Now showing items 1-13 of 13

    • 2-phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53 

      Mattiolo, Paolo; Barbero-Farran A.; Yuste Mateos, Víctor J. (Víctor José); Boix Torras, Jacint; Ribas i Fortuny, Judit (Elsevier, 2014)
      2-Phenylethynesulfonamide (PES) or pifithrin-μ is a promising anticancer agent with preferential toxicity for cancer cells. The type of cell death and the molecular cascades activated by this compound are controversial. ...
    • Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study 

      Casasnovas, Carlos; Ruiz, Montserrat; Schlüter, Agatha; Naudí i Farré, Alba; Fourcade, Stéphane; Veciana, Misericordia; Castañer, Sara; Albertí, Antonia; Bargalló, Nuria; Johnson, Maria; Raymond, Gerald V.; Fatemi, Ali; Moser, Ann B.; Villarroya, Francesc; Portero Otín, Manuel; Artuch, Rafael; Pamplona Gras, Reinald; Pujol, Aurora (Springer Verlag, 2019-05)
      X-Adrenoleukodystrophy (X-ALD) and its adult-onset, most prevalent variant adrenomyeloneuropathy (AMN) are caused by mutations in the peroxisomal transporter of the very long-chain fatty acid ABCD1. AMN patients classically ...
    • Dietary Lipid Unsaturation Influences Survival and Oxidative Modifications of an Amyotrophic Lateral Sclerosis Model in a Gender-Specific Manner 

      Cacabelos Barral, Daniel; Ayala Jové, Ma. Victoria (Maria Victoria); Ramírez-Núñez, Omar; Granado-Serrano, Ana Belén; Boada Pallàs, Jordi; Serrano Casasola, José Carlos Enrique; Cabré Cucó, Rosanna; Nadal Rey, Gisela; Bellmunt i Curcó, Josepa; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Springer, 2014)
      The implication of lipid peroxidation in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) derive from high abundance of peroxidation- prone polyunsaturated fatty acids in central nervous system ...
    • Distinctive Under-Expression Profile of Inflammatory and Redox Genes in the Blood of Elderly Patients with Cardiovascular Disease 

      Milanesi, Elena; Manda, Gina; Dobre, Maria; Codrici, Elena; Neagoe, Ionela Victoria; Popescu, Bogdan Ovidiu; Bajenaru, Ovidiu Alexandru; Spiru, Luiza; Tudose, Catalina; Prada, Gabriel-Ioan; Davidescu, Eugenia Irene; Piñol Ripoll, Gerard; Cuadrado, Antonio (Dove Medical Press, 2021)
      Purpose: Chronic low-grade inflammation and oxidative stress are present in most of the pathologic mechanisms underlying non-communicable diseases. Inflammation and redox biomarkers might therefore have a value in disease ...
    • Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer 

      Granados Principal, Sergio; El-azem, Nuri; Pamplona Gras, Reinald; Ramirez Tortosa, Cesar; Pulido Moran, Mario; Vera Ramirez, Laura; Quiles, Jose L.; Sánchez Rovira, Pedro; Naudí i Farré, Alba; Portero Otín, Manuel; Pérez López, Patricia; Ramírez Tortosa, MCarmen (Elsevier, 2014)
      Oxidative stress is involved in several processes including cancer, aging and cardiovascular disease, and has been shown to potentiate the therapeutic effect of drugs such as doxorubicin. Doxorubicin causes significant ...
    • Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice 

      Sorolla Bardají, Maria Alba; Rodríguez Colman, Maria José; Vall-llaura Espinosa, Núria; Vived Maza, Celia; Fernández Nogales, Marta; Lucas, José J.; Ferrer, Isidre; Cabiscol Català, Elisa (Springer Science, Business Media, 2016-06)
      Oxidative stress has been described as important to Huntington disease (HD) progression. In a previous HD study, we identified several carbonylated proteins, including pyridoxal kinase and antiquitin, both of which are ...
    • Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients 

      Gonzalo Benito, Hugo; Nogueras Penabad, Lara; Gil-Sánchez, Anna; Vicente Hervás, José; Valcheva, Petya; González Mingot, Cristina; Martin-Gari, Meritxell; Canudes, Marc; Peralta Moncusí, Silvia; Solana Moga, M. José; Pamplona Gras, Reinald; Portero Otín, Manuel; Boada Pallàs, Jordi; Serrano Casasola, José Carlos Enrique; Brieva Ruiz, Luis (Frontiers Media, 2019)
      Literature suggests that oxidative stress (OS) may be involved in the pathogenesis of multiple sclerosis (MS), in which the immune system is known to play a key role. However, to date, the OS in peripheral lymphocytes and ...
    • Mitochondrial Dysfunction and Oxidative and Endoplasmic Reticulum Stress in Argyrophilic Grain Disease 

      Ilieva, Ekaterina V.; Kichev, Anton Vladimirov; Naudí i Farré, Alba; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Oxford University Press, 2011)
      Argyrophilic grain disease (AGD) is characterized by the accumulation of hyperphosphorylated 4R tau in dendritic varicosities (i.e."grains") in neurons and pretangles in certain areas of the cerebral cortex and other brain ...
    • Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals 

      Pamplona Gras, Reinald; Portero Otín, Manuel; Riba, David; Ruiz, Cristina; Prat Corominas, Joan; Bellmunt, Maria Josep; Barja, Gustavo (Elsevier, 1998)
      The oxidative stress theory of aging predicts a low degree of fatty acid unsaturation in tissues of longevous animals, because membrane lipids increase their sensitivity to oxidative damage as a function of their unsaturation. ...
    • Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux 

      Ost, Mario; Keipert, Susanne; Schothorst, Evert M. van; Donner, Verena; Stelt, Inge van der; Kipp, Anna P.; Petzke, Klaus-Jürgen; Jové Font, Mariona; Pamplona Gras, Reinald; Portero Otín, Manuel; Keijer, Jaap; Klaus, Susanne (FASEB, 2014)
      Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to ...
    • Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: a paradigm for multifactorial neurodegenerative diseases? 

      Galea, Elena; Launay, Nathalie; Portero Otín, Manuel; Ruiz, Montserrat; Pamplona Gras, Reinald; Aubourg, Patrick; Ferrer, Isidre; Pujol, Aurora (Elsevier, 2012)
      X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disorder expressed as four disease variants characterized by adrenal insufficiency and graded damage in the nervous system. X-ALD is caused by a loss ...
    • Pharmacological Modulation of Reactive Oxygen Species in Cancer Treatment 

      Ribas i Fortuny, Judit; Mattiolo, Paolo; Boix Torras, Jacint (Bentham Science, 2015-01-01)
      Aerobic metabolism of mammalian cells leads to the generation of reactive oxygen species (ROS). To cope with this toxicity, evolution provided cells with effective antioxidant systems like glutathione. Current anticancer ...
    • Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy 

      Morató, Laia; Galino, Jorge; Ruiz, Montserrat; Calingasan, Noel Ylagan; Starkov, Anatoly A.; Dumont, Magali; Naudí i Farré, Alba; Martínez, Juan José; Aubourg, Patrick; Portero Otín, Manuel; Pamplona Gras, Reinald; Galea, Elena; Flint Beal, M.; Ferrer, Isidre; Fourcade, Stéphane; Pujol, Aurora (Oxford Journals, 2013)
      X-linked adrenoleukodystrophy is a neurometabolic disorder caused by inactivation of the peroxisomal ABCD1 transporter of very long-chain fatty acids. In mice, ABCD1 loss causes late onset axonal degeneration in the spinal ...