Recent Submissions

  • Clinical Usefulness of Anthropometric Indices to Predict the Presence of Prediabetes. Data from the ILERVAS Cohort 

    Sánchez, Marta; Sánchez Peña, Enric; Bermúdez López, Marcelino; Torres, Gerard; Farràs-Sallés, Cristina; Pamplona Gras, Reinald; Castro-Boqué, Eva; Valdivielso Revilla, José Manuel; Purroy Garcia, Francisco; Martínez Alonso, Montserrat; Godoy i García, Pere; Mauricio Puente, Dídac; Fernández i Giráldez, Elvira; Hernández García, Marta; Rius, Ferran; Lecube Torelló, Albert (MDPI, 2021-03-23)
    Prediabetes is closely related to excess body weight and adipose distribution. For this reason, we aimed to assess and compare the diagnostic usefulness of ten anthropometric adiposity indices to predict prediabetes. ...
  • Intracellular pathways involved in cell survival are deregulated in mouse and human spinal muscular atrophy motoneurons 

    Sansa Zaragoza, Alba; Fuente Ruiz, Sandra de la; Comella i Carnicé, Joan Xavier; Garcera, Ana; Soler i Tatché, Rosa Ma. (Elsevier, 2021-04-13)
    Spinal Muscular Atrophy (SMA) is a severe neuromuscular disorder caused by loss of the Survival Motor Neuron 1 gene (SMN1). Due to this depletion of the survival motor neuron (SMN) protein, the disease is characterized by ...
  • The sole presence of CDK4 is not a solid criterion for discriminating between tumor and healthy pancreatic tissues 

    Altirriba, Jordi; García, Ainhoa; Sánchez, Begoña; Haba, Laura; Altekruse, Sean; Stratmann, Thomas; Bombí, Josep Antoni; Mezquita, Cristóbal; Gomis, Ramon; Mora Giral, Concepció (Wiley, 2012)
  • In vivo diabetogenic action of CD41+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18 

    Wen, Li; Green, E. Allison; Stratmann, Thomas; Panosa, Anaïs; Gomis, Ramon; Eynon, Elizabeth E.; Flavell, Richard A.; Mezquita, Jovita A.; Mora Giral, Concepció (Wiley, 2011)
    CD4+ T lymphocytes are required to induce spontaneous autoimmune diabetes in the NOD (Non Obese Diabetic) mouse. Since pancreatic β cells upregulate Fas expression upon exposure to proinflammatory cytokines, we studied ...
  • Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice 

    Presa, Maximiliano; Zarama Ortiz, Angela; Garabatos, Nahir; Izquierdo, Cristina; Rivas, Elisa I.; Teyton, Luc; Mora Giral, Concepció; Serreze, David; Stratmann, Thomas (Wiley, 2013)
    The cholera toxin B subunit (CTB) has been used as adjuvant to improve oral vaccine delivery in type 1 diabetes. The effect of CTB/peptide formulations on Ag-specific CD4+ T cells has remained largely unexplored. Here, ...
  • High-Temperature Short-Time and Holder Pasteurization of Donor Milk: Impact on Milk Composition 

    Escuder-Vieco, Diana; Rodríguez, Juan M.; Espinosa-Martos, Irene; Corzo, Nieves; Montilla, Antonia; García-Serrano, Alba; Calvo, M. Visitación; Fontecha, Javier; Serrano Casasola, José Carlos Enrique; Fernández, Leónides; Pallás-Alonso, Carmen Rosa (MDPI, 2021-02-03)
    Holder pasteurization (HoP; 62.5 °C, 30 min) is commonly used to ensure the microbiological safety of donor human milk (DHM) but diminishes its nutritional properties. A high-temperature short-time (HTST) system was designed ...
  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 

    Klionsky, Daniel J.; Cantí Nicolás, Carles; Garcera, Ana; Herreros Danés, Judit; Soler i Tatché, Rosa Ma.; others (Taylor & Francis, 2021-02-08)
    In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant ...
  • Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease 

