Now showing items 315-324 of 324

    • Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy 

      Fourcade, Stéphane; Ruiz, Montserrat; Guilera, Cristina; Hahnen, Eric; Brichta, Lars; Naudí i Farré, Alba; Portero Otín, Manuel; Dacremont, Georges; Cartier, Nathalie; Wanders, Ronald; Kemp, Stephan; Mandel, Jean Louis; Wirth, Brunhilde; Pamplona Gras, Reinald; Aubourg, Patrick; Pujol, Aurora (Oxford University Press, 2010)
      X-linked adrenoleukodystrophy (X-ALD) is a fatal, axonal demyelinating, neurometabolic disease. It results from the functional loss of a member of the peroxisomal ATP-binding cassette transporter subfamily D (ABCD1), ...
    • Vascular calcification induced by chronic kidney disease is mediated by an increase of 1α-hydroxylase expression in vascular smooth muscle cells 

      Torremadé Pascual, Noèlia; Bozić Stanojević, Milica; Panizo García, Sara; Barrio Vazquez, Sara; Fernandez Martín, José L.; Encinas Martín, Mario; Goltzman, David; Arcidiacono, Maria V.; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (Wiley, 2016-04-01)
      Vascular calcification (VC) is a complication of chronic kidney disease that predicts morbidity and mortality. Uremic serum promotes VC, but the mechanism involved is unknown. A role for 1,25(OH)2 D3 in VC has been proposed, ...
    • Vector description of electric and hydrophobic interactions in protein homodimers 

      Mozo Villarías, Angel; Cedano, Juan; Querol, Enrique (Springer, 2016)
      This article describes the formation of homodimers from their constituting monomers, based on the rules set by a simple model of electric and hydrophobic interactions. These interactions are described in terms of the ...
    • Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile 

      Serrano Casasola, José Carlos Enrique; de Lorenzo, David; Cassanyé, Anna; Martín-Gari, Meritxell; Espinel, Alberto; Delgado, Marco Antonio; Pamplona Gras, Reinald; Portero Otín, Manuel (Springer Verlag, 2013)
      Vitamin D receptor polymorphisms may predispose that not all individuals could have benefits from the nutritional supplementation of 25-hydroxyvitamin D. Furthermore, vitamin D-related cardiovascular effects may also ...
    • Voltage-gated calcium channel blockers deregulate macroautophagy in cardiomyocytes 

      Pushparaj, Charumathi; Das, Arindam; Purroy, Rosa; Nàger Grifo, Mireia; Herreros Danés, Judit; Pamplona Gras, Reinald; Cantí Nicolás, Carles (Elsevier, 2015)
      Voltage-gated calcium channel blockers are widely used for the management of cardiovascular diseases, however little is known about their effects on cardiac cells in vitro. We challenged neonatal ventricular cardiomyocytes ...
    • Weak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study 

      Sánchez Peña, Enric; Kerkeni, M.; Hernández García, Marta; Gavaldá, Ricard; Rius, Ferran; Sauret, Ariadna; Torres, Gerard; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Castro-Boqué, Eva; Purroy Garcia, Francisco; Mauricio Puente, Dídac; Farràs-Sallés, Cristina; Buti, Miquel; Godoy i García, Pere; Pamplona Gras, Reinald; Lecube Torelló, Albert (MDPI, 2022)
      A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation ...
    • When cholesterol is not cholesterol: a note on the enzymatic determination of its concentration in model systems containing vegetable extracts 

      Jové Font, Mariona; Serrano Casasola, José Carlos Enrique; Bellmunt i Curcó, Josepa; Cassanyé, Anna; Anglès, Neus; Reguant, Jordi; Morelló, José R.; Pamplona Gras, Reinald; Portero Otín, Manuel (BioMed Central, 2010)
      Background: Experimental evidences demonstrate that vegetable derived extracts inhibit cholesterol absorption in the gastrointestinal tract. To further explore the mechanisms behind, we modeled duodenal contents with several ...
    • Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club 

      Escrichs, Anira; Biarnés, Carles; Garre Olmo, Josep; Fernández Real, Xavier; Ramos, Rafel; Pamplona Gras, Reinald; Brugada, Ramon; Serena, Joaquín; Ramió Torrentà, Lluís; Coll-De-Tuero, Gabriel; Gallart, Luís; Barretina Ginesta, Jordi; Vilanova, Joan Carles; Mayneris Perxachs, Jordi; Essig, Marco; Figley, Chase R.; Pedraza, Salvador; Puig, Josep; Deco, Gustavo (Oxford University Press, 2021)
      Normal aging causes disruptions in the brain that can lead to cognitive decline. Resting-state functional magnetic resonance imaging studies have found significant age-related alterations in functional connectivity across ...
    • Wnt-3a and Wnt-3 differently stimulate proliferation and neurogenesis of spinal neural precursors and promote neurite outgrowth by canonical signaling 

      David, Mónica Delia; Cantí Nicolás, Carles; Herreros Danés, Judit (Wiley, 2010)
      Wnt factors regulate neural stem cell development and neuronal connectivity. Here we investigated whether Wnt-3a and Wnt-3, expressed in the developing spinal cord, regulate proliferation and the neuronal differentiation ...
    • β-catenin signalling in Glioblastoma multiforme and Glioma-initiating cells 

      Nàger Grifo, Mireia; Bhardwaj, Deepshikha; Cantí Nicolás, Carles; Medina Hernández, Loreta Mª; Nogués Bara, Pere; Herreros Danés, Judit (Hindawi Publishing Corporation, 2012)
      Glioblastoma multiforme (GBM) is a commonly occurring brain tumor with a poor prognosis. GBM can develop both “de novo” or evolve from a previous astrocytoma and is characterized by high proliferation and infiltration into ...