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  • The hard-to-close window of T-type calcium channels 

    Visa Pretel, Anna; Shaikh, Soni; Alza, Lía; Herreros Danés, Judit; Cantí Nicolás, Carles (Elsevier, 2019-03-13)
    T-Type calcium channels (TTCCs) are key regulators of membrane excitability, which is the reason why TTCC pharmacology is subject to intensive research in the neurological and cardiovascular fields. TTCCs also play a role ...
  • Effect of information about the benefits and harms of mammography on women's decision making: The InforMa randomised controlled trial 

    Pérez Lacasta, María José; Martínez Alonso, Montserrat; Garcia, Montse; Sala, Maria; Perestelo Pérez, Lilisbeth; Vidal, Carmen; Codern-Bové, Núria; Feijoo Cid, Maria; Toledo Chávarri, Ana; Cardona, Àngels; Pons, Anna; Carles Lavila, Misericordia; Rué i Monné, Montserrat (Public Library of Science, 2019-03-26)
    BACKGROUND: In Spain, women invited to breast screening are not usually informed about potential harms of screening. The objective of the InforMa study is to assess the effect of receiving information about the benefits ...
  • Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment 

    Georgouli, Mirella; Herraiz, Cecilia; Crosas-Molist, Eva; Fanshawe, Bruce; Maiques Carlos, Oscar; Perdrix, Anna; Pandya, Pahini; Rodríguez Hernández, Irene; Ilieva, Kristina M.; Cantelli, Gaia; Karagiannis, Panagiotis; Mele, Silvia; Lam, Hoyin; Josephs, Debra H.; Matias-Guiu, Xavier; Martí Laborda, Rosa Ma.; Nestle, Frank O.; Orgaz, Jose L.; Malanchi, Ilaria; Fruhwirth, Gilbert O.; Karagiannis, Sophia N.; Sanz Moreno, Victoria (Elsevier, 2019)
    ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma cells with high Myosin II activity are predominant ...
  • Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study. 

    Fernández Armenteros, José Manuel; Gómez Arbonés, Javier; Buti-Soler, M.; Betriu i Bars, M. Àngels; Sanmartín Novell, Verònica; Ortega Bravo, Marta; Martínez Alonso, Montserrat; Garí Marsol, Eloi; Portero Otín, Manuel; Santamaria-Babi, L.; Casanova i Seuma, Josep M. (Josep Manel) (Wiley, 2019)
    Abstract Background: Psoriasis is a very prevalent systemic chronic inflammatory disease. Major cardiovascular events are the main cause of mortality in these patients which suggests an association between psoriasis and ...
  • Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts 

    Pérez Fusté, Noel; Guasch Vallés, Marta; Guillén, Pere; Anerillas, Carlos; Cemeli, Tània; Pedraza González, Neus; Ferrezuelo, Francisco; Encinas Martín, Mario; Moralejo Vidal, Mª Angeles; Garí Marsol, Eloi (Elsevier, 2019)
    β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. ...
  • Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia 

    Granado-Serrano, Ana Belén; Martín Garí, Meritxell; Sánchez, V.; Riart Solans, M.; Berdún Hernández, Rebeca; Ludwig, Iziar A.; Rubió Piqué, Laura; Vilaprinyo Terré, Ester; Portero Otín, Manuel; Serrano Casasola, José Carlos Enrique (Nature Research, 2019)
    Gut microbiota has been suggested to affect lipid metabolism. The objective of this study was to characterize the faecal microbiota signature and both short chain fatty acids (SCFAs) and bile acids (BA) profile of ...
  • Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum 

    Colomina i Gabarrella, Neus; Ferrezuelo, Francisco; Wang, Hongyin; Aldea, Martí; Garí Marsol, Eloi (American Society for Biochemistry and Molecular Biology, 2008)
    Whi3 is an RNA-binding protein associated with the endoplasmic reticulum (ER) that binds the CLN3 mRNA and plays a key role in the efficient retention of cyclin Cln3 at the ER. In the present work, we have identified new ...
  • Whi3 binds the mRNA of the G(1) cyclin CLN3 to modulate cell fate in budding yeast 

