Recent Submissions

  • A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers 

    Torres Cabestany, Pascual; Anerillas Aljama, Carlos; Ramírez Núñez, Omar; Encinas Martín, Mario; Povedano, Mònica; Andrés-Benito, Pol; Ferrer, Isidre; Ayala Jové, Ma. Victoria (Maria Victoria); Pamplona Gras, Reinald; Portero Otín, Manuel (The Company of Biologists, 2022)
    To evaluate senescence mechanisms, including senescence associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase ...
  • mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity 

    Mota Martorell, Natàlia; Jové Font, Mariona; Pamplona Gras, Reinald (MDPI, 2022)
    Decreased content and activity of the mechanistic target of rapamycin (mTOR) signalling pathway, as well as the mTOR complex 1 (mTORC1) itself, are key traits for animal species and human longevity. Since mTORC1 acts as ...
  • Differences in Free-Living Patterns of Sedentary Behaviour between Office Employees with Diabetes and Office Employees without Diabetes: A Principal Component Analysis for Clinical Practice 

    Alòs, Francesc; Colomer, M. Àngels (Maria Àngels); Bort Roig, Judit; Chirveches Pérez, Emilia; Cánovas Zaldúa, Yoseba; Martín Cantera, Carlos; Franch-Nadal, Josep; Puig Ribera, Anna (MDPI, 2022)
    Aims: To identify principal components of free-living patterns of sedentary behaviour in office employees with type 2 diabetes (T2D) compared to normal glucose metabolism (NGM) office employees, using principal component ...
  • ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma 

    Concin, Nicole; Matias-Guiu, Xavier; Vergote, Ignace; Cibula, David; Raza Mirza, Mansoor; Marnitz, Simone; Ledermann, Jonathan; Bosse, Tjalling; Chargari, Cyrus; Fagotti, Anna; Fotopoulou, Christina; Gonzalez Martin, Antonio; Lax, Sigurd; Lorusso, Domenica; Marth, Christian; Morice, Philippe; Nout, Remi; O'Donnell, Dearbhaile; Querleu, Denis; Raspollini, Maria Rosaria; Sehouli, Jalid; Sturdza, Alina; Taylor, Alexandra; Westermann, Anneke; Wimberger, Pauline; Colombo, Nicoletta; Planchamp, François; Creutzberg, Carien (BMJ, 2021)
    A European consensus conference on endometrial carcinoma was held in 2014 to produce multi-disciplinary evidence-based guidelines on selected questions. Given the large body of literature on the management of endometrial ...
  • Dietary AGEs as Exogenous Boosters of Inflammation 

    Garay Sevilla, Ma. Eugenia; Rojas, Armando; Portero Otín, Manuel; Uribarri, Jaime (MDPI, 2021)
    Most chronic modern non-transmissible diseases seem to begin as the result of low-grade inflammation extending over prolonged periods of time. The importance of diet as a source of many pro-inflammatory compounds that could ...
  • Corrigendum: Genetic Identification of the Central Nucleus and Other Components of the Central Extended Amygdala in Chicken During Development 

    Vicario Andrade, Alba; Abellán Ródenas, Antonio; Desfilis, Ester; Medina Hernández, Loreta Mª (Frontiers Media, 2021)
  • A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes 

    Altés, Gisela; Vaquero, Marta; Cuesta, Sara; Anerillas Aljama, Carlos; Macià Armengol, Anna; Espinet Mestre, Carme; Ribera i Calvet, Joan; Bellusci, Saverio; Klein, Ophir D.; Yeramian Hakim, Andree; Dolcet Roca, Xavier; Egea Navarro, Joaquim; Encinas Martín, Mario (Springer, 2022)
    The Wolffian ducts (WD) are paired epithelial tubules central to the development of the mammalian genitourinary tract. Outgrowths from the WD known as the ureteric buds (UB) generate the collecting ducts of the kidney. ...
  • Selective brain regional changes in lipid profile with human aging 

