomics Reveals a Tissue-Specific Fingerprint 

      Pradas Barriga, Irene; Huynh, Kevin; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Meikle, Peter J.; Jové Font, Mariona; Pamplona Gras, Reinald (Frontiers Media, 2018)
      In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the compositional level in cell membranes and ...
    • Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome 

      Jové Font, Mariona; Pradas Barriga, Irene; Naudí i Farré, Alba; Rovira-Llopis, Susana; Bañuls, Celia; Rocha, Milagros; Portero Otín, Manuel; Hernández-Mijares, Antonio; Victor, Victor M.; Pamplona Gras, Reinald (Impact Journals, 2017)
      Purpose: In this work, a non-targeted approach was used to unravel changes in the plasma lipidome of PCOS patients. The aim is to offer new insights in PCOS patients strictly selected in order to avoid confounding factors ...
    • Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target 

      Jové Font, Mariona; Pradas Barriga, Irene; Dominguez Gonzalez, Mayelin; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2018)
      The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that ...
    • Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity 

      Mota Martorell, Natàlia; Jové Font, Mariona; Pradas Barriga, Irene; Sanchez, Isabel; Gómez, José; Naudí i Farré, Alba; Barja, Gustavo; Pamplona Gras, Reinald (Elsevier, 2020-07-01)
      Mitochondrial reactive oxygen species (ROS) production, specifically at complex I (Cx I), has been widely suggested to be one of the determinants of species longevity. The present study follows a comparative approach to ...
    • Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women 

      Pradas Barriga, Irene; Rovira-Llopis, Susana; Naudí i Farré, Alba; Bañuls, Celia; Rocha, Milagros; Hernandez-Mijares, Antonio; Pamplona Gras, Reinald; Victor, Victor M.; Jové Font, Mariona (Nature Publishing Group, 2019-11-05)
      Metformin is one of the treatments used for pcoS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin’s effects on lipid metabolism, a crucial ...
    • Redox lipidomics to better understand brain aging and function 

      Pamplona Gras, Reinald; Borràs, Consuelo; Jové Font, Mariona; Pradas Barriga, Irene; Ferrer, Isidre; Viña Ribes, José (Elsevier, 2019)
      Human prefrontal cortex (PFC) is a recently evolutionary emerged brain region involved in cognitive functions. Human cognitive abilities decline during aging. Yet the molecular mechanisms that sustain the preservation or ...
    • Succination of protein thiols in human brain aging 

      Jové Font, Mariona; Pradas Barriga, Irene; Mota Martorell, Natàlia; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Ferrer, Isidre; Pamplona Gras, Reinald (Frontiers Media, 2020-03-06)
      Human brain evolution toward complexity has been achieved with increasing energy supply as the main adaptation in brain metabolism. Energy metabolism, like other biochemical reactions in aerobic cells, is under enzymatic ...
    • The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity 

      Jové Font, Mariona; Mota Martorell, Natàlia; Pradas Barriga, Irene; Martin-Gari, Meritxell; Ayala Jové, Ma. Victoria (Maria Victoria); Pamplona Gras, Reinald (MDPI, 2020-11-01)
      The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of biological membranes and the intracellular oxidative ...
    • The lipidome fingerprint of longevity 

      Jové Font, Mariona; Mota Martorell, Natàlia; Pradas Barriga, Irene; Galo-Licona, José Daniel; Martín-Gari, Meritxell; Obis Monné, Èlia; Sol, Joaquim; Pamplona Gras, Reinald (MDPI, 2020-09-01)
      Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional ...