Browsing Medicina Experimental by Title
Now showing items 26-45 of 324
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Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy
(Oxford University Press, 2015)X-linked adrenomyeloneuropathy (AMN) is an inherited neurometabolic disorder caused by malfunction of the ABCD1 gene, characterized by slowly progressing spastic paraplegia affecting corticospinal tracts, and adrenal ... -
Alzheimer’s disease mutant mice exhibit reduced brain tissue stiffness compared to wild-type mice in both normoxia and following intermittent hypoxia mimicking sleep apnea
(Frontiers Media, 2018)Background: Evidence from patients and animal models suggests that obstructive sleep apnea (OSA) may increase the risk of Alzheimer’s disease (AD) and that AD is associated with reduced brain tissue stiffness. Aim: To ... -
An early and robust activation of caspases heads cells for a regulated form of necrotic-like cell death
(American Society for Biochemistry and Molecular Biology, 2015)Apoptosis is triggered by the activation of caspases and characterized by chromatin condensation and nuclear fragmentation (type II nuclear morphology). Necrosis is depicted by a gain in cell volume (oncosis), swelling ... -
Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons.
(Nature Publishing Group, 2008)We analyzed the survival responses and downstream signaling elicited by GDNF on sympathetic neurons from different Ret knockin mice. Lack of tyrosine 1062, a multidocking site in Ret, completely prevented GDNF-mediated ... -
Analysis of U1snRNP-specific A protein cross-linked complexes
(Wiley, 1990)The organization of the U1snRNP-specific A protein (34 kDa) has been analyzed by 12 and 16 A thiol-reversible chemical cross-linking and Western blotting. A-containing cross-linked complexes had molecular masses of 43, 47, ... -
Anatomía aplicada a la cirugía de los tendones flexores
(Elsevier, 2015)El conocimiento de la anatomía de los tendones flexores es importante para el tratamiento de las lesiones de estas estructuras y su pronóstico. Es imprescindible tener un buen fundamento de las estructuras de los tendones ... -
Anchorage of Candida albicans Ssr1 to the cell wall, and transcript profiling of the null mutant
(Elsevier, 2005-06-22)Incorporation into the wall of Candida albicans Ssr1, a GPI-dependent protein, was investigated by construction of different truncated genes for which the three potential ω sites (S199, S215 and G216) and the corresponding ... -
L'aplicació d'anticossos monoclonals en terapèutica humana
(Col·legi Oficial de Metges de Lleida, 2009) -
L'aplicació d'anticossos monoclonals en terapèutica humana: Farmacologia general i indicacions concretes
(Col·legi Oficial de Metges de Lleida, 2009) -
Are Obesity Indices Useful for Detecting Subclinical Atheromatosis in a Middle-Aged Population?
(Karger Publishers, 2020)Objective: There is a close relationship between excess adiposity and cardiovascular disease. Although body mass index (BMI) is the most used approach to estimate excess weight, other anthropometric indices have been ... -
ARID1A-deficient cells require HDAC6 for progression of endometrial carcinoma
(Federation of European Biochemical SocietiesJohn Wiley & Sons, 2022)AT-rich interactive domain-containing protein 1A (ARID1A) loss-of-function mutation accompanied by a loss of ARID1A protein expression is frequently observed in endometrial carcinomas. However, the molecular mechanisms ... -
Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation
(Elsevier, 2015-12)Autophagy is generally regarded as a mechanism to promote cell survival. However, autophagy can occasionally be the mechanism responsible of cell demise. We have found that a concomitant depletion of glucose, nutrients and ... -
Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer
(Taylor & Francis, 2017)Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in complete tumor remission and are frequently challenged by the appearance of refractory cell clones, eventually resulting in disease ... -
B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse
(Wiley online library, 2016)Autoreactive B lymphocytes play a key role as APCs in diaebetogenesis. However, it remains unclear whether B-cell tolerance is compromised in NOD mice. Here, we describe a new B lymphocyte transgenic NOD mouse model, the ... -
B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes
(Frontiers Media, 2019)Previous studies indicate that B-lymphocytes play a key role activating diabetogenic T-lymphocytes during the development of autoimmune diabetes. Recently, two transgenic NOD mouse models were generated: the NOD-PerIg and ... -
Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts
(Elsevier, 2019)β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. ... -
BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis
(American Association for Cancer Research, 2008)In previous reports we have shown in SH-SY5 cells that Olomoucine and Roscovitine, two inhibitory drugs of Cyclin Dependent Kinases, caused apoptosis independent of the extrinsic pathway. In this experimental paradigm, ... -
Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness
(BMC (part of Springer Nature), 2019)Background: Conventional clinical biomarkers cannot accurately differentiate indolent from aggressive prostate cancer (PCa). We investigated the usefulness of a biomarker panel measured exclusively in biofluids for assessment ... -
Biofortification of crops with nutrients: factors affecting utilization and storage
(Elsevier, 2017-01-06)Biofortification is an effective and economical method to improve the micronutrient content of crops, particularly staples that sustain human populations in developing countries. Whereas conventional fortification requires ... -
Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study
(Springer Verlag, 2019-05)X-Adrenoleukodystrophy (X-ALD) and its adult-onset, most prevalent variant adrenomyeloneuropathy (AMN) are caused by mutations in the peroxisomal transporter of the very long-chain fatty acid ABCD1. AMN patients classically ...