    Mota Martorell, Natàlia; Andrés Benito, Pol; Martín Garí, Meritxell; Galo-Licona, José Daniel; Sol, Joaquim; Fernández Bernal, Anna; Portero Otín, Manuel; Ferrer, Isidre; Jové Font, Mariona; Pamplona Gras, Reinald (Springer, 2022)
    Fatty acids are key components in the structural diversity of lipids and play a strategic role in the functional properties of lipids which determine the integrity of neuronal and glial cell membranes, the generation of ...
  • Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system 

    Gras Artells, Sílvia; Blasco Carmona, Alba; Mòdol-Caballero, Guillem; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Barranco, Alejandro; Das, Tapas; Rueda, Ricardo; Pereira, Suzette L.; Navarro, Xavier; Esquerda Colell, Josep; Calderó i Pardo, Jordi (Impact Journals, 2021)
    Besides skeletal muscle wasting, sarcopenia entails morphological and molecular changes in distinct components of the neuromuscular system, including spinal cord motoneurons (MNs) and neuromuscular junctions (NMJs); moreover, ...
  • SMN is physiologically down-regulated at wild-type motor nerve terminals but aggregates together with neurofilaments in SMA mouse models 

    Franco Espin, Julio; Gatius, Alaó; Armengol, José Ángel; Arumugam, Saravanan; Moradi, Mehdi; Sendtner, Michael; Calderó i Pardo, Jordi; Tabares, Lucía (MDPI, 2022)
    Survival motor neuron (SMN) is an essential and ubiquitously expressed protein that participates in several aspects of RNA metabolism. SMN deficiency causes a devastating motor neuron disease called spinal muscular atrophy ...
  • Lack of extracellular matrix switches TGF-β induced apoptosis of endometrial cells to epithelial to mesenchymal transition 

    Ruiz Mitjana, Anna; Navaridas Fernández de Bobadilla, Raúl; Vidal Sabanés, Maria; Perramon Güell, Aida; Yeramian Hakim, Andree; Felip Nogués, Isidre; Eritja Sánchez, Núria; Egea Navarro, Joaquim; Encinas Martín, Mario; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Nature Research, 2022)
    The extracellular matrix and the correct establishment of epithelial cell polarity plays a critical role in epithelial cell homeostasis and cell polarity. In addition, loss of tissue structure is a hallmark of carcinogenesis. ...
  • Development and Validation of a Personalized, Sex-Specific Prediction Algorithm of Severe Atheromatosis in Middle-Aged Asymptomatic Individuals: The ILERVAS Study 

    Bermúdez López, Marcelino; Martí Antonio, Manuel; Castro-Boqué, Eva; Bretones, María Del Mar; Farràs-Sallés, Cristina; Torres, Gerard; Pamplona Gras, Reinald; Lecube Torelló, Albert; Mauricio Puente, Dídac; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (Frontiers Media, 2022)
    Background: Although European guidelines recommend vascular ultrasound for the assessment of cardiovascular risk in low-to-moderate risk individuals, no algorithm properly identifies patients who could benefit from it. The ...
  • Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1G93A mouse model of amyotrophic lateral sclerosis 

    Salvany, Sara; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Gras Artells, Sílvia; Calderó i Pardo, Jordi; Esquerda Colell, Josep (Wiley Open Access, 2022)
    Early misfolded superoxide dismutase 1 (mfSOD1) accumulation, motor neuron (MN) degeneration, and microgliosis are hallmark pathological features in SOD1G93A amyotrophic lateral sclerosis (ALS) mice. Because of the different ...
  • Evolution of the consumption trend of proton pump inhibitors in the Lleida Health Region between 2002 and 2015 

