Now showing items 1-20 of 91

    • A plasma metabolomic signature discloses human breast cancer 

      Jové Font, Mariona; Collado, Ricardo; Quiles, Jose L.; Ramírez Tortosa, MCarmen; Sol, Joaquim; Ruiz-Sanjuan, Maria; Fernandez, Mónica; de la Torre Cabrera, Capilla; Ramírez-Tortosa, Cesar; Granados Principal, Sergio; Sánchez Rovira, Pedro; Pamplona Gras, Reinald (Impact Journals, 2017)
      Purpose: Metabolomics is the comprehensive global study of metabolites in biological samples. In this retrospective pilot study we explored whether serum metabolomic profile can discriminate the presence of human breast ...
    • A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma 

      Servià Goixart, Lluís; Jové Font, Mariona; Sol, Joaquim; Pamplona Gras, Reinald; Badia Castello, Mariona; Montserrat, Neus; Portero Otín, Manuel; Trujillano Cabello, Javier (BMC (part of Springer Nature), 2019-05-22)
      Background: We wanted to define metabolomic patterns in plasma to predict a negative outcome in severe trauma patients. Methods: A prospective pilot study was designed to evaluate plasma metabolomic patterns, established ...
    • A salmon peptide diet alleviates experimental colitis as compared with fish oil 

      Grimstad, Tore; Bjørndal, Bodil; Cacabelos Barral, Daniel; Aasprong, Ole G.; Omdal, Roald; Svardal, Asbjørn; Bohov, Pavol; Pamplona Gras, Reinald; Portero Otín, Manuel; Berge, Rolf K.; Hausken, Trygve (Cambridge University Press, 2013)
      Fish oil (FO) has been shown to have anti-inflammatory properties in animal models of inflammatory bowel disease, but how fish peptides (FP) influence intestinal inflammation has been less studied. Male Wistar rats, divided ...
    • Aberrant regulation of the GSK-3b/NRF2 axis unveils a novel therapy for adrenoleukodystrophy 

      Ranea-Robles, Pablo; Launay, Nathalie; Ruiz, Montserrat; Calingasan, Noel Ylagan; Dumont, Magali; Naudí i Farré, Alba; Portero Otín, Manuel; Pamplona Gras, Reinald; Ferrer, Isidre; Beal, M. Flint; Fourcade, Stéphane; Pujol, Aurora (Wiley Open Access, 2018)
      The nuclear factor erythroid 2-like 2 (NRF2) is the master regulator of endogenous antioxidant responses. Oxidative damage is a shared and early-appearing feature in X-linked adrenoleukodystrophy (X-ALD) patients and ...
    • Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy 

      Morató, Laia; Ruiz, M.; Boada Pallàs, Jordi; Calingasan, Noel Ylagan; Galino, Jorge; Guilera, Cristina; Jové Font, Mariona; Naudí i Farré, Alba; Ferrer, Isidre; Pamplona Gras, Reinald; Serrano, M.; Portero Otín, Manuel; Beal, M. F.; Fourcade, Stéphane; Pujol, Aurora (Macmillan Publishers, 2015)
      Oxidative stress and mitochondrial failure are prominent factors in the axonal degeneration process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the mitochondrial function, is impaired in the ...
    • Advanced glycation end product precursors impair epidermal growth factor receptor signalin 

      Portero Otín, Manuel; Pamplona Gras, Reinald; Bellmunt i Curcó, Josepa; Cristina Ruiz, Maria; Prat, Joan; Salvayre, Robert; Nègre Salvayre, Anne (American Diabetes Association, 2002-05)
      Formation of advanced glycation end products (AGEs) is considered a potential link between hyperglycemia and chronic diabetic complications, including disturbances in cell signaling. It was hypothesized that AGEs alter ...
    • Alterations in one-carbon metabolism in celiac disease 

      Martin-Masot, Rafael; Mota Martorell, Natàlia; Jové Font, Mariona; Maldonado, José; Pamplona Gras, Reinald; Nestares, Teresa (MDPI, 2020-12-01)
      Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which ...
    • Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy 

