Now showing items 168-187 of 324

    • L'origen de l'home: Darwin i la psicologia 

      Desfilis, Ester (Institut d'Estudis Catalans, 2021-09-13)
      The purpose of this article is to review the psychological evidence presented by Darwin in The Origin of Man and Selection in Relation to Sex, as well as the complex reciprocal relationships between evolutionism and ...
    • Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus 

      Borràs, Consuelo; Abdelaziz, Kheira M.; Díaz, Ana; Gambini,Juan; Jové Font, Mariona; López-Grueso, Raul; Mas-Bargues, Cristina; Monleón, Daniel; Pamplona Gras, Reinald; Viña Ribes, José (Elsevier, 2021-12-01)
      Soya consumption can decrease oxidative stress in animal models. Moreover, phytoestrogens such as genistein, present in soya, can mimic some of the beneficial effects of estrogens and are devoid of significant side effects, ...
    • Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behaviour, without changing mice longevity. 

      Pamplona Gras, Reinald; Portero Otín, Manuel; Naudí i Farré, Alba; Fuente, Monica de la; Barja, Gustavo; López Torres, Mónica; Mate, Ianire; Cruces, Julia; Gómez, José; Sánchez-Roman, Ines; Gómez Rodríguez, Alexia (Wiley Open AccessAnatomical Society of Great Britain and Ireland, 2014)
      The membrane fatty acid unsaturation hypothesis of aging and longevity is experimentally tested for the first time in mammals. Lifelong treatment of mice with the b1-blocker atenolol increased the amount of the ...
    • Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment 

      Andrés Benito, Pol; Gelpí, Ellen; Jové Font, Mariona; Mota Martorell, Natàlia; Obis Monné, Èlia; Portero Otín, Manuel; Povedano, Mònica; Pujol, Aurora; Pamplona Gras, Reinald; Ferrer, Isidre (Wiley, 2020-12)
      Aim. Peroxisomes play a key role in lipid metabolism, and peroxisome defects have been associated with neurodegenerative diseases such as X-adrenoleukodystrophy and Alzheimer's disease. This study aims to elucidate the ...
    • Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis 

      Nogueras Penabad, Lara; Gonzalo Benito, Hugo; Jové Font, Mariona; Sol, Joaquim; Gil-Sánchez, Anna; Hervás, J.V.; Valcheva, Petya; González Mingot, Cristina; Solana Moga, M. José; Peralta Moncusí, Silvia; Pamplona Gras, Reinald; Brieva Ruiz, Luis (Nature Publishing Group, 2019-08-05)
      Multiple sclerosis (MS) is a complex multifactorial neuropathology. Although its etiology remains unclear, it has been demonstrated that the immune system attacks myelin, leading to demyelination and axonal damage. The ...
    • Lipid rafts act as specialised domains for tetanus toxin binding and internalisation in neurons 

      Herreros Danés, Judit; Ng, Toni; Schiavo, Giampietro (American Society for Cell Biology, 2001)
      Tetanus (TeNT) is a zinc protease that blocks neurotransmission by cleaving the synaptic protein vesicle-associated membrane protein/synaptobrevin. Although its intracellular catalytic activity is well established, the ...
    • Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism 

      Gonzalo Benito, Hugo; Brieva Ruiz, Luis; Tatzber, Franz; Jové Font, Mariona; Cacabelos Barral, Daniel; Cassanyé, Anna; Lanau, Lucia; Boada Pallàs, Jordi; Serrano Casasola, José Carlos Enrique; González Mingot, Cristina; Hernández, Lourdes; Peralta Moncusí, Silvia; Pamplona Gras, Reinald; Portero Otín, Manuel (Wiley, 2012)
      Metabolomic and lipidomic analyses have been used for the profiling of neurodegenerative processes, both in targeted and untargeted approaches. In this work we have applied these techniques to the study of CSF samples of ...
    • Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters 

      Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Ramírez-Núñez, Omar; Serrano Casasola, José Carlos Enrique; Cassanyé, Anna; Arola i Ferrer, Lluís; Caimari, Antoni; Bas, Josep M. del; Crescenti, Anna; Pamplona Gras, Reinald; Portero Otín, Manuel (Oxford Journals, 2013)
      Aims Atherosclerosis is the main pathological process contributing to cardiovascular disease, with diet being the most important factor involved. Although the lipidome of atheromatous plaque has been studied previously, ...
    • Lipidomic profiling identifies signatures of metabolic risk 

      Yin, Xiaoyan; Willinger, Christine M.; Keefe, Joshua; Liu, Jun; Fernández Ortiz, Antonio; Ibáñez, Borja; Peñalvo, José L.; Adourian, Aram; Chen, George; Corella, Dolores; Pamplona Gras, Reinald; Portero Otín, Manuel; Jové Font, Mariona; Courchesne, Paul; van Duijn, Cornelia M.; Fuster, Valentín; Ordovás, José M.; Demirkan, Ayşe; Larson, Martin G.; Levy, Daniel (Elsevier, 2020)
      Background: Metabolic syndrome (MetS), the clustering of metabolic risk factors, is associated with cardiovascular disease risk. We sought to determine if dysregulation of the lipidome may contribute to metabolic risk ...
    • Lipidomic traits of plasma and cerebrospinal fluid in amyotrophic lateral sclerosis correlate with disease progression 

