Now showing items 66-85 of 325

    • Characterisation of the inflammatory response triggered by topical ingenol mebutate 0.05% gel in basal cell carcinoma 

      García de la Fuente, María Reyes; Santacana Espasa, Maria; Verdaguer Autonell, Joan; Vilardell, Felip; Garí Marsol, Eloi; Casanova i Seuma, Josep M. (Josep Manel) (WileyAustralasian College of Dermatologists, 2020-01-16)
      Background/Objective Ingenol mebutate gel is approved for actinic keratosis field therapy, but little has been published as a treatment of basal cell carcinoma (BCC). Our objective is to characterise the histopathological ...
    • Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the Ilervas project 

      Sánchez Peña, Enric; Betriu i Bars, M. Àngels; López Cano, Carolina; Hernández García, Marta; Fernández i Giráldez, Elvira; Purroy Garcia, Francisco; Bermúdez López, Marcelino; Farràs-Sallés, Cristina; Barril, Silvia; Pamplona Gras, Reinald; Rius, Ferran; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (BioMed Central, 2019-11-15)
      BACKGROUND: Prediabetes has recently been associated with subclinical atheromatous disease in the middle-aged population. Our aim was to characterize atheromatous plaque burden by the number of affected territories and the ...
    • Characterization of the Cell Death Process Induced by Staurosporine in Human Neuroblastoma Cell Lines 

      Boix Torras, Jacint; Llecha Cano, Núria; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Elsevier, 1997)
      Staurosporine is a potent and non-specific inhibitor of protein kinases. There is also evidence of staurosporine being a potent inducer of apoptosis. In several human neuroblastoma cell lines (SH-SY5Y, NB69, IMR-5 and ...
    • Characterization of the post-prandial insulinemic response and low glycaemic index of a soy beverage 

      Serrano Casasola, José Carlos Enrique; Martín Garí, Meritxell; Cassanyé, Anna; Granado-Serrano, Ana Belén; Portero Otín, Manuel (Public Library of Science, 2017)
      Soybean is recognized as rich source of bioactive compounds for the improvement of glucose homeostasis. However, the post-prandial mechanisms of action have not been extensively described. The aim of this study is to ...
    • Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling 

      Bhardwaj, Deepshikha; Nàger Grifo, Mireia; Camats, Judith; David, Mónica Delia; Benguria, Alberto; Dopazo, Ana; Cantí Nicolás, Carles; Herreros Danés, Judit (Frontiers, 2013)
      Axon morphogenesis is a complex process regulated by a variety of secreted molecules, including morphogens and growth factors, resulting in the establishment of the neuronal circuitry. Our previous work demonstrated that ...
    • Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS 

      Rando, Amaya; Torre, Miriam de la; Martinez-Muriana, Anna; Zaragoza, Pilar; Musaro, Antonio; Hernández i Estanyol, Sara; Navarro, Xavier; Toivonen, Janne M.; Osta, Rosario (Public Library of Science, 2019)
      Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease with no cure. Currently there are only two ALS drugs approved by the FDA, both with a limited therapeutic effect. In the search for drug candidates for ...
    • Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice 

      Presa, Maximiliano; Zarama Ortiz, Angela; Garabatos, Nahir; Izquierdo, Cristina; Rivas, Elisa I.; Teyton, Luc; Mora Giral, Concepció; Serreze, David; Stratmann, Thomas (Wiley, 2013)
      The cholera toxin B subunit (CTB) has been used as adjuvant to improve oral vaccine delivery in type 1 diabetes. The effect of CTB/peptide formulations on Ag-specific CD4+ T cells has remained largely unexplored. Here, ...
    • Chronic treatment with the AMPA agonist AICAR prevents skeletal muscle pathology but fails to improve clinical outcome in a mouse model of severe spinal muscular atrophy 

      Cerveró Cebrià, Clàudia; Montull, Neus; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Esquerda Colell, Josep; Calderó i Pardo, Jordi (Springer Verlag, 2016)
      Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder characterized by spinal and brainstem motor neuron (MN) loss and skeletal muscle paralysis. Currently there is no effective treatment other than supportive ...
    • Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease 

