Now showing items 123-142 of 276

    • High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition 

      Zhu, Changfu; Farré Martinez, Gemma; Zanga, Daniela; Lloveras Vilamanyà, Jaume; Michelena Bárcena, Antonio; Ferrio Díaz, Juan Pedro; Voltas Velasco, Jordi; Slafer, Gustavo A.; Savin, Roxana; Albajes Garcia, Ramon; Eizaguirre Altuna, Matilde; López Alonso, Carmen; Cantero-Martínez, Carlos; Díaz Gómez, Joana; Nogareda, Carmina; Moreno Martínez, José Antonio; Angulo Asensio, Eduardo; Estany Illa, Joan; Pena i Subirà, Ramona Natacha; Tor i Naudí, Marc; Portero Otín, Manuel; Eritja Sánchez, Núria; Arjó Pont, Gemma; Serrano Casasola, José Carlos Enrique; Matias-Guiu, Xavier; Twyman, Richard M.; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Springer Verlag, 2017-06-01)
      Carolight® is a transgenic maize variety that accumulates extraordinary levels of carotenoids, including those with vitamin A activity. The development of Carolight® maize involved the technical implementation of a novel ...
    • High-Temperature Short-Time and Holder Pasteurization of Donor Milk: Impact on Milk Composition 

      Escuder-Vieco, Diana; Rodríguez, Juan M.; Espinosa-Martos, Irene; Corzo, Nieves; Montilla, Antonia; García-Serrano, Alba; Calvo, M. Visitación; Fontecha, Javier; Serrano Casasola, José Carlos Enrique; Fernández, Leónides; Pallás-Alonso, Carmen Rosa (MDPI, 2021-02-03)
      Holder pasteurization (HoP; 62.5 °C, 30 min) is commonly used to ensure the microbiological safety of donor human milk (DHM) but diminishes its nutritional properties. A high-temperature short-time (HTST) system was designed ...
    • Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development 

      García Lopez, Margarita; Abellán Ródenas, Antonio; Legaz, Isabel; Rubenstein, John L.R.; Puelles, Luis; Medina Hernández, Loreta Mª (Wiley, 2008)
      The amygdala controls emotional and social behavior and regulates instinctive reflexes such as defense and reproduction by way of descending projections to the hypothalamus and brainstem. The descending amygdalar projections ...
    • Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer 

      Granados Principal, Sergio; El-azem, Nuri; Pamplona Gras, Reinald; Ramirez Tortosa, Cesar; Pulido Moran, Mario; Vera Ramirez, Laura; Quiles, Jose L.; Sánchez Rovira, Pedro; Naudí i Farré, Alba; Portero Otín, Manuel; Pérez López, Patricia; Ramírez Tortosa, MCarmen (Elsevier, 2014)
      Oxidative stress is involved in several processes including cancer, aging and cardiovascular disease, and has been shown to potentiate the therapeutic effect of drugs such as doxorubicin. Doxorubicin causes significant ...
    • Identification of the anterior nucleus of the ansa lenticularis in birds as the homologue of the mammalian subthalamic nucleus 

      Jiao, Yun; Medina Hernández, Loreta Mª; Veenman, C. Leo; Toledo, Claudio; Puelles, Luis; Reiner, Anton (Society for Neuroscience, 2000)
      In mammals, the subthalamic nucleus (STN) is a glutamatergic diencephalic cell group that develops in the caudal hypothalamus and migrates to a position above the cerebral peduncle. By its input from the external pallidal ...
    • Immunohistochemical analysis of T-type calcium channels in acquired melanocytic nevi and melanoma 

      Maiques Carlos, Oscar; Macià Armengol, Anna; Moreno, Sara; Barceló Gómez, Carla; Santacana Espasa, Maria; Veà Jódar, Àlvar; Herreros Danés, Judit; Gatius Calderó, Sònia; Ortega Izquierdo, Maria Eugenia; Valls Marsal, Joan; Chen, Bo-Juen; Llovet Navàs, David; Matias-Guiu, Xavier; Cantí Nicolás, Carles; Martí Laborda, Rosa Ma. (Wiley Online Library, 2016-10-08)
      BACKGROUND AND OBJECTIVES: Cutaneous malignant melanoma arises from transformed melanocytes de novo or from congenital or acquired melanocytic nevi. We have recently reported that T-type Ca2+ channels (TTCs) are upregulated ...
    • Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy 

