Now showing items 147-166 of 276

    • Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behaviour, without changing mice longevity. 

      Pamplona Gras, Reinald; Portero Otín, Manuel; Naudí i Farré, Alba; Fuente, Monica de la; Barja, Gustavo; Lopez-Torres, Mónica; Mate, Ianire; Cruces, Julia; Gomez, José; Sánchez-Roman, Ines; Gómez, Alexia (Wiley Open AccessAnatomical Society of Great Britain and Ireland, 2014)
      The membrane fatty acid unsaturation hypothesis of aging and longevity is experimentally tested for the first time in mammals. Lifelong treatment of mice with the b1-blocker atenolol increased the amount of the ...
    • Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment 

      Andrés Benito, Pol; Gelpí, Ellen; Jové Font, Mariona; Mota Martorell, Natàlia; Obis Monné, Èlia; Portero Otín, Manuel; Povedano, Mònica; Pujol, Aurora; Pamplona Gras, Reinald; Ferrer, Isidro (Wiley, 2020-12)
      Aim. Peroxisomes play a key role in lipid metabolism, and peroxisome defects have been associated with neurodegenerative diseases such as X-adrenoleukodystrophy and Alzheimer's disease. This study aims to elucidate the ...
    • Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis 

      Nogueras Penabad, Lara; Gonzalo Benito, Hugo; Jové Font, Mariona; Sol, Joaquim; Gil-Sánchez, Anna; Hervás, J.V.; Valcheva, Petya; González Mingot, Cristina; Solana Moga, M. José; Peralta Moncusí, Silvia; Pamplona Gras, Reinald; Brieva Ruiz, Luis (Nature Publishing Group, 2019-08-05)
      Multiple sclerosis (MS) is a complex multifactorial neuropathology. Although its etiology remains unclear, it has been demonstrated that the immune system attacks myelin, leading to demyelination and axonal damage. The ...
    • Lipid rafts act as specialised domains for tetanus toxin binding and internalisation in neurons 

      Herreros Danés, Judit; Ng, Toni; Schiavo, Giampietro (American Society for Cell Biology, 2001)
      Tetanus (TeNT) is a zinc protease that blocks neurotransmission by cleaving the synaptic protein vesicle-associated membrane protein/synaptobrevin. Although its intracellular catalytic activity is well established, the ...
    • Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism 

      Gonzalo Benito, Hugo; Brieva Ruiz, Luis; Tatzber, Franz; Jové Font, Mariona; Cacabelos Barral, Daniel; Cassanyé, Anna; Lanau, Lucia; Boada Pallàs, Jordi; Serrano Casasola, José Carlos Enrique; González Mingot, Cristina; Hernández, Lourdes; Peralta Moncusí, Silvia; Pamplona Gras, Reinald; Portero Otín, Manuel (Wiley, 2012)
      Metabolomic and lipidomic analyses have been used for the profiling of neurodegenerative processes, both in targeted and untargeted approaches. In this work we have applied these techniques to the study of CSF samples of ...
    • Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters 

      Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Ramírez-Núñez, Omar; Serrano Casasola, José Carlos Enrique; Cassanyé, Anna; Arola i Ferrer, Lluís; Caimari, Antoni; Bas, Josep M. del; Crescenti, Anna; Pamplona Gras, Reinald; Portero Otín, Manuel (Oxford Journals, 2013)
      Aims Atherosclerosis is the main pathological process contributing to cardiovascular disease, with diet being the most important factor involved. Although the lipidome of atheromatous plaque has been studied previously, ...
    • Lipidomics Reveals a Tissue-Specific Fingerprint 

      Pradas Barriga, Irene; Huynh, Kevin; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Meikle, Peter J.; Jové Font, Mariona; Pamplona Gras, Reinald (Frontiers Media, 2018)
      In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the compositional level in cell membranes and ...
    • Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome 

      Jové Font, Mariona; Pradas Barriga, Irene; Naudí i Farré, Alba; Rovira-Llopis, Susana; Bañuls, Celia; Rocha, Milagros; Portero Otín, Manuel; Hernández-Mijares, Antonio; Victor, Victor M.; Pamplona Gras, Reinald (Impact Journals, 2017)
      Purpose: In this work, a non-targeted approach was used to unravel changes in the plasma lipidome of PCOS patients. The aim is to offer new insights in PCOS patients strictly selected in order to avoid confounding factors ...
    • Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target 

      Jové Font, Mariona; Pradas Barriga, Irene; Dominguez Gonzalez, Mayelin; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2018)
      The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that ...
    • Localization and dynamic changes of neuregulin-1 at C-type synaptic boutons in association with motor neuron injury and repair 

      Salvany, Sara; Casanovas i Llorens, Anna; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Hernández, Sara; Santafé Martínez, Manel; Soto-Bernardini, María Clara; Calderó i Pardo, Jordi; Schwab, Markus H.; Esquerda Colell, Josep (Federation of American Societies for Experimental Biology, 2019)
      C-type synaptic boutons (C-boutons) provide cholinergic afferent input to spinal cord motor neurons (MNs), which display an endoplasmic reticulum (ER)–related subsurface cistern (SSC) adjacent to their postsynaptic membrane. ...
    • Location-dependent effects of trauma on oxidative stress in humans 