      Ruiz, Montserrat; Jové Font, Mariona; Schlüter, Agatha; Casasnovas, Carlos; Villarroya, Francesc; Guilera, Cristina; Ortega, Francisco J.; Naudí i Farré, Alba; Pamplona Gras, Reinald; Gimeno, Ramón; Fourcade, Stéphane; Portero Otín, Manuel; Pujol, Aurora (Oxford University Press, 2015)
      X-linked adrenomyeloneuropathy (AMN) is an inherited neurometabolic disorder caused by malfunction of the ABCD1 gene, characterized by slowly progressing spastic paraplegia affecting corticospinal tracts, and adrenal ...
    • Are Obesity Indices Useful for Detecting Subclinical Atheromatosis in a Middle-Aged Population? 

      Sánchez Peña, Enric; Sánchez, Marta; Betriu i Bars, M. Àngels; Rius, Ferran; Torres, Gerard; Purroy Garcia, Francisco; Pamplona Gras, Reinald; Ortega, Marta; López Cano, Carolina; Hernández García, Marta; Bueno Díez, Marta; Fernández i Giráldez, Elvira; Salvador, Javier; Lecube Torelló, Albert; ILERVAS project collaborators (Karger Publishers, 2020)
      Objective: There is a close relationship between excess adiposity and cardiovascular disease. Although body mass index (BMI) is the most used approach to estimate excess weight, other anthropometric indices have been ...
    • Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study 

      Casasnovas, Carlos; Ruiz, Montserrat; Schlüter, Agatha; Naudí i Farré, Alba; Fourcade, Stéphane; Veciana, Misericordia; Castañer, Sara; Albertí, Antonia; Bargalló, Nuria; Johnson, Maria; Raymond, Gerald V.; Fatemi, Ali; Moser, Ann B.; Villarroya, Francesc; Portero Otín, Manuel; Artuch, Rafael; Pamplona Gras, Reinald; Pujol, Aurora (Springer Verlag, 2019-05)
      X-Adrenoleukodystrophy (X-ALD) and its adult-onset, most prevalent variant adrenomyeloneuropathy (AMN) are caused by mutations in the peroxisomal transporter of the very long-chain fatty acid ABCD1. AMN patients classically ...
    • Biomarkers of aging in Drosophila 

      Jacobson, Jake; Lambert, Adrian J.; Portero Otín, Manuel; Pamplona Gras, Reinald; Magwere, Tapiwanashe; Miwa, Satomi; Driege, Yasmine; Brand, Martin D.; Partridge, Linda (Wiley, 2010)
      Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases ...
    • Biosynthesis de novo of glycerophospholipids and longevity 

      Mota Martorell, Natàlia; Pradas Barriga, Irene; Jové Font, Mariona; Naudí i Farré, Alba; Pamplona Gras, Reinald (Sociedad Española de Geriatría y Gerontología, 2019-03-30)
      Introducción. Entre los principales componentes lipídicos de las membranas celulares se encuentran los glicerofosfolípidos (GFL), que se sintetizan en una vía de novo a partir del diacilglicerol (DAG). El perfil lipídico ...
    • Caloric restriction reveals a lipidomic and metabolomic signature in liver of male mice 

      Jové Font, Mariona; Naudí i Farré, Alba; Ramírez-Núñez, Omar; Portero Otín, Manuel; Selman, Colin; Withers, Dominic J.; Pamplona Gras, Reinald (John Wiley & SonsAnatomical Society, 2014-10-01)
      Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects ...
    • Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Cassanyé, Anna; Serrano Casasola, José Carlos Enrique; Gonzalo Benito, Hugo; Boada Pallàs, Jordi; Prat Corominas, Joan; Portero Otín, Manuel; Pamplona Gras, Reinald (Hindawi Publishing Corporation, 2012)
      Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron ...
    • Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the Ilervas project 

