Browsing Articles publicats (Medicina Experimental) by Issue Date
Now showing items 21-40 of 323
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Distribution of nitric oxide-producing neurons in the developing and adult mouse amygdalar basolateral complex
(Elsevier, 2005)We analysed the expression of neuronal nitric oxide synthase (nNOS) in the mouse amygdalar basolateral complex (BLC) from embryonic day 15.5 to adult, using standard immunohistochemical methods. Our results indicate that ... -
Expression patterns of developmental regulatory genes show comparable divisions in the telencephalon of Xenopus and mouse: insights into the evolution of the forebrain
(Elsevier, 2005)In this study, we review data on the existence of comparable divisions and subdivisions in the telencephalon of different groups of tetrapods based on expression of some developmental regulatory genes, having a particular ... -
Embryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complex
(Wiley, 2005)We analyzed the development of immunoreactive expression patterns for the neurotransmitter -aminobutyric acid (GABA) and the calcium-binding proteins calbindin, calretinin, and parvalbumin in the embryonic and postnatal ... -
Proteins in human brain cortex are modified by oxidation, glycoxidation and lipoxidation: effects of Alzheimer's disease and identification of lipoxidation targets.
(American Society for Biochemistry and Molecular Biology; Elsevier, 2005)Diverse oxidative pathways, such as direct oxidation of amino acids, glycoxidation, and lipoxidation could contribute to Alzheimer disease pathogenesis. A global survey for the amount of structurally characterized probes ... -
Anchorage of Candida albicans Ssr1 to the cell wall, and transcript profiling of the null mutant
(Elsevier, 2005-06-22)Incorporation into the wall of Candida albicans Ssr1, a GPI-dependent protein, was investigated by construction of different truncated genes for which the three potential ω sites (S199, S215 and G216) and the corresponding ... -
Genomic response programs of Candida albicans following protoplasting and regeneration
(Elsevier, 2005-12-16)Transcription proWling of Candida albicans cells responding to the elimination of the wall (protoplasts) and posterior regeneration was explored. DNA microarrays were used to measure changes in the expression of 6039 genes, ... -
7-Bromoindirubin-3'-oxime induces caspase-independent cell death
(Nature Publishing Group, 2006)Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the aryl hydrocarbon receptor (AhR). Indirubin is the active ... -
(R)-roscovitine (CYC202, Seliciclib) sensitizes SH-SY5Y neuroblastorna cells to nutlin-3-induced apoptosis
(Elsevier, 2006)In this study, we have analyzed the consequences, on several neuroblastoma cell lines, of combined treatments with (R)-roscovitine (CYC202, Seliciclib), a CDK inhibitory drug, and nutlin-3, a p53 activating drug. Both ... -
Critical and distinct roles for key RET tyrosine docking sites in renal development
(Cold Spring Harbor Laboratory Press, 2006)Molecular mechanisms that lead to congenital anomalies of kidneys and the lower urinary tract (CAKUT) are poorly understood. To elucidate the molecular basis for signaling specificity of GDNF-mediated RET signaling in ... -
Pro-NGF from Alzheimer's disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75NTR and apoptosis.
(Elsevier Inc, 2006)The pro form of neurotrophic growth factor (pro-NGF), purified by chromatography from human Alzheimer’s disease (AD)-affected brains (ADhbi-pro-NGF), has been shown to induce apoptotic cell death in neuronal cell cultures ... -
Calcium-binding proteins, neuronal nitric oxide synthase, and GABA help to distinguish different pallial areas in the developing and adult chicken. I. Hippocampal formation and hyperpallium
(Wiley, 2006)To better understand the formation and adult organization of the avian pallium, we studied the expression patterns of gamma-aminobutyric acid (GABA), calbindin (CB), calretinin (CR), and neuronal nitric oxide synthase ... -
Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release
(Rockefeller University Press, 2006)Proper dialogue between presynaptic neurons and their targets is essential for correct synaptic assembly and function. At central synapses, Wnt proteins function as retrograde signals to regulate axon remodeling and the ... -
The biological basis of the aging process
(Institut d'Estudis Catalans. Secció de Ciències i Tecnologia, 2007)El procés biològic bàsic subjacent de l’envelliment va ésser avançat per la teoria de l’envelliment basada en els radicals lliures l’any 1954: la reacció dels radicals lliures actius, produïts fisiològicament en l’organisme, ... -
Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver
(Springer Verlag, 2007)Previous studies have consistently shown that 40% caloric restriction (CR) decreases the rate of mitochondrial ROS production and steady-state levels of markers of oxidative damage to macromolecules including mitochondrial ... -
BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis
(American Association for Cancer Research, 2008)In previous reports we have shown in SH-SY5 cells that Olomoucine and Roscovitine, two inhibitory drugs of Cyclin Dependent Kinases, caused apoptosis independent of the extrinsic pathway. In this experimental paradigm, ... -
7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death
(Elsevier, 2008)The new 7-bromoindirubin-3′-oxime (7BIO) compound induces caspase-independent cell death in all cell lines tested to date. Irrespective of the cell line, a 25 μM treatment for 24 h is lethal for the entire cell population. ... -
Els polimorfimes del citocrom P450 i la seva repercusió en la dosificació dels medicaments
(Col·legi Oficial de Metges de Lleida, 2008) -
Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons.
(Nature Publishing Group, 2008)We analyzed the survival responses and downstream signaling elicited by GDNF on sympathetic neurons from different Ret knockin mice. Lack of tyrosine 1062, a multidocking site in Ret, completely prevented GDNF-mediated ... -
Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development
(Wiley, 2008)The amygdala controls emotional and social behavior and regulates instinctive reflexes such as defense and reproduction by way of descending projections to the hypothalamus and brainstem. The descending amygdalar projections ... -
Comparative functional analysis provides evidence for a crucial role for the homeobox gene Nkx2.1/Titf-1 in forebrain evolution
(Wiley, 2008)Knockout of the Nkx2.1 (Titf-1) homeobox gene in the mouse leads to severe malformation and size reduction of the basal telencephalon/preoptic area and basal hypothalamus, indicating an important role of this gene in ...