Now showing items 146-165 of 351

    • Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity 

      Mota Martorell, Natàlia; Jové Font, Mariona; Pradas Barriga, Irene; Berdún Hernández, Rebeca; Sanchez, Isabel; Naudí i Farré, Alba; Garí Marsol, Eloi; Barja, Gustavo; Pamplona Gras, Reinald (Springer, 2020-08-01)
      Maximum longevity (ML) varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of ML could to converge ...
    • Genetic and experimental evidence supports the continuum of the central extended amygdala and a mutiple embryonic origin of its principal neurons 

      Bupesh, Munisamy; Abellán Ródenas, Antonio; Medina Hernández, Loreta Mª (Wiley, 2011)
      The central extended amygdala is the major output center for telencephalic control of ingestion, fear responses, stress, and anxiety. In spite of the abundant data supporting the similarity in neurochemistry, connections, and ...
    • Genetic identification of the central nucleus and other components of the central extended amygdala in chicken during development 

      Vicario Andrade, Alba; Abellán Ródenas, Antonio; Desfilis, Ester; Medina Hernández, Loreta Mª (Frontiers Media S.A., 2014-09-10)
      In mammals, the central extended amygdala shows a highly complex organization, and is essential for animal survival due to its implication in fear responses. However, many aspects of its evolution are still unknown, and ...
    • Genistein effect on cognition in prodromal Alzheimer's disease patients. The GENIAL clinical trial 

      José, Viña; Escudero, Joaquín; Baquero, Miquel; Cebrián, Mónica; Carbonell Asíns, Juan Antonio; Muñoz, José Enrique; Satorres, Encarnación; Meléndez, Juan Carlos; Ferrer Rebolleda, José; Cózar Santiago, Mª Del Puig; Santabárbara Gómez, Jose Manuel; Jové Font, Mariona; Pamplona Gras, Reinald; Tarazona Santabalbina, Francisco José; Borrás, Consuelo (BMC, 2022)
      Background: Delaying the transition from minimal cognitive impairment to Alzheimer’s dementia is a major concern in Alzheimer’s disease (AD) therapeutics. Pathological signs of AD occur years before the onset of clinical ...
    • Genoarchitecture of the extended amygdala in zebra finch, and expression of FoxP2 in cell corridors of different genetic profile 

      Vicario Andrade, Alba; Mendoza, Ezequiel; Abellán Ródenas, Antonio; Scharff, Constance; Medina Hernández, Loreta Mª (Springer Verlag, 2016)
      We used a battery of genes encoding transcription factors (Pax6, Islet1, Nkx2.1, Lhx6, Lhx5, Lhx9, FoxP2) and neuropeptides to study the extended amygdala in developing zebra finches. We identified different components of ...
    • Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population 

      Brebi, Priscilla; Maldonado, Leonel; Noordhuis, Maartje G.; Ili, Carmen; Leal, Pamela; Garcia, Patricia; Brait, Mariana; Ribas i Fortuny, Judit; Michailidi, Christina; Perez, Jimena; Soudry, Ethan; Tapia, Oscar; Guzman, Pablo; Muñoz, Sergio; Van Neste, Leander; Van Criekinge, Wim; Irizarry, Rafael; Sidransky, David; Roa, Juan C.; Guerrero-Preston, Rafael (Taylor & Francis, 2014-02-01)
      Cervical cancer is a major health concern among women in Latin America due to its high incidence and mortality. Therefore, the discovery of molecular markers for cervical cancer screening and triage is imperative. The aim ...
    • Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study 

      de Rojas, Itziar; Hernández, Isabel; Montrreal, Laura; Quintela, Inés; Calero, Miguel; Royo, Jose Luís; Huerto Vilas, Raquel; González Pérez, Antonio; Franco Macías, Emilio; Macías, Juan; Menéndez González, Manuel; Frank García, Ana; Diez Fairen, Mónica; Lage, Carmen; García Madrona, Sebastián; Aguilera, Nuria; García González, Pablo; Puerta, Raquel; Sotolongo Grau, Oscar; Alonso Lana, Silvia; Rábano, Alberto; Arias Pastor, Alfonso; Pastor, Ana Belén; Corma Gómez, Anaïs; Martín Montes, Ángel; Martínez Rodríguez, Carmen; Buiza Rueda, Dolores; Rodríguez Rodríguez, Eloy; Álvarez, Ignacio; Rosas Allende, Irene; Pineda, Juan A.; Bernal Sánchez-Arjona, María; Fernández Fuertes, Marta; Mendoza, Silvia; Del Ser, Teodoro; García Ribas, Guillermo; Sánchez Juan, Pascual; Pastor, Pau; Bullido, María J.; Álvarez, Victoria; Real, Luis M.; Mir, Pablo; Piñol Ripoll, Gerard; García Alberca, Jose María; Medina, Miguel; Orellana, Adelina; Butler, Chris R.; Marquié, Marta; Sáez, María Eugenia; Carracedo, Angel; Tárraga, Lluís; Boada, Mercè; Ruiz, Agustín (MDPI, 2021)
      Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study ...
    • Genomic response programs of Candida albicans following protoplasting and regeneration 

