Now showing items 241-260 of 287

    • Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1 

      García-Morales, Victoria; Rodríguez-Bey, Guillermo; Gómez-Pérez, Laura; Domínguez-Vías, Germán; González-Forero, David; Portillo, Federico; Campos-Caro, Antonio; Gento-Caro, Ángela; Issaoui, Noura; Soler i Tatché, Rosa Ma.; Garcera, Ana; Moreno-López, Bernardo (Nature Publishing Group, 2019-08-22)
      Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological diseases. The adaptor protein p11, and background potassium ...
    • Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex 

      Cabré Cucó, Rosanna; Jové Font, Mariona; Naudí i Farré, Alba; Ayala Jové, Ma. Victoria (Maria Victoria); Piñol Ripoll, Gerard; Gil Villar, M. Pilar; Dominguez Gonzalez, Mayelin; Obis Monné, Èlia; Berdun, Rebeca; Mota Martorell, Natàlia; Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (Frontiers in Molecular Neurosciencie, 2016)
      Brain neurons offer diverse responses to stresses and detrimental factors during development and aging, and as a result of both neurodegenerative and neuropsychiatric disorders. This multiplicity of responses can be ascribed ...
    • Spinal Muscular Atrophy autophagy profle is tissue-dependent: diferential regulation between muscle and motoneurons 

      Sansa Zaragoza, Alba; Hidalgo, Iván; Miralles, Maria P.; Fuente Ruiz, Sandra de la; Pérez García, María José; Munell, Francina; Soler i Tatché, Rosa Ma.; Garcera, Ana (BioMed Central, 2021)
      Spinal muscular atrophy (SMA) is a neuromuscular genetic disease caused by reduced survival motor neuron (SMN) protein. SMN is ubiquitous and defcient levels cause spinal cord motoneurons (MNs) degeneration and muscle atrophy. ...
    • Sprouty1 controls genitourinary development via its N-terminal tyrosine 

      Vaquero, Marta; Cuesta, Sara; Anerillas, Carlos; Altés, Gisela; Ribera i Calvet, Joan; Basson, M. Albert; Licht, Jonathan D.; Egea Navarro, Joaquim; Encinas Martín, Mario (American Society of Nephrology, 2019-08-01)
      Background: Congenital anomalies of the kidney and urinary tract (CAKUT) is a group of diseases that include a broad spectrum of developmental defects of the genitourinary system. Mouse models indicate that perturbations ...
    • Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice 

      Vaquero, Marta; Macià Armengol, Anna; Anerillas Aljama, Diego; Velasco Sánchez, Ana; Matias-Guiu, Xavier; Ribera i Calvet, Joan; Encinas Martín, Mario (Society for Endocrinology, 2016-02-01)
      Pheochromocytomas (PCCs) are rare catecholamine-secreting tumors arising from the chromaffin cells in the adrenal medulla. Closely related paragangliomas share developmental origin but arise extra-adrenally, in the paraganglia ...
    • Study of community-living Alzheimer’s patients’ adherence to the Mediterranean diet and risks of malnutrition at different disease stages 

      Rocaspana-Garcia, Mariona; Blanco Blanco, Joan; Arias-Pastor, Alfonso; Gea Sánchez, Montserrat; Piñol Ripoll, Gerard (PeerJ, 2018)
      Alzheimer’s disease (AD) is a neurodegenerative disease that is characterized by deficits in episodic memory. It is the most common form of dementia and affects 50–70% of patients with cognitive impairments over the age ...
    • Subcutaneous advanced glycation end-products and lung function according to glucose abnormalities: The ILERVAS project 

      Sánchez Peña, Enric; Lecube Torelló, Albert; Betriu i Bars, M. Àngels; Hernández, Cristina; López Cano, Carolina; Gutiérrez Carrasquilla, Liliana; Kerkeni, M.; Yeramian Hakim, Andree; Purroy Garcia, Francisco; Pamplona Gras, Reinald; Farràs-Sallés, Cristina; Fernández i Giráldez, Elvira; Barbé Illa, Ferran; Simó, Rafael (Elsevier, 2019-12-01)
    • Subdivisions and derivatives of the chicken subpallium based on expression of LIM and other regulatory genes and markers of neuron subpopulations during development 

      Abellán Ródenas, Antonio; Medina Hernández, Loreta Mª (Wiley, 2009)
      Here we studied the combinatory expression patterns of nine developmental regulatory genes and six markers of different neuronal subpopulations in the telencephalic subpallium of developing chicken, from early embryos ...
    • Succination of protein thiols in human brain aging 

      Jové Font, Mariona; Pradas Barriga, Irene; Mota Martorell, Natàlia; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Ferrer, Isidre; Pamplona Gras, Reinald (Frontiers Media, 2020-03-06)
      Human brain evolution toward complexity has been achieved with increasing energy supply as the main adaptation in brain metabolism. Energy metabolism, like other biochemical reactions in aerobic cells, is under enzymatic ...
    • T-type Ca2+ Channels: T for Targetable 

      Crespí Sallán, Marta; Visa Pretel, Anna; Shaikh, Soni; Nàger Grifo, Mireia; Herreros Danés, Judit; Cantí Nicolás, Carles (Taylor & Francis, 2018-01-17)
      In the last decade TTCC have been unveiled as key regulators of cancer cells biology and thus have been proposed as chemotherapeutic targets. Indeed in vitro and in vivo studies indicate that TTCC pharmacological blockers ...
    • T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1 