      López Erauskin, Jone; Galino, Jorge; Ruiz, M.; Cuezva, J. M.; Fabregat, I.; Cacabelos Barral, Daniel; Boada Pallàs, Jordi; Martínez, Juan José; Ferrer, Isidre; Pamplona Gras, Reinald; Villarroya, Francesc; Portero Otín, Manuel; Fourcade, Stéphane; Pujol, A. (Oxford Journals, 2013)
      X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disorder of the nervous system characterized by axonopathy in spinal cords and/or cerebral demyelination, adrenal insufficiency and accumulation of very ...
    • Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice 

      Sorolla Bardají, Maria Alba; Rodríguez Colman, Maria José; Vall-llaura Espinosa, Núria; Vived Maza, Celia; Fernández Nogales, Marta; Lucas, José J.; Ferrer, Isidre; Cabiscol Català, Elisa (Springer Science, Business Media, 2016-06)
      Oxidative stress has been described as important to Huntington disease (HD) progression. In a previous HD study, we identified several carbonylated proteins, including pyridoxal kinase and antiquitin, both of which are ...
    • Impaired Vitamin D Signaling in Endothelial Cell Leads to an Enhanced Leukocyte-Endothelium Interplay: Implications for Atherosclerosis Development 

      Dolcet Roca, Xavier; Encinas Martín, Mario; Bozić Stanojević, Milica; Álvarez, Ángeles; Pablo, Carmen de; Sanchez-Niño, Maria-Dolores; Ortiz, Alberto; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (Public Library of Science, 2015)
      Endothelial cell activation leading to leukocyte recruitment and adhesion plays an essential role in the initiation and progression of atherosclerosis. Vitamin D has cardioprotective actions, while its deficiency is a risk ...
    • Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients 

      Gonzalo Benito, Hugo; Nogueras Penabad, Lara; Gil-Sánchez, Anna; Vicente Hervás, José; Valcheva, Petya; González Mingot, Cristina; Martin-Gari, Meritxell; Canudes, Marc; Peralta Moncusí, Silvia; Solana Moga, M. José; Pamplona Gras, Reinald; Portero Otín, Manuel; Boada Pallàs, Jordi; Serrano Casasola, José Carlos Enrique; Brieva Ruiz, Luis (Frontiers Media, 2019)
      Literature suggests that oxidative stress (OS) may be involved in the pathogenesis of multiple sclerosis (MS), in which the immune system is known to play a key role. However, to date, the OS in peripheral lymphocytes and ...
    • In vitro cell migration, invasion, and adhesion assays: from cell imaging to data analysis 

      Pijuan, Jordi; Barceló, CArla; Moreno, David F.; Maiques Carlos, Oscar; Sisó, Pol; Marti, Rosa M.; Macià Armengol, Anna; Panosa, Anaïs (Frontiers Media, 2019-06)
      Cell migration is a key procedure involved in many biological processes includingembryological development, tissue formation, immune defense or inflammation, andcancer progression. How physical, chemical, and molecularaspects ...
    • In Vivo Anti-Inflammatory Effects and Related Mechanisms of Processed Egg Yolk, a Potential Anti-Inflammaging Dietary Supplement 

      Cunill, Joan; Babot, Clara; Santos, Liliana; Serrano Casasola, José Carlos Enrique; Jové Font, Mariona; Martín Garí, Meritxell; Portero Otín, Manuel (MDPI, 2020-09-04)
      Egg-yolk based supplements have demonstrated biological effects. We have developed a novel processed egg-yolk (PEY) complement, and we have tested whether it has inflammation modulatory properties. These were evaluated in ...
    • In vivo diabetogenic action of CD41+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18 

