Browsing Medicina Experimental by Title

Now showing items 276-295 of 351

    • (R)-roscovitine (CYC202, Seliciclib) sensitizes SH-SY5Y neuroblastorna cells to nutlin-3-induced apoptosis 

      Ribas i Fortuny, Judit; Boix Torras, Jacint; Meijer, Laurent (Elsevier, 2006)
      In this study, we have analyzed the consequences, on several neuroblastoma cell lines, of combined treatments with (R)-roscovitine (CYC202, Seliciclib), a CDK inhibitory drug, and nutlin-3, a p53 activating drug. Both ...

    • Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area 

      Puelles, Luis; Morales Delgado, N.; Merchán, P.; Castro Robles, Beatriz; Martínez de la Torre, M.; Díaz, C.; Ferran, J. L. (Springer Berlin Heidelberg, 2016)
      The telencephalic subpallium is the source of various GABAergic interneuron cohorts that invade the pallium via tangential migration. Based on genoarchitectonic studies, the subpallium has been subdivided into four major ...

    • Redox lipidomics to better understand brain aging and function 

      Pamplona Gras, Reinald; Borràs, Consuelo; Jové Font, Mariona; Pradas Barriga, Irene; Ferrer, Isidre; Viña Ribes, José (Elsevier, 2019)
      Human prefrontal cortex (PFC) is a recently evolutionary emerged brain region involved in cognitive functions. Human cognitive abilities decline during aging. Yet the molecular mechanisms that sustain the preservation or ...

    • Redox proteomic profiling of neuroketal-adducted proteins in human brain: regional vulnerability at middle age increases in the elderly 

      Domínguez, Mayelín; de Oliveira, Eliandre; Odena, María Antonia; Portero Otín, Manuel; Pamplona Gras, Reinald; Ferrer, Isidre (2016)
      Protein lipoxidation was assessed in the parietal cortex (PC), frontal cortex (FC), and cingulate gyrus (CG) in middle-aged and old-aged individuals with no clinical manifestations of cognitive impairment, in order to ...

    • Refocusing Neuroscience: Moving Away from Mental Categories and Toward Complex Behaviors 

      Pessoa, Luiz; Medina Hernández, Loreta Mª; Desfilis, Ester (The Royal Society, 2021)
      Mental terms—such as perception, cognition, action, emotion, as well as attention, memory, decision-making—are epistemically sterile. We support our thesis based on extensive comparative neuroanatomy knowledge of the ...

    • Regulation of membrane unsaturation as antioxidant adaptive mechanism in long-lived animal species 

      Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Phcog.Net, 2011)
      Oxidative stress resulting from biomolecular oxidative damage due to the imbalance between reactive species production and antioxidant response has become an universal constraint of life-history evolution in animals and ...

    • Regulation of survival motor neuron protein by the nuclear factor-kappa B pathway in mouse spinal cord motoneurons 

      Arumugam, Saravanan; Tasheva, Stefka Mincheva; Periyakaruppiah, Ambika; Fuente Ruiz, Sandra de la; Soler i Tatché, Rosa Ma.; Garcera, Ana (Springer Verlag, 2017-08-14)
      Survival motor neuron (SMN) protein deficiency causes the genetic neuromuscular disorder spinal muscular atrophy (SMA), characterized by spinal cord motoneuron degeneration. Since SMN protein level is critical to disease ...

    • Repurposed Analog of GLP-1 Ameliorates Hyperglycemia in Type 1 Diabetic Mice Through Pancreatic Cell Reprogramming 

      Villalba, Adrian; Rodríguez Fernández, Silvia; Perna Barrull, David; Ampudia, Rosa Maria; Gómez Muñoz, Laia; Pujol Autonell, Irma; Aguilera, Eva; Coma, Mireia; Cano Sarabia, Antonia María; Vázquez, Federico; Verdaguer Autonell, Joan; Vives Pi, Marta (Frontiers Media, 2020-05-13)
      Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. An ideal immunotherapy should combine the blockade of the autoimmune response with the recovery of functional target cell ...

    • Restriction of Dietary Advanced Glycation End Products Induces a Differential Plasma Metabolome and Lipidome Profile 

      Berdún Hernández, Rebeca; Jové Font, Mariona; Sol, Joaquim; Cai, Weijing; He, John C.; Rodriguez Mortera, Reyna; Martin Garí, Meritxell; Pamplona Gras, Reinald; Uribarri, Jaime; Portero Otín, Manuel (Wiley, 2021)
      Scope: Diets with low content in advanced glycation end products (AGEs) lead to beneficial properties in highly prevalent age-related diseases. To shed light on the mechanisms behind, the changes induced by a low AGE dietary ...

    • Reversible glutathionylation of Sir2 by monothiol glutaredoxins Grx3/4 regulates stress resistance 

      Vall-llaura Espinosa, Núria; Reverter Branchat, Gemma; Vived Maza, Celia; Weertman, Naomi; Rodríguez Colman, Maria José; Cabiscol Català, Elisa (Elsevier, 2016)
      The regulatory mechanisms of yeast Sir2, the founding member of the sirtuin family involved in oxidative stress and aging, are unknown. Redox signaling controls many cellular functions, especially under stress situations, ...

