Recent Submissions

  • Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease 

    Hernández-Alvarez, María Isabel; Sebastián, David; Vives, Sara; Ivanova, Sa ka; Bartoccioni, Paola; Kakimoto, Pamela; Plana, Natalia; Veiga, Sónia R.; Hernández, Vanessa; Vasconcelos, Nuno; Gopalacharyulu, Peddinti; Adrover, Anna; Jové Font, Mariona; Pamplona Gras, Reinald; Berenguer-Llergo, Antonio; Gordaliza, Isabel; Calvo, Enrique; Cabré, Noemí; Castro, Rui; Kuzmanic, Antonija; Boutant, Marie; Sala, David; Hyotylainen, Tuulia; Oresic, Matej; Fort, Joana; Errasti-Murugarren, Ekaitz; Orozco, Modesto; Joven, Jorge; Cantó, Carles; Palacin, Manuel; Fernández-Veledo, Sonia; Vendrell, Joan; Zorzano, Antonio (Elsevier, 2019-05-02)
    Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies ...
  • Biosynthesis de novo of glycerophospholipids and longevity 

    Mota Martorell, Natalia; Pradas Barriga, Irene; Jové Font, Mariona; Naudí i Farré, Alba; Pamplona Gras, Reinald (Sociedad Española de Geriatría y Gerontología, 2019-03-30)
    Introducción. Entre los principales componentes lipídicos de las membranas celulares se encuentran los glicerofosfolípidos (GFL), que se sintetizan en una vía de novo a partir del diacilglicerol (DAG). El perfil lipídico ...
  • Informed Consent Procedure in Clinical Trials Promoted by the Hospital: Knowledge and Perceptions of Primary Care Physicians 

    Gómez Arbonés, Javier; Salazar-Alarcon, E.; Solanilla Puertolas, Montserrat; Ortega Bravo, Marta; Vallez-Valero, L.; Schoenenberger, Joan Antoni (SciTech Central, 2020-07-20)
    Objectives: To evaluate Primary Care Physician's (PCP) awareness degree concerning their patient's participation in Clinical Trials (CT) analyze the communication methods used and obtain physicians personal views. Methods: ...
  • A salmon peptide diet alleviates experimental colitis as compared with fish oil 

    Grimstad, Tore; Bjørndal, Bodil; Cacabelos Barral, Daniel; Aasprong, Ole G.; Omdal, Roald; Svardal, Asbjørn; Bohov, Pavol; Pamplona Gras, Reinald; Portero Otín, Manuel; Berge, Rolf K.; Hausken, Trygve (Cambridge University Press, 2013)
    Fish oil (FO) has been shown to have anti-inflammatory properties in animal models of inflammatory bowel disease, but how fish peptides (FP) influence intestinal inflammation has been less studied. Male Wistar rats, divided ...
  • Peritoneal Dialysis Is an Independent Factor Associated to Lower Intima Media Thickness in Dialysis Patients Free From Previous Cardiovascular Disease 

    Borràs, Mercè; Cambray Carner, Serafí; Crespo Masip, Maria; Pérez Fontán, Miguel; Bozić Stanojević, Milica; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Betriu i Bars, M. Àngels; Valdivielso Revilla, José Manuel (Frontiers Media, 2018)
  • A plasma metabolomic signature discloses human breast cancer 

    Jové Font, Mariona; Collado, Ricardo; Quiles, Jose L.; Ramírez Tortosa, MCarmen; Sol, Joaquim; Ruiz-Sanjuan, Maria; Fernandez, Mónica; de la Torre Cabrera, Capilla; Ramírez-Tortosa, Cesar; Granados Principal, Sergio; Sánchez Rovira, Pedro; Pamplona Gras, Reinald (Impact Journals, 2017)
    Purpose: Metabolomics is the comprehensive global study of metabolites in biological samples. In this retrospective pilot study we explored whether serum metabolomic profile can discriminate the presence of human breast ...
  • Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity 

