Recent Submissions

  • A 3D MRI‐based atlas of a lizard brain 

    Hoops, Daniel; Desfilis, Ester; Ullmann, Jeremy F.P.; Janke, Andrew L.; Stait‐Gardner, Timothy; Devenyi, Gabriel A.; Price, William S.; Medina Hernández, Loreta Mª; Whiting, Martin J.; Keogh, J. Scott (Wiley, 2018)
    Magnetic resonance imaging (MRI) is an established technique for neuroanatomical analysis, being particularly useful in the medical sciences. However, the application of MRI to evolutionary neuroscience is still in its ...
  • Neuropsychiatric Symptoms and Quality of Life in Spanish Alzheimer's Disease Patients During COVID-19 Lockdown 

    Lara, Beatriz; Carnes, Anna; Dakterzada, Farida; Benitez, Ivan; Piñol Ripoll, Gerard (Wiley, 2020)
    Background and purpose: The COVID epidemic is affecting individuals worldwide, and Alzheimer's disease (AD) and amnesic mild cognitive impairment (MCI) patients are at risk due to their characteristics and age. We analysed ...
  • FAK inhibition induces glioblastoma cell senescence-like state through p62 and p27 

    Alza, Lía; Nàger Grifo, Mireia; Visa Pretel, Anna; Cantí Nicolás, Carles; Herreros Danés, Judit (MDPI, 2020-04-27)
    Focal adhesion kinase (FAK) is a central component of focal adhesions that regulate cancer cell proliferation and migration. Here, we studied the effects of FAK inhibition in glioblastoma (GBM), a fast growing brain tumor ...
  • Adipose Tissue Mitochondrial Factors Profile after Dietary Bioactive Compound Weight Reduction Treatments in a Mice Obesity Model 

    Cassanyé, Anna; Martín-Gari, Meritxell; Portero Otín, Manuel; Serrano Casasola, José Carlos Enrique (MDPI, 2019)
    Prolonged caloric intake above energy needs disturbs the body's ability to store and manage the excess of energy intake, leading to the onset of chronic degenerative diseases. This study aimed to compare the effect of three ...
  • Skin Autofluorescence Measurement in Subclinical Atheromatous Disease: Results from the ILERVAS Project 

    Sánchez Peña, Enric; Betriu i Bars, M. Àngels; Yeramian Hakim, Andree; Fernández i Giráldez, Elvira; Purroy Garcia, Francisco; Sánchez de la Torre, Manuel; Pamplona Gras, Reinald; Miquel, Eva; Kerkeni, M.; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (Japan Atherosclerosis Society, 2019)
    AIM: Advanced glycation end-products (AGEs) have been involved in the atherogenic process in the high-risk population. The goal of this study was to demonstrate that AGEs are related to subclinical atheromatous disease in ...
  • Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness 

    Ruiz‑Plazas, Xavier; Rodríguez‑Gallego, Esther; Alves, Marta; Altuna Coy, Antonio; Lozano‑Bartolomé, Javier; Portero Otín, Manuel; García‑Fontgivell, Joan Francesc; Martínez‑González, Salomé; Segarra, José; Chacón, Matilde R. (BMC (part of Springer Nature), 2019)
    Background: Conventional clinical biomarkers cannot accurately differentiate indolent from aggressive prostate cancer (PCa). We investigated the usefulness of a biomarker panel measured exclusively in biofluids for assessment ...
  • Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients 

    Gonzalo Benito, Hugo; Nogueras, L.; Gil-Sánchez, Anna; Vicente Hervás, José; Valcheva, Petya; González Mingot, Cristina; Martin-Gari, Meritxell; Canudes, Marc; Peralta Moncusí, Silvia; Solana Moga, M. José; Pamplona Gras, Reinald; Portero Otín, Manuel; Boada Pallàs, Jordi; Serrano Casasola, José Carlos Enrique; Brieva Ruiz, Luis (Frontiers Media, 2019)
    Literature suggests that oxidative stress (OS) may be involved in the pathogenesis of multiple sclerosis (MS), in which the immune system is known to play a key role. However, to date, the OS in peripheral lymphocytes and ...
  • Evolution of Pallial Areas and Networks Involved in Sociality: Comparison Between Mammals and Sauropsids 

    Medina Hernández, Loreta Mª; Abellán Ródenas, Antonio; Desfilis, Ester (Frontiers Media, 2019)
    Birds are extremely interesting animals for studying the neurobiological basis of cognition and its evolution. They include species that are highly social and show high cognitive capabilities. Moreover, birds rely more on ...
  • B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes 

    Egia Mendikute, Leire; Arpa i Puigdemont, Berta; Rosell Mases, Estela; Corral-Pujol, Marta; Carrascal, Jorge; Carrillo, Jorge; Mora Giral, Concepció; Chapman, Harold; Panosa, Anaïs; Vives Pi, Marta; Stratmann, Thomas; Serreze, David; Verdaguer Autonell, Joan (Frontiers Media, 2019)
    Previous studies indicate that B-lymphocytes play a key role activating diabetogenic T-lymphocytes during the development of autoimmune diabetes. Recently, two transgenic NOD mouse models were generated: the NOD-PerIg and ...
  • Subcutaneous advanced glycation end-products and lung function according to glucose abnormalities: The ILERVAS project 

    Sánchez Peña, Enric; Lecube Torelló, Albert; Betriu i Bars, M. Àngels; Hernández, Cristina; López Cano, Carolina; Gutiérrez Carrasquilla, Liliana; Kerkeni, M.; Yeramian Hakim, Andree; Purroy Garcia, Francisco; Pamplona Gras, Reinald; Farràs, Cristina; Fernández i Giráldez, Elvira; Barbé Illa, Ferran; Simó, Rafael (Elsevier, 2019-12-01)
  • Redox lipidomics to better understand brain aging and function 