      Castelblanco Echavarría, Esmeralda; Sarrias, Maria-Rosa; Betriu i Bars, M. Àngels; Soldevila, Berta; Barranco Altirriba, María; Franch-Nadal, Josep; Valdivielso Revilla, José Manuel; Bermúdez López, Marcelino; Groop, Per-Henrik; Fernández i Giráldez, Elvira; Alonso, Núria; Mauricio Puente, Dídac (Impact Journals, 2021)
      This study assessed the association of CD5L and soluble CD36 (sCD36) with the risk of a cardiovascular event (CVE), including CV death and all-cause mortality in CKD. We evaluated the association of CD5L and sCD36 with a ...
    • Clinical Usefulness of Anthropometric Indices to Predict the Presence of Prediabetes. Data from the ILERVAS Cohort 

      Sánchez, Marta; Sánchez Peña, Enric; Bermúdez López, Marcelino; Torres, Gerard; Farràs-Sallés, Cristina; Pamplona Gras, Reinald; Castro-Boqué, Eva; Valdivielso Revilla, José Manuel; Purroy Garcia, Francisco; Martínez Alonso, Montserrat; Godoy i García, Pere; Mauricio Puente, Dídac; Fernández i Giráldez, Elvira; Hernández García, Marta; Rius, Ferran; Lecube Torelló, Albert (MDPI, 2021-03-23)
      Prediabetes is closely related to excess body weight and adipose distribution. For this reason, we aimed to assess and compare the diagnostic usefulness of ten anthropometric adiposity indices to predict prediabetes. ...
    • Colonic Microbiota Profile Characterization of the Responsiveness to Dietary Fibre Treatment in Hypercholesterolemia 

      Granado-Serrano, Ana Belén; Martín Garí, Meritxell; Sánchez, Virginia; Riart Solans, Marissa; Lafarga Giribets, Antonia; Berdún Hernández, Rebeca; Vilaprinyo Terré, Ester; Portero Otín, Manuel; Serrano Casasola, José Carlos Enrique (MDPI, 2022)
      This study aimed to determine how the microbiota profile might be predisposed to a better response in blood lipid profiles due to dietary fibre supplementation. A three-arm intervention study that included three different ...
    • Combinatorial expression of Lef1, Lhx2, Lhx5, Lhx9, Lmo3, Lmo4, and Prox1 helps to identify comparable subdivisions in the developing hippocampal formation of mouse and chicken 

      Abellán Ródenas, Antonio; Desfilis, Ester; Medina Hernández, Loreta Mª (Frontiers, 2014)
      We carried out a study of the expression patterns of seven developmental regulatory genes (Lef1, Lhx2, Lhx9, Lhx5, Lmo3, Lmo4, and Prox1), in combination with topological position, to identify the medial pallial derivatives, ...
    • Comparative functional analysis provides evidence for a crucial role for the homeobox gene Nkx2.1/Titf-1 in forebrain evolution 

      van den Akker, Willem M.R.; Brox, Aurora; Puelles, Luis; Durston, Antony J.; Medina Hernández, Loreta Mª (Wiley, 2008)
      Knockout of the Nkx2.1 (Titf-1) homeobox gene in the mouse leads to severe malformation and size reduction of the basal telencephalon/preoptic area and basal hypothalamus, indicating an important role of this gene in ...
    • Confirmation of the cardioprotective effect of MitoGamide in the diabetic heart 

      Park, Min; Nishimura, Takanori; Baeza-Garza, Carlos D.; Caldwell, Stuart T.; Boon Li Pun, Pamela; Prag, Hiran A.; Young, Tim; Sauchanka, Olga; Logan, Angela; Forkink, Marleen; Gruszczyk, Anja V.; Prime, Tracy A.; Arndt, Sabine; Naudí i Farré, Alba; Pamplona Gras, Reinald; Coughlan, Melinda T.; Tate, Mitchel; Ritchie, Rebecca H.; Caicci, Federico; Kaludercic, Nina; Lisa, Fabio Di; Smith, Robin A. J.; Hartley, Richard C.; Murphy, Michael P.; Krieg,Thomas (Springer, 2020-12-01)
      Purpose HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of HFpEF and used ...
    • Contribution of genoarchitecture to understanding forebrain evolution and development, with particular emphasis on the amygdala 