    Torres Bondia, Francisco Ignacio; Batlle Garcia, Jordi de; Galván, Leonardo; Buti, Miquel; Barbé Illa, Ferran; Piñol Ripoll, Gerard (BMC, 2022)
    Background: Proton pump inhibitors (PPIs) are one of the most commonly prescribed pharmacological groups. Their high prevalence and duration of use are of important health concern due to the risk they can cause to patients. ...
  • Developmental-Based Classification of Enkephalin and Somatostatin Containing Neurons of the Chicken Central Extended Amygdala 

    Pross, Alessandra; Hanafi Metwalli, Alek; Desfilis, Ester; Medina Hernández, Loreta Mª (Frontiers Media, 2022)
    The central extended amygdala, including the lateral bed nucleus of the stria terminalis and the central amygdala, plays a key role in stress response. To understand how the central extended amygdala regulates stress it ...
  • Distinct Subdivisions in the Transition Between Telencephalon and Hypothalamus Produce Otp and Sim1 Cells for the Extended Amygdala in Sauropsids 

    Hanafi Metwalli, Alek; Abellán Ródenas, Antonio; Freixes, Júlia; Pross, Alessandra; Desfilis, Ester; Medina Hernández, Loreta Mª (Frontiers Media, 2022)
    Based on the coexpression of the transcription factors Foxg1 and Otp, we recently identified in the mouse a new radial embryonic division named the telencephalon-opto-hypothalamic (TOH) domain that produces the vast majority ...
  • Long-lived Humans Have a Unique Plasma Sphingolipidome 

    Pradas Barriga, Irene; Jové Font, Mariona; Huynh, Kevin; Inglés, Marta; Borràs, Consuelo; Mota Martorell, Natàlia; Galo-Licona, José Daniel; Puig, Josep; Viña Ribes, José; Meikle, Peter J.; Pamplona Gras, Reinald (Oxford University Press, 2022)
    A species-specific lipidome profile is an inherent feature linked to longevity in the animal kingdom. However, there is a lack of lipidomic studies on human longevity. Here, we use mass spectrometry-based lipidomics to ...
  • Microbiota alterations in proline metabolism impact depression 

    Mayneris Perxachs, Jordi; Castells Nobau, Anna; Arnoriaga Rodríguez, María; Martin, Miquel; de la Vega Correa, Lisset; Zapata, Cristina; Burokas, Aurelijus; Blasco Solà, Gerard; Coll, Claudia; Escrichs, Anira; Biarnés, Carles; Moreno Navarrete, José María; Puig, Josep; Garre Olmo, Josep; Ramos, Rafel; Pedraza, Salvador; Brugada, Ramon; Vilanova, Joan Carles; Serena, Joaquín; Gich, Jordi; Ramió Torrentà, Lluís; Pérez Brocal, Vicente; Moya, Andrés; Pamplona Gras, Reinald; Sol, Joaquim; Jové Font, Mariona; Ricart, Wifredo; Portero Otín, Manuel; Deco, Gustavo; Maldonado, Rafael; Fernández Real, José Manuel (Elsevier, 2022)
    The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not ad- dressing ...
  • PEGASO e-Diary: User Engagement and Dietary Behavior Change of a Mobile Food Record for Adolescents 

    Caon, Maurizio; Prinelli, Federica; Angelini, Leonardo; Carrino, Stefano; Mugellini, Elena; Orte, Silvi; Serrano Casasola, José Carlos Enrique; Atkinson, Sarah; Martin, Anne; Adorni, Fulvio (Frontiers Media, 2022)
    Background: Obesity amongst children and adolescents is becoming a major health problem globally and mobile food records can play a crucial role in promoting healthy dietary habits. Objective: To describe the methodology ...
  • Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective 

    Bauer, Kylynda C.; Littlejohn, Paula T.; Ayala Jové, Ma. Victoria (Maria Victoria); Creus Cuadros, Anna; Finlay, Barton Brett (AGA Institute; Elsevier, 2022)
    Nonalcoholic fatty liver disease (NAFLD) is a chronic con dition affecting one quarter of the global population. Although primarily linked to obesity and metabolic syn drome, undernutrition and the altered (dysbiotic) gut ...

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