      Servià Goixart, Lluís; Serrano Casasola, José Carlos Enrique; Pamplona Gras, Reinald; Badia Castello, Mariona; Montserrat, Neus; Portero Otín, Manuel; Trujillano Cabello, Javier (Public Library of Science, 2018)
      Though circulating antioxidant capacity in plasma is homeostatically regulated, it is not known whether acute stressors (i.e. trauma) affecting different anatomical locations could have quantitatively different impacts. ...
    • Long lifespans have evolved with long and monounsaturated fatty acids in birds 

      Galván, Ismael; Naudí i Farré, Alba; Erritzøe, Johannes; Møller, Anders P.; Barja, Gustavo; Pamplona Gras, Reinald (Society for the Study of EvolutionWiley, 2015)
      The evolution of lifespan is a central question in evolutionary biology, begging the question why there is so large variation among taxa. Specifically, a central quest is to unravel proximate causes of ageing. Here, we ...
    • Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance 

      Fourcade, Stéphane; Morató, Laia; Parameswaran, Janani; Ruiz, Montserrat; Ruiz-Cortés, Tatiana; Jové Font, Mariona; Naudí i Farré, Alba; Martínez, Paloma; Dierssen, Mara; Ferrer, Isidre; Villarroya, Francesc; Pamplona Gras, Reinald; Vaquero, Alejandro; Portero Otín, Manuel; Pujol, Aurora (Wiley, 2017)
      Sirtuin 2 (SIRT2) is a member of a family of NAD+-dependent histone deacetylases (HDAC) that play diverse roles in cellular metabolism and especially for aging process. SIRT2 is located in the nucleus, cytoplasm, and ...
    • Loss of virulence in Ustilago maydis by Umchs6 gene disruption 

      Garcera, Ana; Xoconostle Cázares, Beatriz; Rosas Quijano, Raymundo; Ortiz, Lucila; León Ramírez, Claudia; Ruiz Herrera, José; Specht, Charles A.; Sentandreu, Rafael (Elsevier, 2003-11-20)
      A gene encoding a sixth chitin synthase (Umchs6, sequence GenBank accession No. AF030554) from the plant pathogenic hemibasidiomycete Ustilago maydis (DC.) Cda. was isolated and characterized. The predicted protein is 1103 ...
    • Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity 

      Mota Martorell, Natàlia; Jové Font, Mariona; Pradas Barriga, Irene; Sanchez, Isabel; Gómez, José; Naudí i Farré, Alba; Barja, Gustavo; Pamplona Gras, Reinald (Elsevier, 2020-07-01)
      Mitochondrial reactive oxygen species (ROS) production, specifically at complex I (Cx I), has been widely suggested to be one of the determinants of species longevity. The present study follows a comparative approach to ...
    • Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms 

      Bahhir, Diana; Yalgin, Cagri; Ots, Liina; Järvinen, Sampsa; George, Jack; Naudí i Farré, Alba; Krama, Tatjana; Krams, Indrikis; Tamm, Mairi; Andjelković, Ana; Dufour, Eric; González de Cosar, Jose M.; Gerards, Mike; Parhiala, Mikael; Pamplona Gras, Reinald; Jacobs, Howard T.; Jõers, Priit (Public Library of Science, 2019-10-04)
      Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial ...
    • Membrane lipid unsaturation as physiological adaptation to animal longevity 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Frontiers Media, 2013)
      The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and ...
    • Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential 

      Prieto, Ignacio; Rubio Alarcón, Carmen; García-Gómez, Raquel; Berdún Hernández, Rebeca; Urgel, Tamara; Portero Otín, Manuel; Pamplona Gras, Reinald; Martínez-Ruiz, Antonio; Ruiz-Sanz, José Ignacio; Ruiz-Larrea, M. Begoña; Jové Font, Mariona; Cerdán, Sebastián; Monsalve, María (Elsevier, 2020-01-01)
      PGC-1α controls, to a large extent, the capacity of cells to respond to changing nutritional requirements and energetic demands. The key role of metabolic reprogramming in tumor development has highlighted the potential ...
    • Metabolic risk management, physical exercise and lifestyle counselling in low-active adults: controlled randomized trial (BELLUGAT) 

      Ensenyat Solé, Assumpta; Espigares Tribó, Gemma; Machado, Leonardo; Verdejo Amengual, Francisco José; Rodríguez Arregui, Rosa; Serrano Casasola, José Carlos Enrique; Miret, Marta; Galindo Ortego, Gisela; Blanco Nespereira, Alfonso; Marsal Mora, Josep Ramon; Sarriegui, Susana; Sinfreu Bergués, Xènia; Serra Payà, Noemí (BMC, 2017)
      Background: The primary aim of this study is to evaluate the effectiveness of different doses (intensity) of supervised exercise training — concomitant with lifestyle counselling — as a primary care intervention tool for ...
    • Metabolomics predicts neuroimaging characteristics of transient ischemic attack patients 

      Purroy Garcia, Francisco; Cambray Carner, Serafí; Mauri-Capdevila, Gerard; Jové Font, Mariona; Sanahuja Montesinos, Jordi; Farré, Joan; Benabdelhak Abbou, Ikram; Molina Seguin, Jessica; Colàs Campàs, Laura; Begué Gómez, Robert; Gil, M. Isabel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2016)
      Background: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite ...