Now showing items 162-181 of 276

    • Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms 

      Bahhir, Diana; Yalgin, Cagri; Ots, Liina; Järvinen, Sampsa; George, Jack; Naudí i Farré, Alba; Krama, Tatjana; Krams, Indrikis; Tamm, Mairi; Andjelković, Ana; Dufour, Eric; González de Cosar, Jose M.; Gerards, Mike; Parhiala, Mikael; Pamplona Gras, Reinald; Jacobs, Howard T.; Jõers, Priit (Public Library of Science, 2019-10-04)
      Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial ...
    • Membrane lipid unsaturation as physiological adaptation to animal longevity 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Frontiers Media, 2013)
      The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and ...
    • Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential 

      Prieto, Ignacio; Rubio Alarcón, Carmen; García-Gómez, Raquel; Berdún Hernández, Rebeca; Urgel, Tamara; Portero Otín, Manuel; Pamplona Gras, Reinald; Martínez-Ruiz, Antonio; Ruiz-Sanz, José Ignacio; Ruiz-Larrea, M. Begoña; Jové Font, Mariona; Cerdán, Sebastián; Monsalve, María (Elsevier, 2020-01-01)
      PGC-1α controls, to a large extent, the capacity of cells to respond to changing nutritional requirements and energetic demands. The key role of metabolic reprogramming in tumor development has highlighted the potential ...
    • Metabolic risk management, physical exercise and lifestyle counselling in low-active adults: controlled randomized trial (BELLUGAT) 

      Ensenyat Solé, Assumpta; Espigares Tribó, Gemma; Machado, Leonardo; Verdejo Amengual, Francisco José; Rodríguez Arregui, Rosa; Serrano Casasola, José Carlos Enrique; Miret, Marta; Galindo Ortego, Gisela; Blanco Nespereira, Alfonso; Marsal Mora, Josep Ramon; Sarriegui, Susana; Sinfreu Bergués, Xènia; Serra Payà, Noemí (BMC, 2017)
      Background: The primary aim of this study is to evaluate the effectiveness of different doses (intensity) of supervised exercise training — concomitant with lifestyle counselling — as a primary care intervention tool for ...
    • Metabolomics predicts neuroimaging characteristics of transient ischemic attack patients 

      Purroy Garcia, Francisco; Cambray Carner, Serafí; Mauri-Capdevila, Gerard; Jové Font, Mariona; Sanahuja Montesinos, Jordi; Farré, Joan; Benabdelhak Abbou, Ikram; Molina Seguin, Jessica; Colàs Campàs, Laura; Begué Gómez, Robert; Gil, M. Isabel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2016)
      Background: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite ...
    • Metabolomics predicts stroke recurrence after transient ischemic attack 

      Jové Font, Mariona; Mauri-Capdevila, Gerard; Suárez-Luis, Idalmis; Cambray Carner, Serafí; Sanahuja Montesinos, Jordi; Quilez Martínez, Alejandro; Farré, Joan; Benabdelhak Abbou, Ikram; Pamplona Gras, Reinald; Portero Otín, Manuel; Purroy Garcia, Francisco (American Academy of Neurology, 2015)
      Objective: To discover, by using metabolomics, novel candidate biomarkers for stroke recurrence (SR) with a higher prediction power than present ones. Methods: Metabolomic analysis was performed by liquid chromatography ...
    • La metabolómica en el ictus isquémico, nuevos biomarcadores diagnósticos y pronósticos 

      Mauri-Capdevila, Gerard; Jové Font, Mariona; Suárez-Luis, Idalmis; Portero Otín, Manuel; Purroy Garcia, Francisco (Viguera Editores, 2013)
      El estudio de biomarcadores relacionados con el ictus isquémico está adquiriendo una mayor importancia en vistas de conocer mejor los cambios fisiopatológicos de la enfermedad cerebrovascular y facilitar un diagnóstico ...
    • Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism 

      Jové Font, Mariona; Gatius Calderó, Sònia; Yeramian Hakim, Andree; Portero Otín, Manuel; Eritja Sánchez, Núria; Santacana Espasa, Maria; Colás, Eva; Ruiz, M.; Pamplona Gras, Reinald; Matias-Guiu, Xavier (Impact Journals, 2016)
      Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we ...
    • Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women 

      Pradas Barriga, Irene; Rovira-Llopis, Susana; Naudí i Farré, Alba; Bañuls, Celia; Rocha, Milagros; Hernandez-Mijares, Antonio; Pamplona Gras, Reinald; Victor, Victor M.; Jové Font, Mariona (Nature Publishing Group, 2019-11-05)
      Metformin is one of the treatments used for pcoS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin’s effects on lipid metabolism, a crucial ...
    • Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury 

      Salvany, Sara; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Tarabal Mostazo, Olga; Hernández, Sara; Calderó i Pardo, Jordi; Esquerda Colell, Josep (Wiley, 2021-01-02)
      Peripheral nerve section with subsequent disconnection of motor neuron (MN) cell bodies from their skeletal muscle targets leads to a rapid reactive response involving the recruitment and activation of microglia. In addition, ...
    • Mitochondria and ageing 

      Leeuwenburgh, Christiaan; Pamplona Gras, Reinald; Sanz, Alberto (Hindawi Publishing Corporation, 2011)
    • Mitochondrial ATP-Synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer's disease pathology 

      Terni, Beatrice; Boada Pallàs, Jordi; Portero Otín, Manuel; Pamplona Gras, Reinald; Ferrer, Isidre (Wiley, 2010)
      Oxidative stress has been implicated in the pathogenesis of several neurodegenerative diseases including Alzheimer's disease (AD). Several proteins have been identified as targets of oxidative damage in AD dementia (usually ...
    • Mitochondrial DNA damage and animal longevity: insights from comparative studies 

      Pamplona Gras, Reinald (Hindawi Publishing Corporation, 2011)
      Chemical reactions in living cells are under strict enzyme control and conform to a tightly regulated metabolic program. However, uncontrolled and potentially deleterious endogenous reactions occur, even under physiological ...
    • Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice 

      Hiona, Asimina; Sanz, Alberto; Kujoth, Gregory C.; Pamplona Gras, Reinald; Seo, Arnold Y.; Hofer, Tim; Someya, Shinichi; Miyakawa, Takuya; Nakayama, Chie; Samhan-Arias, Alejandro K.; Servais, Stephane; Barger, Jamie L.; Portero Otín, Manuel; Tanokura, Masaru; Prolla, Tomas A.; Leeuwenburgh, Christiaan (Public Library of Science (PLoS), 2010)
      Background: Aging results in a progressive loss of skeletal muscle, a condition known as sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal muscle and correlate with muscle loss, although no ...
    • Mitochondrial Dysfunction and Oxidative and Endoplasmic Reticulum Stress in Argyrophilic Grain Disease 

      Ilieva, Ekaterina V.; Kichev, Anton Vladimirov; Naudí i Farré, Alba; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Oxford University Press, 2011)
      Argyrophilic grain disease (AGD) is characterized by the accumulation of hyperphosphorylated 4R tau in dendritic varicosities (i.e."grains") in neurons and pretangles in certain areas of the cerebral cortex and other brain ...
    • Molecular phenomics of a high-calorie diet-induced porcine model of prepubertal obesity 

      Jové Font, Mariona; Tibau, Joan; Serrano Casasola, José Carlos Enrique; Berdún Hernández, Rebeca; Rodríguez Palmero, María; Font-i-Furnols, Maria; Cassanyé, Anna; Rodriguez Mortera, Reyna; Sol, Joaquim; Rassendren, Helene; Fàbrega, Emma; Crescenti, Anna; Castell, Anna; Sabater, Mónica; Ortega, Francisco J.; Martín Garí, Meritxell; Quintanilla Aguado, Raquel; Puigjaner, Joaquim; Moreno, José Antonio; Prat, Joan; Arola i Ferrer, Lluís; Fernández Real, José Manuel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2020-09-01)
      As obesity incidence is alarmingly rising among young individuals, we aimed to characterize an experimental model of this situation, considering the similarity between human and porcine physiology. For this reason, we fed ...
    • Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice 

      Blasco Carmona, Alba; Gras Artells, Sílvia; Mòdol-Caballero, Guillem; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Barranco, Alejandro; Das, Tapas; Pereira, Suzette L.; Navarro, Xavier; Rueda, Ricardo; Esquerda Colell, Josep; Calderó i Pardo, Jordi (Wiley, 2020-07-20)
      Background The cellular mechanisms underlying the age‐associated loss of muscle mass and function (sarcopenia) are poorly understood, hampering the development of effective treatment strategies. Here, we performed a detailed ...
    • Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs 

      Franco-Serrano, Luis; Huerta, Mario; Hernández, Sergio; Cedano, Juan; Perez-Pons, Josep Antoni; Piñol, Jaume; Mozo Villarías, Angel; Amela, Isaac; Querol, Enrique (Springer Verlag, 2018)
      Multifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases ...
    • Multilayer OMIC data in medullary thyroid carcinoma identifies the STAT3 pathway as a potential therapeutic target in RETM918T tumors 

      Mancikova, Veronica; Montero Conde, Cristina; Perales Paton, Javier; Fernandez, Agustin F; Santacana Espasa, Maria; Jodkowska, Karolina; Inglada-Pérez, Lucía; Castelblanco Echavarría, Esmeralda; Borrego, Salud; Encinas Martín, Mario; Matias-Guiu, Xavier; Fraga, Mario; Robledo, Mercedes (American Association for Cancer Research., 2016-09-12)
      Purpose: Medullary thyroid carcinoma (MTC) is a rare disease with few genetic drivers, and the etiology specific to each known susceptibility mutation remains unknown. Exploiting multilayer genomic data, we focused our ...
    • Multiple telencephalic and extratelencephalic embryonic domains contribute neurons to the medial extended amygdala 

      Bupesh, Munisamy; Legaz, Isabel; Abellán Ródenas, Antonio; Medina Hernández, Loreta Mª (Wiley, 2011)
      Dysfunctions in emotional control and social behavior are behind human neuropsychiatric disorders, some of which are associated with an alteration of amygdalar development. The medial extended amygdala is a key telencephalic ...