Browsing Medicina Experimental by Title
Now showing items 226-245 of 278
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Separation of rooster spermatogenic nuclei by means of centrifugal elutriation
(Wiley, 1993)By application of minor variations in the usual method of centrifugal elutriation, we have been able to separate a nuclear suspension from rooster testes. We have obtained a population of elongated or late spermatid ... -
Serum Deprivation and Protein Synthesis Inhibition Induce Two Different Apoptotic Processes in N18 Neuroblastoma Cells
(Elsevier, 1998)N18 are murine neuroblastoma cells that underwent cell death upon serum deprivation or inhibition of protein synthesis by means of cycloheximide (CHX). In both cases, an ultrastructural morphology and an internucleosomal ... -
Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release
(Rockefeller University Press, 2006)Proper dialogue between presynaptic neurons and their targets is essential for correct synaptic assembly and function. At central synapses, Wnt proteins function as retrograde signals to regulate axon remodeling and the ... -
Signalling by neurotrophins and hepatocyte growth factor regulates axon morphogenesis by differential β-catenin phosphorylation
(Company of Biologist, 2008)Tyrosine phosphorylation of ß-catenin, a component of adhesion complexes and the Wnt pathway, affects cell adhesion, migration and gene transcription. By reducing ßcatenin availability using shRNA-mediated gene silencing ... -
Similarities and differences in the forebrain expression of Lhx1 and Lhx5 between chicken and mouse: insights for understanding telencephalic development and evolution
(Wiley, 2010)We compared expression of the paralogous LIM-homeodomain genes Lhx1 and Lhx5 in the developing rostral forebrain of mouse and chicken. Both genes are expressed in similar patterns in the septum, preoptic region, and ... -
Sixty years old is the breakpoint of human frontal cortex aging
(Elsevier, 2017)Human brain aging is the physiological process which underlies as cause of cognitive decline in the elderly and the main risk factor for neurodegenerative diseases such as Alzheimer's disease. Human neurons are functional ... -
Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system
(American Physiological Society, 2013)Ectopic expression of uncoupling protein 1 (UCP1) in skeletal muscle (SM) mitochondria increases lifespan considerably in high-fat diet-fed UCP1 Tg mice compared with wild types (WT). To clarify the underlying mechanisms, ... -
Skin Autofluorescence Measurement in Subclinical Atheromatous Disease: Results from the ILERVAS Project
(Japan Atherosclerosis Society, 2019)AIM: Advanced glycation end-products (AGEs) have been involved in the atherogenic process in the high-risk population. The goal of this study was to demonstrate that AGEs are related to subclinical atheromatous disease in ... -
Smn-deficiency increases the intrinsic excitability of motoneurons
(Frontiers Media, 2017)During development, motoneurons experience significant changes in their size and in the number and strength of connections that they receive, which requires adaptive changes in their passive and active electrical properties. ... -
Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1
(Nature Publishing Group, 2019-08-22)Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological diseases. The adaptor protein p11, and background potassium ... -
Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex
(Frontiers in Molecular Neurosciencie, 2016)Brain neurons offer diverse responses to stresses and detrimental factors during development and aging, and as a result of both neurodegenerative and neuropsychiatric disorders. This multiplicity of responses can be ascribed ... -
Spinal Muscular Atrophy autophagy profle is tissue-dependent: diferential regulation between muscle and motoneurons
(BMC, 2021)Spinal muscular atrophy (SMA) is a neuromuscular genetic disease caused by reduced survival motor neuron (SMN) protein. SMN is ubiquitous and defcient levels cause spinal cord motoneurons (MNs) degeneration and muscle atrophy. ... -
Sprouty1 controls genitourinary development via its N-terminal tyrosine
(American Society of Nephrology, 2019-08-01)Background: Congenital anomalies of the kidney and urinary tract (CAKUT) is a group of diseases that include a broad spectrum of developmental defects of the genitourinary system. Mouse models indicate that perturbations ... -
Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice
(Society for Endocrinology, 2016-02-01)Pheochromocytomas (PCCs) are rare catecholamine-secreting tumors arising from the chromaffin cells in the adrenal medulla. Closely related paragangliomas share developmental origin but arise extra-adrenally, in the paraganglia ... -
Study of community-living Alzheimer’s patients’ adherence to the Mediterranean diet and risks of malnutrition at different disease stages
(PeerJ, 2018)Alzheimer’s disease (AD) is a neurodegenerative disease that is characterized by deficits in episodic memory. It is the most common form of dementia and affects 50–70% of patients with cognitive impairments over the age ... -
Subdivisions and derivatives of the chicken subpallium based on expression of LIM and other regulatory genes and markers of neuron subpopulations during development
(Wiley, 2009)Here we studied the combinatory expression patterns of nine developmental regulatory genes and six markers of different neuronal subpopulations in the telencephalic subpallium of developing chicken, from early embryos ... -
Succination of protein thiols in human brain aging
(Frontiers Media, 2020-03-06)Human brain evolution toward complexity has been achieved with increasing energy supply as the main adaptation in brain metabolism. Energy metabolism, like other biochemical reactions in aerobic cells, is under enzymatic ... -
T-type Ca2+ Channels: T for Targetable
(Taylor & Francis, 2018-01-17)In the last decade TTCC have been unveiled as key regulators of cancer cells biology and thus have been proposed as chemotherapeutic targets. Indeed in vitro and in vivo studies indicate that TTCC pharmacological blockers ... -
T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1
(Wiley, 2018)Melanoma is a malignant tumor derived from melanocytes. Once disseminated, it is usually highly resistant to chemotherapy and is associated with poor prognosis. We have recently reported that T-type calcium channels (TTCCs) ...