Now showing items 1-4 of 4

    • B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse 

      Carrascal, Jorge; Carrillo, Jorge; Arpa i Puigdemont, Berta; Egia-Mendikute, Leire; Rosell Mases, Estela; Pujol Autonell, Irma; Planas, Raquel; Mora Giral, Concepció; Mauricio Puente, Dídac; Ampudia, Rosa Maria; Vives Pi, Marta; Verdaguer Autonell, Joan (Wiley online library, 2016)
      Autoreactive B lymphocytes play a key role as APCs in diaebetogenesis. However, it remains unclear whether B-cell tolerance is compromised in NOD mice. Here, we describe a new B lymphocyte transgenic NOD mouse model, the ...
    • Efferocytosis promotes suppressive effects on dendritic cells through prostaglandin E2 production in the context of autoimmunity 

      Pujol-Autonell, Irma; Ampudia, Rosa Maria; Planas, Raquel; Marin-Gallen, Silvia; Carrascal, Jorge; Sanchez, Alex; Marin, Ana; Puig-Domingo, Manuel; Pujol-Borrell, Ricardo; Verdaguer Autonell, Joan; Vives Pi, Marta (Public Library of Science, 2013)
      Introduction: Efferocytosis is a crucial process by which apoptotic cells are cleared by phagocytes, maintaining immune tolerance to self in the absence of inflammation. Peripheral tolerance, lost in autoimmune processes, ...
    • Repurposed Analog of GLP-1 Ameliorates Hyperglycemia in Type 1 Diabetic Mice Through Pancreatic Cell Reprogramming 

      Villalba, Adrian; Rodríguez Fernández, Silvia; Perna Barrull, David; Ampudia, Rosa Maria; Gómez Muñoz, Laia; Pujol Autonell, Irma; Aguilera, Eva; Coma, Mireia; Cano Sarabia, Antonia María; Vázquez, Federico; Verdaguer Autonell, Joan; Vives Pi, Marta (Frontiers Media, 2020-05-13)
      Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. An ideal immunotherapy should combine the blockade of the autoimmune response with the recovery of functional target cell ...
    • Use of Autoantigen-Loaded Phosphatidylserine-Liposomes to Arrest Autoimmunity in Type 1 Diabetes 

      Pujol Autonell, Irma; Serracant Prat, Arnau; Cano Sarabia, Antonia María; Ampudia, Rosa Maria; Rodríguez Fernández, Silvia; Sánchez (Sànchez Pla), Álex; Izquierdo, Cristina; Stratmann, Thomas; Puig-Domingo, Manuel; Maspoch, Daniel; Verdaguer Autonell, Joan; Vives Pi, Marta (Public Library Science, 2015-06-03)