Now showing items 181-200 of 281

    • Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice 

      Blasco Carmona, Alba; Gras Artells, Sílvia; Mòdol-Caballero, Guillem; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Barranco, Alejandro; Das, Tapas; Pereira, Suzette L.; Navarro, Xavier; Rueda, Ricardo; Esquerda Colell, Josep; Calderó i Pardo, Jordi (Wiley, 2020-07-20)
      Background The cellular mechanisms underlying the age‐associated loss of muscle mass and function (sarcopenia) are poorly understood, hampering the development of effective treatment strategies. Here, we performed a detailed ...
    • Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs 

      Franco-Serrano, Luis; Huerta, Mario; Hernández, Sergio; Cedano, Juan; Perez-Pons, Josep Antoni; Piñol, Jaume; Mozo Villarías, Angel; Amela, Isaac; Querol, Enrique (Springer Verlag, 2018)
      Multifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases ...
    • Multilayer OMIC data in medullary thyroid carcinoma identifies the STAT3 pathway as a potential therapeutic target in RETM918T tumors 

      Mancikova, Veronica; Montero Conde, Cristina; Perales Paton, Javier; Fernandez, Agustin F; Santacana Espasa, Maria; Jodkowska, Karolina; Inglada-Pérez, Lucía; Castelblanco Echavarría, Esmeralda; Borrego, Salud; Encinas Martín, Mario; Matias-Guiu, Xavier; Fraga, Mario; Robledo, Mercedes (American Association for Cancer Research., 2016-09-12)
      Purpose: Medullary thyroid carcinoma (MTC) is a rare disease with few genetic drivers, and the etiology specific to each known susceptibility mutation remains unknown. Exploiting multilayer genomic data, we focused our ...
    • Multiple telencephalic and extratelencephalic embryonic domains contribute neurons to the medial extended amygdala 

      Bupesh, Munisamy; Legaz, Isabel; Abellán Ródenas, Antonio; Medina Hernández, Loreta Mª (Wiley, 2011)
      Dysfunctions in emotional control and social behavior are behind human neuropsychiatric disorders, some of which are associated with an alteration of amygdalar development. The medial extended amygdala is a key telencephalic ...
    • MultitaskProtDB: a database of multitasking proteins 

      Hernández, Sergio; Ferragut, Gabriela; Amela, Isaac; Perez-Pons, Josep Antoni; Piñol, Jaume; Mozo Villarías, Angel; Cedano, Juan; Querol, Enrique (Oxford University Press, 2014)
      We have compiled MultitaskProtDB, available online at http://wallace.uab.es/multitask, to provide a repository where the many multitasking proteins found in the literature can be stored. Multitasking or moonlighting ...
    • Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux 

      Ost, Mario; Keipert, Susanne; Schothorst, Evert M. van; Donner, Verena; Stelt, Inge van der; Kipp, Anna P.; Petzke, Klaus-Jürgen; Jové Font, Mariona; Pamplona Gras, Reinald; Portero Otín, Manuel; Keijer, Jaap; Klaus, Susanne (FASEB, 2014)
      Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to ...
    • Natural-mente: no existen dos narices iguales 

      Desfilis, Ester (2017-05-01)
      La forma en què sentim una carícia, un so, un color, un sabor o una olor és igual per a tots? Els sistemes sensorials de distintes espècies són diferents, varien respecte al tipus d'energia (per exemple, hi ha animals ...
    • Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells 

      Green, E. Allison; Wong, F. Susan; Eshima, Koji; Mora Giral, Concepció; Flavell, Richard A. (Rockefeller University Press, 2000)
      Neonatal islet-specific expression of tumor necrosis factor (TNF)-α in nonobese diabetic mice promotes diabetes by provoking islet-infiltrating antigen-presenting cells to present islet peptides to autoreactive T cells. ...
    • Neuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury 

      Casanovas i Llorens, Anna; Salvany, Sara; Lahoz, Víctor; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Sabater, Raimundo; Hernández, Sara; Calderó i Pardo, Jordi; Esquerda Colell, Josep (Nature, 2017)
      The electric activity of lower motor neurons (MNs) appears to play a role in determining cell-vulnerability in MN diseases. MN excitability is modulated by cholinergic inputs through C-type synaptic boutons, which display ...
    • Neuregulin-1 is associated to postsynaptic sites contacting afferent C-type cholinergic terminals on lower motoneurons: changes in murine models of motoneuron diseases 

      Gallart-Palau, Xavier; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Sábado, Javier; Correa, Francisco; Cerveró Cebrià, Clàudia; Hereu, Marta; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Esquerda Colell, Josep (2014)
      Pioneering ultrastructural studies have defined different types of synapses (F-, S- and C-type boutons) on lower motoneurons (MNs). C-Type boutons are large nerve terminals characteristic of somatic alpha-MNs and display ...
    • Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice Correlations With Plaques, Tangles, and Oligomeric Species 

