Browsing Medicina Experimental by Title
Now showing items 175-194 of 300
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Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms
(Public Library of Science, 2019-10-04)Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial ... -
Membrane lipid unsaturation as physiological adaptation to animal longevity
(Frontiers Media, 2013)The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and ... -
Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential
(Elsevier, 2020-01-01)PGC-1α controls, to a large extent, the capacity of cells to respond to changing nutritional requirements and energetic demands. The key role of metabolic reprogramming in tumor development has highlighted the potential ... -
Metabolic risk management, physical exercise and lifestyle counselling in low-active adults: controlled randomized trial (BELLUGAT)
(BMC, 2017)Background: The primary aim of this study is to evaluate the effectiveness of different doses (intensity) of supervised exercise training — concomitant with lifestyle counselling — as a primary care intervention tool for ... -
Metabolomics predicts neuroimaging characteristics of transient ischemic attack patients
(Elsevier, 2016)Background: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite ... -
Metabolomics predicts stroke recurrence after transient ischemic attack
(American Academy of Neurology, 2015)Objective: To discover, by using metabolomics, novel candidate biomarkers for stroke recurrence (SR) with a higher prediction power than present ones. Methods: Metabolomic analysis was performed by liquid chromatography ... -
La metabolómica en el ictus isquémico, nuevos biomarcadores diagnósticos y pronósticos
(Viguera Editores, 2013)El estudio de biomarcadores relacionados con el ictus isquémico está adquiriendo una mayor importancia en vistas de conocer mejor los cambios fisiopatológicos de la enfermedad cerebrovascular y facilitar un diagnóstico ... -
Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism
(Impact Journals, 2016)Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we ... -
Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women
(Nature Publishing Group, 2019-11-05)Metformin is one of the treatments used for pcoS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin’s effects on lipid metabolism, a crucial ... -
Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury
(Wiley, 2021-01-02)Peripheral nerve section with subsequent disconnection of motor neuron (MN) cell bodies from their skeletal muscle targets leads to a rapid reactive response involving the recruitment and activation of microglia. In addition, ... -
Mitochondria and ageing
(Hindawi Publishing Corporation, 2011) -
Mitochondrial ATP-Synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer's disease pathology
(Wiley, 2010)Oxidative stress has been implicated in the pathogenesis of several neurodegenerative diseases including Alzheimer's disease (AD). Several proteins have been identified as targets of oxidative damage in AD dementia (usually ... -
Mitochondrial DNA damage and animal longevity: insights from comparative studies
(Hindawi Publishing Corporation, 2011)Chemical reactions in living cells are under strict enzyme control and conform to a tightly regulated metabolic program. However, uncontrolled and potentially deleterious endogenous reactions occur, even under physiological ... -
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice
(Public Library of Science (PLoS), 2010)Background: Aging results in a progressive loss of skeletal muscle, a condition known as sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal muscle and correlate with muscle loss, although no ... -
Mitochondrial Dysfunction and Oxidative and Endoplasmic Reticulum Stress in Argyrophilic Grain Disease
(Oxford University Press, 2011)Argyrophilic grain disease (AGD) is characterized by the accumulation of hyperphosphorylated 4R tau in dendritic varicosities (i.e."grains") in neurons and pretangles in certain areas of the cerebral cortex and other brain ... -
Molecular phenomics of a high-calorie diet-induced porcine model of prepubertal obesity
(Elsevier, 2020-09-01)As obesity incidence is alarmingly rising among young individuals, we aimed to characterize an experimental model of this situation, considering the similarity between human and porcine physiology. For this reason, we fed ... -
Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice
(Wiley, 2020-07-20)Background The cellular mechanisms underlying the age‐associated loss of muscle mass and function (sarcopenia) are poorly understood, hampering the development of effective treatment strategies. Here, we performed a detailed ... -
mTORC1 is also involved in longevity between species
(Impact Journals, 2021-05-29) -
Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs
(Springer Verlag, 2018)Multifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases ... -
Multilayer OMIC data in medullary thyroid carcinoma identifies the STAT3 pathway as a potential therapeutic target in RETM918T tumors
(American Association for Cancer Research., 2016-09-12)Purpose: Medullary thyroid carcinoma (MTC) is a rare disease with few genetic drivers, and the etiology specific to each known susceptibility mutation remains unknown. Exploiting multilayer genomic data, we focused our ...