Now showing items 21-40 of 276

    • Advanced glycation end product precursors impair epidermal growth factor receptor signalin 

      Portero Otín, Manuel; Pamplona Gras, Reinald; Bellmunt i Curcó, Josepa; Cristina Ruiz, Maria; Prat, Joan; Salvayre, Robert; Nègre Salvayre, Anne (American Diabetes Association, 2002-05)
      Formation of advanced glycation end products (AGEs) is considered a potential link between hyperglycemia and chronic diabetic complications, including disturbances in cell signaling. It was hypothesized that AGEs alter ...
    • Adverse effects of a SOD1-peptide immunotherapy on SOD1(G93A) mouse slow model of amyotrophic lateral sclerosi 

      Sábado, J.; Casanovas i Llorens, Anna; Rodrigo, H.; Arqué, G.; Esquerda Colell, Josep (Elsevier, 2015-12-01)
      Previous reports from our lab had shown that some anti-purinergic receptor P2X4 antibodies cross-reacted with misfolded forms of mutant Cu/Zn superoxide dismutase 1 (SOD1), linked to amyotrophic lateral sclerosis (ALS). ...
    • Alterations in one-carbon metabolism in celiac disease 

      Martin-Masot, Rafael; Mota Martorell, Natàlia; Jové Font, Mariona; Maldonado, José; Pamplona Gras, Reinald; Nestares, Teresa (MDPI, 2020-12-01)
      Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which ...
    • Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy 

      Ruiz, Montserrat; Jové Font, Mariona; Schlüter, Agatha; Casasnovas, Carlos; Villarroya, Francesc; Guilera, Cristina; Ortega, Francisco J.; Naudí i Farré, Alba; Pamplona Gras, Reinald; Gimeno, Ramón; Fourcade, Stéphane; Portero Otín, Manuel; Pujol, Aurora (Oxford University Press, 2015)
      X-linked adrenomyeloneuropathy (AMN) is an inherited neurometabolic disorder caused by malfunction of the ABCD1 gene, characterized by slowly progressing spastic paraplegia affecting corticospinal tracts, and adrenal ...
    • Alzheimer’s disease mutant mice exhibit reduced brain tissue stiffness compared to wild-type mice in both normoxia and following intermittent hypoxia mimicking sleep apnea 

      Menal Castellote, Maria José; Jorba, Ignasi; Torres, Marta; Montserrat i Capdevila, Josep; Gozal, David; Colell, Anna; Piñol Ripoll, Gerard; Navajas, Daniel; Almendros, Isaac; Farré, Ramon (Frontiers Media, 2018)
      Background: Evidence from patients and animal models suggests that obstructive sleep apnea (OSA) may increase the risk of Alzheimer’s disease (AD) and that AD is associated with reduced brain tissue stiffness. Aim: To ...
    • An early and robust activation of caspases heads cells for a regulated form of necrotic-like cell death 

      Garcia-Belinchón, Mercè; Sánchez-Osuna, María; Martínez-Escardó, Laura; Granados-Colomina, Carla; Pascual-Guiral, Sònia; Iglesias-Guimarais, Victoria; Casanelles, Elisenda; Ribas i Fortuny, Judit; Yuste Mateos, Víctor J. (Víctor José) (American Society for Biochemistry and Molecular Biology, 2015)
      Apoptosis is triggered by the activation of caspases and characterized by chromatin condensation and nuclear fragmentation (type II nuclear morphology). Necrosis is depicted by a gain in cell volume (oncosis), swelling of ...
    • Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons. 

      Encinas Martín, Mario; Rozen, Esteban Javier; Dolcet Roca, Xavier; Jain, Sanjay; Comella i Carnicé, Joan Xavier; Milbrandt, Jeffrey; Johnson, Eugene M. (Nature Publishing Group, 2008)
      We analyzed the survival responses and downstream signaling elicited by GDNF on sympathetic neurons from different Ret knockin mice. Lack of tyrosine 1062, a multidocking site in Ret, completely prevented GDNF-mediated ...
    • Analysis of U1snRNP-specific A protein cross-linked complexes 

      Boix Torras, Jacint; Habets, W.J; van Venrooij, W.J.; Smith, H.C. (Wiley, 1990)
      The organization of the U1snRNP-specific A protein (34 kDa) has been analyzed by 12 and 16 A thiol-reversible chemical cross-linking and Western blotting. A-containing cross-linked complexes had molecular masses of 43, 47, ...
    • Anatomía aplicada a la cirugía de los tendones flexores 

      Morro Martí, M. R.; Pérez, M. Llusá; Carrera Burgaya, A.; Forcada Calvet, Pau; Mustafa Gondolbeu, A. (Elsevier, 2015)
      El conocimiento de la anatomía de los tendones flexores es importante para el tratamiento de las lesiones de estas estructuras y su pronóstico. Es imprescindible tener un buen fundamento de las estructuras de los tendones ...
    • Anchorage of Candida albicans Ssr1 to the cell wall, and transcript profiling of the null mutant 

      Garcera, Ana; Castillo, Luis; Martínez, Ana Isabel; Elorza, M. Victoria; Valentín, Eulogio; Sentandreu, Rafael (Elsevier, 2005-06-22)
      Incorporation into the wall of Candida albicans Ssr1, a GPI-dependent protein, was investigated by construction of different truncated genes for which the three potential ω sites (S199, S215 and G216) and the corresponding ...
    • L'aplicació d'anticossos monoclonals en terapèutica humana 

      Boix Torras, Jacint; Cirera i Torres, Judit (Col·legi Oficial de Metges de Lleida, 2009)
    • L'aplicació d'anticossos monoclonals en terapèutica humana: Farmacologia general i indicacions concretes 

      Boix Torras, Jacint; Cirera i Torres, Judit (Col·legi Oficial de Metges de Lleida, 2009)
    • Are Obesity Indices Useful for Detecting Subclinical Atheromatosis in a Middle-Aged Population? 