    • Revised Nomenclature for Avian Telencephalon and Some Related Brainstem Nuclei 

      Reiner, Anton; Perkel, David J.; Bruce, Laura L.; Butler, Ann B.; Csillag, András; Kuenzel, Wayne J.; Medina Hernández, Loreta Mª; Paxinos, George; Shimizu, Toru; Striedter, George; Wild, Martin; Ball, Gregori F.; Durand, Sarah; Gütürkün, Onur; Lee, Diane W.; Mello, Claudio V.; Powers, Alice; White, Stephanie A.; Hough, Gerald; Kubikova, Lubica; Smulders, Tom V.; Wada, Kazuhiro; Dugas-Ford, Jennifer; Husband, Scott; Yamamoto, Keiko; Yu, Jing; Siang, Connie; Jarvis, Erich D. (Wiley, 2004)

    • Role of Pir1 in the construction of the Candida albicans cell wall 

      Martínez, Ana Isabel; Castillo, Luis; Garcera, Ana; Elorza, M. Victoria; Valentín, Eulogio; Sentandreu, Rafael (Microbiology Society, 2004-10)
      Searches in a Candida albicans database (http://genolist.pasteur.fr/CandidaDB/) identified two Individual Protein Files (IPF 15363 and 19968) whose deduced amino acid sequences showed 42% and 45% homology with Saccharomyces ...

    • Selective brain regional changes in lipid profile with human aging 

      Mota Martorell, Natàlia; Andrés Benito, Pol; Martín Garí, Meritxell; Galo-Licona, José Daniel; Sol, Joaquim; Fernández Bernal, Anna; Portero Otín, Manuel; Ferrer, Isidre; Jové Font, Mariona; Pamplona Gras, Reinald (Springer, 2022)
      Fatty acids are key components in the structural diversity of lipids and play a strategic role in the functional properties of lipids which determine the integrity of neuronal and glial cell membranes, the generation of ...

    • Separation of rooster spermatogenic nuclei by means of centrifugal elutriation 

      Boix Torras, Jacint; Roca, Joaquim (Wiley, 1993)
      By application of minor variations in the usual method of centrifugal elutriation, we have been able to separate a nuclear suspension from rooster testes. We have obtained a population of elongated or late spermatid ...

    • Seroprevalence of SARS-CoV-2 in a Cohort of Patients with Multiple Sclerosis under Disease-Modifying Therapies 

      Sancho Saldaña, Agustín; Gil Sánchez, Anna; Quirant Sánchez, Bibiana; Nogueras Penabad, Lara; Peralta Moncusí, Silvia; Solana Moga, M. José; González Mingot, Cristina; Gallego, Yhovanni; Quibus, Laura; Ramo Tello, Cristina; Presas Rodríguez, Silvia; Martínez Cáceres, Eva; Torres Cabestany, Pascual; Hervás, J.V.; Valls, Joan; Brieva Ruiz, Luis (MDPI, 2022)
      Background: Disease-modifying therapies (DMTs) used to treat multiple sclerosis (MS) alter the immune system and therefore increase the risk of infection. There is growing concern about the impact of COVID-19 on patients ...

    • Serum Deprivation and Protein Synthesis Inhibition Induce Two Different Apoptotic Processes in N18 Neuroblastoma Cells 

      Fibla Palazón, Joan; Yuste Mateos, Víctor J. (Víctor José); Piulats, J.M; Llecha Cano, Núria; Comella i Carnicé, Joan Xavier; Boix Torras, Jacint (Elsevier, 1998)
      N18 are murine neuroblastoma cells that underwent cell death upon serum deprivation or inhibition of protein synthesis by means of cycloheximide (CHX). In both cases, an ultrastructural morphology and an internucleosomal ...

    • Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release 

      Ahmad-Annuar, Azlina; Ciani, Lorenza; Simeonidis, Iordanis; Herreros Danés, Judit; Ben Fredj, Naila; Rosso, Silvana B.; Hall, Anita; Brickley, Stephen; Salinas, Patricia C. (Rockefeller University Press, 2006)
      Proper dialogue between presynaptic neurons and their targets is essential for correct synaptic assembly and function. At central synapses, Wnt proteins function as retrograde signals to regulate axon remodeling and the ...

    • Signalling by neurotrophins and hepatocyte growth factor regulates axon morphogenesis by differential β-catenin phosphorylation 

      David, Mónica Delia; Yeramian Hakim, Andree; Duñach, Mireia; Llovera i Tomàs, Marta; Cantí Nicolás, Carles; Garcia de Herreros, Antonio; Comella i Carnicé, Joan Xavier; Herreros Danés, Judit (Company of Biologist, 2008)
      Tyrosine phosphorylation of ß-catenin, a component of adhesion complexes and the Wnt pathway, affects cell adhesion, migration and gene transcription. By reducing ßcatenin availability using shRNA-mediated gene silencing ...

    • Similarities and differences in the forebrain expression of Lhx1 and Lhx5 between chicken and mouse: insights for understanding telencephalic development and evolution 

      Abellán Ródenas, Antonio; Vernier, Baptiste; Rétaux, Sylvie; Medina Hernández, Loreta Mª (Wiley, 2010)
      We compared expression of the paralogous LIM-homeodomain genes Lhx1 and Lhx5 in the developing rostral forebrain of mouse and chicken. Both genes are expressed in similar patterns in the septum, preoptic region, and ...

    • Sixty years old is the breakpoint of human frontal cortex aging 

      Cabré Cucó, Rosanna; Naudí i Farré, Alba; Dominguez Gonzalez, Mayelin; Ayala Jové, Ma. Victoria (Maria Victoria); Jové Font, Mariona; Mota Martorell, Natàlia; Piñol Ripoll, Gerard; Gil Villar, M. Pilar; Rué i Monné, Montserrat; Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2017)
      Human brain aging is the physiological process which underlies as cause of cognitive decline in the elderly and the main risk factor for neurodegenerative diseases such as Alzheimer's disease. Human neurons are functional ...