      Maiques Carlos, Oscar; Barceló Gómez, Carla; Panosa, Anaïs; Pijuan Marquilles, Jordi; Orgaz, Jose L.; Rodríguez Hernández, Irene; Matas Nadal, Clara; Tell, Gemma; Vilella, Ramón; Fabra, Angels; Puig, Susana; Sanz Moreno, Victoria; Matias-Guiu, Xavier; Cantí Nicolás, Carles; Herreros Danés, Judit; Martí Laborda, Rosa Ma.; Macià Armengol, Anna (Wiley, 2018)
      Melanoma is a malignant tumor derived from melanocytes. Once disseminated, it is usually highly resistant to chemotherapy and is associated with poor prognosis. We have recently reported that T-type calcium channels (TTCCs) ...
    • T-type Cav3.1 channels mediate progression and chemotherapeutic resistance in glioblastoma 

      Visa Pretel, Anna; Crespí Sallán, Marta; Maiques Carlos, Oscar; Alza, Lía; Talavera, Elisabeth; López-Ortega, Ricard; Santacana Espasa, Maria; Herreros Danés, Judit; Cantí Nicolás, Carles (American Association for Cancer Research, 2019)
      T-type Ca2+ channels (TTCC) have been identified as key regulators of cancer cell cycle and survival. In vivo studies in glioblastoma (GBM) murine xenografts have shown that drugs able to block TTCC in vitro (such as ...
    • Target of rapamycin activation predicts lifespan in fruit flies 

      Scialò, Filippo; Sriram, Ashwin; Naudí i Farré, Alba; Ayala Jové, Ma. Victoria (Maria Victoria); Jové Font, Mariona; Pamplona Gras, Reinald; Sanz, Alberto (Taylor & Francis, 2015-09)
      Aging and age-related diseases are one of the most important health issues that the world will confront during the 21st century. Only by understanding the proximal causes will we be able to find treatments to reduce or ...
    • Targeting T-type channels in cancer: what is on and what is off? 

      Visa Pretel, Anna; Alza, Lía; Casas Benito, Adrian; Herreros Danés, Judit; Cantí Nicolás, Carles (Elsevier, 2021-11-25)
      Over the last 20 years several studies have demonstrated a pivotal role of T‐type calcium channels (TTCCs) in tumor progression. Cytotoxic effects of TTCC pharmacological blockers have been reported in vitro and in preclinical ...
    • The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity 

      Jové Font, Mariona; Mota Martorell, Natàlia; Pradas Barriga, Irene; Martin-Gari, Meritxell; Ayala Jové, Ma. Victoria (Maria Victoria); Pamplona Gras, Reinald (MDPI, 2020-11-01)
      The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of biological membranes and the intracellular oxidative ...
    • The Avian Brain Nomenclature Forum: Terminology for a New Century in Comparative Neuroanatomy. 

      Reiner, Anton; Perkel, David J.; Bruce, Laura L.; Butler, Ann B.; Csillag, András; Kuenzel, Wayne J.; Medina Hernández, Loreta Mª; Paxinos, George; Shimizu, Toru; Striedter, George; Wild, Martin; Ball, Gregori F.; Durand, Sarah; Gütürkün, Onur; Lee, Diane W.; Mello, Claudio V.; Powers, Alice; White, Stephanie A.; Hough, Gerald; Kubikova, Lubica; Smulders, Tom V.; Wada, Kazuhiro; Dugas-Ford, Jennifer; Husband, Scott; Yamamoto, Keiko; Yu, Jing; Siang, Connie; Jarvis, Erich D. (Wiley, 2004)
      Many of the assumptions of homology on which the standard nomenclature for the cell groups and fiber tracts of avian brains have been based are in error, and as a result that terminology promotes misunderstanding of the ...
    • The avian subpallium: new insights into structural and functional subdivisions occupying the lateral subpallial wall and their embryological origins 

      Kuenzel, Wayne J.; Medina Hernández, Loreta Mª; Csillag, Andras; Perkel, David J.; Reiner, Anton (Elsevier, 2011)
      The subpallial region of the avian telencephalon contains neural systems whose functions are critical to the survival of individual vertebrates and their species. The subpallial neural structures can be grouped into five ...
    • The biological basis of the aging process 

      Naudí i Farré, Alba; Jové Font, Mariona; Cacabelos Barral, Daniel; Llieva, E.; Boada Pallàs, Jordi; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Pamplona Gras, Reinald (Institut d'Estudis Catalans. Secció de Ciències i Tecnologia, 2007)
      El procés biològic bàsic subjacent de l’envelliment va ésser avançat per la teoria de l’envelliment basada en els radicals lliures l’any 1954: la reacció dels radicals lliures actius, produïts fisiològicament en l’organisme, ...
    • The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB and TGFβ pathways in hepatic stellate cells 

      Enguita, Mónica; Razquin, Nerea; Pamplona Gras, Reinald; Quiroga, Jorge; Prieto, Jesús; Fortes, Puri (Nature Research, 2019)
      Liver cirrhosis results from chronic hepatic damage and is characterized by derangement of the organ architecture with increased liver fibrogenesis and defective hepatocellular function. It frequently evolves into progressive ...
    • The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage 

      Moreno Martínez, José Antonio; Díaz-Gómez, J.; Nogareda, Carmina; Angulo Asensio, Eduardo; Sandmann, Gerhard; Portero Otín, Manuel; Serrano Casasola, José Carlos Enrique; Twyman, Richard M.; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (Nature, 2016)
      Carotenoids are important dietary nutrients with health-promoting effects. The biofortification of staple foods with carotenoids provides an efficient delivery strategy but little is known about the fate and distribution ...