Now showing items 220-239 of 352

    • Mitochondrial DNA damage and animal longevity: insights from comparative studies 

      Pamplona Gras, Reinald (Hindawi Publishing Corporation, 2011)
      Chemical reactions in living cells are under strict enzyme control and conform to a tightly regulated metabolic program. However, uncontrolled and potentially deleterious endogenous reactions occur, even under physiological ...
    • Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice 

      Hiona, Asimina; Sanz, Alberto; Kujoth, Gregory C.; Pamplona Gras, Reinald; Seo, Arnold Y.; Hofer, Tim; Someya, Shinichi; Miyakawa, Takuya; Nakayama, Chie; Samhan-Arias, Alejandro K.; Servais, Stephane; Barger, Jamie L.; Portero Otín, Manuel; Tanokura, Masaru; Prolla, Tomas A.; Leeuwenburgh, Christiaan (Public Library of Science (PLoS), 2010)
      Background: Aging results in a progressive loss of skeletal muscle, a condition known as sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal muscle and correlate with muscle loss, although no ...
    • Mitochondrial Dysfunction and Oxidative and Endoplasmic Reticulum Stress in Argyrophilic Grain Disease 

      Ilieva, Ekaterina V.; Kichev, Anton Vladimirov; Naudí i Farré, Alba; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Oxford University Press, 2011)
      Argyrophilic grain disease (AGD) is characterized by the accumulation of hyperphosphorylated 4R tau in dendritic varicosities (i.e."grains") in neurons and pretangles in certain areas of the cerebral cortex and other brain ...
    • Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals 

      Pamplona Gras, Reinald; Portero Otín, Manuel; Riba, David; Ruiz, Cristina; Prat Corominas, Joan; Bellmunt, Maria Josep; Barja, Gustavo (Elsevier, 1998)
      The oxidative stress theory of aging predicts a low degree of fatty acid unsaturation in tissues of longevous animals, because membrane lipids increase their sensitivity to oxidative damage as a function of their unsaturation. ...
    • Molecular and structural antioxidant defenses against oxidative stressin animals 

      Pamplona Gras, Reinald; Costantini, David (American Physiological Society, 2011)
      In this review, it is our aim 1) to describe the high diversity in molecular and structural antioxidant defenses against oxidative stress in animals, 2) to extend the traditional concept of antioxidant to other structural ...
    • Molecular phenomics of a high-calorie diet-induced porcine model of prepubertal obesity 

      Jové Font, Mariona; Tibau, Joan; Serrano Casasola, José Carlos Enrique; Berdún Hernández, Rebeca; Rodríguez Palmero, María; Font-i-Furnols, Maria; Cassanyé, Anna; Rodriguez Mortera, Reyna; Sol, Joaquim; Rassendren, Helene; Fàbrega, Emma; Crescenti, Anna; Castell, Anna; Sabater, Mónica; Ortega, Francisco J.; Martín Garí, Meritxell; Quintanilla Aguado, Raquel; Puigjaner, Joaquim; Moreno, José Antonio; Prat, Joan; Arola i Ferrer, Lluís; Fernández Real, José Manuel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2020-09-01)
      As obesity incidence is alarmingly rising among young individuals, we aimed to characterize an experimental model of this situation, considering the similarity between human and porcine physiology. For this reason, we fed ...
    • Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice 

      Blasco Carmona, Alba; Gras Artells, Sílvia; Mòdol-Caballero, Guillem; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Barranco, Alejandro; Das, Tapas; Pereira, Suzette L.; Navarro, Xavier; Rueda, Ricardo; Esquerda Colell, Josep; Calderó i Pardo, Jordi (Wiley, 2020-07-20)
      Background The cellular mechanisms underlying the age‐associated loss of muscle mass and function (sarcopenia) are poorly understood, hampering the development of effective treatment strategies. Here, we performed a detailed ...
    • mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity 

      Mota Martorell, Natàlia; Jové Font, Mariona; Pamplona Gras, Reinald (MDPI, 2022)
      Decreased content and activity of the mechanistic target of rapamycin (mTOR) signalling pathway, as well as the mTOR complex 1 (mTORC1) itself, are key traits for animal species and human longevity. Since mTORC1 acts as ...
    • mTORC1 is also involved in longevity between species 

      Barja, Gustavo; Pamplona Gras, Reinald (Impact Journals, 2021-05-29)
    • Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs 

      Franco-Serrano, Luis; Huerta, Mario; Hernández, Sergio; Cedano, Juan; Perez-Pons, Josep Antoni; Piñol, Jaume; Mozo Villarías, Angel; Amela, Isaac; Querol, Enrique (Springer Verlag, 2018)
      Multifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases ...
    • Multilayer OMIC data in medullary thyroid carcinoma identifies the STAT3 pathway as a potential therapeutic target in RETM918T tumors 