      Castillo, Luis; Martínez, Ana Isabel; Garcera, Ana; García-Martínez, José; Ruiz-Herrera, José; Valentín, Eulogio; Sentandreu, Rafael (Elsevier, 2005-12-16)
      Transcription proWling of Candida albicans cells responding to the elimination of the wall (protoplasts) and posterior regeneration was explored. DNA microarrays were used to measure changes in the expression of 6039 genes, ...
    • Glial activation and central synapse loss, but not motoneuron degeneration, are prevented by the sigma-1 receptor agonist PRE-084 in the Smn2B/- mouse model of spinal muscular atrophy 

      Cerveró Cebrià, Clàudia; Blasco Carmona, Alba; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Navarro, Xavier; Esquerda Colell, Josep; Calderó i Pardo, Jordi (American Association of Neuropathologists, 2018)
      Spinal muscular atrophy (SMA) is characterized by the loss of α-motoneurons (MNs) with concomitant muscle denervation. MN excitability and vulnerability to disease are particularly regulated by cholinergic synaptic afferents ...
    • Gossypol Treatment Restores Insufficient Apoptotic Function of DFF40/CAD in Human Glioblastoma Cells 

      Martínez Escardó, Laura; Alemany, Montse; Sánchez Osuna, María; Sánchez Chardi, Alejandro; Roig Martínez, Meritxell; Suárez García, Salvio; Ruiz Molina, Daniel; Vidal, Noemí; Plans, Gerard; Majós, Carles; Ribas i Fortuny, Judit; Baltrons, María Antonia; Bayascas Ramírez, José Ramón; Barcia, Carlos; Bruna, Jordi; Yuste Mateos, Víctor J. (Víctor José) (MDPI, 2021)
      Glioblastoma (GBM) is a highly aggressive brain tumor and almost all patients die because of relapses. GBM-derived cells undergo cell death without nuclear fragmentation upon treatment with different apoptotic agents. ...
    • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 

      Klionsky, Daniel J.; Cantí Nicolás, Carles; Garcera, Ana; Herreros Danés, Judit; Soler i Tatché, Rosa Ma.; others (Taylor & Francis, 2021-02-08)
      In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant ...
    • Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile 

      Arnoriaga Rodríguez, María; Mayneris Perxachs, Jordi; Burokas, Aurelijus; Pérez Brocal, Vicente; Moya, Andrés; Portero Otín, Manuel; Ricart, Wifredo; Maldonado, Rafael; Fernández Real, José Manuel (Biomed Central, 2020-04-30)
      Background The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associations ...
    • Gut microbes shape microglia and cognitive function during malnutrition 

      Bauer, Kylynda C.; York, Elisa M.; Cirstea, Mihai; Radisavljevic, Nina; Petersen, Charisse; Huus, Kelsey E.; Brown, Eric M.; Bozorgmehr, Tahereh; Berdún Hernández, Rebeca; Bernier, Louis-Philippe; Lee, Amy H.Y.; Woodward, Sarah E.; Krekhno, Zakhar; Han, Jun; Hancock, Robert E.W.; Ayala Jové, Ma. Victoria (Maria Victoria); MacVicar, Brian A.; Finlay, Barton Brett (Wiley Periodicals, 2022)
      Fecal-oral contamination promotes malnutrition pathology. Lasting consequences of early life malnutrition include cognitive impairment, but the underlying pathology and influence of gut microbes remain largely unknown. ...
    • High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition 

