Browsing Medicina Experimental by Title
Now showing items 260-279 of 301
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Study of community-living Alzheimer’s patients’ adherence to the Mediterranean diet and risks of malnutrition at different disease stages
(PeerJ, 2018)Alzheimer’s disease (AD) is a neurodegenerative disease that is characterized by deficits in episodic memory. It is the most common form of dementia and affects 50–70% of patients with cognitive impairments over the age ... -
Subdivisions and derivatives of the chicken subpallium based on expression of LIM and other regulatory genes and markers of neuron subpopulations during development
(Wiley, 2009)Here we studied the combinatory expression patterns of nine developmental regulatory genes and six markers of different neuronal subpopulations in the telencephalic subpallium of developing chicken, from early embryos ... -
Succination of protein thiols in human brain aging
(Frontiers Media, 2020-03-06)Human brain evolution toward complexity has been achieved with increasing energy supply as the main adaptation in brain metabolism. Energy metabolism, like other biochemical reactions in aerobic cells, is under enzymatic ... -
T-type Ca2+ Channels: T for Targetable
(Taylor & Francis, 2018-01-17)In the last decade TTCC have been unveiled as key regulators of cancer cells biology and thus have been proposed as chemotherapeutic targets. Indeed in vitro and in vivo studies indicate that TTCC pharmacological blockers ... -
T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1
(Wiley, 2018)Melanoma is a malignant tumor derived from melanocytes. Once disseminated, it is usually highly resistant to chemotherapy and is associated with poor prognosis. We have recently reported that T-type calcium channels (TTCCs) ... -
T-type Cav3.1 channels mediate progression and chemotherapeutic resistance in glioblastoma
(American Association for Cancer Research, 2019)T-type Ca2+ channels (TTCC) have been identified as key regulators of cancer cell cycle and survival. In vivo studies in glioblastoma (GBM) murine xenografts have shown that drugs able to block TTCC in vitro (such as ... -
Target of rapamycin activation predicts lifespan in fruit flies
(Taylor & Francis, 2015-09)Aging and age-related diseases are one of the most important health issues that the world will confront during the 21st century. Only by understanding the proximal causes will we be able to find treatments to reduce or ... -
Targeting T-type channels in cancer: what is on and what is off?
(Elsevier, 2021-11-25)Over the last 20 years several studies have demonstrated a pivotal role of T‐type calcium channels (TTCCs) in tumor progression. Cytotoxic effects of TTCC pharmacological blockers have been reported in vitro and in preclinical ... -
The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity
(MDPI, 2020-11-01)The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of biological membranes and the intracellular oxidative ... -
The Avian Brain Nomenclature Forum: Terminology for a New Century in Comparative Neuroanatomy.
(Wiley, 2004)Many of the assumptions of homology on which the standard nomenclature for the cell groups and fiber tracts of avian brains have been based are in error, and as a result that terminology promotes misunderstanding of the ... -
The avian subpallium: new insights into structural and functional subdivisions occupying the lateral subpallial wall and their embryological origins
(Elsevier, 2011)The subpallial region of the avian telencephalon contains neural systems whose functions are critical to the survival of individual vertebrates and their species. The subpallial neural structures can be grouped into five ... -
The biological basis of the aging process
(Institut d'Estudis Catalans. Secció de Ciències i Tecnologia, 2007)El procés biològic bàsic subjacent de l’envelliment va ésser avançat per la teoria de l’envelliment basada en els radicals lliures l’any 1954: la reacció dels radicals lliures actius, produïts fisiològicament en l’organisme, ... -
The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB and TGFβ pathways in hepatic stellate cells
(Nature Research, 2019)Liver cirrhosis results from chronic hepatic damage and is characterized by derangement of the organ architecture with increased liver fibrogenesis and defective hepatocellular function. It frequently evolves into progressive ... -
The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage
(Nature, 2016)Carotenoids are important dietary nutrients with health-promoting effects. The biofortification of staple foods with carotenoids provides an efficient delivery strategy but little is known about the fate and distribution ... -
The functional anatomy of the basal ganglia of birds
(Swets & Zeitlinger, 1999)To study how the basal ganglia can control movement in birds, we have reinvestigated the connections of the pigeon dorsal pallidum. Our results indicate that avian basal ganglia appear to control movement through major ... -
The hard-to-close window of T-type calcium channels
(Elsevier, 2019)T-Type calcium channels (TTCCs) are key regulators of membrane excitability, which is the reason why TTCC pharmacology is subject to intensive research in the neurological and cardiovascular fields. TTCCs also play a role ... -
The lipidome fingerprint of longevity
(MDPI, 2020-09-01)Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional ... -
The olfactory amygdala in amniotes: an evo-devo approach
(Wiley, 2013)In tetrapods, the medial amygdala is a forebrain center that integrates olfactory and/or vomeronasal signals with the endocrine and autonomic systems, playing a key role in different social behaviors. The vomeronasal system ... -
The prevention of the staurosporine-induced apoptosis by Bcl-XL, but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells
(Wiley, 2002)Staurosporine is one of the best apoptotic inducers in different cell types including neuroblastomas. In this study we have compared the efficiency and final outcome of three different anti-apoptotic strategies in ...