Browsing Articles publicats (Pedagogia i Psicologia) by Author "Pavón, Francisco Javier"
Now showing items 1-16 of 16
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A place for the hippocampus in the cocaine addiction circuit: Potential roles for adult hippocampal neurogenesis
Castilla Ortega, Estela; Serrano, Antonia; Blanco Calvo, Eduardo; Araos, Pedro; Suárez, Juan; Pavón, Francisco Javier; Rodríguez de Fonseca, Fernando; Santín, Luis (Elsevier, 2016-07-01)Cocaine addiction is a chronic brain disease in which the drug seeking habits and profound cognitive, emotional and motivational alterations emerge from drug-induced neuroadaptations on a vulnerable brain. Therefore, a ... -
Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA1 receptor results in increased alcohol consumption
Castilla Ortega, Estela; Pavón, Francisco Javier; Sanchez Marín, Laura; Estivill Torrús, Guillermo; Pedraza, Carmen; Blanco Calvo, Eduardo; Suárez, Juan; Santín, Luis; Rodríguez de Fonseca, Fernando; Serrano, Antonia (Elsevier, 2016-04-01)BACKGROUND: Lysophosphatidic acid species (LPA) are lipid bioactive signaling molecules that have been recently implicated in the modulation of emotional and motivational behaviors. The present study investigates the ... -
Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus
Blanco Calvo, Eduardo; Galeano, Pablo; Palomino, Ana; Pavón, Francisco Javier; Rivera, Patricia; Serrano, Antonia; Alen, Francisco; Rubio, Leticia; Vargas, Antonio; Castilla Ortega, Estela; Decara, Juan; Bilbao, Ainhoa; Rodríguez de Fonseca, Fernando; Suárez, Juan (Elsevier, 2016-03-01)In the reward mesocorticolimbic circuits, the glutamatergic and endocannabinoid systems are implicated in neurobiological mechanisms underlying cocaine addiction. However, the involvement of both systems in the hippocampus, ... -
Cocaine-induced behavioral sensitization is associated with changes in the expression of endocannabinoid and glutamatergic signaling systems in the mouse prefrontal cortex
Blanco Calvo, Eduardo; Pavón, Francisco Javier; Palomino, Ana; Luque-Rojas, María Jesús; Serrano, Antonia; Rivera, Patricia; Bilbao, Ainhoa; Alen, Francisco; Vida, Margarita; Suárez, Juan; Rodríguez de Fonseca, Fernando (Oxford University Press, 2015-01-01)Abstract Background: Endocannabinoids modulate the glutamatergic excitatory transmission by acting as retrograde messengers. A growing body of studies has reported that both signaling systems in the mesocorticolimbic neural ... -
Diet-dependent modulation of hippocampal expression of endocannabinoid signaling-related proteins in cannabinoid antagonist-treated obese rats
Rivera, Patricia; Luque-Rojas, María Jesús; Pastor, Antoni; Blanco Calvo, Eduardo; Pavón, Francisco Javier; Serrano, Antonia; Crespillo, Ana; Vida, Margarita; Grondona, Jesús M.; Cifuentes, Manuel; Bermúdez-Silva, Francisco J.; De la Torre, Rafael; Rodríguez de Fonseca, Fernando; Suárez, Juan (Federation of European Neuroscience Societies and John Wiley & Sons, 2013)Diet-induced obesity produces changes in endocannabinoid signaling (ECS), influencing the regulation of energy homeostasis. Recently, we demonstrated that, in high-fat-diet-fed rats, blockade of CB1 receptor by AM251 not ... -
Effects of acute versus repeated cocaine exposure on the expression of endocannabinoid signaling-related proteins in the mouse cerebellum
Palomino, Ana; Pavón, Francisco Javier; Blanco Calvo, Eduardo; Serrano, Antonia; Arrabal, Sergio; Rivera, Patricia; Alén, Francisco; Vargas, Antonio; Bilbao, Ainhoa; Rubio, Leticia; Rodríguez de Fonseca, Fernando; Suárez, Juan (Frontiers Media S.A., 2014-03-05)Growing awareness of cerebellar involvement in addiction is based on the cerebellum's intermediary position between motor and reward, potentially acting as an interface between motivational and cognitive functions. Here, ... -
Environmental Enrichment, Age, and PPARα Interact to Regulate Proliferation in Neurogenic Niches
Pérez Martín, Margarita; Rivera, Patricia; Blanco Calvo, Eduardo; Lorefice, Clara; Decara, Juan; Pavón, Francisco Javier; Serrano, Antonia; Rodríguez de Fonseca, Fernando; Suárez, Juan (Frontiers Media, 2016)Peroxisome proliferator-activated receptor alpha (PPARα) ligands have been shown to modulate recovery after brain insults such as ischemia and irradiation by enhancing neurogenesis. In the present study, we investigated ... -
Evaluation of plasma-free endocannabinoids and their congeners in abstinent cocaine addicts seeking outpatient treatment: impact of psychiatric co-morbidity