      Zhu, Changfu; Farré Martinez, Gemma; Zanga, Daniela; Lloveras Vilamanyà, Jaume; Michelena Bárcena, Antonio; Ferrio Díaz, Juan Pedro; Voltas Velasco, Jordi; Slafer, Gustavo A.; Savin, Roxana; Albajes Garcia, Ramon; Eizaguirre Altuna, Matilde; López Alonso, Carmen; Cantero-Martínez, Carlos; Díaz Gómez, Joana; Nogareda, Carmina; Moreno Martínez, José Antonio; Angulo Asensio, Eduardo; Estany Illa, Joan; Pena i Subirà, Ramona Natacha; Tor i Naudí, Marc; Portero Otín, Manuel; Eritja Sánchez, Núria; Arjó Pont, Gemma; Serrano Casasola, José Carlos Enrique; Matias-Guiu, Xavier; Twyman, Richard M.; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Springer Verlag, 2017-06-01)
      Carolight® is a transgenic maize variety that accumulates extraordinary levels of carotenoids, including those with vitamin A activity. The development of Carolight® maize involved the technical implementation of a novel ...
    • High-Temperature Short-Time and Holder Pasteurization of Donor Milk: Impact on Milk Composition 

      Escuder-Vieco, Diana; Rodríguez, Juan M.; Espinosa-Martos, Irene; Corzo, Nieves; Montilla, Antonia; García-Serrano, Alba; Calvo, M. Visitación; Fontecha, Javier; Serrano Casasola, José Carlos Enrique; Fernández, Leónides; Pallás-Alonso, Carmen Rosa (MDPI, 2021-02-03)
      Holder pasteurization (HoP; 62.5 °C, 30 min) is commonly used to ensure the microbiological safety of donor human milk (DHM) but diminishes its nutritional properties. A high-temperature short-time (HTST) system was designed ...
    • Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development 

      García Lopez, Margarita; Abellán Ródenas, Antonio; Legaz, Isabel; Rubenstein, John L.R.; Puelles, Luis; Medina Hernández, Loreta Mª (Wiley, 2008)
      The amygdala controls emotional and social behavior and regulates instinctive reflexes such as defense and reproduction by way of descending projections to the hypothalamus and brainstem. The descending amygdalar projections ...
    • Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer 

      Granados Principal, Sergio; El-azem, Nuri; Pamplona Gras, Reinald; Ramirez Tortosa, Cesar; Pulido Moran, Mario; Vera Ramirez, Laura; Quiles, Jose L.; Sánchez Rovira, Pedro; Naudí i Farré, Alba; Portero Otín, Manuel; Pérez López, Patricia; Ramírez Tortosa, MCarmen (Elsevier, 2014)
      Oxidative stress is involved in several processes including cancer, aging and cardiovascular disease, and has been shown to potentiate the therapeutic effect of drugs such as doxorubicin. Doxorubicin causes significant ...
    • I Congreso Interdisciplinar de Estudiantes de Neurología y Neurociencia (CIEN2). Programa y resúmenes de las comunicaciones 

      Congreso Interdisciplinar de Estudiantes de Neurología y Neurociencia (1r : 2017 : Lleida) (Edicions de la Universitat de Lleida, 2017)
      El Congreso Interdisciplinar para Estudiantes de Neurología y Neurociencia (CIEN2) se trata de una iniciativa de estudiantes de la Facultad de Medicina de la Universidad de Lleida (UdL) enfocada para otros estudiantes. Por ...
    • Identification of the anterior nucleus of the ansa lenticularis in birds as the homologue of the mammalian subthalamic nucleus 

      Jiao, Yun; Medina Hernández, Loreta Mª; Veenman, C. Leo; Toledo, Claudio; Puelles, Luis; Reiner, Anton (Society for Neuroscience, 2000)
      In mammals, the subthalamic nucleus (STN) is a glutamatergic diencephalic cell group that develops in the caudal hypothalamus and migrates to a position above the cerebral peduncle. By its input from the external pallidal ...
    • Immunohistochemical analysis of T-type calcium channels in acquired melanocytic nevi and melanoma 

      Maiques Carlos, Oscar; Macià Armengol, Anna; Moreno, Sara; Barceló Gómez, Carla; Santacana Espasa, Maria; Veà Jódar, Àlvar; Herreros Danés, Judit; Gatius Calderó, Sònia; Ortega Izquierdo, Maria Eugenia; Valls Marsal, Joan; Chen, Bo-Juen; Llovet Navàs, David; Matias-Guiu, Xavier; Cantí Nicolás, Carles; Martí Laborda, Rosa Ma. (Wiley Online Library, 2016-10-08)
      BACKGROUND AND OBJECTIVES: Cutaneous malignant melanoma arises from transformed melanocytes de novo or from congenital or acquired melanocytic nevi. We have recently reported that T-type Ca2+ channels (TTCs) are upregulated ...