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dc.contributor.authorRué i Monné, Montserrat
dc.contributor.authorVilaprinyo Terré, Ester
dc.contributor.authorLee, Sandra
dc.contributor.authorMartínez Alonso, Montserrat
dc.contributor.authorCarles Lavila, Misericordia
dc.contributor.authorMarcos-Gragera, Rafael
dc.contributor.authorPla, Roger
dc.contributor.authorEspinàs, Josep Alfons
dc.description.abstractBackground: At present, it is complicated to use screening trials to determine the optimal age intervals and periodicities of breast cancer early detection. Mathematical models are an alternative that has been widely used. The aim of this study was to estimate the effect of different breast cancer early detection strategies in Catalonia (Spain), in terms of breast cancer mortality reduction (MR) and years of life gained (YLG), using the stochastic models developed by Lee and Zelen (LZ). Methods: We used the LZ model to estimate the cumulative probability of death for a cohort exposed to different screening strategies after T years of follow-up. We also obtained the cumulative probability of death for a cohort with no screening. These probabilities were used to estimate the possible breast cancer MR and YLG by age, period and cohort of birth. The inputs of the model were: incidence of, mortality from and survival after breast cancer, mortality from other causes, distribution of breast cancer stages at diagnosis and sensitivity of mammography. The outputs were relative breast cancer MR and YLG. Results: Relative breast cancer MR varied from 20% for biennial exams in the 50 to 69 age interval to 30% for annual exams in the 40 to 74 age interval. When strategies differ in periodicity but not in the age interval of exams, biennial screening achieved almost 80% of the annual screening MR. In contrast to MR, the effect on YLG of extending screening from 69 to 74 years of age was smaller than the effect of extending the screening from 50 to 45 or 40 years. Conclusion: In this study we have obtained a measure of the effect of breast cancer screening in terms of mortality and years of life gained. The Lee and Zelen mathematical models have been very useful for assessing the impact of different modalities of early detection on MR and YLG in Catalonia (Spain).ca_ES
dc.publisherBioMed Centralca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofBMC Cancer, 2009, vol. 9, núm. 326, p. 1-10ca_ES
dc.rightscc-by, (c) Rue et al., 2009ca_ES
dc.subject.otherMama -- Càncer -- Catalunyaca_ES
dc.subject.otherMama -- Càncer -- Diagnòsticca_ES
dc.subject.otherMama -- Càncer -- Mortalitat -- Catalunyaca_ES
dc.titleEffectiveness of early detection on breast cancer mortality reduction in Catalonia (Spain)ca_ES

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