Now showing items 1-20 of 64

    • 7-dehydrocholesterol efficiently supports Ret signaling in a mouse model of Smith-Opitz-Lemli syndrome 

      Gou Fàbregas, Myriam; Macià Armengol, Anna; Anerillas, Carlos; Vaquero, Marta; Jové Font, Mariona; Jain, Sanjay; Ribera i Calvet, Joan; Encinas Martín, Mario (Nature Publishing Group, 2016)
      Smith-Lemli-Opitz syndrome (SLOS) is a rare disorder of cholesterol synthesis. Affected individuals exhibit growth failure, intellectual disability and a broad spectrum of developmental malformations. Among them, renal ...
    • A plasma metabolomic signature discloses human breast cancer 

      Jové Font, Mariona; Collado, Ricardo; Quiles, Jose L.; Ramírez Tortosa, MCarmen; Sol, Joaquim; Ruiz-Sanjuan, Maria; Fernandez, Mónica; de la Torre Cabrera, Capilla; Ramírez-Tortosa, Cesar; Granados Principal, Sergio; Sánchez Rovira, Pedro; Pamplona Gras, Reinald (Impact Journals, 2017)
      Purpose: Metabolomics is the comprehensive global study of metabolites in biological samples. In this retrospective pilot study we explored whether serum metabolomic profile can discriminate the presence of human breast ...
    • A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma 

      Servià Goixart, Lluís; Jové Font, Mariona; Sol, Joaquim; Pamplona Gras, Reinald; Badia Castello, Mariona; Montserrat, Neus; Portero Otín, Manuel; Trujillano Cabello, Javier (BMC (part of Springer Nature), 2019-05-22)
      Background: We wanted to define metabolomic patterns in plasma to predict a negative outcome in severe trauma patients. Methods: A prospective pilot study was designed to evaluate plasma metabolomic patterns, established ...
    • Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy 

      Morató, Laia; Ruiz, M.; Boada Pallàs, Jordi; Calingasan, Noel Ylagan; Galino, Jorge; Guilera, Cristina; Jové Font, Mariona; Naudí i Farré, Alba; Ferrer, Isidre; Pamplona Gras, Reinald; Serrano, M.; Portero Otín, Manuel; Beal, M. F.; Fourcade, Stéphane; Pujol, Aurora (Macmillan Publishers, 2015)
      Oxidative stress and mitochondrial failure are prominent factors in the axonal degeneration process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the mitochondrial function, is impaired in the ...
    • Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence 

      Moreno-Navarrete, José María; Liñares-Pose, Laura; Sabater, Mónica; Rial-Pensado, Eva; Comas, Ferran; Jové Font, Mariona; Latorre, Jèsica; Ortega Delgado, Francisco José; Ricart, Wifredo; Portero Otín, Manuel; López, Miguel; Fernández Real, José Manuel (Karger Publishers Open Access, 2018-11-18)
      Background/Aims: Thyroid hormones have been recently linked to senescence and longevity. Given the recent description of TSHB mRNA in human adipose tissue (AT), we aimed to investigate the relationship ...
    • Age-Related Changes in Lipidome of Rat Frontal Cortex and Cerebellum Are Partially Reversed by Methionine Restriction Applied in Old Age 

      Jové Font, Mariona; Cabré, Rosanna; Mota Martorell, Natàlia; Martin Garí, Meritxell; Obis, Èlia; Ramos, Paula; Canales , Iván; Galo-Licona, José Daniel; Sol, Joaquim; Nogueras Penabad, Lara; Torres Cabestany, Pascual; Portero Otín, Manuel; Ayala Jové, Ma. Victoria (Maria Victoria); Ferrer, Isidre; Pamplona Gras, Reinald (MDPI, 2021-11-20)
      Lipids are closely associated with brain structure and function. However, the potential changes in the lipidome induced by aging remain to be elucidated. In this study, we used chromatographic techniques and a mass ...
    • Alterations in one-carbon metabolism in celiac disease 

      Martin-Masot, Rafael; Mota Martorell, Natàlia; Jové Font, Mariona; Maldonado, José; Pamplona Gras, Reinald; Nestares, Teresa (MDPI, 2020-12-01)
      Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which ...
    • Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy 

      Ruiz, Montserrat; Jové Font, Mariona; Schlüter, Agatha; Casasnovas, Carlos; Villarroya, Francesc; Guilera, Cristina; Ortega, Francisco J.; Naudí i Farré, Alba; Pamplona Gras, Reinald; Gimeno, Ramón; Fourcade, Stéphane; Portero Otín, Manuel; Pujol, Aurora (Oxford University Press, 2015)
      X-linked adrenomyeloneuropathy (AMN) is an inherited neurometabolic disorder caused by malfunction of the ABCD1 gene, characterized by slowly progressing spastic paraplegia affecting corticospinal tracts, and adrenal ...
    • Biosynthesis de novo of glycerophospholipids and longevity 

      Mota Martorell, Natàlia; Pradas Barriga, Irene; Jové Font, Mariona; Naudí i Farré, Alba; Pamplona Gras, Reinald (Sociedad Española de Geriatría y Gerontología, 2019-03-30)
      Introducción. Entre los principales componentes lipídicos de las membranas celulares se encuentran los glicerofosfolípidos (GFL), que se sintetizan en una vía de novo a partir del diacilglicerol (DAG). El perfil lipídico ...
    • Caloric restriction reveals a lipidomic and metabolomic signature in liver of male mice 