      Sol, Joaquim; Jové Font, Mariona; Povedano, Mònica; Sproviero, William; Dominguez, Raul; Piñol Ripoll, Gerard; Romero Guevara, Ricardo; Hye, Abdul; Al-Chalabi, Ammar; Torres Cabestany, Pascual; Andrés Benito, Pol; Area Gomez, Estela; Pamplona Gras, Reinald; Ferrer, Isidre; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel (Oxford University Press, 2021)
      Since amyotrophic lateral sclerosis cases exhibit significant heterogeneity, we aim to investigate the association of lipid composition of plasma and CSF with amyotrophic lateral sclerosis diagnosis, its progression and ...
    • Lipidomics Reveals a Tissue-Specific Fingerprint 

      Pradas Barriga, Irene; Huynh, Kevin; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Meikle, Peter J.; Jové Font, Mariona; Pamplona Gras, Reinald (Frontiers Media, 2018)
      In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the compositional level in cell membranes and ...
    • Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome 

      Jové Font, Mariona; Pradas Barriga, Irene; Naudí i Farré, Alba; Rovira-Llopis, Susana; Bañuls, Celia; Rocha, Milagros; Portero Otín, Manuel; Hernández-Mijares, Antonio; Victor, Victor M.; Pamplona Gras, Reinald (Impact Journals, 2017)
      Purpose: In this work, a non-targeted approach was used to unravel changes in the plasma lipidome of PCOS patients. The aim is to offer new insights in PCOS patients strictly selected in order to avoid confounding factors ...
    • Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target 

      Jové Font, Mariona; Pradas Barriga, Irene; Dominguez Gonzalez, Mayelin; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2018)
      The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that ...
    • Localization and dynamic changes of neuregulin-1 at C-type synaptic boutons in association with motor neuron injury and repair 

      Salvany, Sara; Casanovas i Llorens, Anna; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Hernández, Sara; Santafé Martínez, Manel; Soto-Bernardini, María Clara; Calderó i Pardo, Jordi; Schwab, Markus H.; Esquerda Colell, Josep (Federation of American Societies for Experimental Biology, 2019)
      C-type synaptic boutons (C-boutons) provide cholinergic afferent input to spinal cord motor neurons (MNs), which display an endoplasmic reticulum (ER)–related subsurface cistern (SSC) adjacent to their postsynaptic membrane. ...
    • Location-dependent effects of trauma on oxidative stress in humans 

      Servià Goixart, Lluís; Serrano Casasola, José Carlos Enrique; Pamplona Gras, Reinald; Badia Castello, Mariona; Montserrat, Neus; Portero Otín, Manuel; Trujillano Cabello, Javier (Public Library of Science, 2018)
      Though circulating antioxidant capacity in plasma is homeostatically regulated, it is not known whether acute stressors (i.e. trauma) affecting different anatomical locations could have quantitatively different impacts. ...
    • Long lifespans have evolved with long and monounsaturated fatty acids in birds 

      Galván, Ismael; Naudí i Farré, Alba; Erritzøe, Johannes; Møller, Anders P.; Barja, Gustavo; Pamplona Gras, Reinald (Society for the Study of EvolutionWiley, 2015)
      The evolution of lifespan is a central question in evolutionary biology, begging the question why there is so large variation among taxa. Specifically, a central quest is to unravel proximate causes of ageing. Here, we ...
    • Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance 

      Fourcade, Stéphane; Morató, Laia; Parameswaran, Janani; Ruiz, Montserrat; Ruiz-Cortés, Tatiana; Jové Font, Mariona; Naudí i Farré, Alba; Martínez, Paloma; Dierssen, Mara; Ferrer, Isidre; Villarroya, Francesc; Pamplona Gras, Reinald; Vaquero, Alejandro; Portero Otín, Manuel; Pujol, Aurora (Wiley, 2017)
      Sirtuin 2 (SIRT2) is a member of a family of NAD+-dependent histone deacetylases (HDAC) that play diverse roles in cellular metabolism and especially for aging process. SIRT2 is located in the nucleus, cytoplasm, and ...
    • Loss of virulence in Ustilago maydis by Umchs6 gene disruption 

      Garcera, Ana; Xoconostle Cázares, Beatriz; Rosas Quijano, Raymundo; Ortiz, Lucila; León Ramírez, Claudia; Ruiz Herrera, José; Specht, Charles A.; Sentandreu, Rafael (Elsevier, 2003-11-20)
      A gene encoding a sixth chitin synthase (Umchs6, sequence GenBank accession No. AF030554) from the plant pathogenic hemibasidiomycete Ustilago maydis (DC.) Cda. was isolated and characterized. The predicted protein is 1103 ...
    • Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity 

      Mota Martorell, Natàlia; Jové Font, Mariona; Pradas Barriga, Irene; Sanchez, Isabel; Gómez, José; Naudí i Farré, Alba; Barja, Gustavo; Pamplona Gras, Reinald (Elsevier, 2020-07-01)
      Mitochondrial reactive oxygen species (ROS) production, specifically at complex I (Cx I), has been widely suggested to be one of the determinants of species longevity. The present study follows a comparative approach to ...
    • Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness 

      Cambray Carner, Serafí; Ibarz Escuer, Mercedes; Bermúdez López, Marcelino; Marti Antonio, Manuel; Bozić Stanojević, Milica; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (MDPI, 2020)
      Classical risk factors of atherosclerosis in the general population show paradoxical effects in chronic kidney disease (CKD) patients. Thus, low low-density lipoprotein (LDL) cholesterol levels have been associated with ...