Ara es mostren els elements 1-20 de 278

    • Spinal Muscular Atrophy autophagy profle is tissue-dependent: diferential regulation between muscle and motoneurons 

      Sansa Zaragoza, Alba; Hidalgo, Iván; Miralles, Maria P.; Fuente Ruiz, Sandra de la; Perez‑Garcia, M. Jose; Munell, Francina; Soler i Tatché, Rosa Ma.; Garcera, Ana (BMC, 2021)
      Spinal muscular atrophy (SMA) is a neuromuscular genetic disease caused by reduced survival motor neuron (SMN) protein. SMN is ubiquitous and defcient levels cause spinal cord motoneurons (MNs) degeneration and muscle atrophy. ...
    • Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype 

      Torres-Querol, Coral; Torres, Pascual; Vidal, Noemí; Portero Otín, Manuel; Arque, Gloria; Purroy Garcia, Francisco (Nature Research, 2021)
      Senescent cells are capable of expressing a myriad of infammatory cytokines and this proinfammatory phenomenon is known as senescence-associated secretory phenotype (SASP). The contribution of this phenomenon in brain ...
    • Metabolic risk management, physical exercise and lifestyle counselling in low-active adults: controlled randomized trial (BELLUGAT) 

      Ensenyat Solé, Assumpta; Espigares Tribó, Gemma; Machado, Leonardo; Verdejo Amengual, Francisco José; Rodríguez Arregui, Rosa; Serrano Casasola, José Carlos Enrique; Miret, Marta; Galindo Ortego, Gisela; Blanco Nespereira, Alfonso; Marsal Mora, Josep Ramon; Sarriegui, Susana; Sinfreu Bergués, Xènia; Serra Payà, Noemí (BMC, 2017)
      Background: The primary aim of this study is to evaluate the effectiveness of different doses (intensity) of supervised exercise training — concomitant with lifestyle counselling — as a primary care intervention tool for ...
    • Papel del frijol negro Phaseolus vulgaris en el estado nutricional de la población guatemalteca 

      Serrano Casasola, José Carlos Enrique; Goñi Cambrodón, Isabel (Sociedad Latinoamericana de Nutrición, 2004)
      En Guatemala existe un fenómeno de superposición epidemiológica, en el que coexisten problemas de salud propios de países desarrollados con otros característicos de poblaciones en vías de desarrollo. Se observan ...
    • In vitro cell migration, invasion, and adhesion assays: from cell imaging to data analysis 

      Pijuan, Jordi; Barceló, CArla; Moreno, David F.; Maiques Carlos, Oscar; Sisó, Pol; Marti, Rosa M.; Macià Armengol, Anna; Panosa, Anaïs (Frontiers Media, 2019-06)
      Cell migration is a key procedure involved in many biological processes includingembryological development, tissue formation, immune defense or inflammation, andcancer progression. How physical, chemical, and molecularaspects ...
    • Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional study 

      Purroy Garcia, Francisco; Arqué, G. (Public Library of Science, 2021)
      Background COVID-19 may predispose to both venous and arterial thromboembolism event (TEE). Reports on the prevalence and prognosis of thrombotic complications are still emerging. Objective To describe the rate of TEE ...
    • Regulation of membrane unsaturation as antioxidant adaptive mechanism in long-lived animal species 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Phcog.Net, 2011)
      Oxidative stress resulting from biomolecular oxidative damage due to the imbalance between reactive species production and antioxidant response has become an universal constraint of life-history evolution in animals and ...
    • Target of rapamycin activation predicts lifespan in fruit flies 

      Scialò, Filippo; Sriram, Ashwin; Naudí i Farré, Alba; Ayala Jové, Ma. Victoria (Maria Victoria); Jové Font, Mariona; Pamplona Gras, Reinald; Sanz, Alberto (Taylor & Francis, 2015-09)
      Aging and age-related diseases are one of the most important health issues that the world will confront during the 21st century. Only by understanding the proximal causes will we be able to find treatments to reduce or ...
    • Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment 

