Browsing Medicina Experimental by Title

Now showing items 6-25 of 351

    • A 3D MRI‐based atlas of a lizard brain 

      Hoops, Daniel; Desfilis, Ester; Ullmann, Jeremy F.P.; Janke, Andrew L.; Stait‐Gardner, Timothy; Devenyi, Gabriel A.; Price, William S.; Medina Hernández, Loreta Mª; Whiting, Martin J.; Keogh, J. Scott (Wiley, 2018)
      Magnetic resonance imaging (MRI) is an established technique for neuroanatomical analysis, being particularly useful in the medical sciences. However, the application of MRI to evolutionary neuroscience is still in its ...

    • A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes 

      Altés, Gisela; Vaquero, Marta; Cuesta, Sara; Anerillas Aljama, Carlos; Macià Armengol, Anna; Espinet Mestre, Carme; Ribera i Calvet, Joan; Bellusci, Saverio; Klein, Ophir D.; Yeramian Hakim, Andree; Dolcet Roca, Xavier; Egea Navarro, Joaquim; Encinas Martín, Mario (Springer, 2022)
      The Wolffian ducts (WD) are paired epithelial tubules central to the development of the mammalian genitourinary tract. Outgrowths from the WD known as the ureteric buds (UB) generate the collecting ducts of the kidney. ...

    • A model of protein association based on their hydrophobic and electric interactions 

      Mozo Villarías, Angel; Cedano, Juan; Querol, Enrique (Public Library of Science, 2014)
      The propensity of many proteins to oligomerize and associate to form complex structures from their constituent monomers, is analyzed in terms of their hydrophobic (H), and electric pseudo-dipole (D) moment vectors. In ...

    • A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers 

      Torres Cabestany, Pascual; Anerillas Aljama, Carlos; Ramírez Núñez, Omar; Encinas Martín, Mario; Povedano, Mònica; Andrés-Benito, Pol; Ferrer, Isidre; Ayala Jové, Ma. Victoria (Maria Victoria); Pamplona Gras, Reinald; Portero Otín, Manuel (The Company of Biologists, 2022)
      To evaluate senescence mechanisms, including senescence associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase ...

    • A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts 

      Ribas i Fortuny, Judit; Ni, Xiaohua; Castanares, Mark; Liu, Minzhi M.; Esopi, David; Yegnasubramanian, Srinivasan; Rodriguez, Ronald; Mendell, Joshua T.; Lupold, Shawn E. (Oxford University Press, 2012)
      miR-21 is the most commonly over-expressed microRNA (miRNA) in cancer and a proven oncogene. Hsa-miR-21 is located on chromosome 17q23.2, immediately downstream of the vacuole membrane protein-1 (VMP1) gene, also known as ...

    • A plasma metabolomic signature discloses human breast cancer 

      Jové Font, Mariona; Collado, Ricardo; Quiles, Jose L.; Ramírez Tortosa, MCarmen; Sol, Joaquim; Ruiz-Sanjuan, Maria; Fernandez, Mónica; de la Torre Cabrera, Capilla; Ramírez-Tortosa, Cesar; Granados Principal, Sergio; Sánchez Rovira, Pedro; Pamplona Gras, Reinald (Impact Journals, 2017)
      Purpose: Metabolomics is the comprehensive global study of metabolites in biological samples. In this retrospective pilot study we explored whether serum metabolomic profile can discriminate the presence of human breast ...

    • A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma 

      Servià Goixart, Lluís; Jové Font, Mariona; Sol, Joaquim; Pamplona Gras, Reinald; Badia Castello, Mariona; Montserrat, Neus; Portero Otín, Manuel; Trujillano Cabello, Javier (BMC (part of Springer Nature), 2019-05-22)
      Background: We wanted to define metabolomic patterns in plasma to predict a negative outcome in severe trauma patients. Methods: A prospective pilot study was designed to evaluate plasma metabolomic patterns, established ...

    • A salmon peptide diet alleviates experimental colitis as compared with fish oil 

      Grimstad, Tore; Bjørndal, Bodil; Cacabelos Barral, Daniel; Aasprong, Ole G.; Omdal, Roald; Svardal, Asbjørn; Bohov, Pavol; Pamplona Gras, Reinald; Portero Otín, Manuel; Berge, Rolf K.; Hausken, Trygve (Cambridge University Press, 2013)
      Fish oil (FO) has been shown to have anti-inflammatory properties in animal models of inflammatory bowel disease, but how fish peptides (FP) influence intestinal inflammation has been less studied. Male Wistar rats, divided ...

    • A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium 

      Eritja Sánchez, Núria; Felip Nogués, Isidre; Dosil Garcia, Maria Alba; Vigezzi, Lucia; Mirantes Barbeito, Cristina; Yeramian Hakim, Andree; Navaridas Fernández de Bobadilla, Raúl; Santacana Espasa, Maria; Llobet Navàs, David; Yoshimura, Akihiko; Nomura, Masatoshi; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Nature Publishing Group, 2017-05-19)
      The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apoptosis, and their alterations lead to cancer development. TGF-β acts as a tumor suppressor in premalignant cells, but it ...

    • Aberrant regulation of the GSK-3b/NRF2 axis unveils a novel therapy for adrenoleukodystrophy 

      Ranea-Robles, Pablo; Launay, Nathalie; Ruiz, Montserrat; Calingasan, Noel Ylagan; Dumont, Magali; Naudí i Farré, Alba; Portero Otín, Manuel; Pamplona Gras, Reinald; Ferrer, Isidre; Beal, M. Flint; Fourcade, Stéphane; Pujol, Aurora (Wiley Open Access, 2018)
      The nuclear factor erythroid 2-like 2 (NRF2) is the master regulator of endogenous antioxidant responses. Oxidative damage is a shared and early-appearing feature in X-linked adrenoleukodystrophy (X-ALD) patients and ...