      Sánchez Peña, Enric; Sánchez, Marta; Betriu i Bars, M. Àngels; Rius, Ferran; Torres, Gerard; Purroy Garcia, Francisco; Pamplona Gras, Reinald; Ortega, Marta; López Cano, Carolina; Hernández García, Marta; Bueno Díez, Marta; Fernández i Giráldez, Elvira; Salvador, Javier; Lecube Torelló, Albert; ILERVAS project collaborators (Karger Publishers, 2020)
      Objective: There is a close relationship between excess adiposity and cardiovascular disease. Although body mass index (BMI) is the most used approach to estimate excess weight, other anthropometric indices have been ...
    • Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation 

      Mattiolo, Paolo; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Elsevier, 2015-12)
      Autophagy is generally regarded as a mechanism to promote cell survival. However, autophagy can occasionally be the mechanism responsible of cell demise. We have found that a concomitant depletion of glucose, nutrients and ...
    • Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer 

      Eritja Sánchez, Núria; Chen, Bo-Juen; Rodríguez Barrueco, Ruth; Santacana Espasa, Maria; Gatius Calderó, Sònia; Vidal, August; Martí, Maria Dolores; Ponce, Jordi; Bergadà Bertran, Laura; Yeramian Hakim, Andree; Encinas Martín, Mario; Ribera i Calvet, Joan; Reventós, Jaume; Boyd, Jeff; Villanueva, Alberto; Matias-Guiu, Xavier; Dolcet Roca, Xavier; Llobet Navàs, David (Taylor & Francis, 2017)
      Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in complete tumor remission and are frequently challenged by the appearance of refractory cell clones, eventually resulting in disease ...
    • B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse 

      Carrascal, Jorge; Carrillo, Jorge; Arpa i Puigdemont, Berta; Egia-Mendikute, Leire; Rosell Mases, Estela; Pujol Autonell, Irma; Planas, Raquel; Mora Giral, Concepció; Mauricio Puente, Dídac; Ampudia, Rosa Maria; Vives Pi, Marta; Verdaguer Autonell, Joan (Wiley online library, 2016)
      Autoreactive B lymphocytes play a key role as APCs in diaebetogenesis. However, it remains unclear whether B-cell tolerance is compromised in NOD mice. Here, we describe a new B lymphocyte transgenic NOD mouse model, the ...
    • B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes 

      Egia-Mendikute, Leire; Arpa i Puigdemont, Berta; Rosell Mases, Estela; Corral-Pujol, Marta; Carrascal, Jorge; Carrillo, Jorge; Mora Giral, Concepció; Chapman, Harold; Panosa, Anaïs; Vives Pi, Marta; Stratmann, Thomas; Serreze, David; Verdaguer Autonell, Joan (Frontiers Media, 2019)
      Previous studies indicate that B-lymphocytes play a key role activating diabetogenic T-lymphocytes during the development of autoimmune diabetes. Recently, two transgenic NOD mouse models were generated: the NOD-PerIg and ...
    • Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts 

      Pérez Fusté, Noel; Guasch Vallés, Marta; Guillén, Pere; Anerillas, Carlos; Cemeli, Tània; Pedraza González, Neus; Ferrezuelo, Francisco; Encinas Martín, Mario; Moralejo Vidal, Mª Angeles; Garí Marsol, Eloi (Elsevier, 2019)
      β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. ...
    • BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis 

      Garrofé Ochoa, Xènia; Melero Fernández de Mera, Raquel M; Fernández Gómez, Francisco J.; Ribas i Fortuny, Judit; Jordán Bueso, Joaquín; Boix Torras, Jacint (American Association for Cancer Research, 2008)
      In previous reports we have shown in SH-SY5 cells that Olomoucine and Roscovitine, two inhibitory drugs of Cyclin Dependent Kinases, caused apoptosis independent of the extrinsic pathway. In this experimental paradigm, ...
    • Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness 

      Ruiz‑Plazas, Xavier; Rodríguez‑Gallego, Esther; Alves, Marta; Altuna Coy, Antonio; Lozano‑Bartolomé, Javier; Portero Otín, Manuel; García‑Fontgivell, Joan Francesc; Martínez‑González, Salomé; Segarra, José; Chacón, Matilde R. (BMC (part of Springer Nature), 2019)
      Background: Conventional clinical biomarkers cannot accurately differentiate indolent from aggressive prostate cancer (PCa). We investigated the usefulness of a biomarker panel measured exclusively in biofluids for assessment ...