Now showing items 1-10 of 10

    • Effects of aging and methionine restriction on rat kidney metabolome 

      Pradas Barriga, Irene; Jové Font, Mariona; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Mota Martorell, Natàlia; Pamplona Gras, Reinald (MDPI, 2019-11-14)
      Methionine restriction (MetR) in animal models extends maximum longevity and seems to promote renoprotection by attenuating kidney injury. MetR has also been proven to affect several metabolic pathways including lipid ...
    • Essential Physiological Differences Characterize Short- and Long-Lived Strains of Drosophila melanogaster 

      Gubina, Nina; Naudí i Farré, Alba; Stefanatos, Rhoda; Jové Font, Mariona; Scialò, Filippo; Fernández Ayala, Daniel J.; Rantapero, Tommi; Yurkevych, Ihor; Portero Otín, Manuel; Nykter, Matti; Lushchak, Oleh; Navas, Placido; Pamplona Gras, Reinald; Sanz, Alberto (Gerontological Society of America; Oxford University Press, 2019)
      Aging is a multifactorial process which affects all animals. Aging as a result of damage accumulation is the most accepted explanation but the proximal causes remain to be elucidated. There is also evidence indicating that ...
    • In Vivo Anti-Inflammatory Effects and Related Mechanisms of Processed Egg Yolk, a Potential Anti-Inflammaging Dietary Supplement 

      Cunill, Joan; Babot, Clara; Santos, Liliana; Serrano Casasola, José Carlos Enrique; Jové Font, Mariona; Martín Garí, Meritxell; Portero Otín, Manuel (MDPI, 2020-09-04)
      Egg-yolk based supplements have demonstrated biological effects. We have developed a novel processed egg-yolk (PEY) complement, and we have tested whether it has inflammation modulatory properties. These were evaluated in ...
    • Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment 

      Andrés Benito, Pol; Gelpí, Ellen; Jové Font, Mariona; Mota Martorell, Natàlia; Obis Monné, Èlia; Portero Otín, Manuel; Povedano, Mònica; Pujol, Aurora; Pamplona Gras, Reinald; Ferrer, Isidre (Wiley, 2020-12)
      Aim. Peroxisomes play a key role in lipid metabolism, and peroxisome defects have been associated with neurodegenerative diseases such as X-adrenoleukodystrophy and Alzheimer's disease. This study aims to elucidate the ...
    • Lipidomics Reveals a Tissue-Specific Fingerprint 

      Pradas Barriga, Irene; Huynh, Kevin; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Meikle, Peter J.; Jové Font, Mariona; Pamplona Gras, Reinald (Frontiers Media, 2018)
      In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the compositional level in cell membranes and ...
    • Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome 

      Jové Font, Mariona; Pradas Barriga, Irene; Naudí i Farré, Alba; Rovira-Llopis, Susana; Bañuls, Celia; Rocha, Milagros; Portero Otín, Manuel; Hernández-Mijares, Antonio; Victor, Victor M.; Pamplona Gras, Reinald (Impact Journals, 2017)
      Purpose: In this work, a non-targeted approach was used to unravel changes in the plasma lipidome of PCOS patients. The aim is to offer new insights in PCOS patients strictly selected in order to avoid confounding factors ...
    • Molecular phenomics of a high-calorie diet-induced porcine model of prepubertal obesity 

      Jové Font, Mariona; Tibau, Joan; Serrano Casasola, José Carlos Enrique; Berdún Hernández, Rebeca; Rodríguez Palmero, María; Font-i-Furnols, Maria; Cassanyé, Anna; Rodriguez Mortera, Reyna; Sol, Joaquim; Rassendren, Helene; Fàbrega, Emma; Crescenti, Anna; Castell, Anna; Sabater, Mónica; Ortega, Francisco J.; Martín Garí, Meritxell; Quintanilla Aguado, Raquel; Puigjaner, Joaquim; Moreno, José Antonio; Prat, Joan; Arola i Ferrer, Lluís; Fernández Real, José Manuel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2020-09-01)
      As obesity incidence is alarmingly rising among young individuals, we aimed to characterize an experimental model of this situation, considering the similarity between human and porcine physiology. For this reason, we fed ...
    • Plasma profiling reveals a blood-based metabolic fingerprint of obstructive sleep apnea 

      Pinilla, Lucía; Benítez, Iván; Santamaría Martos, Fernando; Targa, Adriano; Moncusí Moix, Anna; Dalmases, Mireia; Minguez Roure, Olga; Aguilà, Maria; Jové Font, Mariona; Sol, Joaquim; Pamplona Gras, Reinald; Barbé Illa, Ferran; Sánchez de la Torre, Manuel (Elsevier, 2022)
      Introduction: Obstructive sleep apnea (OSA) is a chronic, heterogeneous and multicomponent disorder with associated cardiovascular and metabolic alterations. Despite being the most common sleep-disordered breathing, it ...
    • Redox lipidomics to better understand brain aging and function 

      Pamplona Gras, Reinald; Borràs, Consuelo; Jové Font, Mariona; Pradas Barriga, Irene; Ferrer, Isidre; Viña Ribes, José (Elsevier, 2019)
      Human prefrontal cortex (PFC) is a recently evolutionary emerged brain region involved in cognitive functions. Human cognitive abilities decline during aging. Yet the molecular mechanisms that sustain the preservation or ...
    • The lipidome fingerprint of longevity 

      Jové Font, Mariona; Mota Martorell, Natàlia; Pradas Barriga, Irene; Galo-Licona, José Daniel; Martín Garí, Meritxell; Obis Monné, Èlia; Sol, Joaquim; Pamplona Gras, Reinald (MDPI, 2020-09-01)
      Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional ...