Browsing Articles publicats (Medicina Experimental) by Author "Klaus, Susanne"

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Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux

Ost, Mario; Keipert, Susanne; Schothorst, Evert M. van; Donner, Verena; Stelt, Inge van der; Kipp, Anna P.; Petzke, Klaus-Jürgen; Jové Font, Mariona; Pamplona Gras, Reinald; Portero Otín, Manuel; Keijer, Jaap; Klaus, Susanne (FASEB, 2014)

Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to ...
Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system

Keipert, Susanne; Ost, Mario; Chadt, A.; Voigt, A.; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Pamplona Gras, Reinald; Al-Hasani, H.; Klaus, Susanne (American Physiological Society, 2013)

Ectopic expression of uncoupling protein 1 (UCP1) in skeletal muscle (SM) mitochondria increases lifespan considerably in high-fat diet-fed UCP1 Tg mice compared with wild types (WT). To clarify the underlying mechanisms, ...