    Mota Martorell, Natalia; Jové Font, Mariona; Pradas Barriga, Irene; Sanchez, Isabel; Gómez, José; Naudí i Farré, Alba; Barja, Gustavo; Pamplona Gras, Reinald (Elsevier, 2020-07-01)
    Mitochondrial reactive oxygen species (ROS) production, specifically at complex I (Cx I), has been widely suggested to be one of the determinants of species longevity. The present study follows a comparative approach to ...
  • CDK11 promotes cytokine-induced apoptosis in pancreatic beta cells independently of glucose concentration and is regulated by inflammation in the NOD mouse model 

    Sala Solé, Ester; Vived Maza, Celia; Luna Salinas, Júlia; Saavedra Ávila, Noemí Alejandra; Sengupta, Upasana; Castaño, A. Raúl; Villar-Pazos, Sabrina; Haba, Laura; Verdaguer Autonell, Joan; Ropero, Ana Belén; Stratmann, Thomas; Pizarro, Javier; Vázquez-Carrera, Manuel; Nadal, Ángel; Lahti, Jill M.; Mora Giral, Concepció (Frontiers, 2021-02-10)
    Background: Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D). We found that the Cdk11(Cyclin Dependent Kinase 11) is ...
  • Repurposed Analog of GLP-1 Ameliorates Hyperglycemia in Type 1 Diabetic Mice Through Pancreatic Cell Reprogramming 

    Villalba, Adrian; Rodríguez Fernández, Silvia; Perna Barrull, David; Ampudia, Rosa Maria; Gómez Muñoz, Laia; Pujol Autonell, Irma; Aguilera, Eva; Coma, Mireia; Cano Sarabia, Antonia María; Vázquez, Federico; Verdaguer Autonell, Joan; Vives Pi, Marta (Frontiers Media, 2020-05-13)
    Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. An ideal immunotherapy should combine the blockade of the autoimmune response with the recovery of functional target cell ...
  • Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury 

    Salvany, Sara; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Tarabal Mostazo, Olga; Hernández, Sara; Calderó i Pardo, Jordi; Esquerda Colell, Josep (Wiley, 2021-01-02)
    Peripheral nerve section with subsequent disconnection of motor neuron (MN) cell bodies from their skeletal muscle targets leads to a rapid reactive response involving the recruitment and activation of microglia. In addition, ...
  • Succination of protein thiols in human brain aging 

    Jové Font, Mariona; Pradas Barriga, Irene; Mota Martorell, Natalia; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Ferrer, Isidre; Pamplona Gras, Reinald (Frontiers Media, 2020-03-06)
    Human brain evolution toward complexity has been achieved with increasing energy supply as the main adaptation in brain metabolism. Energy metabolism, like other biochemical reactions in aerobic cells, is under enzymatic ...
  • Confirmation of the cardioprotective effect of MitoGamide in the diabetic heart 

    Park, Min; Nishimura, Takanori; Baeza-Garza, Carlos D.; Caldwell, Stuart T.; Boon Li Pun, Pamela; Prag, Hiran A.; Young, Tim; Sauchanka, Olga; Logan, Angela; Forkink, Marleen; Gruszczyk, Anja V.; Prime, Tracy A.; Arndt, Sabine; Naudí i Farré, Alba; Pamplona Gras, Reinald; Coughlan, Melinda T.; Tate, Mitchel; Ritchie, Rebecca H.; Caicci, Federico; Kaludercic, Nina; Lisa, Fabio Di; Smith, Robin A. J.; Hartley, Richard C.; Murphy, Michael P.; Krieg,Thomas (Springer, 2020-12-01)
    Purpose HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of HFpEF and used ...
  • The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity 

    Jové Font, Mariona; Mota Martorell, Natalia; Pradas Barriga, Irene; Martin-Gari, Meritxell; Ayala Jové, Ma. Victoria (Maria Victoria); Pamplona Gras, Reinald (MDPI, 2020-11-01)
    The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of biological membranes and the intracellular oxidative ...
  • The lipidome fingerprint of longevity 