      Mancikova, Veronica; Montero Conde, Cristina; Perales Paton, Javier; Fernandez, Agustin F; Santacana Espasa, Maria; Jodkowska, Karolina; Inglada-Pérez, Lucía; Castelblanco Echavarría, Esmeralda; Borrego, Salud; Encinas Martín, Mario; Matias-Guiu, Xavier; Fraga, Mario; Robledo, Mercedes (American Association for Cancer Research., 2016-09-12)
      Purpose: Medullary thyroid carcinoma (MTC) is a rare disease with few genetic drivers, and the etiology specific to each known susceptibility mutation remains unknown. Exploiting multilayer genomic data, we focused our ...
    • Multiple telencephalic and extratelencephalic embryonic domains contribute neurons to the medial extended amygdala 

      Bupesh, Munisamy; Legaz, Isabel; Abellán Ródenas, Antonio; Medina Hernández, Loreta Mª (Wiley, 2011)
      Dysfunctions in emotional control and social behavior are behind human neuropsychiatric disorders, some of which are associated with an alteration of amygdalar development. The medial extended amygdala is a key telencephalic ...
    • MultitaskProtDB: a database of multitasking proteins 

      Hernández, Sergio; Ferragut, Gabriela; Amela, Isaac; Perez-Pons, Josep Antoni; Piñol, Jaume; Mozo Villarías, Angel; Cedano, Juan; Querol, Enrique (Oxford University Press, 2014)
      We have compiled MultitaskProtDB, available online at http://wallace.uab.es/multitask, to provide a repository where the many multitasking proteins found in the literature can be stored. Multitasking or moonlighting ...
    • Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux 

      Ost, Mario; Keipert, Susanne; Schothorst, Evert M. van; Donner, Verena; Stelt, Inge van der; Kipp, Anna P.; Petzke, Klaus-Jürgen; Jové Font, Mariona; Pamplona Gras, Reinald; Portero Otín, Manuel; Keijer, Jaap; Klaus, Susanne (FASEB, 2014)
      Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to ...
    • Natural-mente: no existen dos narices iguales 

      Desfilis, Ester (2017-05-01)
      La forma en què sentim una carícia, un so, un color, un sabor o una olor és igual per a tots? Els sistemes sensorials de distintes espècies són diferents, varien respecte al tipus d'energia (per exemple, hi ha animals ...
    • Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells 

      Green, E. Allison; Wong, F. Susan; Eshima, Koji; Mora Giral, Concepció; Flavell, Richard A. (Rockefeller University Press, 2000)
      Neonatal islet-specific expression of tumor necrosis factor (TNF)-α in nonobese diabetic mice promotes diabetes by provoking islet-infiltrating antigen-presenting cells to present islet peptides to autoreactive T cells. ...
    • Neural architecture of the vertebrate brain: implications for the interaction between emotion and cognition 

      Pessoa, Luiz; Medina Hernández, Loreta Mª; Hof, Patrick R.; Desfilis, Ester (Elsevier, 2019)
      Cognition is considered a hallmark of the primate brain that requires a high degree of signal integration, such as achieved in the prefrontal cortex. Moreover, it is often assumed that cognitive capabilities imply “superior” ...
    • Neuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury 

      Casanovas i Llorens, Anna; Salvany, Sara; Lahoz, Víctor; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Sabater, Raimundo; Hernández, Sara; Calderó i Pardo, Jordi; Esquerda Colell, Josep (Nature, 2017)
      The electric activity of lower motor neurons (MNs) appears to play a role in determining cell-vulnerability in MN diseases. MN excitability is modulated by cholinergic inputs through C-type synaptic boutons, which display ...
    • Neuregulin-1 is associated to postsynaptic sites contacting afferent C-type cholinergic terminals on lower motoneurons: changes in murine models of motoneuron diseases 

      Gallart-Palau, Xavier; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Sábado, Javier; Correa, Francisco; Cerveró Cebrià, Clàudia; Hereu, Marta; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Esquerda Colell, Josep (2014)
      Pioneering ultrastructural studies have defined different types of synapses (F-, S- and C-type boutons) on lower motoneurons (MNs). C-Type boutons are large nerve terminals characteristic of somatic alpha-MNs and display ...
    • Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice Correlations With Plaques, Tangles, and Oligomeric Species 

      López González, Irene; Schlüter, Agatha; Aso, Ester; García Esparcia, Paula; Ansoleaga, Belen; Llorens, Franc; Moreno, Jesús; Fuso, Andrea; Portero Otín, Manuel; Pamplona Gras, Reinald; Pujol, Aurora; Ferrer, Isidre; Carmona, Margarita (Oxford Journals, 2015)
      To understand neuroinflammation-related gene regulation during normal aging and in sporadic Alzheimer disease (sAD), we performed functional genomics analysis and analyzed messenger RNA (mRNA) expression by quantitative ...