Now showing items 1-4 of 4

    • Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms 

      Bahhir, Diana; Yalgin, Cagri; Ots, Liina; Järvinen, Sampsa; George, Jack; Naudí i Farré, Alba; Krama, Tatjana; Krams, Indrikis; Tamm, Mairi; Andjelković, Ana; Dufour, Eric; González de Cosar, Jose M.; Gerards, Mike; Parhiala, Mikael; Pamplona Gras, Reinald; Jacobs, Howard T.; Jõers, Priit (Public Library of Science, 2019-10-04)
      Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial ...
    • Mitochondria and ageing 

      Leeuwenburgh, Christiaan; Pamplona Gras, Reinald; Sanz, Alberto (Hindawi Publishing Corporation, 2011)
    • Mitochondrial DNA damage and animal longevity: insights from comparative studies 

      Pamplona Gras, Reinald (Hindawi Publishing Corporation, 2011)
      Chemical reactions in living cells are under strict enzyme control and conform to a tightly regulated metabolic program. However, uncontrolled and potentially deleterious endogenous reactions occur, even under physiological ...
    • Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice 

      Hiona, Asimina; Sanz, Alberto; Kujoth, Gregory C.; Pamplona Gras, Reinald; Seo, Arnold Y.; Hofer, Tim; Someya, Shinichi; Miyakawa, Takuya; Nakayama, Chie; Samhan-Arias, Alejandro K.; Servais, Stephane; Barger, Jamie L.; Portero Otín, Manuel; Tanokura, Masaru; Prolla, Tomas A.; Leeuwenburgh, Christiaan (Public Library of Science (PLoS), 2010)
      Background: Aging results in a progressive loss of skeletal muscle, a condition known as sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal muscle and correlate with muscle loss, although no ...