    Hernández-Alvarez, María Isabel; Sebastián, David; Vives, Sara; Ivanova, Sa ka; Bartoccioni, Paola; Kakimoto, Pamela; Plana, Natalia; Veiga, Sónia R.; Hernández, Vanessa; Vasconcelos, Nuno; Gopalacharyulu, Peddinti; Adrover, Anna; Jové Font, Mariona; Pamplona Gras, Reinald; Berenguer-Llergo, Antonio; Gordaliza, Isabel; Calvo, Enrique; Cabré, Noemí; Castro, Rui; Kuzmanic, Antonija; Boutant, Marie; Sala, David; Hyotylainen, Tuulia; Oresic, Matej; Fort, Joana; Errasti-Murugarren, Ekaitz; Orozco, Modesto; Joven, Jorge; Cantó, Carles; Palacin, Manuel; Fernández-Veledo, Sonia; Vendrell, Joan; Zorzano, Antonio (Elsevier, 2019-05-02)
    Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies ...
  • Biosynthesis de novo of glycerophospholipids and longevity 

    Mota Martorell, Natàlia; Pradas Barriga, Irene; Jové Font, Mariona; Naudí i Farré, Alba; Pamplona Gras, Reinald (Sociedad Española de Geriatría y Gerontología, 2019-03-30)
    Introducción. Entre los principales componentes lipídicos de las membranas celulares se encuentran los glicerofosfolípidos (GFL), que se sintetizan en una vía de novo a partir del diacilglicerol (DAG). El perfil lipídico ...
  • Informed Consent Procedure in Clinical Trials Promoted by the Hospital: Knowledge and Perceptions of Primary Care Physicians 

    Gómez Arbonés, Javier; Salazar-Alarcon, E.; Solanilla Puertolas, Montserrat; Ortega Bravo, Marta; Vallez-Valero, L.; Schoenenberger, Joan Antoni (SciTech Central, 2020-07-20)
    Objectives: To evaluate Primary Care Physician's (PCP) awareness degree concerning their patient's participation in Clinical Trials (CT) analyze the communication methods used and obtain physicians personal views. Methods: ...
  • A salmon peptide diet alleviates experimental colitis as compared with fish oil 

    Grimstad, Tore; Bjørndal, Bodil; Cacabelos Barral, Daniel; Aasprong, Ole G.; Omdal, Roald; Svardal, Asbjørn; Bohov, Pavol; Pamplona Gras, Reinald; Portero Otín, Manuel; Berge, Rolf K.; Hausken, Trygve (Cambridge University Press, 2013)
    Fish oil (FO) has been shown to have anti-inflammatory properties in animal models of inflammatory bowel disease, but how fish peptides (FP) influence intestinal inflammation has been less studied. Male Wistar rats, divided ...
  • Peritoneal Dialysis Is an Independent Factor Associated to Lower Intima Media Thickness in Dialysis Patients Free From Previous Cardiovascular Disease 

    Borràs, Mercè; Cambray Carner, Serafí; Crespo Masip, Maria; Pérez Fontán, Miguel; Bozić Stanojević, Milica; Bermúdez López, Marcelino; Fernández i Giráldez, Elvira; Betriu i Bars, M. Àngels; Valdivielso Revilla, José Manuel (Frontiers Media, 2018)
  • A plasma metabolomic signature discloses human breast cancer 

    Jové Font, Mariona; Collado, Ricardo; Quiles, Jose L.; Ramírez Tortosa, MCarmen; Sol, Joaquim; Ruiz-Sanjuan, Maria; Fernandez, Mónica; de la Torre Cabrera, Capilla; Ramírez-Tortosa, Cesar; Granados Principal, Sergio; Sánchez Rovira, Pedro; Pamplona Gras, Reinald (Impact Journals, 2017)
    Purpose: Metabolomics is the comprehensive global study of metabolites in biological samples. In this retrospective pilot study we explored whether serum metabolomic profile can discriminate the presence of human breast ...
  • Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity 

