Recent Submissions

  • Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus 

    Tapia, Olga; Narcís, Oriol J.; Riancho, Javier; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Berciano, Maria T.; Lafarga, Miguel (Elsevier, 2017)
    Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs). The best ...
  • Glial activation and central synapse loss, but not motoneuron degeneration, are prevented by the sigma-1 receptor agonist PRE-084 in the Smn2B/- mouse model of spinal muscular atrophy 

    Cerveró Cebrià, Clàudia; Blasco Carmona, Alba; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Navarro, X. (Xavier); Esquerda Colell, Josep; Calderó i Pardo, Jordi (American Association of Neuropathologists, 2018)
    Spinal muscular atrophy (SMA) is characterized by the loss of α-motoneurons (MNs) with concomitant muscle denervation. MN excitability and vulnerability to disease are particularly regulated by cholinergic synaptic afferents ...
  • Localization and dynamic changes of neuregulin-1 at C-type synaptic boutons in association with motor neuron injury and repair 

    Salvany, Sara; Casanovas i Llorens, Anna; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Hernández, Sara; Santafé Martínez, Manel; Soto-Bernardini, María Clara; Calderó i Pardo, Jordi; Schwab, Markus H.; Esquerda Colell, Josep (Federation of American Societies for Experimental Biology, 2019)
    C-type synaptic boutons (C-boutons) provide cholinergic afferent input to spinal cord motor neurons (MNs), which display an endoplasmic reticulum (ER)–related subsurface cistern (SSC) adjacent to their postsynaptic membrane. ...
  • A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma 

    Servià Goixart, Lluís; Jové Font, Mariona; Sol, Joaquim; Pamplona Gras, Reinald; Badia Castello, Mariona; Montserrat, Neus; Portero Otín, Manuel; Trujillano Cabello, Javier (BMC (part of Springer Nature), 2019-05-22)
    Background: We wanted to define metabolomic patterns in plasma to predict a negative outcome in severe trauma patients. Methods: A prospective pilot study was designed to evaluate plasma metabolomic patterns, established ...
  • Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study 

    Casasnovas, Carlos; Ruiz, Montserrat; Schlüter, Agatha; Naudí i Farré, Alba; Fourcade, Stéphane; Veciana, Misericordia; Castañer, Sara; Albertí, Antonia; Bargalló, Nuria; Johnson, Maria; Raymond, Gerald V.; Fatemi, Ali; Moser, Ann B.; Villarroya, Francesc; Portero Otín, Manuel; Artuch, Rafael; Pamplona Gras, Reinald; Pujol, Aurora (Springer Verlag, 2019-05)
    X-Adrenoleukodystrophy (X-ALD) and its adult-onset, most prevalent variant adrenomyeloneuropathy (AMN) are caused by mutations in the peroxisomal transporter of the very long-chain fatty acid ABCD1. AMN patients classically ...
  • Adipose Tissue Protein Glycoxidation is Associated with Weight‐Loss Potential 

    Serrano Casasola, José Carlos Enrique; Baena-Fustegueras, Juan A; Martín Garí, Meritxell; Rassendren, Helene; Cassanyé, Anna; Naudí i Farré, Alba; López Cano, Carolina; Sánchez Peña, Enric; Fuente Juárez, Mari Cruz de la; Herrería González, Fernando; Olsina Kissler, Jorge Juan; Lecube Torelló, Albert; Portero Otín, Manuel (Wiley online library, 2019-05)
    Objective: This study aimed to characterize the differences in protein oxidation biomarkers in adipose tissue (AT) as an indicator of AT metabolism and bariatric surgery weight‐loss success. Methods: A human model, in ...
  • Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1 

    García-Morales, Victoria; Rodríguez-Bey, Guillermo; Gómez-Pérez, Laura; Domínguez-Vías, Germán; González-Forero, David; Portillo, Federico; Campos-Caro, Antonio; Gento-Caro, Ángela; Issaoui, Noura; Soler i Tatché, Rosa Ma.; Garcera, Ana; Moreno-López, Bernardo (Nature Publishing Group, 2019-08-22)
    Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological diseases. The adaptor protein p11, and background potassium ...
  • Sprouty1 controls genitourinary development via its N-terminal tyrosine 

    Vaquero, Marta; Cuesta, Sara; Anerillas, Carlos; Altés, Gisela; Ribera i Calvet, Joan; Basson, M. Albert; Licht, Jonathan D.; Egea Navarro, Joaquim; Encinas Martín, Mario (American Society of Nephrology, 2019-08-01)
    Background: Congenital anomalies of the kidney and urinary tract (CAKUT) is a group of diseases that include a broad spectrum of developmental defects of the genitourinary system. Mouse models indicate that perturbations ...
  • Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk 

    Bhardwaj, Deepshikha; Nàger Grifo, Mireia; Visa Pretel, Anna; Crespí Sallán, Marta; Coopman, PJ; Cantí Nicolás, Carles; Herreros Danés, Judit (Willey, 2018-04-01)
    β-catenin is a central component of adherent junctions and a key effector of canonical Wnt signalling, in which dephosphorylated Ser/Thr β-catenin regulates gene transcription. β-catenin phosphorylation at Tyr142 (PTyr142 ...
  • The Secrets of the Brain. An evolutionary perspective on neuroscience 

