Browsing Articles publicats (Pedagogia i Psicologia) by Author "Holubiec, Mariana Inés"
Now showing items 1-8 of 8
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Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia
Galeano, Pablo; Blanco Calvo, Eduardo; Logica, Tamara; Romero, Juan Ignacio; Holubiec, Mariana Inés; Rodríguez de Fonseca, Fernando; Capani, Francisco (Frontiers Media S.A., 2015-01-05)Continuous environmental stimulation induced by exposure to enriched environment (EE) has yielded cognitive benefits in different models of brain injury. Perinatal asphyxia results from a lack of oxygen supply to the fetus ... -
Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats
Galeano, Pablo; Romero, Juan Ignacio; Luque-Rojas, María Jesús; Suárez, Juan; Holubiec, Mariana Inés; Bisagno, Verónica; Santín Núñez, Luis Javier; Rodríguez de Fonseca, Fernando; Capani, Francisco; Blanco Calvo, Eduardo (Wiley Periodicals, 2013)Perinatal asphyxia (PA) increases the likelihood of suffering from dopamine-related disorders, such as ADHD and schizophrenia. Since dopaminergic transmission plays a major role in cocaine sensitization, the purpose of ... -
Neuronal damage induced by perinatal asphyxia is attenuated by postinjury glutaredoxin-2 administration
Romero, Juan Ignacio; Holubiec, Mariana Inés; Logica, Tamara; Rivière, Stéphanie; Hanschmann, Eva Maria; Kölliker Frers, Rodolfo; Tau, Julia; Blanco Calvo, Eduardo; Galeano, Pablo; Rodríguez de Fonseca, Fernando; Horst Lillig, Christopher; Capani, Francisco (Hindawi Publishing Corporation, 2017)The general disruption of redox signaling following an ischemia-reperfusion episode has been proposed as a crucial component in neuronal death and consequently brain damage. Thioredoxin (Trx) family proteins control redox ... -
Neuroprotective effects of hypothermia on synaptic actin cytoskeletal changes induced by perinatal asphyxia
Muñiz, Javier; Romero, Juan Ignacio; Holubiec, Mariana Inés; Barreto, George; González, Janneth; Saint-Martin, Madeleine; Blanco Calvo, Eduardo; Cavicchia, Juan Carlos; Castilla, Rocío; Capani, Francisco (Elsevier, 2014-05-14)Cerebral hypoxia-ischemia damages synaptic proteins, resulting in cytoskeletal alterations, protein aggregation and neuronal death. In the previous works, we have shown neuronal and synaptic changes in rat neostriatum ... -
Oleoylethanolamide and Palmitoylethanolamide Protect Cultured Cortical Neurons Against Hypoxia
Portavella, Manuel; Rodríguez Espinosa, Nieves; Galeano, Pablo; Blanco Calvo, Eduardo; Romero, Juan I.; Holubiec, Mariana Inés; Rodríguez de Fonseca, Fernando; Fernández Espejo, Emilio (Mary Ann Liebert, 2018-09-19)Introduction: Perinatal hypoxic-ischemic (HI) encephalopathy is defined as a neurological syndrome where the newborn suffers from acute ischemia and hypoxia during the perinatal period. New therapies are needed. The ... -
Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia
Holubiec, Mariana Inés; Romero, Juan I.; Suárez, Juan; Portavella, Manuel; Fernández Espejo, Emilio; Blanco Calvo, Eduardo; Galeano, Pablo; Rodríguez de Fonseca, Fernando (Springer Verlag, 2018)Neonatal anoxia-ischemia (AI) particularly affects the central nervous system. Despite the many treatments that have been tested, none of them has proven to be completely successful. Palmitoylethanolamide (PEA) and ... -
Perinatal asphyxia results in altered expression of the hippocampal acylethanolamide/endocannabinoid signaling system associated to memory impairments in postweaned rats
Blanco Calvo, Eduardo; Holubiec, Mariana Inés; Romero, Juan Ignacio; Logica, Tamara; Rivera, Patricia; Pavón, Francisco Javier; Suárez, Juan; Capani, Francisco; Rodríguez de Fonseca, Fernando; Galeano, Pablo (Frontiers, 2015)Perinatal asphyxia (PA) is an obstetric complication that strongly affects the CNS. The endocannabinoid system (ECS) is a lipid transmitter system involved in several physiological processes including synaptic plasticity, ... -
Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia
Romero, Juan Ignacio; Hanschmann, Eva Maria; Gellert,Manuela; Eitner,Susanne; Holubiec, Mariana Inés; Blanco Calvo, Eduardo; Lillig, Christopher Horst; Capani, Francisco (Elsevier, 2015-06-01)BACKGROUND: Thioredoxin (Trx) family proteins are crucial mediators of cell functions via regulation of the thiol redox state of various key proteins and the levels of the intracellular second messenger hydrogen peroxide. ...