    Garí Marsol, Eloi; Volpe, Tom; Wang, Hongyin; Gallego, Carme; Futcher, Bruce; Aldea, Martí (Cold Spring Harbor Laboratory Press, 2001)
    Eukaryotic cells commit in G1 to a new mitotic cycle or to diverse differentiation processes. Here we show that Whi3 is a negative regulator of Cln3, a G1 cyclin that promotes transcription of many genes to trigger the ...
  • Pathologic Prognostic Factors in Endometrial Carcinoma (Other Than Tumor Type and Grade) 

    Singh, Naveena; Hirschowitz, Lynn; Zaino, Richard; Alvarado-Cabrero, Isabel; Duggan, Máire; Ali-Fehmi, Rouba; Euscher, Elizabeth; Hecht, Jonathan; Horn, Lars-Christian; Ioffe, Olga; Matias-Guiu, Xavier; McCluggage, W. Glenn; Mikami, Yoshiki; Ordi, Jaume; Parkash, Vinita; Quddus, M. Ruhul; Quick, Charles; Staebler, Annette; Zaloudek, Charles; Nucci, Marisa; Malpica, Anais; Oliva, Esther (Lippincott, Williams & Wilkins, 2019)
    Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase in both incidence and mortality over the next few decades. The ...
  • Endometrial Carcinoma, Grossing and Processing Issues: Recommendations of the International Society of Gynecologic Pathologists 

    Malpica, Anais; Euscher, Elizabeth; Hecht, Jonathan; Ali-Fehmi, Rouba; Quick, Charles; Singh, Naveena; Horn, Lars-Christian; Alvarado-Cabrero, Isabel; Matias-Guiu, Xavier; Hirschowitz, Lynn; Duggan, Máire; Ordi, Jaume; Parkash, Vinita; Mikami, Yoshiki; Quddus, M. Ruhul; Zaino, Richard; Staebler, Annette; Zaloudek, Charles; McCluggage, W. Glenn; Oliva, Esther (Lippincott, Williams & Wilkins, 2019)
    Endometrial cancer is the most common gynecologic neoplasm in developed countries; however, updated universal guidelines are currently not available to handle specimens obtained during the surgical treatment of patients ...
  • T-type Cav3.1 channels mediate progression and chemotherapeutic resistance in glioblastoma 

    Visa Pretel, Anna; Crespí Sallán, Marta; Maiques Carlos, Oscar; Alza, Lía; Talavera, Elisabeth; López-Ortega, Ricard; Santacana Espasa, Maria; Herreros Danés, Judit; Cantí Nicolás, Carles (American Association for Cancer Research, 2019)
    T-type Ca2+ channels (TTCC) have been identified as key regulators of cancer cell cycle and survival. In vivo studies in glioblastoma (GBM) murine xenografts have shown that drugs able to block TTCC in vitro (such as ...
  • High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations 

    Murali, Rajmohan; Davidson, Ben; Fadare, Oluwole; Carlson, Joseph A.; Crum, Christopher; Gilks, C. Blake; Irving, Julie A.; Malpica, Anais; Matias-Guiu, Xavier; McCluggage, W. Glenn; Mittal, Khush; Oliva, Esther; Parkash, Vinita; Rutgers, Joanne; Staats, Paul; Stewart, Colin; Tornos, Carmen; Soslow, Robert A. (Lippincott, Williams & Wilkins, 2019)
    This review of challenging diagnostic issues concerning high-grade endometrial carcinomasisderivedfromtheauthors’ reviewoftheliteraturefollowedbydiscussionsatthe Endometrial Cancer Workshop sponsored by the International ...
  • International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project: Guidelines From the Special Techniques and Ancillary Studies Group 

    Cho, Kathleen R.; Cooper, Kumarasen; Croce, Sabrina; Djordevic, Bojana; Herrington, Simon; Howitt, Brooke; Ip, Philip; Koebel, Martin; Lax, Sigurd; Quade, Bradley; Shaw, Patricia; Vidal, August; Yemelyanova, Anna; Clarke, Blaise; Hedrick Ellenson, Lora; Longacre, Teri A; Shih, Ie-Ming; McCluggage, W. Glenn; Malpica, Anais; Oliva, Esther; Parkash, Vinita; Matias-Guiu, Xavier (Lippincott, Williams & Wilkins, 2019)
    The aim of this article is to propose guidelines and recommendations in problematic areas in pathologic reporting of endometrial carcinoma (EC) regarding special techniques and ancillary studies. An organizing committee ...
  • A multicentre study investigating parameters which influence direct bacterial identification from urine 