    Mota Martorell, Natàlia; Jové Font, Mariona; Pradas Barriga, Irene; Sanchez, Isabel; Gómez, José; Naudí i Farré, Alba; Barja, Gustavo; Pamplona Gras, Reinald (Elsevier, 2020-07-01)
    Mitochondrial reactive oxygen species (ROS) production, specifically at complex I (Cx I), has been widely suggested to be one of the determinants of species longevity. The present study follows a comparative approach to ...
  • CDK11 promotes cytokine-induced apoptosis in pancreatic beta cells independently of glucose concentration and is regulated by inflammation in the NOD mouse model 

    Sala Solé, Ester; Vived Maza, Celia; Luna Salinas, Júlia; Saavedra Ávila, Noemí Alejandra; Sengupta, Upasana; Castaño, A. Raúl; Villar-Pazos, Sabrina; Haba, Laura; Verdaguer Autonell, Joan; Ropero, Ana Belén; Stratmann, Thomas; Pizarro, Javier; Vázquez-Carrera, Manuel; Nadal, Ángel; Lahti, Jill M.; Mora Giral, Concepció (Frontiers, 2021-02-10)
    Background: Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D). We found that the Cdk11(Cyclin Dependent Kinase 11) is ...
  • Repurposed Analog of GLP-1 Ameliorates Hyperglycemia in Type 1 Diabetic Mice Through Pancreatic Cell Reprogramming 

    Villalba, Adrian; Rodríguez Fernández, Silvia; Perna Barrull, David; Ampudia, Rosa Maria; Gómez Muñoz, Laia; Pujol Autonell, Irma; Aguilera, Eva; Coma, Mireia; Cano Sarabia, Antonia María; Vázquez, Federico; Verdaguer Autonell, Joan; Vives Pi, Marta (Frontiers Media, 2020-05-13)
    Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. An ideal immunotherapy should combine the blockade of the autoimmune response with the recovery of functional target cell ...
  • Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury 

    Salvany, Sara; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Tarabal Mostazo, Olga; Hernández, Sara; Calderó i Pardo, Jordi; Esquerda Colell, Josep (Wiley, 2021-01-02)
    Peripheral nerve section with subsequent disconnection of motor neuron (MN) cell bodies from their skeletal muscle targets leads to a rapid reactive response involving the recruitment and activation of microglia. In addition, ...
  • Succination of protein thiols in human brain aging 

    Jové Font, Mariona; Pradas Barriga, Irene; Mota Martorell, Natàlia; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Ferrer, Isidre; Pamplona Gras, Reinald (Frontiers Media, 2020-03-06)
    Human brain evolution toward complexity has been achieved with increasing energy supply as the main adaptation in brain metabolism. Energy metabolism, like other biochemical reactions in aerobic cells, is under enzymatic ...
  • Confirmation of the cardioprotective effect of MitoGamide in the diabetic heart 

    Park, Min; Nishimura, Takanori; Baeza-Garza, Carlos D.; Caldwell, Stuart T.; Boon Li Pun, Pamela; Prag, Hiran A.; Young, Tim; Sauchanka, Olga; Logan, Angela; Forkink, Marleen; Gruszczyk, Anja V.; Prime, Tracy A.; Arndt, Sabine; Naudí i Farré, Alba; Pamplona Gras, Reinald; Coughlan, Melinda T.; Tate, Mitchel; Ritchie, Rebecca H.; Caicci, Federico; Kaludercic, Nina; Lisa, Fabio Di; Smith, Robin A. J.; Hartley, Richard C.; Murphy, Michael P.; Krieg,Thomas (Springer, 2020-12-01)
    Purpose HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of HFpEF and used ...
  • The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity 

    Jové Font, Mariona; Mota Martorell, Natàlia; Pradas Barriga, Irene; Martin-Gari, Meritxell; Ayala Jové, Ma. Victoria (Maria Victoria); Pamplona Gras, Reinald (MDPI, 2020-11-01)
    The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of biological membranes and the intracellular oxidative ...

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