Now showing items 242-261 of 276

    • T-type Ca2+ Channels: T for Targetable 

      Crespí Sallán, Marta; Visa Pretel, Anna; Shaikh, Soni; Nàger Grifo, Mireia; Herreros Danés, Judit; Cantí Nicolás, Carles (Taylor & Francis, 2018-01-17)
      In the last decade TTCC have been unveiled as key regulators of cancer cells biology and thus have been proposed as chemotherapeutic targets. Indeed in vitro and in vivo studies indicate that TTCC pharmacological blockers ...
    • T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1 

      Maiques Carlos, Oscar; Barceló Gómez, Carla; Panosa, Anaïs; Pijuan Marquilles, Jordi; Orgaz, Jose L.; Rodríguez Hernández, Irene; Matas Nadal, Clara; Tell, Gemma; Vilella, Ramón; Fabra, Angels; Puig, Susana; Sanz Moreno, Victoria; Matias-Guiu, Xavier; Cantí Nicolás, Carles; Herreros Danés, Judit; Martí Laborda, Rosa Ma.; Macià Armengol, Anna (Wiley, 2018)
      Melanoma is a malignant tumor derived from melanocytes. Once disseminated, it is usually highly resistant to chemotherapy and is associated with poor prognosis. We have recently reported that T-type calcium channels (TTCCs) ...
    • T-type Cav3.1 channels mediate progression and chemotherapeutic resistance in glioblastoma 

      Visa Pretel, Anna; Crespí Sallán, Marta; Maiques Carlos, Oscar; Alza, Lía; Talavera, Elisabeth; López-Ortega, Ricard; Santacana Espasa, Maria; Herreros Danés, Judit; Cantí Nicolás, Carles (American Association for Cancer Research, 2019)
      T-type Ca2+ channels (TTCC) have been identified as key regulators of cancer cell cycle and survival. In vivo studies in glioblastoma (GBM) murine xenografts have shown that drugs able to block TTCC in vitro (such as ...
    • Target of rapamycin activation predicts lifespan in fruit flies 

      Scialò, Filippo; Sriram, Ashwin; Naudí i Farré, Alba; Ayala Jové, Ma. Victoria (Maria Victoria); Jové Font, Mariona; Pamplona Gras, Reinald; Sanz, Alberto (Taylor & Francis, 2015-09)
      Aging and age-related diseases are one of the most important health issues that the world will confront during the 21st century. Only by understanding the proximal causes will we be able to find treatments to reduce or ...
    • The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity 

      Jové Font, Mariona; Mota Martorell, Natàlia; Pradas Barriga, Irene; Martin-Gari, Meritxell; Ayala Jové, Ma. Victoria (Maria Victoria); Pamplona Gras, Reinald (MDPI, 2020-11-01)
      The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of biological membranes and the intracellular oxidative ...
    • The Avian Brain Nomenclature Forum: Terminology for a New Century in Comparative Neuroanatomy. 

      Reiner, Anton; Perkel, David J.; Bruce, Laura L.; Butler, Ann B.; Csillag, András; Kuenzel, Wayne J.; Medina Hernández, Loreta Mª; Paxinos, George; Shimizu, Toru; Striedter, George; Wild, Martin; Ball, Gregori F.; Durand, Sarah; Gütürkün, Onur; Lee, Diane W.; Mello, Claudio V.; Powers, Alice; White, Stephanie A.; Hough, Gerald; Kubikova, Lubica; Smulders, Tom V.; Wada, Kazuhiro; Dugas-Ford, Jennifer; Husband, Scott; Yamamoto, Keiko; Yu, Jing; Siang, Connie; Jarvis, Erich D. (Wiley, 2004)
      Many of the assumptions of homology on which the standard nomenclature for the cell groups and fiber tracts of avian brains have been based are in error, and as a result that terminology promotes misunderstanding of the ...
    • The avian subpallium: new insights into structural and functional subdivisions occupying the lateral subpallial wall and their embryological origins 

      Kuenzel, Wayne J.; Medina Hernández, Loreta Mª; Csillag, Andras; Perkel, David J.; Reiner, Anton (Elsevier, 2011)
      The subpallial region of the avian telencephalon contains neural systems whose functions are critical to the survival of individual vertebrates and their species. The subpallial neural structures can be grouped into five ...
    • The biological basis of the aging process 

      Naudí i Farré, Alba; Jové Font, Mariona; Cacabelos Barral, Daniel; Llieva, E.; Boada Pallàs, Jordi; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Pamplona Gras, Reinald (Institut d'Estudis Catalans. Secció de Ciències i Tecnologia, 2007)
      El procés biològic bàsic subjacent de l’envelliment va ésser avançat per la teoria de l’envelliment basada en els radicals lliures l’any 1954: la reacció dels radicals lliures actius, produïts fisiològicament en l’organisme, ...
    • The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB and TGFβ pathways in hepatic stellate cells 