      Medina Hernández, Loreta Mª; Bupesh, Munisamy; Abellán Ródenas, Antonio (Karger, 2011)
      The amygdala is a forebrain center involved in functions and behaviors that are critical for survival (such as control of the neuroendocrine system and homeostasis, and reproduction and fear/escape responses) and in cognitive ...
    • Critical and distinct roles for key RET tyrosine docking sites in renal development 

      Jain, Sanjay; Encinas Martín, Mario; Johnson, Eugene M.; Milbrandt, Jeffrey (Cold Spring Harbor Laboratory Press, 2006)
      Molecular mechanisms that lead to congenital anomalies of kidneys and the lower urinary tract (CAKUT) are poorly understood. To elucidate the molecular basis for signaling specificity of GDNF-mediated RET signaling in ...
    • Cyclin D3 promotes pancreatic beta-cell fitness and viability in a cell cycle-independent manner and is targeted in autoimmune diabetes 

      Saavedra Ávila, Noemí Alejandra; Sengupta, Upasana; Sánchez, Begoña; Sala, Ester; Haba, Laura; Stratmann, Thomas; Verdaguer Autonell, Joan; Mauricio Puente, Dídac; Mezquita, Bélen; Ropero, Ana Belén; Nadal, Ángel; Mora Giral, Concepció (PNAS, 2014-08-04)
      Type 1 diabetes is an autoimmune condition caused by the lymphocyte-mediated destruction of the insulin-producing β cells in pancreatic islets. We aimed to identify final molecular entities targeted by the autoimmune assault ...
    • Decrease in sleep depth is associated with higher cerebrospinal fluid neurofilament light levels in patients with Alzheimer's disease 

      Targa, Adriano; Dakterzada, Farida; Benítez, Iván; López Ortega, Ricard; Pujol, Montserrat; Dalmases, Mireia; Arias Pastor, Alfonso; Sánchez de la Torre, Manuel; Zetterberg, Henrik; Blennow, Kaj; Pamplona Gras, Reinald; Jové Font, Mariona; Barbé Illa, Ferran; Piñol Ripoll, Gerard (Oxford University Press, 2021)
      STUDY OBJECTIVES: The majority of studies investigating the association between sleep and Alzheimer's disease (AD) biomarkers have been performed in healthy participants. Our objective was to investigate the association ...
    • Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease 

      Hernández-Alvarez, María Isabel; Sebastián, David; Vives, Sara; Ivanova, Sa ka; Bartoccioni, Paola; Kakimoto, Pamela; Plana, Natalia; Veiga, Sónia R.; Hernández, Vanessa; Vasconcelos, Nuno; Gopalacharyulu, Peddinti; Adrover, Anna; Jové Font, Mariona; Pamplona Gras, Reinald; Berenguer-Llergo, Antonio; Gordaliza, Isabel; Calvo, Enrique; Cabré, Noemí; Castro, Rui; Kuzmanic, Antonija; Boutant, Marie; Sala, David; Hyotylainen, Tuulia; Oresic, Matej; Fort, Joana; Errasti-Murugarren, Ekaitz; Orozco, Modesto; Joven, Jorge; Cantó, Carles; Palacin, Manuel; Fernández-Veledo, Sonia; Vendrell, Joan; Zorzano, Antonio (Elsevier, 2019-05-02)
      Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies ...
    • Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease 

      Ilieva, Ekaterina V.; Naudí i Farré, Alba; Kichev, Anton Vladimirov; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2010)
      Both oxidative and endoplasmic reticulum (ER) stress is associated with multiple neurodegenerative, age-related diseases. The rare disorder Pick disease (PiD) shares some pathological hallmarks of other neurodegenerative ...