      Jové Font, Mariona; Naudí i Farré, Alba; Ramírez-Núñez, Omar; Portero Otín, Manuel; Selman, Colin; Withers, Dominic J.; Pamplona Gras, Reinald (John Wiley & Sons; Anatomical Society, 2014-10-01)
      Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects ...
    • Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Cassanyé, Anna; Serrano Casasola, José Carlos Enrique; Gonzalo Benito, Hugo; Boada Pallàs, Jordi; Prat Corominas, Joan; Portero Otín, Manuel; Pamplona Gras, Reinald (Hindawi Publishing Corporation, 2012)
      Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron ...
    • Decrease in sleep depth is associated with higher cerebrospinal fluid neurofilament light levels in patients with Alzheimer's disease 

      Targa, Adriano; Dakterzada, Farida; Benítez, Iván; López Ortega, Ricard; Pujol, Montserrat; Dalmases, Mireia; Arias Pastor, Alfonso; Sánchez de la Torre, Manuel; Zetterberg, Henrik; Blennow, Kaj; Pamplona Gras, Reinald; Jové Font, Mariona; Barbé Illa, Ferran; Piñol Ripoll, Gerard (Oxford University Press, 2021)
      STUDY OBJECTIVES: The majority of studies investigating the association between sleep and Alzheimer's disease (AD) biomarkers have been performed in healthy participants. Our objective was to investigate the association ...
    • Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease 

      Hernández-Alvarez, María Isabel; Sebastián, David; Vives, Sara; Ivanova, Sa ka; Bartoccioni, Paola; Kakimoto, Pamela; Plana, Natalia; Veiga, Sónia R.; Hernández, Vanessa; Vasconcelos, Nuno; Gopalacharyulu, Peddinti; Adrover, Anna; Jové Font, Mariona; Pamplona Gras, Reinald; Berenguer-Llergo, Antonio; Gordaliza, Isabel; Calvo, Enrique; Cabré, Noemí; Castro, Rui; Kuzmanic, Antonija; Boutant, Marie; Sala, David; Hyotylainen, Tuulia; Oresic, Matej; Fort, Joana; Errasti-Murugarren, Ekaitz; Orozco, Modesto; Joven, Jorge; Cantó, Carles; Palacin, Manuel; Fernández-Veledo, Sonia; Vendrell, Joan; Zorzano, Antonio (Elsevier, 2019-05-02)
      Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies ...
    • Effects of aging and methionine restriction on rat kidney metabolome 

      Pradas Barriga, Irene; Jové Font, Mariona; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Mota Martorell, Natàlia; Pamplona Gras, Reinald (MDPI, 2019-11-14)
      Methionine restriction (MetR) in animal models extends maximum longevity and seems to promote renoprotection by attenuating kidney injury. MetR has also been proven to affect several metabolic pathways including lipid ...
    • Essential Physiological Differences Characterize Short- and Long-Lived Strains of Drosophila melanogaster 

      Gubina, Nina; Naudí i Farré, Alba; Stefanatos, Rhoda; Jové Font, Mariona; Scialò, Filippo; Fernández Ayala, Daniel J.; Rantapero, Tommi; Yurkevych, Ihor; Portero Otín, Manuel; Nykter, Matti; Lushchak, Oleh; Navas, Placido; Pamplona Gras, Reinald; Sanz, Alberto (Gerontological Society of America; Oxford University Press, 2019)
      Aging is a multifactorial process which affects all animals. Aging as a result of damage accumulation is the most accepted explanation but the proximal causes remain to be elucidated. There is also evidence indicating that ...
    • Exceptional human longevity is associated with a specific plasma phenotype of ether lipids 

      Pradas Barriga, Irene; Jové Font, Mariona; Huynh, Karina; Puig Farré, Josep; Inglés, Marta; Borràs, Consuelo; Viña Ribes, José; Meikle, Peter J.; Pamplona Gras, Reinald (Elsevier, 2019)
      A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to ...
    • Fatty acids in the placenta of appropiate- versus small-for-gestational-age infants at term birth 

      Gómez Vilarrubla, Ariadna; Mas Parés, Berta; Díaz, Marta; Xargay Torrent, Sílvia; Carreras Badosa, Gemma; Jové Font, Mariona; Martin Garí, Meritxell; Bonmatí Santané, Alexandra; Zegher, Francis de; Ibañez, Lourdes; López Bermejo, Abel; Bassols, Judit (Elsevier, 2021)
      Introduction: Fatty acids are essential nutrients for the fetus and are supplied by the mother through the placenta. Desaturase and elongase enzymes play an important role in modulating the fatty acid composition of body ...
    • Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction 

      Naudí i Farré, Alba; Jové Font, Mariona; Cacabelos Barral, Daniel; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Caro, Pilar; Gómez, José; Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Springer Verlag, 2013)
      Maillard reaction contributes to the chemical modification and cross-linking of proteins. This process plays a significant role in the aging process and determination of animal longevity. Oxidative conditions promote the ...
    • Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity 

      Mota Martorell, Natàlia; Jové Font, Mariona; Pradas Barriga, Irene; Berdún Hernández, Rebeca; Sanchez, Isabel; Naudí i Farré, Alba; Garí Marsol, Eloi; Barja, Gustavo; Pamplona Gras, Reinald (Springer, 2020-08-01)
      Maximum longevity (ML) varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of ML could to converge ...
    • In Vivo Anti-Inflammatory Effects and Related Mechanisms of Processed Egg Yolk, a Potential Anti-Inflammaging Dietary Supplement 

      Cunill, Joan; Babot, Clara; Santos, Liliana; Serrano Casasola, José Carlos Enrique; Jové Font, Mariona; Martín Garí, Meritxell; Portero Otín, Manuel (MDPI, 2020-09-04)
      Egg-yolk based supplements have demonstrated biological effects. We have developed a novel processed egg-yolk (PEY) complement, and we have tested whether it has inflammation modulatory properties. These were evaluated in ...