Pavón, Francisco Javier; Araos, Pedro; Pastor, Antoni; Calado, Montserrat; Pedraz, María; Campos Cloute, Rafael; Ruiz, Juan Jesús; Serrano, Antonia; Blanco Calvo, Eduardo; Rivera, Patricia; Suárez, Juan; Romero-Cuevas, Miguel; Pujadas, Mitona; Vergara-Moragues, Esperanza; Gornemann, Isolde; Torrens, Marta; De la Torre, Rafael; Rodríguez de Fonseca, Fernando (John Wiley & Sons, 2013-11-14)Cocaine is associated with serious health problems including psychiatric co-morbidity. There is a need for the identification of biomarkers for the stratification of cocaine-addicted subjects. Several studies have evaluated ... -
Lipid Transmitter Signaling as a New Target for Treatment of Cocaine Addiction: New Roles for Acylethanolamides and Lysophosphatidic Acid
Orio, Laura; Pavón, Francisco Javier; Blanco Calvo, Eduardo; Serrano, Antonia; Araos, Pedro; Pedraz, María; Rivera, Patricia; Calado, Montserrat; Suárez, Juan; Rodríguez de Fonseca, Fernando (Bentham Science Publishers, 2013)This review analyzes the roles of lipid transmitters, especially those derived from the cleavage of membrane phospholipids, in cocaine-associated behaviors. These lipid signals are important modulators of information ... -
Localization of peroxisome proliferator-activated receptor alpha (PPARa) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus
Rivera, Patricia; Arrabal, Sergio; Vargas, Antonio; Blanco Calvo, Eduardo; Serrano, Antonia; Pavón, Francisco Javier; Rodríguez de Fonseca, Fernando; Suárez, Juan (Frontiers Media S.A., 2014-03-17)The N-acylethanolamines (NAEs), oleoylethanolamide (OEA) and palmithylethanolamide (PEA) are known to be endogenous ligands of PPARα receptors, and their presence requires the activation of a specific phospholipase D ... -
Perinatal asphyxia results in altered expression of the hippocampal acylethanolamide/endocannabinoid signaling system associated to memory impairments in postweaned rats
Blanco Calvo, Eduardo; Holubiec, Mariana Inés; Romero, Juan Ignacio; Logica, Tamara; Rivera, Patricia; Pavón, Francisco Javier; Suárez, Juan; Capani, Francisco; Rodríguez de Fonseca, Fernando; Galeano, Pablo (Frontiers, 2015)Perinatal asphyxia (PA) is an obstetric complication that strongly affects the CNS. The endocannabinoid system (ECS) is a lipid transmitter system involved in several physiological processes including synaptic plasticity, ... -
Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain
Blanco Calvo, Eduardo; Rodríguez de Fonseca, Fernando; Rivera, Patricia; Suárez, Juan; Bindila, Laura; Alén, Francisco; Rubio, Leticia; Vargas, Antonio; Pavón, Francisco Javier; Serrano, Antonia; Lutz, Beat (Frontiers, 2015)Chronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor ... -
Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat
Blanco Calvo, Eduardo; Rivera, Patricia; Arrabal, Sergio; Vargas, Antonio; Pavón, Francisco Javier; Serrano, Antonia; Castilla Ortega, Estela; Galeano, Pablo; Rubio, Leticia; Suárez, Juan; Rodríguez de Fonseca, Fernando (Frontiers Media S.A., 2014-01-08)Addiction to major drugs of abuse, such as cocaine, has recently been linked to alterations in adult neurogenesis in the hippocampus. The endogenous cannabinoid system modulates this proliferative response as demonstrated ... -
Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure
Rivera, Patricia; Fernández Arjona, María del Mar; Silva Peña, Daniel; Blanco Calvo, Eduardo; Vargas, Antonio; López Ávalos, María Dolores; Grondona, Jesús M.; Serrano, Antonia; Pavón, Francisco Javier; Rodríguez de Fonseca, Fernando; Suárez, Juan (Elsevier, 2018)Changes in endogenous cannabinoid homeostasis are associated with both ethanol-related neuroinflammation and memory decline. Extensive research is still required to unveil the role of endocannabinoid signaling activation ... -
Pharmacological reduction of adult hippocampal neurogenesis modifies functional brain circuits in mice exposed to a cocaine conditioned place preference paradigm
Castilla Ortega, Estela; Blanco Calvo, Eduardo; Serrano, Antonia; Ladrón de Guevara-Miranda, David; Pedraz, María; Estivill Torrús, Guillermo; Pavón, Francisco Javier; Rodríguez de Fonseca, Fernando; Santín Núñez, Luis Javier (John Wiley & Sons, 2015-03-14)We investigated the role of adult hippocampal neurogenesis in cocaine-induced conditioned place preference (CPP) behaviour and the functional brain circuitry involved. Adult hippocampal neurogenesis was pharmacologically ... -
The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental parkinsonism
González Aparicio, Ramiro José; Blanco Calvo, Eduardo; Serrano, Antonia; Pavón, Francisco Javier; Parsons, Loren H.; Maldonado, Rafael; Robledo, Patrícia; Fernández Espejo, Emilio; Rodríguez de Fonseca, Fernando (Oxford University Press; Collegium Internationale Neuro-Psychopharmacologicum (CINP), 2014-03-01)Oleoylethanolamide (OEA) is an agonist of the peroxisome proliferator-activated receptor α (PPARα) and has been described to exhibit neuroprotective properties when administered locally in animal models of several neurological ...