Browsing Medicina Experimental by Title
Now showing items 36-55 of 278
-
B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse
(Wiley online library, 2016)Autoreactive B lymphocytes play a key role as APCs in diaebetogenesis. However, it remains unclear whether B-cell tolerance is compromised in NOD mice. Here, we describe a new B lymphocyte transgenic NOD mouse model, the ... -
B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes
(Frontiers Media, 2019)Previous studies indicate that B-lymphocytes play a key role activating diabetogenic T-lymphocytes during the development of autoimmune diabetes. Recently, two transgenic NOD mouse models were generated: the NOD-PerIg and ... -
Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts
(Elsevier, 2019)β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. ... -
BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis
(American Association for Cancer Research, 2008)In previous reports we have shown in SH-SY5 cells that Olomoucine and Roscovitine, two inhibitory drugs of Cyclin Dependent Kinases, caused apoptosis independent of the extrinsic pathway. In this experimental paradigm, ... -
Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness
(BMC (part of Springer Nature), 2019)Background: Conventional clinical biomarkers cannot accurately differentiate indolent from aggressive prostate cancer (PCa). We investigated the usefulness of a biomarker panel measured exclusively in biofluids for assessment ... -
Biofortification of crops with nutrients: factors affecting utilization and storage
(Elsevier, 2017-01-06)Biofortification is an effective and economical method to improve the micronutrient content of crops, particularly staples that sustain human populations in developing countries. Whereas conventional fortification requires ... -
Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study
(Springer Verlag, 2019-05)X-Adrenoleukodystrophy (X-ALD) and its adult-onset, most prevalent variant adrenomyeloneuropathy (AMN) are caused by mutations in the peroxisomal transporter of the very long-chain fatty acid ABCD1. AMN patients classically ... -
Biomarkers of aging in Drosophila
(Wiley, 2010)Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases ... -
Biosynthesis de novo of glycerophospholipids and longevity
(Sociedad Española de Geriatría y Gerontología, 2019-03-30)Introducción. Entre los principales componentes lipídicos de las membranas celulares se encuentran los glicerofosfolípidos (GFL), que se sintetizan en una vía de novo a partir del diacilglicerol (DAG). El perfil lipídico ... -
Cadherin expression delineates the divisions of the postnatal and adult mouse amygdala
(Wiley, 2012)The amygdaloid complex represents a group of telencephalic nuclei and cortical areas that control emotional and social behavior. Amygdalar development is poorly understood. It is generally accepted that the structures of ... -
Calcium channel expression and applicability as targeted therapies in melanoma
(Hindawi Publishing Corporation, 2015)The remodeling of Ca2+ signaling is a common finding in cancer pathophysiology serving the purpose of facilitating proliferation, migration, or survival of cancer cells subjected to stressful conditions. One particular ... -
Calcium-binding proteins, neuronal nitric oxide synthase, and GABA help to distinguish different pallial areas in the developing and adult chicken. I. Hippocampal formation and hyperpallium
(Wiley, 2006)To better understand the formation and adult organization of the avian pallium, we studied the expression patterns of gamma-aminobutyric acid (GABA), calbindin (CB), calretinin (CR), and neuronal nitric oxide synthase ... -
Caloric restriction reveals a lipidomic and metabolomic signature in liver of male mice
(John Wiley & SonsAnatomical Society, 2014-10-01)Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects ... -
Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model
(Elsevier, 2014)Amyotrophic Lateral Sclerosis (ALS), a severe neurodegenerative disease, affects the upper and lower motor neurons in the brain and spinal cord. In some studies, ALS disease progression has been associatedwith an increase ... -
Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice
(Springer Verlag, 2018)Spinal muscular atrophy (SMA), a leading genetic cause of infant death, is caused by the loss of survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration and loss of spinal cord motoneurons (MNs), ... -
Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models
(Springer Nature, 2020-06-25)Spinal muscular atrophy (SMA) is a severe neuromuscular disorder caused by loss of the survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration of spinal cord motoneurons (MNs), progressive skeletal ... -
Carotenoid-enriched transgenic corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis
(John Wiley & SonsWiley-Blackwell, 2015)Carotenoids are health-promoting organic molecules that act as antioxidants and essential nutrients. We show that chickens raised on a diet enriched with an engineered corn variety containing very high levels of four key ... -
Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs
(Elsevier, 2005)Olomoucine and Roscovitine are pharmacological inhibitors of cyclin-dependent kinases (CDK) displaying a promising profile as anticancer agents. Both compounds are effective inductors of apoptosis in a human neuroblastoma ... -
Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton
(Ferrata Storti Foundation, 2009)Background Programmed cell death has been traditionally related with caspase activation. However, it is now accepted that caspase-independent forms of programmed cell death also regulate cell death. In chronic lymphocytic ... -
CDK11 promotes cytokine-induced apoptosis in pancreatic beta cells independently of glucose concentration and is regulated by inflammation in the NOD mouse model
(Frontiers, 2021-02-10)Background: Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D). We found that the Cdk11(Cyclin Dependent Kinase 11) is ...