    Jové Font, Mariona; Mota Martorell, Natalia; Pradas Barriga, Irene; Galo-Licona, José Daniel; Martín-Gari, Meritxell; Obis Monné, Èlia; Sol, Joaquim; Pamplona Gras, Reinald (MDPI, 2020-09-01)
    Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional ...
  • Alterations in one-carbon metabolism in celiac disease 

    Martin-Masot, Rafael; Mota Martorell, Natalia; Jové Font, Mariona; Maldonado, José; Pamplona Gras, Reinald; Nestares, Teresa (MDPI, 2020-12-01)
    Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which ...
  • Neuregulin-1 is associated to postsynaptic sites contacting afferent C-type cholinergic terminals on lower motoneurons: changes in murine models of motoneuron diseases 

    Gallart-Palau, Xavier; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Sábado, Javier; Correa, Francisco; Cerveró Cebrià, Clàudia; Hereu, Marta; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Esquerda Colell, Josep (2014)
    Pioneering ultrastructural studies have defined different types of synapses (F-, S- and C-type boutons) on lower motoneurons (MNs). C-Type boutons are large nerve terminals characteristic of somatic alpha-MNs and display ...
  • Nivel de conocimiento de la enfermedad de Alzheimer en cuidadores y población general 

    Jorge, C.; Cetó, M.; Arias, A.; Blasco, E.; Gil, M. P.; López, R.; Dakterzada, Farida; Purroy Garcia, Francisco; Piñol Ripoll, Gerard (Elsevier, 2019-05-11)
    Introducción El conocimiento de la enfermedad de Alzheimer es fundamental para el diagnóstico precoz y para reducir la sobrecarga del cuidador. El objetivo fue evaluar el grado de conocimiento de la enfermedad de Alzheimer ...
  • Inhibition of BCR Signaling Using the Syk Inhibitor TAK-659 Prevents Stroma-Mediated Signaling in Chronic Lymphocytic Leukemia Cells 

    Purroy, Noelia; Carabia, Júlia; Abrisqueta, Pau; Egia-Mendikute, Leire; Aguiló, Meritxell; Carpio, Cecilia; Palacio, Carles; Crespo, Marta; Bosch, Francesc (Impact Journals, 2017-01-03)
    Proliferation and survival of chronic lymphocytic leukemia (CLL) cells depend on microenvironmental signals coming from lymphoid organs. One of the key players involved in the crosstalk between CLL cells and the microenvironment ...
  • Dietary intervention reverses fatty liver and altered gut microbiota during early-life undernutrition 

    Bauer, Katharina Christin; Huus, Kelsey E.; Brown, Eric M.; Bozorgmehr, Tahereh; Petersen, Charisse; Cirstea, Mihai; Woodward, S.; Mccoy, Jessica J.; Hun, Jeudyla; Pamplona Gras, Reinald; Ayala, Victor; Finlay, B. Brett (American Society for Microbiology, 2020)
    Nonalcoholic fatty liver disease (NAFLD), largely studied as a condition of overnutrition, also presents in undernourished populations. Like NAFLD, undernutrition disrupts systemic metabolism and has been linked to gut ...
  • In Vivo Anti-Inflammatory Effects and Related Mechanisms of Processed Egg Yolk, a Potential Anti-Inflammaging Dietary Supplement 

    Cunill, Joan; Babot, Clara; Santos, Liliana; Serrano Casasola, José Carlos Enrique; Jové Font, Mariona; Martín Garí, Meritxell; Portero Otín, Manuel (MDPI, 2020-09-04)
    Egg-yolk based supplements have demonstrated biological effects. We have developed a novel processed egg-yolk (PEY) complement, and we have tested whether it has inflammation modulatory properties. These were evaluated in ...

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