      Enguita, Mónica; Razquin, Nerea; Pamplona Gras, Reinald; Quiroga, Jorge; Prieto, Jesús; Fortes, Puri (Nature Research, 2019)
      Liver cirrhosis results from chronic hepatic damage and is characterized by derangement of the organ architecture with increased liver fibrogenesis and defective hepatocellular function. It frequently evolves into progressive ...
    • The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage 

      Moreno Martínez, José Antonio; Díaz-Gómez, J.; Nogareda, Carmina; Angulo Asensio, Eduardo; Sandmann, Gerhard; Portero Otín, Manuel; Serrano Casasola, José Carlos Enrique; Twyman, Richard M.; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (Nature, 2016)
      Carotenoids are important dietary nutrients with health-promoting effects. The biofortification of staple foods with carotenoids provides an efficient delivery strategy but little is known about the fate and distribution ...
    • The functional anatomy of the basal ganglia of birds 

      Medina Hernández, Loreta Mª; Jiao, Yun; Reiner, Anton (Swets & Zeitlinger, 1999)
      To study how the basal ganglia can control movement in birds, we have reinvestigated the connections of the pigeon dorsal pallidum. Our results indicate that avian basal ganglia appear to control movement through major ...
    • The hard-to-close window of T-type calcium channels 

      Visa Pretel, Anna; Shaikh, Soni; Alza, Lía; Herreros Danés, Judit; Cantí Nicolás, Carles (Elsevier, 2019)
      T-Type calcium channels (TTCCs) are key regulators of membrane excitability, which is the reason why TTCC pharmacology is subject to intensive research in the neurological and cardiovascular fields. TTCCs also play a role ...
    • The lipidome fingerprint of longevity 

      Jové Font, Mariona; Mota Martorell, Natàlia; Pradas Barriga, Irene; Galo-Licona, José Daniel; Martín-Gari, Meritxell; Obis Monné, Èlia; Sol, Joaquim; Pamplona Gras, Reinald (MDPI, 2020-09-01)
      Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional ...
    • The olfactory amygdala in amniotes: an evo-devo approach 

      Abellán Ródenas, Antonio; Desfilis, Ester; Medina Hernández, Loreta Mª (Wiley, 2013)
      In tetrapods, the medial amygdala is a forebrain center that integrates olfactory and/or vomeronasal signals with the endocrine and autonomic systems, playing a key role in different social behaviors. The vomeronasal system ...
    • The prevention of the staurosporine-induced apoptosis by Bcl-XL, but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells 

      Yuste Mateos, Víctor J. (Víctor José); Sánchez-López, Isabel; Solé Serra, Carme; Encinas Martín, Mario; Bayascas Ramírez, José Ramón; Boix Torras, Jacint; Comella i Carnicé, Joan Xavier (Wiley, 2002)
      Staurosporine is one of the best apoptotic inducers in different cell types including neuroblastomas. In this study we have compared the efficiency and final outcome of three different anti-apoptotic strategies in ...
    • The Secrets of the Brain. An evolutionary perspective on neuroscience 

      Desfilis, Ester; Medina Hernández, Loreta Mª (Universitat de València, 2016-05-15)
    • The sole presence of CDK4 is not a solid criterion for discriminating between tumor and healthy pancreatic tissues 

      Altirriba, Jordi; García, Ainhoa; Sánchez, Begoña; Haba, Laura; Altekruse, Sean; Stratmann, Thomas; Bombí, Josep Antoni; Mezquita, Cristóbal; Gomis, Ramon; Mora Giral, Concepció (Wiley, 2012)
    • The Y172 monoclonal antibody against p-c-Jun (Ser63) is a marker of the postsynaptic compartement of c-type cholinergic afferent synapses on motoneurons 

      Gatius, Alaó; Tarabal Mostazo, Olga; Cayuela, Paula; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Salvany, Sara; Hernández, Sara; Soler i Tatché, Rosa Ma.; Esquerda Colell, Josep; Calderó i Pardo, Jordi (Frontiers Media, 2020-01-24)
      C-bouton-type cholinergic afferents exert an important function in controlling motoneuron (MN) excitability. During the immunocytochemical analysis of the role of c-Jun in MNs with a monoclonal (clone Y172) antibody against ...
    • Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival 

      Sundaram, Venkatraghavan; Ivanova Petkova, Mima; Pujol Carrión, Núria; Boada Pallàs, Jordi; Torre Ruiz, M. A. de la (John Wiley & Sons, 2015-07-22)
      Here we show that Mtl1, member of the cell wall integrity pathway of Saccharomyces cerevisiae, plays a positive role in chronological life span (CLS). The absence of Mtl1 shortens CLS and causes impairment in the mitochondrial ...
    • Trancriptional modulation of apoptotis regulators by Roscovitine and related compounds 

      Garrofé Ochoa, Xènia; Cosialls, Ana M; Ribas i Fortuny, Judit; Gil, Joan; Boix Torras, Jacint (Springer Science Business Media, 2011)
      Chemical inhibitors of cyclin-dependent kinase (CDK), like roscovitine, are promising drugs in thecontext of new cancer therapies. Roscovitine and related compounds, like seliciclib and olomoucine, are effective inducers ...