Browsing Medicina Experimental by Title
Now showing items 122-141 of 300
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Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity
(Springer, 2020-08-01)Maximum longevity (ML) varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of ML could to converge ... -
Genetic and experimental evidence supports the continuum of the central extended amygdala and a mutiple embryonic origin of its principal neurons
(Wiley, 2011)The central extended amygdala is the major output center for telencephalic control of ingestion, fear responses, stress, and anxiety. In spite of the abundant data supporting the similarity in neurochemistry, connections, and ... -
Genetic identification of the central nucleus and other components of the central extended amygdala in chicken during development
(Frontiers Media S.A., 2014-09-10)In mammals, the central extended amygdala shows a highly complex organization, and is essential for animal survival due to its implication in fear responses. However, many aspects of its evolution are still unknown, and ... -
Genoarchitecture of the extended amygdala in zebra finch, and expression of FoxP2 in cell corridors of different genetic profile
(Springer Verlag, 2016)We used a battery of genes encoding transcription factors (Pax6, Islet1, Nkx2.1, Lhx6, Lhx5, Lhx9, FoxP2) and neuropeptides to study the extended amygdala in developing zebra finches. We identified different components of ... -
Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population
(Taylor & Francis, 2014-02-01)Cervical cancer is a major health concern among women in Latin America due to its high incidence and mortality. Therefore, the discovery of molecular markers for cervical cancer screening and triage is imperative. The aim ... -
Genomic response programs of Candida albicans following protoplasting and regeneration
(Elsevier, 2005-12-16)Transcription proWling of Candida albicans cells responding to the elimination of the wall (protoplasts) and posterior regeneration was explored. DNA microarrays were used to measure changes in the expression of 6039 genes, ... -
Glial activation and central synapse loss, but not motoneuron degeneration, are prevented by the sigma-1 receptor agonist PRE-084 in the Smn2B/- mouse model of spinal muscular atrophy
(American Association of Neuropathologists, 2018)Spinal muscular atrophy (SMA) is characterized by the loss of α-motoneurons (MNs) with concomitant muscle denervation. MN excitability and vulnerability to disease are particularly regulated by cholinergic synaptic afferents ... -
Gossypol Treatment Restores Insufficient Apoptotic Function of DFF40/CAD in Human Glioblastoma Cells
(MDPI, 2021)Glioblastoma (GBM) is a highly aggressive brain tumor and almost all patients die because of relapses. GBM-derived cells undergo cell death without nuclear fragmentation upon treatment with different apoptotic agents. ... -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
(Taylor & Francis, 2021-02-08)In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant ... -
Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile
(Biomed Central, 2020-04-30)Background The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associations ... -
High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition
(Springer Verlag, 2017-06-01)Carolight® is a transgenic maize variety that accumulates extraordinary levels of carotenoids, including those with vitamin A activity. The development of Carolight® maize involved the technical implementation of a novel ... -
High-Temperature Short-Time and Holder Pasteurization of Donor Milk: Impact on Milk Composition
(MDPI, 2021-02-03)Holder pasteurization (HoP; 62.5 °C, 30 min) is commonly used to ensure the microbiological safety of donor human milk (DHM) but diminishes its nutritional properties. A high-temperature short-time (HTST) system was designed ... -
Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development
(Wiley, 2008)The amygdala controls emotional and social behavior and regulates instinctive reflexes such as defense and reproduction by way of descending projections to the hypothalamus and brainstem. The descending amygdalar projections ... -
Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer
(Elsevier, 2014)Oxidative stress is involved in several processes including cancer, aging and cardiovascular disease, and has been shown to potentiate the therapeutic effect of drugs such as doxorubicin. Doxorubicin causes significant ... -
I Congreso Interdisciplinar de Estudiantes de Neurología y Neurociencia (CIEN2). Programa y resúmenes de las comunicaciones
(Edicions de la Universitat de Lleida, 2017)El Congreso Interdisciplinar para Estudiantes de Neurología y Neurociencia (CIEN2) se trata de una iniciativa de estudiantes de la Facultad de Medicina de la Universidad de Lleida (UdL) enfocada para otros estudiantes. Por ... -
Identification of the anterior nucleus of the ansa lenticularis in birds as the homologue of the mammalian subthalamic nucleus
(Society for Neuroscience, 2000)In mammals, the subthalamic nucleus (STN) is a glutamatergic diencephalic cell group that develops in the caudal hypothalamus and migrates to a position above the cerebral peduncle. By its input from the external pallidal ... -
Immunohistochemical analysis of T-type calcium channels in acquired melanocytic nevi and melanoma
(Wiley Online Library, 2016-10-08)BACKGROUND AND OBJECTIVES: Cutaneous malignant melanoma arises from transformed melanocytes de novo or from congenital or acquired melanocytic nevi. We have recently reported that T-type Ca2+ channels (TTCs) are upregulated ... -
Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy
(Oxford Journals, 2013)X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disorder of the nervous system characterized by axonopathy in spinal cords and/or cerebral demyelination, adrenal insufficiency and accumulation of very ... -
Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice
(Springer Science, Business Media, 2016-06)Oxidative stress has been described as important to Huntington disease (HD) progression. In a previous HD study, we identified several carbonylated proteins, including pyridoxal kinase and antiquitin, both of which are ... -
Impaired Vitamin D Signaling in Endothelial Cell Leads to an Enhanced Leukocyte-Endothelium Interplay: Implications for Atherosclerosis Development
(Public Library of Science, 2015)Endothelial cell activation leading to leukocyte recruitment and adhesion plays an essential role in the initiation and progression of atherosclerosis. Vitamin D has cardioprotective actions, while its deficiency is a risk ...