    • Accumulation of misfolded SOD1 in dorsal root ganglion degenerating propioceptive sensory neurons of transgenic mice with amyotrophic lateral sclerosis 

      Sábado, Javier; Casanovas i Llorens, Anna; Tarabal Mostazo, Olga; Hereu, Marta; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Esquerda Colell, Josep (Hindawi Publishing Corporation, 2014)
      Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disease affecting upper and lower motoneurons (MNs). Although the motor phenotype is a hallmark for ALS, there is increasing evidence that ...

    • Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1G93A mouse model of amyotrophic lateral sclerosis 

      Salvany, Sara; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Gras Artells, Sílvia; Calderó i Pardo, Jordi; Esquerda Colell, Josep (Wiley Open Access, 2022)
      Early misfolded superoxide dismutase 1 (mfSOD1) accumulation, motor neuron (MN) degeneration, and microgliosis are hallmark pathological features in SOD1G93A amyotrophic lateral sclerosis (ALS) mice. Because of the different ...

    • Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA 

      Narcís, Oriol J.; Tapia, Olga; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Berciano, Maria T.; Lafarga, Miguel (Nature Research, 2018)
      Spinal muscular atrophy (SMA) is a severe motor neuron (MN) disease caused by the deletion or mutation of the survival motor neuron 1 (SMN1) gene, which results in reduced levels of the SMN protein and the selective ...

    • Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy 

      Morató, Laia; Ruiz, M.; Boada Pallàs, Jordi; Calingasan, Noel Ylagan; Galino, Jorge; Guilera, Cristina; Jové Font, Mariona; Naudí i Farré, Alba; Ferrer, Isidre; Pamplona Gras, Reinald; Serrano, M.; Portero Otín, Manuel; Beal, M. F.; Fourcade, Stéphane; Pujol, Aurora (Macmillan Publishers, 2015)
      Oxidative stress and mitochondrial failure are prominent factors in the axonal degeneration process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the mitochondrial function, is impaired in the ...

    • Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype 

      Torres-Querol, Coral; Torres Cabestany, Pascual; Vidal, Noemí; Portero Otín, Manuel; Arque, Gloria; Purroy Garcia, Francisco (Nature Research, 2021)
      Senescent cells are capable of expressing a myriad of infammatory cytokines and this proinfammatory phenomenon is known as senescence-associated secretory phenotype (SASP). The contribution of this phenomenon in brain ...

    • Adipose Tissue Mitochondrial Factors Profile after Dietary Bioactive Compound Weight Reduction Treatments in a Mice Obesity Model 

      Cassanyé, Anna; Martín Garí, Meritxell; Portero Otín, Manuel; Serrano Casasola, José Carlos Enrique (MDPI, 2019)
      Prolonged caloric intake above energy needs disturbs the body's ability to store and manage the excess of energy intake, leading to the onset of chronic degenerative diseases. This study aimed to compare the effect of three ...

    • Adipose Tissue Protein Glycoxidation is Associated with Weight‐Loss Potential 

      Serrano Casasola, José Carlos Enrique; Baena-Fustegueras, Juan A; Martín Garí, Meritxell; Rassendren, Helene; Cassanyé, Anna; Naudí i Farré, Alba; López Cano, Carolina; Sánchez Peña, Enric; Fuente Juárez, Mari Cruz de la; Herrería González, Fernando; Olsina Kissler, Jorge Juan; Lecube Torelló, Albert; Portero Otín, Manuel (Wiley online library, 2019-05)
      Objective: This study aimed to characterize the differences in protein oxidation biomarkers in adipose tissue (AT) as an indicator of AT metabolism and bariatric surgery weight‐loss success. Methods: A human model, in ...

    • Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence 

      Moreno-Navarrete, José María; Liñares-Pose, Laura; Sabater, Mónica; Rial-Pensado, Eva; Comas, Ferran; Jové Font, Mariona; Latorre, Jèssica; Ortega Delgado, Francisco José; Ricart, Wifredo; Portero Otín, Manuel; López, Miguel; Fernández Real, José Manuel (Karger Publishers Open Access, 2018-11-18)
      Background/Aims: Thyroid hormones have been recently linked to senescence and longevity. Given the recent description of TSHB mRNA in human adipose tissue (AT), we aimed to investigate the relationship ...

    • Advanced glycation end product precursors impair epidermal growth factor receptor signalin 

      Portero Otín, Manuel; Pamplona Gras, Reinald; Bellmunt i Curcó, Josepa; Cristina Ruiz, Maria; Prat, Joan; Salvayre, Robert; Nègre Salvayre, Anne (American Diabetes Association, 2002-05)
      Formation of advanced glycation end products (AGEs) is considered a potential link between hyperglycemia and chronic diabetic complications, including disturbances in cell signaling. It was hypothesized that AGEs alter ...

    • Advanced lipoprotein parameters could better explain atheromatosis in non-diabetic chronic kidney disease patients 

      Bermúdez López, Marcelino; Perpiñán, Hèctor; Amigó, Núria; Castro-Boqué, Eva; Alonso, Núria; Mauricio Puente, Dídac; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (European Renal Association - European Dialysis and Transplant Association (ERA-EDTA); Oxford University Press, 2021)
      Background: Chronic kidney disease (CKD) patients have a high burden of atheromatous cardiovascular disease (ASCVD) not fully explained by traditional lipid parameters. Lipoprotein composition and subclass particle number ...