      Andrés Benito, Pol; Gelpí, Ellen; Jové Font, Mariona; Mota Martorell, Natàlia; Obis Monné, Èlia; Portero Otín, Manuel; Povedano, Mònica; Pujol, Aurora; Pamplona Gras, Reinald; Ferrer, Isidro (Wiley, 2020-12)
      Aim. Peroxisomes play a key role in lipid metabolism, and peroxisome defects have been associated with neurodegenerative diseases such as X-adrenoleukodystrophy and Alzheimer's disease. This study aims to elucidate the ...
    • Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways 

      Arnoriaga Rodríguez, María; Mayneris Perxachs, Jordi; Contreras-Rodríguez, Oren; Burokas, Aurelijus; Ortega Sánchez, Juan Antonio; Blasco Solà, Gerard; Coll, Claudia; Biarnés, Carles; Castells Nobau, Anna; Puig, Josep; Garre Olmo, Josep; Ramos, Rafel; Pedraza, Salvador; Brugada, Ramon; Vilanova, Joan Carles; Serena, Joaquín; Barretina Ginesta, Jordi; Gich Fullà, Jordi; Pérez Brocal, Vicente; Moya, Andrés; Fernández Real, Xavier; Ramió Torrentà, Lluís; Pamplona Gras, Reinald; Sol, Joaquim; Jové Font, Mariona; Ricart, Wifredo; Portero Otín, Manuel; Maldonado, Rafael; Fernández Real, José Manuel (BMJ Publishing GroupBritish Society of Gastroenterology, 2021-01)
      Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We ...
    • Clinical Usefulness of Anthropometric Indices to Predict the Presence of Prediabetes. Data from the ILERVAS Cohort 

      Sánchez, Marta; Sánchez Peña, Enric; Bermúdez López, Marcelino; Torres, Gerard; Farràs-Sallés, Cristina; Pamplona Gras, Reinald; Castro-Boqué, Eva; Valdivielso Revilla, José Manuel; Purroy Garcia, Francisco; Martínez Alonso, Montserrat; Godoy i García, Pere; Mauricio Puente, Dídac; Fernández i Giráldez, Elvira; Hernández García, Marta; Rius, Ferran; Lecube Torelló, Albert (MDPI, 2021-03-23)
      Prediabetes is closely related to excess body weight and adipose distribution. For this reason, we aimed to assess and compare the diagnostic usefulness of ten anthropometric adiposity indices to predict prediabetes. ...
    • Intracellular pathways involved in cell survival are deregulated in mouse and human spinal muscular atrophy motoneurons 

      Sansa Zaragoza, Alba; Fuente Ruiz, Sandra de la; Comella i Carnicé, Joan Xavier; Garcera, Ana; Soler i Tatché, Rosa Ma. (Elsevier, 2021-04-13)
      Spinal Muscular Atrophy (SMA) is a severe neuromuscular disorder caused by loss of the Survival Motor Neuron 1 gene (SMN1). Due to this depletion of the survival motor neuron (SMN) protein, the disease is characterized by ...
    • The sole presence of CDK4 is not a solid criterion for discriminating between tumor and healthy pancreatic tissues 

      Altirriba, Jordi; García, Ainhoa; Sánchez, Begoña; Haba, Laura; Altekruse, Sean; Stratmann, Thomas; Bombí, Josep Antoni; Mezquita, Cristóbal; Gomis, Ramon; Mora Giral, Concepció (Wiley, 2012)
    • In vivo diabetogenic action of CD41+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18 

      Wen, Li; Green, E. Allison; Stratmann, Thomas; Panosa, Anaïs; Gomis, Ramon; Eynon, Elizabeth E.; Flavell, Richard A.; Mezquita, Jovita A.; Mora Giral, Concepció (Wiley, 2011)
      CD4+ T lymphocytes are required to induce spontaneous autoimmune diabetes in the NOD (Non Obese Diabetic) mouse. Since pancreatic β cells upregulate Fas expression upon exposure to proinflammatory cytokines, we studied ...
    • Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice 