    Desfilis, Ester; Medina Hernández, Loreta Mª (Universitat de València, 2016-05-15)
  • Revised Nomenclature for Avian Telencephalon and Some Related Brainstem Nuclei 

    Reiner, Anton; Perkel, David J.; Bruce, Laura L.; Butler, Ann B.; Csillag, András; Kuenzel, Wayne J.; Medina Hernández, Loreta Mª; Paxinos, George; Shimizu, Toru; Striedter, George; Wild, Martin; Ball, Gregori F.; Durand, Sarah; Gütürkün, Onur; Lee, Diane W.; Mello, Claudio V.; Powers, Alice; White, Stephanie A.; Hough, Gerald; Kubikova, Lubica; Smulders, Tom V.; Wada, Kazuhiro; Dugas-Ford, Jennifer; Husband, Scott; Yamamoto, Keiko; Yu, Jing; Siang, Connie; Jarvis, Erich D. (Wiley, 2004)
  • The functional anatomy of the basal ganglia of birds 

    Medina Hernández, Loreta Mª; Jiao, Yun; Reiner, Anton (Swets & Zeitlinger, 1999)
    To study how the basal ganglia can control movement in birds, we have reinvestigated the connections of the pigeon dorsal pallidum. Our results indicate that avian basal ganglia appear to control movement through major ...
  • The hard-to-close window of T-type calcium channels 

    Visa Pretel, Anna; Shaikh, Soni; Alza, Lía; Herreros Danés, Judit; Cantí Nicolás, Carles (Elsevier, 2019)
    T-Type calcium channels (TTCCs) are key regulators of membrane excitability, which is the reason why TTCC pharmacology is subject to intensive research in the neurological and cardiovascular fields. TTCCs also play a role ...
  • Identification of the anterior nucleus of the ansa lenticularis in birds as the homologue of the mammalian subthalamic nucleus 

    Jiao, Yun; Medina Hernández, Loreta Mª; Veenman, C. Leo; Toledo, Claudio; Puelles, Luis; Reiner, Anton (Society for Neuroscience, 2000)
    In mammals, the subthalamic nucleus (STN) is a glutamatergic diencephalic cell group that develops in the caudal hypothalamus and migrates to a position above the cerebral peduncle. By its input from the external pallidal ...
  • The Avian Brain Nomenclature Forum: Terminology for a New Century in Comparative Neuroanatomy. 

    Reiner, Anton; Perkel, David J.; Bruce, Laura L.; Butler, Ann B.; Csillag, András; Kuenzel, Wayne J.; Medina Hernández, Loreta Mª; Paxinos, George; Shimizu, Toru; Striedter, George; Wild, Martin; Ball, Gregori F.; Durand, Sarah; Gütürkün, Onur; Lee, Diane W.; Mello, Claudio V.; Powers, Alice; White, Stephanie A.; Hough, Gerald; Kubikova, Lubica; Smulders, Tom V.; Wada, Kazuhiro; Dugas-Ford, Jennifer; Husband, Scott; Yamamoto, Keiko; Yu, Jing; Siang, Connie; Jarvis, Erich D. (Wiley, 2004)
    Many of the assumptions of homology on which the standard nomenclature for the cell groups and fiber tracts of avian brains have been based are in error, and as a result that terminology promotes misunderstanding of the ...
  • Evolutionary and developmental contributions for understanding the organization of the basal ganglia 

    Medina Hernández, Loreta Mª; Abellán Ródenas, Antonio; Vicario Andrade, Alba; Desfilis, Ester (Karger, 2014-04-24)
    Herein we take advantage of the evolutionary developmental biology approach in order to improve our understanding of both the functional organization and the evolution of the basal ganglia, with a particular focus on the ...
  • Effects of Mediterranean Diet and Physical Activity on Pulmonary Function: A Cross-Sectional Analysis in the ILERVAS Project 

    Gutiérrez Carrasquilla, Liliana; Sánchez Peña, Enric; Hernández García, Marta; Polanco, Dinora; Salas-Salvadó, Jordi; Betriu i Bars, M. Àngels; Gaeta, Anna Michela; Carmona, Paola; Purroy Garcia, Francisco; Pamplona Gras, Reinald; Farràs, Cristina; López Cano, Carolina; Fernández i Giráldez, Elvira; Lecube Torelló, Albert (MDPI, 2019)
    A few studies showed that both adherence to Mediterranean diet (MedDiet) and physical activity practice have a positive impact on pulmonary function in subjects with lung disease. These associations are not well studied ...
  • Exceptional human longevity is associated with a specific plasma phenotype of ether lipids 

    Pradas Barriga, Irene; Jové Font, Mariona; Huynh, Karina; Puig Farré, Josep; Inglés, Marta; Borràs, Consuelo; Viña Ribes, José; Meikle, Peter J.; Pamplona Gras, Reinald (Elsevier, 2019)
    A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to ...
  • Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts 

    Pérez Fusté, Noel; Guasch Vallés, Marta; Guillén, Pere; Anerillas, Carlos; Cemeli, Tània; Pedraza González, Neus; Ferrezuelo, Francisco; Encinas Martín, Mario; Moralejo Vidal, Mª Angeles; Garí Marsol, Eloi (Elsevier, 2019)
    β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. ...
  • Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target 

    Jové Font, Mariona; Pradas Barriga, Irene; Dominguez Gonzalez, Mayelin; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2018)
    The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that ...

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