Now showing items 1-3 of 3

    • Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS 

      Cacabelos Barral, Daniel; Ramírez-Núñez, Omar; Granado-Serrano, Ana Belén; Torres Cabestany, Pascual; Ayala Jové, Ma. Victoria (Maria Victoria); Moiseeva, Victoria; Povedano, Mònica; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel; Boada Pallàs, Jordi (BioMed Central, 2016)
      Introduction: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with a gender bias towards major prevalence in male individuals. Several data suggest the involvement of oxidative stress and mitochondrial dysfunction ...
    • Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment 

      Andrés Benito, Pol; Gelpí, Ellen; Jové Font, Mariona; Mota Martorell, Natàlia; Obis Monné, Èlia; Portero Otín, Manuel; Povedano, Mònica; Pujol, Aurora; Pamplona Gras, Reinald; Ferrer, Isidre (Wiley, 2020-12)
      Aim. Peroxisomes play a key role in lipid metabolism, and peroxisome defects have been associated with neurodegenerative diseases such as X-adrenoleukodystrophy and Alzheimer's disease. This study aims to elucidate the ...
    • Lipidomic traits of plasma and cerebrospinal fluid in amyotrophic lateral sclerosis correlate with disease progression 

      Sol, Joaquim; Jové Font, Mariona; Povedano, Mònica; Sproviero, William; Dominguez, Raul; Piñol Ripoll, Gerard; Romero Guevara, Ricardo; Hye, Abdul; Al-Chalabi, Ammar; Torres Cabestany, Pascual; Andrés Benito, Pol; Area Gomez, Estela; Pamplona Gras, Reinald; Ferrer, Isidre; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel (Oxford University Press, 2021)
      Since amyotrophic lateral sclerosis cases exhibit significant heterogeneity, we aim to investigate the association of lipid composition of plasma and CSF with amyotrophic lateral sclerosis diagnosis, its progression and ...