      Presa, Maximiliano; Zarama Ortiz, Angela; Garabatos, Nahir; Izquierdo, Cristina; Rivas, Elisa I.; Teyton, Luc; Mora Giral, Concepció; Serreze, David; Stratmann, Thomas (Wiley, 2013)
      The cholera toxin B subunit (CTB) has been used as adjuvant to improve oral vaccine delivery in type 1 diabetes. The effect of CTB/peptide formulations on Ag-specific CD4+ T cells has remained largely unexplored. Here, ...
    • High-Temperature Short-Time and Holder Pasteurization of Donor Milk: Impact on Milk Composition 

      Escuder-Vieco, Diana; Rodríguez, Juan M.; Espinosa-Martos, Irene; Corzo, Nieves; Montilla, Antonia; García-Serrano, Alba; Calvo, M. Visitación; Fontecha, Javier; Serrano Casasola, José Carlos Enrique; Fernández, Leónides; Pallás-Alonso, Carmen Rosa (MDPI, 2021-02-03)
      Holder pasteurization (HoP; 62.5 °C, 30 min) is commonly used to ensure the microbiological safety of donor human milk (DHM) but diminishes its nutritional properties. A high-temperature short-time (HTST) system was designed ...
    • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 

      Klionsky, Daniel J.; Cantí Nicolás, Carles; Garcera, Ana; Herreros Danés, Judit; Soler i Tatché, Rosa Ma.; others (Taylor & Francis, 2021-02-08)
      In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant ...
    • Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease 

      Hernández-Alvarez, María Isabel; Sebastián, David; Vives, Sara; Ivanova, Sa ka; Bartoccioni, Paola; Kakimoto, Pamela; Plana, Natalia; Veiga, Sónia R.; Hernández, Vanessa; Vasconcelos, Nuno; Gopalacharyulu, Peddinti; Adrover, Anna; Jové Font, Mariona; Pamplona Gras, Reinald; Berenguer-Llergo, Antonio; Gordaliza, Isabel; Calvo, Enrique; Cabré, Noemí; Castro, Rui; Kuzmanic, Antonija; Boutant, Marie; Sala, David; Hyotylainen, Tuulia; Oresic, Matej; Fort, Joana; Errasti-Murugarren, Ekaitz; Orozco, Modesto; Joven, Jorge; Cantó, Carles; Palacin, Manuel; Fernández-Veledo, Sonia; Vendrell, Joan; Zorzano, Antonio (Elsevier, 2019-05-02)
      Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies ...
    • Biosynthesis de novo of glycerophospholipids and longevity 

      Mota Martorell, Natàlia; Pradas Barriga, Irene; Jové Font, Mariona; Naudí i Farré, Alba; Pamplona Gras, Reinald (Sociedad Española de Geriatría y Gerontología, 2019-03-30)
      Introducción. Entre los principales componentes lipídicos de las membranas celulares se encuentran los glicerofosfolípidos (GFL), que se sintetizan en una vía de novo a partir del diacilglicerol (DAG). El perfil lipídico ...
    • Informed Consent Procedure in Clinical Trials Promoted by the Hospital: Knowledge and Perceptions of Primary Care Physicians 

      Gómez Arbonés, Javier; Salazar-Alarcon, E.; Solanilla Puertolas, Montserrat; Ortega Bravo, Marta; Vallez-Valero, L.; Schoenenberger, Joan Antoni (SciTech Central, 2020-07-20)
      Objectives: To evaluate Primary Care Physician's (PCP) awareness degree concerning their patient's participation in Clinical Trials (CT) analyze the communication methods used and obtain physicians personal views. Methods: ...