      López González, Irene; Schlüter, Agatha; Aso, Ester; García Esparcia, Paula; Ansoleaga, Belen; Llorens, Franc; Moreno, Jesús; Fuso, Andrea; Portero Otín, Manuel; Pamplona Gras, Reinald; Pujol, Aurora; Ferrer, Isidre; Carmona, Margarita (Oxford Journals, 2015)
      To understand neuroinflammation-related gene regulation during normal aging and in sporadic Alzheimer disease (sAD), we performed functional genomics analysis and analyzed messenger RNA (mRNA) expression by quantitative ...
    • Neuroprotection by neurotrophic factors and membrane depolarization is regulated by calmodulin kinase IV 

      Pérez García, María José; Gou Fàbregas, Myriam; Pablo Llavall, Yolanda de; Llovera i Tomàs, Marta; Comella i Carnicé, Joan Xavier; Soler i Tatché, Rosa Ma. (American Society for Biochemistry and Molecular Biology, 2008)
      Neurotrophic factors promote motoneuron (MN) survival through increased intracellular calcium (Ca(2+)) and regulation of the phosphatidylinositol (PI) 3-kinase/protein kinase B (PKB) pathway by calmodulin (CaM). Activation ...
    • Neuropsychiatric Symptoms and Quality of Life in Spanish Alzheimer's Disease Patients During COVID-19 Lockdown 

      Lara, Beatriz; Carnes, Anna; Dakterzada, Farida; Benitez, Ivan; Piñol Ripoll, Gerard (Wiley, 2020)
      Background and purpose: The COVID epidemic is affecting individuals worldwide, and Alzheimer's disease (AD) and amnesic mild cognitive impairment (MCI) patients are at risk due to their characteristics and age. We analysed ...
    • NF-κB signaling pathways: role in nervous system physiology and pathology 

      Tasheva, Stefka Mincheva; Soler i Tatché, Rosa Ma. (Sage, 2013-04)
      Intracellular pathways related to cell survival regulate neuronal physiology during development and neurodegenerative disorders. One of the pathways that have recently emerged with an important role in these processes is ...
    • Nivel de conocimiento de la enfermedad de Alzheimer en cuidadores y población general 

      Jorge, C.; Cetó, M.; Arias, A.; Blasco, E.; Gil, M. P.; López, R.; Dakterzada, Farida; Purroy Garcia, Francisco; Piñol Ripoll, Gerard (Elsevier, 2019-05-11)
      Introducción El conocimiento de la enfermedad de Alzheimer es fundamental para el diagnóstico precoz y para reducir la sobrecarga del cuidador. El objetivo fue evaluar el grado de conocimiento de la enfermedad de Alzheimer ...
    • Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Portero Otín, Manuel; Pamplona Gras, Reinald (MDPI, 2013)
      Non-enzymatic modification of aminophospholipids by lipid peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes ...
    • Nusinersen ameliorates motor function and prevents motoneuron Cajal body disassembly and abnormal poly(A) RNA distribution in a SMA mouse model 

      Berciano, Maria T.; Puente-Bedia, Alba; Medina‑Samamé, Almundena; Rodriguez-Rey, José C.; Calderó i Pardo, Jordi; Lafarga, Miguel; Tapia, Olga (Nature Publishing Group, 2020)
      Spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease characterized by degeneration of spinal cord alpha motor neurons (αMNs). SMA is caused by the homozygous deletion or mutation of the ...
    • Obesity changes the human gut mycobiome 

      Portero Otín, Manuel; Pamplona Gras, Reinald; Jové Font, Mariona; Rodríguez, M. Mar; Pérez, Daniel; Chaves, Felipe Javier; Esteve, Eduardo; Marin-Garcia, Pablo; Xifra, Gemma; Vendrell, Joan; Ricart, Wifredo; Chacón, Matilde R.; Fernández Real, José Manuel (Nature Publishing Group, 2015)
      The human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes to normal physiology and disease susceptibility. Here, the fungal microbiota (mycobiome) in ...
    • Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways 

      Arnoriaga Rodríguez, María; Mayneris Perxachs, Jordi; Contreras-Rodríguez, Oren; Burokas, Aurelijus; Ortega Sánchez, Juan Antonio; Blasco Solà, Gerard; Coll, Claudia; Biarnés, Carles; Castells Nobau, Anna; Puig, Josep; Garre Olmo, Josep; Ramos, Rafel; Pedraza, Salvador; Brugada, Ramon; Vilanova, Joan Carles; Serena, Joaquín; Barretina Ginesta, Jordi; Gich Fullà, Jordi; Pérez Brocal, Vicente; Moya, Andrés; Fernández Real, Xavier; Ramió Torrentà, Lluís; Pamplona Gras, Reinald; Sol, Joaquim; Jové Font, Mariona; Ricart, Wifredo; Portero Otín, Manuel; Maldonado, Rafael; Fernández Real, José Manuel (BMJ Publishing GroupBritish Society of Gastroenterology, 2021-01)
      Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We ...
    • Olfactory and amygdalar structures of the chicken ventral pallium based on the combinatorial expression patterns of LIM and other developmental regulatory genes 

      Abellán Ródenas, Antonio; Legaz, Isabel; Vernier, Baptiste; Rétaux, Sylvie; Medina Hernández, Loreta Mª (Wiley, 2009)
      We compared the combinatorial expression patterns of several LIM domain-containing regulatory genes in the ventrolateral pallium of mouse and chicken, in order to identify the homologues of the ventral pallial amygdala ...