      Sánchez Peña, Enric; Betriu i Bars, M. Àngels; López Cano, Carolina; Hernández García, Marta; Fernández i Giráldez, Elvira; Purroy Garcia, Francisco; Bermúdez López, Marcelino; Farràs-Sallés, Cristina; Barril, Silvia; Pamplona Gras, Reinald; Rius, Ferran; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (BioMed Central, 2019-11-15)
      BACKGROUND: Prediabetes has recently been associated with subclinical atheromatous disease in the middle-aged population. Our aim was to characterize atheromatous plaque burden by the number of affected territories and the ...
    • Clinical Usefulness of Anthropometric Indices to Predict the Presence of Prediabetes. Data from the ILERVAS Cohort 

      Sánchez, Marta; Sánchez Peña, Enric; Bermúdez López, Marcelino; Torres, Gerard; Farràs-Sallés, Cristina; Pamplona Gras, Reinald; Castro-Boqué, Eva; Valdivielso Revilla, José Manuel; Purroy Garcia, Francisco; Martínez Alonso, Montserrat; Godoy i García, Pere; Mauricio Puente, Dídac; Fernández i Giráldez, Elvira; Hernández García, Marta; Rius, Ferran; Lecube Torelló, Albert (MDPI, 2021-03-23)
      Prediabetes is closely related to excess body weight and adipose distribution. For this reason, we aimed to assess and compare the diagnostic usefulness of ten anthropometric adiposity indices to predict prediabetes. ...
    • Confirmation of the cardioprotective effect of MitoGamide in the diabetic heart 

      Park, Min; Nishimura, Takanori; Baeza-Garza, Carlos D.; Caldwell, Stuart T.; Boon Li Pun, Pamela; Prag, Hiran A.; Young, Tim; Sauchanka, Olga; Logan, Angela; Forkink, Marleen; Gruszczyk, Anja V.; Prime, Tracy A.; Arndt, Sabine; Naudí i Farré, Alba; Pamplona Gras, Reinald; Coughlan, Melinda T.; Tate, Mitchel; Ritchie, Rebecca H.; Caicci, Federico; Kaludercic, Nina; Lisa, Fabio Di; Smith, Robin A. J.; Hartley, Richard C.; Murphy, Michael P.; Krieg,Thomas (Springer, 2020-12-01)
      Purpose HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of HFpEF and used ...
    • Decrease in sleep depth is associated with higher cerebrospinal fluid neurofilament light levels in patients with Alzheimer's disease 

      Targa, Adriano; Dakterzada, Faride; Benítez, Iván; López, Ricard; Pujol, Montserrat; Dalmases, Mireia; Arias, Alfonso; Sánchez de la Torre, Manuel; Zetterberg, Henrik; Blennow, Kaj; Pamplona Gras, Reinald; Jové, Mariona; Barbé Illa, Ferran; Piñol Ripoll, Gerard (Oxford University Press, 2021)
      STUDY OBJECTIVES: The majority of studies investigating the association between sleep and Alzheimer's disease (AD) biomarkers have been performed in healthy participants. Our objective was to investigate the association ...
    • Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease 

      Hernández-Alvarez, María Isabel; Sebastián, David; Vives, Sara; Ivanova, Sa ka; Bartoccioni, Paola; Kakimoto, Pamela; Plana, Natalia; Veiga, Sónia R.; Hernández, Vanessa; Vasconcelos, Nuno; Gopalacharyulu, Peddinti; Adrover, Anna; Jové Font, Mariona; Pamplona Gras, Reinald; Berenguer-Llergo, Antonio; Gordaliza, Isabel; Calvo, Enrique; Cabré, Noemí; Castro, Rui; Kuzmanic, Antonija; Boutant, Marie; Sala, David; Hyotylainen, Tuulia; Oresic, Matej; Fort, Joana; Errasti-Murugarren, Ekaitz; Orozco, Modesto; Joven, Jorge; Cantó, Carles; Palacin, Manuel; Fernández-Veledo, Sonia; Vendrell, Joan; Zorzano, Antonio (Elsevier, 2019-05-02)
      Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies ...
    • Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease 

      Ilieva, Ekaterina V.; Naudí i Farré, Alba; Kichev, Anton Vladimirov; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2010)
      Both oxidative and endoplasmic reticulum (ER) stress is associated with multiple neurodegenerative, age-related diseases. The rare disorder Pick disease (PiD) shares some pathological hallmarks of other neurodegenerative ...