      Wen, Li; Green, E. Allison; Stratmann, Thomas; Panosa, Anaïs; Gomis, Ramon; Eynon, Elizabeth E.; Flavell, Richard A.; Mezquita, Jovita A.; Mora Giral, Concepció (Wiley, 2011)
      CD4+ T lymphocytes are required to induce spontaneous autoimmune diabetes in the NOD (Non Obese Diabetic) mouse. Since pancreatic β cells upregulate Fas expression upon exposure to proinflammatory cytokines, we studied ...
    • Induced neuroprotection by remote ischemic perconditioning as a new paradigm in ischemic stroke at the acute phase, a systematic review 

      Purroy Garcia, Francisco; García, Cristina; Mauri-Capdevila, Gerard; Pereira, Cristina; Torres, Coral; Vazquez-Justes, Daniel; Vicente-Pascual, Mikel; Vena Martínez, Ana Belén; Arque, Gloria (BMC, 2020)
      Background: Remote ischemic conditioning during cerebral ischemia (remote ischemic perconditioning, RIPerC) refers to the application of several cycles of brief ischemia and reperfusion (I/R) commonly to a limb, and it ...
    • Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional study 

      Purroy Garcia, Francisco; Arqué, G. (Public Library of Science, 2021)
      Background COVID-19 may predispose to both venous and arterial thromboembolism event (TEE). Reports on the prevalence and prognosis of thrombotic complications are still emerging. Objective To describe the rate of TEE ...
    • Informed Consent Procedure in Clinical Trials Promoted by the Hospital: Knowledge and Perceptions of Primary Care Physicians 

      Gómez Arbonés, Javier; Salazar-Alarcon, E.; Solanilla Puertolas, Montserrat; Ortega Bravo, Marta; Vallez-Valero, L.; Schoenenberger, Joan Antoni (SciTech Central, 2020-07-20)
      Objectives: To evaluate Primary Care Physician's (PCP) awareness degree concerning their patient's participation in Clinical Trials (CT) analyze the communication methods used and obtain physicians personal views. Methods: ...
    • Informing primary care physicians of patients' involvement in clinical trials carried out at a specialist care level 

      Schoenenberger, Joan Antoni; Solanilla Puertolas, Montserrat; Acer Puig, Maria; Gómez Arbonés, Javier (Dove Medical Press, 2017-07-27)
      Background: Patients enrolled in clinical trials continue to have frequent contacts with primary care physicians because of comorbidities or toxicities. The aim of the present study was to analyze the information provided ...
    • Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy 

      Piras, Antonio; Schiaffino, Lorenzo; Boido, Marina; Valsecchi, Valeria; Guglielmotto, Michela; Amicis, Elena De; Puyal, Julien; Garcera, Ana; Tamagno, Elena; Soler i Tatché, Rosa Ma.; Vercelli, Alessandro (Nature Publishing Group, 2017)
      Spinal muscular atrophy (SMA) is a recessive autosomal neuromuscular disease, due to homozygous mutations or deletions in the telomeric survival motoneuron gene 1 (SMN1). SMA is characterized by motor impairment, muscle ...
    • Inhibition of BCR Signaling Using the Syk Inhibitor TAK-659 Prevents Stroma-Mediated Signaling in Chronic Lymphocytic Leukemia Cells 

      Purroy, Noelia; Carabia, Júlia; Abrisqueta, Pau; Egia-Mendikute, Leire; Aguiló, Meritxell; Carpio, Cecilia; Palacio, Carles; Crespo, Marta; Bosch, Francesc (Impact Journals, 2017-01-03)
      Proliferation and survival of chronic lymphocytic leukemia (CLL) cells depend on microenvironmental signals coming from lymphoid organs. One of the key players involved in the crosstalk between CLL cells and the microenvironment ...
    • Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers 

      Nàger Grifo, Mireia; Crespí Sallán, Marta; Visa Pretel, Anna; Pushparaj, Charumathi; Santacana Espasa, Maria; Macià Armengol, Anna; Yeramian Hakim, Andree; Cantí Nicolás, Carles; Herreros Danés, Judit (Taylor & Francis, 2018-01-09)
      WNT-CTNN1B signaling promotes cancer cell proliferation and stemness. Furthermore, recent evidence indicates that macroautophagy/autophagy regulates WNT signaling. Here we investigated the impact of inhibiting WNT signaling ...