    Zboromyrska, Yuliya; Bosch Mestres, Jordi; Aramburu, Jesus; Cuadros, Juan; García-Riestra, Carlos; Liébana Martos, Carmen; Loza, Elena; Muñoz-Algarra, María; Ruiz de Alegría, Carlos; Sánchez-Hellín, Victoria; Vila, Jordi (Public Library of Science, 2018)
    Rapid diagnosis is one of the best ways to improve patient management and prognosis as well as to combat the development of bacterial resistance. The aim of this study was to study parameters that impact the achievement ...
  • Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA 

    Narcís, Oriol J.; Tapia, Olga; Tarabal Mostazo, Olga; Piedrafita Llorens, Lídia; Calderó i Pardo, Jordi; Berciano, Maria T.; Lafarga, Miguel (Nature Research, 2018)
    Spinal muscular atrophy (SMA) is a severe motor neuron (MN) disease caused by the deletion or mutation of the survival motor neuron 1 (SMN1) gene, which results in reduced levels of the SMN protein and the selective ...
  • Quality of care indicators for a resuscitation unit: A descriptive study and proposal 

    Yuguero Torres, Oriol; Vena Martínez, Ana Belén; Forné, Carles; Lacasta García, José Daniel; Llobet, Cecilia; Abadías, María José (Lippincott, Williams & Wilkins, 2018)
    There are lack of indicators of quality of care in resuscitation units of emergency departments. With the aim of proposing a series of indicators to evaluate the quality of care delivered in hospital resuscitation areas, ...
  • Dissecting the Transcriptional Regulatory Properties of Human Chromosome 16 Highly Conserved Non-Coding Regions 

    Royo Sánchez-Palencia, José Luis; Hidalgo, Carmen; Roncero, Yolanda; Seda, María Ángeles; Akalin, Altuna; Lenhard, Boris; Casares, Fernando; Gómez-Skarmeta, José Luis (Public Library of Science, 2011)
    Non-coding DNA conservation across species has been often used as a predictor for transcriptional enhancer activity. However, only a few systematic analyses of the function of these highly conserved non-coding regions ...
  • Identification and Analysis of Conserved cis-Regulatory Regions of the MEIS1 Gene 

    Royo Sánchez-Palencia, José Luis; Bessa, José; Hidalgo, Carmen; Fernández-Miñán, Ana; Tena Aguilar, Juan Jesús; Roncero, Yolanda; Gómez-Skarmeta, José Luis; Casares, Fernando (Public Library of Science, 2012)
    Meis1, a conserved transcription factor of the TALE-homeodomain class, is expressed in a wide variety of tissues during development. Its complex expression pattern is likely to be controlled by an equally complex regulatory ...
  • proBDNF is modified by advanced glycation end products in Alzheimer’s disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing 

    Fleitas Pérez, Catherine; Piñol Ripoll, Gerard; Marfull, Pau; Rocandio, Daniel; Ferrer, Isidre; Rampon, Claire; Egea Navarro, Joaquim; Espinet Mestre, Carme (BMC, 2018)
    Alzheimer disease (AD) is a complex pathology related to multiple causes including oxidative stress. Brain-derived neurotrophic factor (BDNF) is a neutrotrophic factor essential for the survival and differentiation of ...
  • Creixement tumoral i metabolisme de l'hoste: dues cares d'una mateixa moneda 

    Argilés, Josep M.; Llovera i Tomàs, Marta; López-Soriano, Francisco J. (Institut d'Estudis Catalans, 1993)
    L'etiologia del càncer es basa fonamentalment en l'aparició d'un dany genètic en una cèl·lula que ocasiona una expressió anormal de determinats gens, els productes dels quals canvien dramàticament el fenotip cel·lular. Com ...

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