Browsing Medicina Experimental by Title
Now showing items 78-97 of 300
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Decrease in sleep depth is associated with higher cerebrospinal fluid neurofilament light levels in patients with Alzheimer's disease
(Oxford University Press, 2021)STUDY OBJECTIVES: The majority of studies investigating the association between sleep and Alzheimer's disease (AD) biomarkers have been performed in healthy participants. Our objective was to investigate the association ... -
Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease
(Elsevier, 2019-05-02)Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies ... -
Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease
(Elsevier, 2010)Both oxidative and endoplasmic reticulum (ER) stress is associated with multiple neurodegenerative, age-related diseases. The rare disorder Pick disease (PiD) shares some pathological hallmarks of other neurodegenerative ... -
Development and evolution of the pallium
(Elsevier, 2009)The neocortex is the most representative and elaborated structure of the mammalian brain and is related to the achievement of complex cognitive capabilities, which are disturbed following malformation or lesion. Searching ... -
Development of neurons and fibers containing calcium binding proteins in the pallial amygdala of mouse, with special emphasis on those of the basolateral amygdalar complex
(Wiley, 2005)We studied the development of neurons and fibers containing calbindin, calretinin, and parvalbumin in the mouse pallial amygdala, with special emphasis on those of the basolateral amygdalar complex. Numerous calbindin-im ... -
Dietary intake of bioactive ingredients impacts liver and adipose tissue transcriptomes in a porcine model of prepubertal early obesity
(Nature Research, 2020)Global prevalence of obesity has increased to epidemic proportions over the past 40 years, with childhood obesity reaching alarming rates. In this study, we determined changes in liver and adipose tissue transcriptomes of ... -
Dietary intervention reverses fatty liver and altered gut microbiota during early-life undernutrition
(American Society for Microbiology, 2020)Nonalcoholic fatty liver disease (NAFLD), largely studied as a condition of overnutrition, also presents in undernourished populations. Like NAFLD, undernutrition disrupts systemic metabolism and has been linked to gut ... -
Dietary Lipid Unsaturation Influences Survival and Oxidative Modifications of an Amyotrophic Lateral Sclerosis Model in a Gender-Specific Manner
(Springer, 2014)The implication of lipid peroxidation in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) derive from high abundance of peroxidation- prone polyunsaturated fatty acids in central nervous system ... -
Differential expression of LIM-Homeodomain factors in Cajal-Retzius cells of primates, rodents, and birds
(Oxford Journals, 2010)Reelin-expressing Cajal-Retzius (CR) cells are among the earliest generated cells in the mammalian cerebral cortex and are believed to be crucial for both the development and the evolution of a laminated pattern in the ... -
Dissimilar impact of Mediterranean diet and physical activity on estimated body composition: A cross-sectional study from the ILERVAS project
(MDPI, 2019-06-17)There is a close relationship between lifestyle behaviors and excess adiposity. Althoughbody mass index (BMI) is the most used approach to estimate excess weight, other anthropometricindices have been developed to ... -
Distribution of nitric oxide-producing neurons in the developing and adult mouse amygdalar basolateral complex
(Elsevier, 2005)We analysed the expression of neuronal nitric oxide synthase (nNOS) in the mouse amygdalar basolateral complex (BLC) from embryonic day 15.5 to adult, using standard immunohistochemical methods. Our results indicate that ... -
Do primary health centres and hospitals contribute equally towards achievement of the transversal clinical competencies of medical students? Performance on the Objective Structured Clinical Examination (OSCE) in competency acquisition
(Elsevier España, 2016)Objectives: The adaptation of the educational programmes of European faculties of medicine to the European Higher Education Area guidelines has focused curricula design on competence acquisition. Competencies are defined ... -
Double-edged sword behaviour of gallic acid and its interaction with peroxidases in human microvascular endothelial cell culture (HMEC-1). Antioxidant and pro-oxidant effects*
(Polish Biochemical Society, 2010)A previous report from our group had shown in vitro a direct interaction between peroxidases and dietary antioxidants at physiological concentrations, where in the absence of H2O2, the antioxidants could serve as ... -
Drosophila expressing human SOD1 successfully recapitulates mitochondrial phenotypic features of familial amyotrophic lateral sclerosis
(Elsevier, 2016)Mitochondrial pathology is a seminal pathogenic hallmark of familial amyotrophic lateral sclerosis (FALS) which is extensively manifested by human patients and mutant SOD1G93A mammalian models. Rodents expressing human ... -
Dynamic expression of tyrosine hydroxylase mRNA and protein in neurons of the striatum and amygdala of mice, and experimental evidence of their multiple embryonic origin
(Springer Berlin, 2013)Emotional and motivational dysfunctions observed in Parkinson’s disease, schizophrenia, and drug addiction are associated to an alteration of the mesocortical and mesolimbic dopaminergic pathways, which include axons ... -
Dynamic patterns of colocalization of calbindin, parvalbumin and GABA in subpopulations of mouse basolateral amygdalar cells during development
(Elsevier, 2008)Calbindin cells represent a major interneuron subtype of the cortical/pallial regions, such as the basolateral amygdala, which are often analyzed in studies of tangential migration of interneurons from the subpallial ... -
Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome
(Public Library of Science, 2013)Individuals with Down syndrome (DS) present important motor deficits that derive from altered motor development of infants and young children. DYRK1A, a candidate gene for DS abnormalities has been implicated in motor ... -
Dysregulated protein phosphorylation: A determining condition in the continuum of brain aging and Alzheimer's disease
(John Wiley & Sons Ltd, 2021-11-01)Tau hyperphosphorylation is the first step of neurofibrillary tangle (NFT) formation. In the present study, samples of the entorhinal cortex (EC) and frontal cortex area 8 (FC) of cases with NFT pathology classified as ... -
Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS
(BioMed Central, 2016)Introduction: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with a gender bias towards major prevalence in male individuals. Several data suggest the involvement of oxidative stress and mitochondrial dysfunction ... -
Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver
(Springer Verlag, 2007)Previous studies have consistently shown that 40% caloric restriction (CR) decreases the rate of mitochondrial ROS production and steady-state levels of markers of oxidative damage to macromolecules including mitochondrial ...