    Pamplona Gras, Reinald; Borràs, Consuelo; Jové Font, Mariona; Pradas Barriga, Irene; Ferrer, Isidre; Viña Ribes, José (Elsevier, 2019)
    Human prefrontal cortex (PFC) is a recently evolutionary emerged brain region involved in cognitive functions. Human cognitive abilities decline during aging. Yet the molecular mechanisms that sustain the preservation or ...
  • Effects of aging and methionine restriction on rat kidney metabolome 

    Pradas Barriga, Irene; Jové Font, Mariona; Cabré Cucó, Rosanna; Ayala Jové, Ma. Victoria (Maria Victoria); Mota Martorell, Natalia; Pamplona Gras, Reinald (MDPI, 2019-11-14)
    Methionine restriction (MetR) in animal models extends maximum longevity and seems to promote renoprotection by attenuating kidney injury. MetR has also been proven to affect several metabolic pathways including lipid ...
  • The Y172 monoclonal antibody against p-c-Jun (Ser63) is a marker of the postsynaptic compartement of c-type cholinergic afferent synapses on motoneurons 

    Gatius, Alaó; Tarabal Mostazo, Olga; Cayuela, Paula; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Salvany, Sara; Hernández, Sara; Soler i Tatché, Rosa Ma.; Esquerda Colell, Josep; Calderó i Pardo, Jordi (Frontiers Media, 2020-01-24)
    C-bouton-type cholinergic afferents exert an important function in controlling motoneuron (MN) excitability. During the immunocytochemical analysis of the role of c-Jun in MNs with a monoclonal (clone Y172) antibody against ...
  • Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the Ilervas project 

    Sánchez Peña, Enric; Betriu i Bars, M. Àngels; López Cano, Carolina; Hernández García, Marta; Fernández i Giráldez, Elvira; Purroy Garcia, Francisco; Bermúdez López, Marcelino; Farràs-Sallés, Cristina; Barril, Silvia; Pamplona Gras, Reinald; Rius, Ferran; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (BioMed Central, 2019-11-15)
    BACKGROUND: Prediabetes has recently been associated with subclinical atheromatous disease in the middle-aged population. Our aim was to characterize atheromatous plaque burden by the number of affected territories and the ...
  • Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms 

    Bahhir, Diana; Yalgin, Cagri; Ots, Liina; Järvinen, Sampsa; George, Jack; Naudí i Farré, Alba; Krama, Tatjana; Krams, Indrikis; Tamm, Mairi; Andjelković, Ana; Dufour, Eric; González de Cosar, Jose M.; Gerards, Mike; Parhiala, Mikael; Pamplona Gras, Reinald; Jacobs, Howard T.; Jõers, Priit (Public Library of Science, 2019-10-04)
    Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial ...
  • Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women 

    Pradas Barriga, Irene; Rovira-Llopis, Susana; Naudí i Farré, Alba; Bañuls, Celia; Rocha, Milagros; Hernandez-Mijares, Antonio; Pamplona Gras, Reinald; Victor, Victor M.; Jové Font, Mariona (Nature Publishing Group, 2019-11-05)
    Metformin is one of the treatments used for pcoS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin’s effects on lipid metabolism, a crucial ...
  • Dissimilar impact of Mediterranean diet and physical activity on estimated body composition: A cross-sectional study from the ILERVAS project 

    Sánchez, Marta; Sánchez Peña, Enric; Hernández García, Marta; González, Jessica; Purroy Garcia, Francisco; Rius, Ferran; Pamplona Gras, Reinald; Farràs-Sallés, Cristina; Gutiérrez Carrasquilla, Liliana; Fernández i Giráldez, Elvira; Bermúdez López, Marcelino; Salvador, Javier; Salas-Salvadó, Jordi; Lecube Torelló, Albert (MDPI, 2019-06-17)
    There is a close relationship between lifestyle behaviors and excess adiposity. Althoughbody mass index (BMI) is the most used approach to estimate excess weight, other anthropometricindices have been developed to ...
  • Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis 

    Nogueras, L.; Gonzalo Benito, Hugo; Jové Font, Mariona; Sol, Joaquim; Gil-Sanchez, A.; Hervás, J.V.; Valcheva, P.; González Mingot, Cristina; Solana Moga, M. José; Peralta Moncusí, Silvia; Pamplona Gras, Reinald; Brieva Ruiz, Luis (Nature Publishing Group, 2019-08-05)
    Multiple sclerosis (MS) is a complex multifactorial neuropathology. Although its etiology remains unclear, it has been demonstrated that the immune system attacks myelin, leading to demyelination and axonal damage. The ...
  • Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus 

    Tapia, Olga; Narcís, Oriol J.; Riancho, Javier; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Berciano, Maria T.; Lafarga, Miguel (Elsevier, 2017)
    Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs). The best ...
  • Glial activation and central synapse loss, but not motoneuron degeneration, are prevented by the sigma-1 receptor agonist PRE-084 in the Smn2B/- mouse model of spinal muscular atrophy 

    Cerveró Cebrià, Clàudia; Blasco Carmona, Alba; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Navarro, X. (Xavier); Esquerda Colell, Josep; Calderó i Pardo, Jordi (American Association of Neuropathologists, 2018)
    Spinal muscular atrophy (SMA) is characterized by the loss of α-motoneurons (MNs) with concomitant muscle denervation. MN excitability and vulnerability to disease are particularly regulated by cholinergic synaptic afferents ...

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